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2-Fluoro-4-Chlorobromobenzene
Linshang Chemical
|
HS Code |
186777 |
| Chemical Formula | C6H3BrClF |
| Molecular Weight | 225.44 |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | Approximately 200 - 205°C |
| Density | Around 1.8 - 1.9 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Vapor Pressure | Low at room temperature |
| Flash Point | Relatively high, indicating low flammability |
As an accredited 2-Fluoro-4-Chlorobromobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 2 - fluoro - 4 - chlorobromobenzene packaged in a sealed glass bottle. |
| Storage | 2 - fluoro - 4 - chlorobromobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and strong oxidizing agents. Store it in a tightly closed container, preferably made of corrosion - resistant materials, to prevent leakage. Label the container clearly to avoid misidentification. |
| Shipping | 2 - fluoro - 4 - chlorobromobenzene is shipped in well - sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations, ensuring proper labeling and secure packaging to prevent leakage during transit. |
Competitive 2-Fluoro-4-Chlorobromobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 2-Fluoro-4-Chlorobromobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 2-fluoro-4-chlorobromobenzene?
2-Fluoro-4-chlorobrombenzene is also an organic compound. It has the generality of halogenated aromatics and shows its unique characteristics in chemical reactions.
This compound has a unique reactivity due to the existence of fluorine, chlorine and bromine trihalides. Fluorine atoms have strong electronegativity, which can reduce the density of the electron cloud of the benzene ring, and the electrophilic substitution reaction is difficult to occur. However, it can enhance the polarity of molecules, which may be a key factor in specific reactions.
Chlorine atoms and bromine atoms also affect the distribution of the electron cloud of the benzene ring, and due to the difference in atomic radius, it has an effect on the reactivity and selectivity. In nucleophilic substitution reactions, bromine atoms are easier to leave due to relatively small bond energy, providing an opportunity for nucleophilic reagents to attack.
2-fluoro-4-chlorobromobenzene has good solubility in organic solvents, which facilitates its participation in various organic synthesis reactions. Its stability is acceptable at room temperature and pressure, but it may be dangerous in case of high temperature, open flame or strong oxidant.
In the field of organic synthesis, 2-fluoro-4-chlorobromobenzene is an important intermediate. Complex organic molecular structures can be constructed by means of nucleophilic substitution, coupling reactions, etc. If it reacts with nucleophiles containing specific functional groups, new groups can be introduced to expand the diversity of molecules.
In short, 2-fluoro-4-chlorobromobenzene plays a pivotal role in the field of organic chemical synthesis due to its unique chemical properties, providing possibilities and approaches for the preparation of many organic compounds.
This compound has a unique reactivity due to the existence of fluorine, chlorine and bromine trihalides. Fluorine atoms have strong electronegativity, which can reduce the density of the electron cloud of the benzene ring, and the electrophilic substitution reaction is difficult to occur. However, it can enhance the polarity of molecules, which may be a key factor in specific reactions.
Chlorine atoms and bromine atoms also affect the distribution of the electron cloud of the benzene ring, and due to the difference in atomic radius, it has an effect on the reactivity and selectivity. In nucleophilic substitution reactions, bromine atoms are easier to leave due to relatively small bond energy, providing an opportunity for nucleophilic reagents to attack.
2-fluoro-4-chlorobromobenzene has good solubility in organic solvents, which facilitates its participation in various organic synthesis reactions. Its stability is acceptable at room temperature and pressure, but it may be dangerous in case of high temperature, open flame or strong oxidant.
In the field of organic synthesis, 2-fluoro-4-chlorobromobenzene is an important intermediate. Complex organic molecular structures can be constructed by means of nucleophilic substitution, coupling reactions, etc. If it reacts with nucleophiles containing specific functional groups, new groups can be introduced to expand the diversity of molecules.
In short, 2-fluoro-4-chlorobromobenzene plays a pivotal role in the field of organic chemical synthesis due to its unique chemical properties, providing possibilities and approaches for the preparation of many organic compounds.
What are the physical properties of 2-fluoro-4-chlorobromobenzene?
2-Fluoro-4-chlorobromobenzene is also an organic compound. Its physical properties are particularly important, and it is related to its behavior in various situations.
First of all, its phase and appearance, under normal temperature and pressure, 2-fluoro-4-chlorobromobenzene is colorless to light yellow liquid, which is clear and has a certain fluidity. Its color and morphology are important basis for preliminary identification.
