Linshang Chemical
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2-Fluoro-4-Bromochlorobenzene
Linshang Chemical
|
HS Code |
530045 |
| Chemical Formula | C6H3BrClF |
| Molar Mass | 225.44 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | Approx. 188 - 190 °C |
| Density | Approx. 1.84 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Flash Point | Approx. 77 °C |
| Vapor Pressure | Low at room temperature |
| Stability | Stable under normal conditions, but may react with strong oxidizing agents |
As an accredited 2-Fluoro-4-Bromochlorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 2 - fluoro - 4 - bromochlorobenzene packaged in a sealed glass bottle. |
| Storage | 2 - fluoro - 4 - bromochlorobenzene should be stored in a cool, dry, well - ventilated area away from sources of ignition. Keep it in a tightly closed container to prevent vapor leakage. Store it separately from oxidizing agents and incompatible substances. Since it's a potentially hazardous chemical, proper labeling and storage in a designated chemical storage area, following safety regulations, is essential. |
| Shipping | 2 - fluoro - 4 - bromochlorobenzene is shipped in specialized, leak - proof containers. These are well - labeled for chemical identification. Transport follows strict safety regulations, ensuring secure delivery to prevent environmental and safety risks. |
Competitive 2-Fluoro-4-Bromochlorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 2-Fluoro-4-Bromochlorobenzene in China?
As a trusted 2-Fluoro-4-Bromochlorobenzene manufacturer, we deliver:
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 2-Fluoro-4-Bromochlorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 2-fluoro-4-bromochlorobenzene?
2-Fluoro-4-bromochlorobenzene is one of the organic compounds. Its chemical properties are quite noteworthy.
The first part of its substitution reaction. Because of the presence of fluorine, bromine and chlorine atoms on the benzene ring, the electron cloud density of the benzene ring is reduced, so the electrophilic substitution reaction is more difficult than that of benzene. However, the atoms at specific positions can still be replaced under appropriate conditions. In the case of nucleophiles, although fluorine atoms have high electronegativity and high carbon-fluorine bond energy, they may also be replaced by nucleophiles under extreme conditions such as strong bases or high temperatures, and nucleophilic substitution reactions may occur.
The second part of its addition reaction. The benzene ring in this compound has a certain degree of unsaturation. Under specific catalysts and suitable conditions, it can undergo an addition reaction with hydrogen, etc., and the conjugate system of the benzene ring is destroyed to form a saturated alicyclic compound.
Furthermore, the halogen atom-related reaction. Bromine and chlorine atoms can participate in many organic reactions. In the presence of metal catalysts, it can be coupled with organometallic reagents, which has great application value in the reaction of building carbon-carbon bonds and can be used to synthesize more complex organic molecules.
In addition, its chemical properties are also affected by the interaction of atoms in the molecule. The electron-absorbing induction effect of fluorine atoms can affect the distribution of electron clouds in ortho and para-sites, and then affect the reactivity of bromine and chlorine atoms. At the same time, the spatial structure of molecules and electronic effects jointly determine their performance in various chemical reactions.
First of all, the chemical properties of 2-fluoro-4-bromochlorobenzene are determined by their molecular structure. It has many potential applications in organic synthesis and other fields, and various chemical transformations can be realized under different reaction conditions.
The first part of its substitution reaction. Because of the presence of fluorine, bromine and chlorine atoms on the benzene ring, the electron cloud density of the benzene ring is reduced, so the electrophilic substitution reaction is more difficult than that of benzene. However, the atoms at specific positions can still be replaced under appropriate conditions. In the case of nucleophiles, although fluorine atoms have high electronegativity and high carbon-fluorine bond energy, they may also be replaced by nucleophiles under extreme conditions such as strong bases or high temperatures, and nucleophilic substitution reactions may occur.
The second part of its addition reaction. The benzene ring in this compound has a certain degree of unsaturation. Under specific catalysts and suitable conditions, it can undergo an addition reaction with hydrogen, etc., and the conjugate system of the benzene ring is destroyed to form a saturated alicyclic compound.
