Linshang Chemical
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2,-Fluoro-3-Chloro-4-Ethoxybenzeneboronicacid
Linshang Chemical
|
HS Code |
554755 |
| Name | 2-Fluoro-3-Chloro-4-Ethoxybenzeneboronic acid |
| Chemical Formula | C8H10BClFO3 |
| Molecular Weight | 220.427 g/mol |
| Appearance | Solid (usually white to off - white) |
| Melting Point | Typically in the range of 100 - 120°C (approximate, may vary) |
| Solubility In Water | Low solubility, sparingly soluble |
| Solubility In Organic Solvents | Soluble in some polar organic solvents like DMSO, THF |
| Pka | The boronic acid moiety has a pKa around 8 - 9 (approximate) |
| Stability | Stable under normal conditions, but may react with strong oxidizing agents |
As an accredited 2,-Fluoro-3-Chloro-4-Ethoxybenzeneboronicacid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 2 -fluoro-3 -chloro-4 -ethoxybenzeneboronic acid packaged in a sealed plastic bottle. |
| Storage | 2, -fluoro - 3 - chloro - 4 - ethoxybenzeneboronic acid should be stored in a cool, dry place away from direct sunlight. Keep it in a tightly - sealed container to prevent moisture absorption and contact with air, as boronic acids can be reactive. Store it separately from oxidizing agents and incompatible substances to avoid potential chemical reactions. Ensure the storage area has good ventilation. |
| Shipping | 2, -fluoro - 3 - chloro - 4 - ethoxybenzeneboronic acid is shipped in well - sealed containers to prevent leakage. Shipment follows strict chemical transportation regulations, ensuring safety during transit to the destination. |
Competitive 2,-Fluoro-3-Chloro-4-Ethoxybenzeneboronicacid prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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What are the main uses of -fluoro-3-chloro-4-ethoxybenzeneboronic acid?
2%2C+-fluoro-3-chloro-4-ethoxybenzeneboronic acid is 2-fluoro-3-chloro-4-ethoxyphenylboronic acid, which has a wide range of uses and is a key raw material in the field of organic synthesis.
In the construction of complex organic molecular structures, it can use its own unique structure to form carbon-carbon bonds with many organic halides, etc., through palladium-catalyzed coupling reactions, such as Suzuki-Miyaura coupling reactions, etc., and then build novel and complex organic frameworks. It opens up an effective way to create compounds with specific biological activities or physical properties.
In the field of pharmaceutical chemistry, this compound has a significant effect. Due to the presence of boron atoms and halogen atoms in its structure, it can become a key check point for the design and synthesis of new drug molecules. Through coupling reactions and other means, it can be connected with other structural units containing specific active groups, or molecules with unique pharmacological activities can be constructed, providing the possibility for the development of drugs for the treatment of various diseases.
In the field of materials science, 2-fluoro-3-chloro-4-ethoxyphenylboronic acid is also useful. In the process of synthesizing functional materials, it can be introduced as a key structural unit to endow materials with special electrical and optical properties. For example, in the preparation of organic optoelectronic materials, the molecular structures they participate in the construction may have a positive impact on the material's luminous efficiency, charge transport performance, etc., helping to develop new high-performance optoelectronic materials.
In the construction of complex organic molecular structures, it can use its own unique structure to form carbon-carbon bonds with many organic halides, etc., through palladium-catalyzed coupling reactions, such as Suzuki-Miyaura coupling reactions, etc., and then build novel and complex organic frameworks. It opens up an effective way to create compounds with specific biological activities or physical properties.
In the field of pharmaceutical chemistry, this compound has a significant effect. Due to the presence of boron atoms and halogen atoms in its structure, it can become a key check point for the design and synthesis of new drug molecules. Through coupling reactions and other means, it can be connected with other structural units containing specific active groups, or molecules with unique pharmacological activities can be constructed, providing the possibility for the development of drugs for the treatment of various diseases.
In the field of materials science, 2-fluoro-3-chloro-4-ethoxyphenylboronic acid is also useful. In the process of synthesizing functional materials, it can be introduced as a key structural unit to endow materials with special electrical and optical properties. For example, in the preparation of organic optoelectronic materials, the molecular structures they participate in the construction may have a positive impact on the material's luminous efficiency, charge transport performance, etc., helping to develop new high-performance optoelectronic materials.
What are the synthesis methods of -fluoro-3-chloro-4-ethoxybenzeneboronic acid?
There are various ways to synthesize 2-fluoro-3-chloro-4-ethoxyphenylboronic acid, which you have described in detail today.