Secondary and boiling point, the boiling point of this compound is about a specific temperature range. The boiling point is the temperature when the substance changes from liquid to gas. The boiling point of 2-fluoro-4-chlorobromobenzene allows us to obtain pure substances according to temperature control during separation operations such as distillation. Different substances have different boiling points, and this characteristic can precipitate them from the mixture.
In addition, the melting point is also a key physical property. The melting point is the temperature at which the substance melts from solid to liquid. Knowing the melting point of 2-fluoro-4-chlorobromobenzene, when storing and handling, it can avoid unprovoked changes in its phase state according to temperature conditions and keep its properties stable.
Density is also a property that cannot be ignored. The density of 2-fluoro-4-chlorobrobenzene is higher than that of water, which shows its use in liquid-liquid separation. If it is mixed with insoluble liquids such as water, it can be layered by itself due to density differences, so that it can be separated by liquid separation and other methods.
In terms of solubility, 2-fluoro-4-chlorobrobenzene has a certain solubility in organic solvents such as ethanol and ether. However, its solubility in water is very small, because of the characteristics of its molecular structure, the organic structure of halogen atoms, and the weak force between water molecules, so it is difficult to dissolve in water. This difference in solubility can be used as a basis for selecting suitable solvents for separation and purification in extraction and other operations.
And volatile, 2-fluoro-4-chlorobromobenzene has a certain volatility. In an open environment, its molecules escape the liquid surface due to thermal movement and gradually enter the gas phase. This characteristic needs to be taken into account when storing, and it should be sealed to avoid the loss of its volatilization and environmental pollution.
In summary, the physical properties of 2-fluoro-4-chlorobromobenzene, such as phase state, boiling point, melting point, density, solubility, and volatility, are of great significance in its preparation, storage, separation, purification, and application. It is an indispensable knowledge for chemists to control this substance.
First of all, its phase and appearance, under normal temperature and pressure, 2-fluoro-4-chlorobromobenzene is colorless to light yellow liquid, which is clear and has a certain fluidity. Its color and morphology are important basis for preliminary identification.
Secondary and boiling point, the boiling point of this compound is about a specific temperature range. The boiling point is the temperature when the substance changes from liquid to gas. The boiling point of 2-fluoro-4-chlorobromobenzene allows us to obtain pure substances according to temperature control during separation operations such as distillation. Different substances have different boiling points, and this characteristic can precipitate them from the mixture.
In addition, the melting point is also a key physical property. The melting point is the temperature at which the substance melts from solid to liquid. Knowing the melting point of 2-fluoro-4-chlorobromobenzene, when storing and handling, it can avoid unprovoked changes in its phase state according to temperature conditions and keep its properties stable.
Density is also a property that cannot be ignored. The density of 2-fluoro-4-chlorobrobenzene is higher than that of water, which shows its use in liquid-liquid separation. If it is mixed with insoluble liquids such as water, it can be layered by itself due to density differences, so that it can be separated by liquid separation and other methods.
In terms of solubility, 2-fluoro-4-chlorobrobenzene has a certain solubility in organic solvents such as ethanol and ether. However, its solubility in water is very small, because of the characteristics of its molecular structure, the organic structure of halogen atoms, and the weak force between water molecules, so it is difficult to dissolve in water. This difference in solubility can be used as a basis for selecting suitable solvents for separation and purification in extraction and other operations.
And volatile, 2-fluoro-4-chlorobromobenzene has a certain volatility. In an open environment, its molecules escape the liquid surface due to thermal movement and gradually enter the gas phase. This characteristic needs to be taken into account when storing, and it should be sealed to avoid the loss of its volatilization and environmental pollution.
In summary, the physical properties of 2-fluoro-4-chlorobromobenzene, such as phase state, boiling point, melting point, density, solubility, and volatility, are of great significance in its preparation, storage, separation, purification, and application. It is an indispensable knowledge for chemists to control this substance.
What are 2-fluoro-4-chlorobromobenzene synthesis methods?
The synthesis of 2-fluoro-4-chlorobromobenzene is an important topic in the field of organic synthesis. There are several common methods for preparing this compound.
One can be achieved by halogenation reaction. Using a suitable benzene derivative as the starting material, fluorine atoms are first introduced. If benzene is used as the substrate, under specific conditions, an electrophilic substitution reaction is used, and a suitable fluorine-containing reagent is selected, such as a boron trifluoride ether complex, which reacts with benzene to introduce fluorine atoms into the benzene ring to generate fluorobenzene. Subsequently, under different reaction conditions, chlorination reagents, such as chlorine under the action of light or catalysts such as iron trichloride, are used to carry out chlorination reactions, and chlorine atoms are introduced at specific positions of fluorobenzene to obtain 4-chlorofluorobenzene. Finally, through a bromination reaction, 4-chlorofluorobenzene is brominated with brominating reagents such as N-bromosuccinimide (NBS) in the presence of suitable initiators such as benzoyl peroxide, and bromine atoms are introduced at specific positions to obtain 2-fluoro-4-chlorobromobenzene.