Furthermore, the halogen atom-related reaction. Bromine and chlorine atoms can participate in many organic reactions. In the presence of metal catalysts, it can be coupled with organometallic reagents, which has great application value in the reaction of building carbon-carbon bonds and can be used to synthesize more complex organic molecules.
In addition, its chemical properties are also affected by the interaction of atoms in the molecule. The electron-absorbing induction effect of fluorine atoms can affect the distribution of electron clouds in ortho and para-sites, and then affect the reactivity of bromine and chlorine atoms. At the same time, the spatial structure of molecules and electronic effects jointly determine their performance in various chemical reactions.
First of all, the chemical properties of 2-fluoro-4-bromochlorobenzene are determined by their molecular structure. It has many potential applications in organic synthesis and other fields, and various chemical transformations can be realized under different reaction conditions.
What are the main uses of 2-fluoro-4-bromochlorobenzene?
2-Fluoro-4-bromochlorobenzene is a crucial compound in the field of organic synthesis and has a wide range of uses.
In the field of medicinal chemistry, this compound can be used as a key intermediate for the creation of various drugs. Due to its unique chemical structure, molecular structures with specific biological activities can be constructed through ingenious organic reactions. For example, in the development of antibacterial drugs, a series of chemical modifications to 2-fluoro-4-bromochlorobenzene can be used to introduce functional groups that can bind to specific bacterial targets, thereby giving the drug excellent antibacterial properties.
In the field of materials science, 2-fluoro-4-bromochlorobenzene is also useful. It can be used as a raw material to participate in the preparation of high-performance organic materials, such as organic optoelectronic materials. Due to the presence of halogen atoms in its structure, it can adjust the electron cloud distribution of the material, which in turn affects the optical and electrical properties of the material. Organic optoelectronic materials synthesized on the basis of this compound may exhibit excellent photoelectric conversion efficiency and play an important role in the manufacture of solar cells, Light Emitting Diodes and other devices.
In addition, in the field of pesticide chemistry, 2-fluoro-4-bromochlorobenzene is also often used as a starting material for the synthesis of new pesticides. Through chemical synthesis, it can be converted into pesticide products with efficient pest killing effect and environmental friendliness. Due to the characteristics of halogen atoms, it may enhance the interaction between pesticide molecules and target check points in pests, and improve the insecticidal activity and selectivity of pesticides. In short, 2-fluoro-4-bromochlorobenzene has its unique structure, which cannot be ignored in many important fields.
In the field of medicinal chemistry, this compound can be used as a key intermediate for the creation of various drugs. Due to its unique chemical structure, molecular structures with specific biological activities can be constructed through ingenious organic reactions. For example, in the development of antibacterial drugs, a series of chemical modifications to 2-fluoro-4-bromochlorobenzene can be used to introduce functional groups that can bind to specific bacterial targets, thereby giving the drug excellent antibacterial properties.
In the field of materials science, 2-fluoro-4-bromochlorobenzene is also useful. It can be used as a raw material to participate in the preparation of high-performance organic materials, such as organic optoelectronic materials. Due to the presence of halogen atoms in its structure, it can adjust the electron cloud distribution of the material, which in turn affects the optical and electrical properties of the material. Organic optoelectronic materials synthesized on the basis of this compound may exhibit excellent photoelectric conversion efficiency and play an important role in the manufacture of solar cells, Light Emitting Diodes and other devices.
In addition, in the field of pesticide chemistry, 2-fluoro-4-bromochlorobenzene is also often used as a starting material for the synthesis of new pesticides. Through chemical synthesis, it can be converted into pesticide products with efficient pest killing effect and environmental friendliness. Due to the characteristics of halogen atoms, it may enhance the interaction between pesticide molecules and target check points in pests, and improve the insecticidal activity and selectivity of pesticides. In short, 2-fluoro-4-bromochlorobenzene has its unique structure, which cannot be ignored in many important fields.
What are 2-fluoro-4-bromochlorobenzene synthesis methods?
The method of preparing 2-fluoro-4-bromochlorobenzene depends on the technique of organic synthesis. Common ones include halogenation reactions.
