Linshang Chemical
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2-Fluoro-4-Chloronitrobenzene
Linshang Chemical
|
HS Code |
538309 |
| Chemical Formula | C6H3ClFNO2 |
| Molecular Weight | 177.545 |
| Appearance | Yellow - to - brown liquid |
| Boiling Point | 213 - 215 °C |
| Melting Point | 24 - 26 °C |
| Density | 1.497 g/cm³ |
| Solubility In Water | Insoluble |
| Flash Point | 92.7 °C |
| Vapor Pressure | Low |
| Odor | Pungent |
| Stability | Stable under normal conditions |
| Hazard Class | 6.1 (Toxic) |
As an accredited 2-Fluoro-4-Chloronitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 2 - fluoro - 4 - chloronitrobenzene packaged in a sealed chemical - grade bottle. |
| Storage | 2 - Fluoro - 4 - chloronitrobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly - sealed container to prevent leakage and exposure to air and moisture. Label the storage container clearly to avoid confusion and ensure proper handling and safety. |
| Shipping | 2 - fluoro - 4 - chloronitrobenzene is a chemical. For its shipping, it must be packaged in suitable containers to prevent leakage. It should be transported following regulations for hazardous chemicals, with proper labeling and documentation. |
Competitive 2-Fluoro-4-Chloronitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 2-Fluoro-4-Chloronitrobenzene in China?
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 2-Fluoro-4-Chloronitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 2-fluoro-4-chloronitrobenzene?
2-Fluoro-4-chloronitrobenzene is an important intermediate in organic synthesis. It has a wide range of uses and has significant applications in the fields of medicine, pesticides, dyes, etc.
In the field of medicine, this compound is often the key starting material for the synthesis of specific drugs. Due to the characteristics of fluorine, chlorine and nitro in its structure, it can participate in a variety of chemical reactions and help to construct molecular structures with specific pharmacological activities. For example, in the synthesis path of some antibacterial drugs and nervous system drugs, 2-fluoro-4-chloronitrobenzene can introduce key functional groups through a series of reactions to achieve the expected drug activity.
In the field of pesticides, it also plays an indispensable role. It can be used as an important intermediate for the synthesis of new and efficient pesticides. By reacting with other organic compounds, pesticide products with good insecticidal, bactericidal or herbicidal properties can be generated. Due to its unique chemical structure, it endows the synthesized pesticides with a specific mechanism of action and selectivity, enhancing the effect and safety of pesticides.
In the dye industry, 2-fluoro-4-chloronitrobenzene can participate in the synthesis of a variety of dyes with bright colors and excellent fastness. By reacting with different aromatic amines, phenols and other compounds, a complex conjugate system is constructed, thereby endowing the dyes with unique colors and properties. It can be used in dyeing processes in textile, leather and other industries to meet the market demand for high-quality dyes.
In addition, 2-fluoro-4-chloronitrobenzene is also a commonly used model compound in the study of organic synthetic chemistry. Chemists can explore new reaction paths and methods by studying its reactivity, which can promote the development of organic synthetic chemistry. Due to its polyfunctional group characteristics, it can carry out various types of reactions such as nucleophilic substitution and reduction, providing rich strategies and ideas for organic synthesis. In short, 2-fluoro-4-chloronitrobenzene is of great value in many chemical fields and has made great contributions to the development of related industries.
In the field of medicine, this compound is often the key starting material for the synthesis of specific drugs. Due to the characteristics of fluorine, chlorine and nitro in its structure, it can participate in a variety of chemical reactions and help to construct molecular structures with specific pharmacological activities. For example, in the synthesis path of some antibacterial drugs and nervous system drugs, 2-fluoro-4-chloronitrobenzene can introduce key functional groups through a series of reactions to achieve the expected drug activity.
In the field of pesticides, it also plays an indispensable role. It can be used as an important intermediate for the synthesis of new and efficient pesticides. By reacting with other organic compounds, pesticide products with good insecticidal, bactericidal or herbicidal properties can be generated. Due to its unique chemical structure, it endows the synthesized pesticides with a specific mechanism of action and selectivity, enhancing the effect and safety of pesticides.
In the dye industry, 2-fluoro-4-chloronitrobenzene can participate in the synthesis of a variety of dyes with bright colors and excellent fastness. By reacting with different aromatic amines, phenols and other compounds, a complex conjugate system is constructed, thereby endowing the dyes with unique colors and properties. It can be used in dyeing processes in textile, leather and other industries to meet the market demand for high-quality dyes.
In addition, 2-fluoro-4-chloronitrobenzene is also a commonly used model compound in the study of organic synthetic chemistry. Chemists can explore new reaction paths and methods by studying its reactivity, which can promote the development of organic synthetic chemistry. Due to its polyfunctional group characteristics, it can carry out various types of reactions such as nucleophilic substitution and reduction, providing rich strategies and ideas for organic synthesis. In short, 2-fluoro-4-chloronitrobenzene is of great value in many chemical fields and has made great contributions to the development of related industries.
What are the physical properties of 2-fluoro-4-chloronitrobenzene?
2-Fluoro-4-chloronitrobenzene is one of the organic compounds. Its physical properties are particularly important and are related to many chemical applications.
First of all, its properties are mostly light yellow to brown crystalline powders at room temperature. Looking at it, this shape is easy to identify, and it is easy to use and operate.