Second, metal-organic reagents can also be used to participate in the reaction synthesis. First, fluorine-containing aryl halides are prepared and reacted with magnesium to form Grignard reagents. For example, 4-chlorobrombenzene is used as a raw material, and magnesium is reacted with anhydrous ether and other solvents to generate corresponding Grignard reagents. After that, fluorine-containing electrophilic reagents, such as fluorophenyl trifluoromethanesulfonate, are added to the Grignard reagent. After nucleophilic substitution, fluorine atoms can be introduced to obtain the target product 2-fluoro-4-chlorobrombenzene.
Furthermore, palladium-catalyzed cross-coupling reactions can also be used. Select suitable halogenated aromatics, such as chlorine and bromine-containing benzene derivatives, fluorine-containing borate esters or other fluorinated reagents, and react in suitable solvents in the presence of palladium catalysts such as tetra (triphenylphosphine) palladium (0) and suitable bases such as potassium carbonate. By precisely regulating the reaction conditions, such as temperature and reaction time, the cross-coupling of halogenated aromatics and fluorinated reagents is promoted to realize the synthesis of 2-fluoro-4-chlorobromobenzene.
These methods have their own advantages and disadvantages. In the actual synthesis, the appropriate synthesis route needs to be carefully selected according to many factors such as the availability of raw materials, the difficulty of controlling the reaction conditions, and the purity requirements of the target product.
One can be achieved by halogenation reaction. Using a suitable benzene derivative as the starting material, fluorine atoms are first introduced. If benzene is used as the substrate, under specific conditions, an electrophilic substitution reaction is used, and a suitable fluorine-containing reagent is selected, such as a boron trifluoride ether complex, which reacts with benzene to introduce fluorine atoms into the benzene ring to generate fluorobenzene. Subsequently, under different reaction conditions, chlorination reagents, such as chlorine under the action of light or catalysts such as iron trichloride, are used to carry out chlorination reactions, and chlorine atoms are introduced at specific positions of fluorobenzene to obtain 4-chlorofluorobenzene. Finally, through a bromination reaction, 4-chlorofluorobenzene is brominated with brominating reagents such as N-bromosuccinimide (NBS) in the presence of suitable initiators such as benzoyl peroxide, and bromine atoms are introduced at specific positions to obtain 2-fluoro-4-chlorobromobenzene.
Second, metal-organic reagents can also be used to participate in the reaction synthesis. First, fluorine-containing aryl halides are prepared and reacted with magnesium to form Grignard reagents. For example, 4-chlorobrombenzene is used as a raw material, and magnesium is reacted with anhydrous ether and other solvents to generate corresponding Grignard reagents. After that, fluorine-containing electrophilic reagents, such as fluorophenyl trifluoromethanesulfonate, are added to the Grignard reagent. After nucleophilic substitution, fluorine atoms can be introduced to obtain the target product 2-fluoro-4-chlorobrombenzene.
Furthermore, palladium-catalyzed cross-coupling reactions can also be used. Select suitable halogenated aromatics, such as chlorine and bromine-containing benzene derivatives, fluorine-containing borate esters or other fluorinated reagents, and react in suitable solvents in the presence of palladium catalysts such as tetra (triphenylphosphine) palladium (0) and suitable bases such as potassium carbonate. By precisely regulating the reaction conditions, such as temperature and reaction time, the cross-coupling of halogenated aromatics and fluorinated reagents is promoted to realize the synthesis of 2-fluoro-4-chlorobromobenzene.
These methods have their own advantages and disadvantages. In the actual synthesis, the appropriate synthesis route needs to be carefully selected according to many factors such as the availability of raw materials, the difficulty of controlling the reaction conditions, and the purity requirements of the target product.
In what areas is 2-fluoro-4-chlorobromobenzene applied?
2-Fluoro-4-chlorobromobenzene has important applications in chemical synthesis, pharmaceutical research and development, material preparation and many other fields.
In the field of chemical synthesis, it is often a key intermediate. Due to the unique reactivity of fluorine, chlorine and bromine atoms on the benzene ring, multiple functional groups can be introduced through nucleophilic substitution, coupling and other reactions, and then complex organic compounds can be synthesized. For example, by reacting with nucleophiles containing specific functional groups, organic molecular frameworks with special structures and properties can be built, laying the foundation for the preparation of subsequent fine chemicals.