One method can be started with halogenated aromatics. Take 2-fluoro-3-chloro-4-ethoxybromobenzene first, react it with magnesium chips, and prepare Grignard's reagent in anhydrous ether or tetrahydrofuran. This reaction requires water and oxygen to prevent Grignard's reagent from decomposing in contact with water or oxygen. After the Grignard reagent is prepared, trimethyl borate is introduced, the reaction is completed, and the dilute acid is hydrolyzed to obtain 2-fluoro-3-chloro-4-ethoxyphenylboronic acid. In this process, the Grignard reagent has high activity and must be operated with caution.
Another method can be borrowed from the Suzuki reaction principle. Using 2-fluoro-3-chloro-4-ethoxyhalobenzene and pinacol biborate as raw materials, in the presence of palladium catalysts such as tetrakis (triphenylphosphine) palladium (0), and bases such as potassium carbonate and sodium carbonate, it reacts in organic solvents such as toluene and dioxane. The reaction temperature and time need to be precisely controlled to promote the complete reaction. After the reaction is separated and purified, the target product is also obtained. This method has good selectivity and few side reactions.
Another method can be started from 2-fluoro-3-chloro-4-ethoxyaniline. First, it is diazotized, and it reacts with sodium nitrite and hydrochloric acid at low temperature to form a diazonium salt. Then the diazonium salt is reacted with boric acid or borate ester, and after appropriate treatment, it can be converted into 2-fluoro-3-chloro-4-ethoxyphenylboronic acid. This route step is slightly complicated, and the diazotization reaction conditions are harsh. If the temperature is too high, it is easy to cause the decomposition of diazonium salts.
Although there are many methods of synthesis, each has its advantages and disadvantages. It is necessary to weigh the availability of raw materials, cost, reaction conditions, yield, purity requirements and many other factors, and choose the optimal method to achieve the purpose of synthesis.
One method can be started with halogenated aromatics. Take 2-fluoro-3-chloro-4-ethoxybromobenzene first, react it with magnesium chips, and prepare Grignard's reagent in anhydrous ether or tetrahydrofuran. This reaction requires water and oxygen to prevent Grignard's reagent from decomposing in contact with water or oxygen. After the Grignard reagent is prepared, trimethyl borate is introduced, the reaction is completed, and the dilute acid is hydrolyzed to obtain 2-fluoro-3-chloro-4-ethoxyphenylboronic acid. In this process, the Grignard reagent has high activity and must be operated with caution.
Another method can be borrowed from the Suzuki reaction principle. Using 2-fluoro-3-chloro-4-ethoxyhalobenzene and pinacol biborate as raw materials, in the presence of palladium catalysts such as tetrakis (triphenylphosphine) palladium (0), and bases such as potassium carbonate and sodium carbonate, it reacts in organic solvents such as toluene and dioxane. The reaction temperature and time need to be precisely controlled to promote the complete reaction. After the reaction is separated and purified, the target product is also obtained. This method has good selectivity and few side reactions.
Another method can be started from 2-fluoro-3-chloro-4-ethoxyaniline. First, it is diazotized, and it reacts with sodium nitrite and hydrochloric acid at low temperature to form a diazonium salt. Then the diazonium salt is reacted with boric acid or borate ester, and after appropriate treatment, it can be converted into 2-fluoro-3-chloro-4-ethoxyphenylboronic acid. This route step is slightly complicated, and the diazotization reaction conditions are harsh. If the temperature is too high, it is easy to cause the decomposition of diazonium salts.
Although there are many methods of synthesis, each has its advantages and disadvantages. It is necessary to weigh the availability of raw materials, cost, reaction conditions, yield, purity requirements and many other factors, and choose the optimal method to achieve the purpose of synthesis.
What are the physical properties of -fluoro-3-chloro-4-ethoxybenzeneboronic acid?
2%2C+-fluoro-3-chloro-4-ethoxybenzeneboronic acid is 2-fluoro-3-chloro-4-ethoxyphenylboronic acid. This is an organoboron compound, which has a wide range of uses in the field of organic synthesis. It is often used as a key intermediate to participate in the formation of carbon-carbon bonds and other reactions. Its physical properties are as follows:
- ** Appearance characteristics **: Under normal circumstances, it is mostly white to off-white solid powder. This appearance feature is conducive to observation and identification. In laboratory operations or industrial production, its purity and state can be preliminarily judged by its appearance. White to off-white indicates that the compound has high purity. If there is variegation, it may mean that impurities are mixed.
- ** Melting point **: The melting point is usually in a specific temperature range, and different literature reports or experimental conditions vary slightly. Accurate determination of the melting point is essential for the identification of the compound. The melting point is the inherent physical property of the substance. By comparing with the literature value, its purity can be judged. If the measured melting point is consistent with the standard value and the melting range is narrow, it means that the purity is good; conversely, the wide melting range may contain impurities.