First, appropriate aromatic compounds are used as starting materials, such as derivatives of benzene. First, bromine atoms are introduced into the benzene ring, which can be achieved by bromination reaction. Under appropriate reaction conditions, such as in the presence of a catalyst, liquid bromine is reacted with benzene derivatives, so that bromine atoms are selectively attached to specific positions in the benzene ring. The catalysts used are often iron filings or iron tribromide, etc., which are used to form complexes with bromine to enhance the electrophilicity of bromine and promote the reaction to occur easily.
After the bromine atom is successfully introduced, the fluorination reaction is carried out. The fluorination process, or the nucleophilic substitution reaction is used. With a suitable fluorine source, such as potassium fluoride, under specific solvent and reaction conditions, the fluorine atom is substituted for the group at the appropriate position on the benzene ring, and then 2-fluoro-4-bromochlorobenzene is obtained. Among them, the choice of solvent is quite critical, and it is necessary to consider its solubility to the reactants and products, as well as the effect on the reaction rate and selectivity.
In addition, there may be other synthesis paths. For example, chlorine atoms are introduced first, and then bromine and fluorine atoms are introduced. However, each step of the reaction requires precise control of the reaction conditions, such as temperature, reaction time, and the proportion of reactants, in order to obtain the target product 2-fluoro-4-bromochlorobenzene with higher yield and purity. And during the reaction process, various separation and purification methods, such as distillation, recrystallization, column chromatography, etc., are often used to remove impurities and obtain pure products.
First, appropriate aromatic compounds are used as starting materials, such as derivatives of benzene. First, bromine atoms are introduced into the benzene ring, which can be achieved by bromination reaction. Under appropriate reaction conditions, such as in the presence of a catalyst, liquid bromine is reacted with benzene derivatives, so that bromine atoms are selectively attached to specific positions in the benzene ring. The catalysts used are often iron filings or iron tribromide, etc., which are used to form complexes with bromine to enhance the electrophilicity of bromine and promote the reaction to occur easily.
After the bromine atom is successfully introduced, the fluorination reaction is carried out. The fluorination process, or the nucleophilic substitution reaction is used. With a suitable fluorine source, such as potassium fluoride, under specific solvent and reaction conditions, the fluorine atom is substituted for the group at the appropriate position on the benzene ring, and then 2-fluoro-4-bromochlorobenzene is obtained. Among them, the choice of solvent is quite critical, and it is necessary to consider its solubility to the reactants and products, as well as the effect on the reaction rate and selectivity.
In addition, there may be other synthesis paths. For example, chlorine atoms are introduced first, and then bromine and fluorine atoms are introduced. However, each step of the reaction requires precise control of the reaction conditions, such as temperature, reaction time, and the proportion of reactants, in order to obtain the target product 2-fluoro-4-bromochlorobenzene with higher yield and purity. And during the reaction process, various separation and purification methods, such as distillation, recrystallization, column chromatography, etc., are often used to remove impurities and obtain pure products.
2-fluoro-4-bromochlorobenzene What are the precautions in storage and transportation?
2-Fluoro-4-bromochlorobenzene is also an organic compound. During storage and transportation, many matters need to be paid attention to.
First word storage. This compound is active or active, afraid of heat and light. Therefore, it should be stored in a cool, dry and well-ventilated place, away from fire, heat sources, and protected from direct light. Because it has a certain chemical activity, if exposed to heat or light, it may decompose, deteriorate, damage its quality, and even be dangerous. It must also be separated from oxidants, acids, bases and other substances to prevent chemical reactions caused by interaction. Because its chemical structure contains halogen atoms, it is easy to react when encountering specific chemicals, and mixing is dangerous. At the same time, the storage area should be equipped with suitable containment of leaking materials in case of leakage and can be dealt with in time.
Second talk about transportation. The packaging must be tight during transportation to ensure that there is no risk of leakage. Because of its toxicity and irritation, leakage endangers the environment and personnel safety. Transportation vehicles must be properly selected, with fire and explosion-proof capabilities. And the transportation process should avoid high temperature periods and routes, slow and steady, to prevent packaging damage caused by bumps. Escort personnel must also be professionally trained, familiar with the characteristics of this compound and emergency disposal methods. Once there is a leak on the way, it can be dealt with quickly according to the plan, and the harm can be minimized. In short, the storage and transportation of 2-fluoro-4-bromochlorobenzene should be done with great care and in accordance with regulations to ensure safety.