In the field of pharmaceutical research and development, 2-fluoro-4-chlorobromobenzene also plays an important role. Its structure can be modified to meet the needs of specific drug targets. Due to the introduction of fluorine, chlorine, and bromine atoms, the lipid solubility, stability, and interaction with drug molecules can be changed, thus enhancing drug activity, selectivity, and metabolic properties. In the development process of many new drugs, using this as the starting material and constructing active molecules through multi-step reactions, it is expected to develop drugs with better efficacy and less side effects.
In the field of material preparation, it can be used to prepare photoelectric materials. With its unique electronic structure and reactivity, it participates in the construction of material molecular structures and endows materials with special photoelectric properties, such as organic Light Emitting Diode (OLED) materials, solar cell materials, etc. Through rational design and synthesis, the properties of materials such as charge transport and luminous efficiency can be optimized, and the progress of materials science can be promoted.
In conclusion, 2-fluoro-4-chlorobromobenzene has shown indispensable value in many important fields due to its own structural characteristics, and plays a key role in promoting the development of related industries.
In the field of chemical synthesis, it is often a key intermediate. Due to the unique reactivity of fluorine, chlorine and bromine atoms on the benzene ring, multiple functional groups can be introduced through nucleophilic substitution, coupling and other reactions, and then complex organic compounds can be synthesized. For example, by reacting with nucleophiles containing specific functional groups, organic molecular frameworks with special structures and properties can be built, laying the foundation for the preparation of subsequent fine chemicals.
In the field of pharmaceutical research and development, 2-fluoro-4-chlorobromobenzene also plays an important role. Its structure can be modified to meet the needs of specific drug targets. Due to the introduction of fluorine, chlorine, and bromine atoms, the lipid solubility, stability, and interaction with drug molecules can be changed, thus enhancing drug activity, selectivity, and metabolic properties. In the development process of many new drugs, using this as the starting material and constructing active molecules through multi-step reactions, it is expected to develop drugs with better efficacy and less side effects.
In the field of material preparation, it can be used to prepare photoelectric materials. With its unique electronic structure and reactivity, it participates in the construction of material molecular structures and endows materials with special photoelectric properties, such as organic Light Emitting Diode (OLED) materials, solar cell materials, etc. Through rational design and synthesis, the properties of materials such as charge transport and luminous efficiency can be optimized, and the progress of materials science can be promoted.
In conclusion, 2-fluoro-4-chlorobromobenzene has shown indispensable value in many important fields due to its own structural characteristics, and plays a key role in promoting the development of related industries.
What is the market outlook for 2-fluoro-4-chlorobromobenzene?
Today, there is 2-fluoro-4-chlorobromobenzene, which has considerable market prospects. This compound has a wide range of uses in the field of organic synthesis. In medicinal chemistry, it can be a key intermediate for the creation of new drugs. Nowadays, the pharmaceutical industry is developing rapidly, and the demand for various new drugs is increasing day by day. 2-fluoro-4-chlorobromobenzene can participate in many key reactions and help drug molecules build specific structures, so the demand is also rising.
Furthermore, in the field of materials science, it also has its application. With the advancement of high-tech materials, the demand for compounds with special properties is increasing. The unique structure of 2-fluoro-4-chlorobromobenzene may endow the material with special electrical and optical properties, adding to the research and development of new materials, and the market prospect is quite bright.
However, the market also faces some challenges. The process of preparing this compound may need to be refined to reduce costs and increase output. And the chemical industry is fiercely competitive, and many companies and scientific research institutions are concerned about such compounds. In order to occupy a favorable place in the market, it is necessary to continuously innovate processes to improve product quality and competitiveness. Although there are challenges, overall, 2-fluoro-4-chlorobromobenzene still has broad market prospects and huge development potential due to its important uses in medicine and materials.
Furthermore, in the field of materials science, it also has its application. With the advancement of high-tech materials, the demand for compounds with special properties is increasing. The unique structure of 2-fluoro-4-chlorobromobenzene may endow the material with special electrical and optical properties, adding to the research and development of new materials, and the market prospect is quite bright.
However, the market also faces some challenges. The process of preparing this compound may need to be refined to reduce costs and increase output. And the chemical industry is fiercely competitive, and many companies and scientific research institutions are concerned about such compounds. In order to occupy a favorable place in the market, it is necessary to continuously innovate processes to improve product quality and competitiveness. Although there are challenges, overall, 2-fluoro-4-chlorobromobenzene still has broad market prospects and huge development potential due to its important uses in medicine and materials.
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