- ** Solubility **: It has a certain solubility in common organic solvents such as dichloromethane, N, N-dimethylformamide (DMF), tetrahydrofuran (THF), etc. This property is of great significance in organic synthesis, and the solubility determines the choice of reaction solvent. Dichloromethane has moderate polarity and good solubility to most organic compounds. If the reaction is carried out in a homogeneous solution, dichloromethane can be considered as a solvent to fully contact the reactants and speed up the reaction rate. Polar aprotic solvents such as DMF and THF can promote the smooth progress of the reaction for some reactions that require a specific solvent environment. However, the solubility in water is relatively low, because its molecular structure has a large proportion of hydrophobic groups, which limits its ability to form hydrogen bonds with water.
- ** Stability **: It is relatively stable under general conditions, but needs to be properly stored. It is more sensitive to humidity, and it is prone to hydrolysis when exposed to water, resulting in structural damage and affecting its activity and effect in the reaction. Therefore, it should be stored in a dry environment, and a desiccant can be used to maintain the dry storage environment. At the same time, avoid contact with strong oxidants, strong bases and other substances, because the boron atoms in the structure and the substituents on the benzene ring will chemically react with these substances and change their chemical properties.
- ** Appearance characteristics **: Under normal circumstances, it is mostly white to off-white solid powder. This appearance feature is conducive to observation and identification. In laboratory operations or industrial production, its purity and state can be preliminarily judged by its appearance. White to off-white indicates that the compound has high purity. If there is variegation, it may mean that impurities are mixed.
- ** Melting point **: The melting point is usually in a specific temperature range, and different literature reports or experimental conditions vary slightly. Accurate determination of the melting point is essential for the identification of the compound. The melting point is the inherent physical property of the substance. By comparing with the literature value, its purity can be judged. If the measured melting point is consistent with the standard value and the melting range is narrow, it means that the purity is good; conversely, the wide melting range may contain impurities.
- ** Solubility **: It has a certain solubility in common organic solvents such as dichloromethane, N, N-dimethylformamide (DMF), tetrahydrofuran (THF), etc. This property is of great significance in organic synthesis, and the solubility determines the choice of reaction solvent. Dichloromethane has moderate polarity and good solubility to most organic compounds. If the reaction is carried out in a homogeneous solution, dichloromethane can be considered as a solvent to fully contact the reactants and speed up the reaction rate. Polar aprotic solvents such as DMF and THF can promote the smooth progress of the reaction for some reactions that require a specific solvent environment. However, the solubility in water is relatively low, because its molecular structure has a large proportion of hydrophobic groups, which limits its ability to form hydrogen bonds with water.
- ** Stability **: It is relatively stable under general conditions, but needs to be properly stored. It is more sensitive to humidity, and it is prone to hydrolysis when exposed to water, resulting in structural damage and affecting its activity and effect in the reaction. Therefore, it should be stored in a dry environment, and a desiccant can be used to maintain the dry storage environment. At the same time, avoid contact with strong oxidants, strong bases and other substances, because the boron atoms in the structure and the substituents on the benzene ring will chemically react with these substances and change their chemical properties.
2, what are the chemical properties of -fluoro-3-chloro-4-ethoxybenzeneboronic acid
2%2C+-fluoro-3-chloro-4-ethoxybenzeneboronic acid is 2-fluoro-3-chloro-4-ethoxyphenylboronic acid, which is an organoboronic acid compound. Its chemical properties are unique and it has a wide range of uses in the field of organic synthesis.
In terms of reactivity, the boric acid group (-B (OH) -2) in this compound has typical boric acid chemical properties and can participate in many classical reactions. For example, under the catalysis of transition metals, Suzuki-Miyaura coupling reactions can occur with halogenated aromatics, olefins, etc. This reaction is extremely important and is often used to construct carbon-carbon bonds, whereby benzene rings can be connected with other organic groups to realize the construction of complex organic molecules. In the reaction, the boric acid group first undergoes a series of complex steps such as oxidative addition with the metal catalyst, and finally forms a new carbon-carbon bond with the halogenate, providing an efficient and selective synthesis method for organic synthesis chemists.
Its stability is relatively stable, but it will also change under specific conditions. Under basic conditions, the boric acid group may deprotonate to form borate ions, which will affect its reactivity and selectivity. At the same time, if there are nucleophiles in the system, it may also react with the boric acid group, resulting in changes in the molecular structure.
In addition, the fluorine and chlorine atoms in this compound also give it special properties. Fluorine atoms have strong electronegativity, which will affect the electron cloud distribution of molecules, thereby changing their physical and chemical properties, such as enhancing the lipophilicity of molecules. Chlorine atoms also affect the electronic structure of molecules, and under appropriate conditions, they can be used as leaving groups to participate in reactions such as nucleophilic substitution, and cooperate with the reaction of boric acid groups to provide a variety of paths for organic synthesis.