First word storage. This compound is active or active, afraid of heat and light. Therefore, it should be stored in a cool, dry and well-ventilated place, away from fire, heat sources, and protected from direct light. Because it has a certain chemical activity, if exposed to heat or light, it may decompose, deteriorate, damage its quality, and even be dangerous. It must also be separated from oxidants, acids, bases and other substances to prevent chemical reactions caused by interaction. Because its chemical structure contains halogen atoms, it is easy to react when encountering specific chemicals, and mixing is dangerous. At the same time, the storage area should be equipped with suitable containment of leaking materials in case of leakage and can be dealt with in time.
Second talk about transportation. The packaging must be tight during transportation to ensure that there is no risk of leakage. Because of its toxicity and irritation, leakage endangers the environment and personnel safety. Transportation vehicles must be properly selected, with fire and explosion-proof capabilities. And the transportation process should avoid high temperature periods and routes, slow and steady, to prevent packaging damage caused by bumps. Escort personnel must also be professionally trained, familiar with the characteristics of this compound and emergency disposal methods. Once there is a leak on the way, it can be dealt with quickly according to the plan, and the harm can be minimized. In short, the storage and transportation of 2-fluoro-4-bromochlorobenzene should be done with great care and in accordance with regulations to ensure safety.
What are the effects of 2-fluoro-4-bromochlorobenzene on the environment and human health?
2-Fluoro-4-bromochlorobenzene is one of the organic compounds. The impact on the environment and human health is of great concern.
Looking at its impact on the environment, this compound has certain stability and is difficult to degrade in the natural environment. If released in water bodies, it can persist for a long time, causing water pollution. It may be ingested by aquatic organisms, transmitted and enriched through the food chain, endangering aquatic ecosystems. In soil, it can affect the activity and community structure of soil microorganisms, which in turn is detrimental to soil fertility and plant growth.
As for the impact on human health, 2-fluoro-4-bromochlorobenzene may be potentially toxic. After ingesting the human body through respiratory tract, skin contact or diet, it may involve multiple systems. First, it may irritate the respiratory tract, causing symptoms such as cough and asthma, and long-term exposure or damage to lung function. Second, skin contact may cause skin allergies and inflammation, such as itching and erythema. Third, after entering the human body, it may interfere with the endocrine system, affect hormone balance, and cause reproductive and developmental problems. Furthermore, studies have also shown that it may be potentially carcinogenic, and long-term exposure or increase the risk of cancer.
From this perspective, 2-fluoro-4-bromochlorobenzene has a significant impact on the environment and human health. During its production, use and disposal, it is necessary to maintain a prudent attitude and take effective measures to reduce the harm to the environment and people.
Looking at its impact on the environment, this compound has certain stability and is difficult to degrade in the natural environment. If released in water bodies, it can persist for a long time, causing water pollution. It may be ingested by aquatic organisms, transmitted and enriched through the food chain, endangering aquatic ecosystems. In soil, it can affect the activity and community structure of soil microorganisms, which in turn is detrimental to soil fertility and plant growth.
As for the impact on human health, 2-fluoro-4-bromochlorobenzene may be potentially toxic. After ingesting the human body through respiratory tract, skin contact or diet, it may involve multiple systems. First, it may irritate the respiratory tract, causing symptoms such as cough and asthma, and long-term exposure or damage to lung function. Second, skin contact may cause skin allergies and inflammation, such as itching and erythema. Third, after entering the human body, it may interfere with the endocrine system, affect hormone balance, and cause reproductive and developmental problems. Furthermore, studies have also shown that it may be potentially carcinogenic, and long-term exposure or increase the risk of cancer.
From this perspective, 2-fluoro-4-bromochlorobenzene has a significant impact on the environment and human health. During its production, use and disposal, it is necessary to maintain a prudent attitude and take effective measures to reduce the harm to the environment and people.
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