From the perspective of solubility, due to the presence of polar boric acid groups and relatively non-polar benzene ring, ethoxy group and other structures, there should be a certain solubility in common organic solvents such as ethanol and dichloromethane. The specific solubility is affected by factors such as temperature and solvent polarity. In organic synthesis operations, it is necessary to choose a suitable solvent according to its solubility characteristics to ensure the smooth progress of the reaction.
In terms of reactivity, the boric acid group (-B (OH) -2) in this compound has typical boric acid chemical properties and can participate in many classical reactions. For example, under the catalysis of transition metals, Suzuki-Miyaura coupling reactions can occur with halogenated aromatics, olefins, etc. This reaction is extremely important and is often used to construct carbon-carbon bonds, whereby benzene rings can be connected with other organic groups to realize the construction of complex organic molecules. In the reaction, the boric acid group first undergoes a series of complex steps such as oxidative addition with the metal catalyst, and finally forms a new carbon-carbon bond with the halogenate, providing an efficient and selective synthesis method for organic synthesis chemists.
Its stability is relatively stable, but it will also change under specific conditions. Under basic conditions, the boric acid group may deprotonate to form borate ions, which will affect its reactivity and selectivity. At the same time, if there are nucleophiles in the system, it may also react with the boric acid group, resulting in changes in the molecular structure.
In addition, the fluorine and chlorine atoms in this compound also give it special properties. Fluorine atoms have strong electronegativity, which will affect the electron cloud distribution of molecules, thereby changing their physical and chemical properties, such as enhancing the lipophilicity of molecules. Chlorine atoms also affect the electronic structure of molecules, and under appropriate conditions, they can be used as leaving groups to participate in reactions such as nucleophilic substitution, and cooperate with the reaction of boric acid groups to provide a variety of paths for organic synthesis.
From the perspective of solubility, due to the presence of polar boric acid groups and relatively non-polar benzene ring, ethoxy group and other structures, there should be a certain solubility in common organic solvents such as ethanol and dichloromethane. The specific solubility is affected by factors such as temperature and solvent polarity. In organic synthesis operations, it is necessary to choose a suitable solvent according to its solubility characteristics to ensure the smooth progress of the reaction.
What is the price range of -fluoro-3-chloro-4-ethoxybenzeneboronic acid in the market?
I think what you are asking is that 2-fluoro-3-chloro-4-ethoxyphenylboronic acid is in the market price range. However, the price of this compound is difficult to hide. Its price often changes due to various factors, and the market is also dynamic.
The first to bear the brunt is the price of raw materials. If the price of fluoride, chloride and ethoxylated raw materials required to synthesize this acid is high, the price of the finished product will also be high. The stability of the supply of raw materials also affects the price. If the supply of raw materials is short, the price will rise.
Furthermore, the simplicity of the preparation process is related to the cost. If special reaction conditions are required, such as high temperature, high pressure, or expensive catalysts, the cost will increase, resulting in an increase in the price of the product.
In addition, market demand and competition also determine its price. If the demand for this compound is strong and the supply is limited, the price will tend to rise; conversely, if the market is oversupplied, merchants may reduce the price in order to sell their goods.
As far as I know, it is difficult to determine the exact price range without detailed investigation of the current market conditions. However, generally speaking, the price of such fine chemicals may have a large span due to the difficulty of preparation and the characteristics of their uses. For small-scale laboratory-level purchases, the price per gram may range from tens to hundreds of yuan; if it is an industrial-scale demand and a large-scale purchase, the price per kilogram may be reduced due to the scale effect, but it also depends on the specific supply, demand and cost, or around thousands of yuan per kilogram. This is only a rough guess, and the actual price should be based on the real-time market situation.
The first to bear the brunt is the price of raw materials. If the price of fluoride, chloride and ethoxylated raw materials required to synthesize this acid is high, the price of the finished product will also be high. The stability of the supply of raw materials also affects the price. If the supply of raw materials is short, the price will rise.
Furthermore, the simplicity of the preparation process is related to the cost. If special reaction conditions are required, such as high temperature, high pressure, or expensive catalysts, the cost will increase, resulting in an increase in the price of the product.
In addition, market demand and competition also determine its price. If the demand for this compound is strong and the supply is limited, the price will tend to rise; conversely, if the market is oversupplied, merchants may reduce the price in order to sell their goods.
As far as I know, it is difficult to determine the exact price range without detailed investigation of the current market conditions. However, generally speaking, the price of such fine chemicals may have a large span due to the difficulty of preparation and the characteristics of their uses. For small-scale laboratory-level purchases, the price per gram may range from tens to hundreds of yuan; if it is an industrial-scale demand and a large-scale purchase, the price per kilogram may be reduced due to the scale effect, but it also depends on the specific supply, demand and cost, or around thousands of yuan per kilogram. This is only a rough guess, and the actual price should be based on the real-time market situation.
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