As for the melting point, it is about 27-29 degrees Celsius. The characteristics of the melting point are of great significance in the purification and identification of substances. Due to the different melting points of different compounds, their purity can be judged. If the melting point of the sample is consistent with the established value and the melting range is very narrow, the purity is quite high; conversely, if the melting range is wide and deviates from the established value, there is no doubt that it contains impurities.
In terms of boiling point, it is about 236-238 degrees Celsius. Knowledge of boiling point is indispensable in separation methods such as distillation. 2-fluoro-4-chloronitrobenzene can be separated from the mixture according to the difference in boiling point.
Solubility is also an important physical property. In organic solvents, such as ethanol, ether, benzene, etc., its solubility is good. This property allows for the selection of suitable organic solvents in organic synthesis reactions to promote the smooth progress of the reaction. Because the reactants must be fully dissolved, the molecules can effectively collide to achieve the purpose of the reaction. However, in water, its solubility is not good. Due to the molecular structure of the compound, which contains fluorine, chlorine, nitro and other functional groups, it is highly hydrophobic, so it is difficult to dissolve in water.
The density is about 1.52 g/cm ³. The density data is very important when it comes to mass and volume conversion, as well as mixture stratification. For example, in some liquid-liquid extraction processes, the density difference can be used to realize the separation of the compound from other substances.
The physical properties of 2-fluoro-4-chloronitrobenzene, such as properties, melting point, boiling point, solubility and density, are of important guiding value in chemical research, industrial production and related application fields.
First of all, its properties are mostly light yellow to brown crystalline powders at room temperature. Looking at it, this shape is easy to identify, and it is easy to use and operate.
As for the melting point, it is about 27-29 degrees Celsius. The characteristics of the melting point are of great significance in the purification and identification of substances. Due to the different melting points of different compounds, their purity can be judged. If the melting point of the sample is consistent with the established value and the melting range is very narrow, the purity is quite high; conversely, if the melting range is wide and deviates from the established value, there is no doubt that it contains impurities.
In terms of boiling point, it is about 236-238 degrees Celsius. Knowledge of boiling point is indispensable in separation methods such as distillation. 2-fluoro-4-chloronitrobenzene can be separated from the mixture according to the difference in boiling point.
Solubility is also an important physical property. In organic solvents, such as ethanol, ether, benzene, etc., its solubility is good. This property allows for the selection of suitable organic solvents in organic synthesis reactions to promote the smooth progress of the reaction. Because the reactants must be fully dissolved, the molecules can effectively collide to achieve the purpose of the reaction. However, in water, its solubility is not good. Due to the molecular structure of the compound, which contains fluorine, chlorine, nitro and other functional groups, it is highly hydrophobic, so it is difficult to dissolve in water.
The density is about 1.52 g/cm ³. The density data is very important when it comes to mass and volume conversion, as well as mixture stratification. For example, in some liquid-liquid extraction processes, the density difference can be used to realize the separation of the compound from other substances.
The physical properties of 2-fluoro-4-chloronitrobenzene, such as properties, melting point, boiling point, solubility and density, are of important guiding value in chemical research, industrial production and related application fields.
What is the chemistry of 2-fluoro-4-chloronitrobenzene?
2-Fluoro-4-chloronitrobenzene is also an organic compound. Its molecules contain fluorine, chlorine, nitro and other groups, which give it unique chemical properties.
Fluorine atoms have the characteristics of high electronegativity, which can reduce the electron cloud density of the benzene ring and reduce the activity of the electrophilic substitution reaction of the benzene ring. And the existence of fluorine atoms changes the spatial structure of the molecule and affects its reaction selectivity.
Chlorine atoms on the benzene ring can also reduce the electron cloud density of the benzene ring. However, compared with fluorine atoms, their electronegativity is slightly lower. In chemical reactions, chlorine atoms can be used as leaving groups to participate in nucleophilic substitution and other reactions.
Nitro is a strong electron-absorbing group, which has a great influence on the electron cloud density of the benzene ring, which can greatly reduce the electron cloud density of the ortho and para-site of the benzene ring, making the electrophilic substitution reaction more likely to occur in the meta-site. At the same time, the presence of nitro groups enhances the polarity of molecules and affects their physical properties, such as boiling point and solubility.
2-fluoro-4-chloronitrobenzene has active chemical properties and can undergo a variety of reactions. In the nucleophilic substitution reaction, fluorine and chlorine atoms can be replaced by nucleophilic reagents. Due to the strong binding force between fluorine atoms and benzene rings, the substitution reaction conditions may be harsh; while chlorine atoms are relatively easy to be replaced. In addition, its nitro groups can Under suitable conditions, other reactions on benzene ring, such as halogenation and sulfonation, can also occur, but the reaction activity has changed significantly due to the influence of fluorine, chlorine and nitro groups compared with benzene.
Fluorine atoms have the characteristics of high electronegativity, which can reduce the electron cloud density of the benzene ring and reduce the activity of the electrophilic substitution reaction of the benzene ring. And the existence of fluorine atoms changes the spatial structure of the molecule and affects its reaction selectivity.
Chlorine atoms on the benzene ring can also reduce the electron cloud density of the benzene ring. However, compared with fluorine atoms, their electronegativity is slightly lower. In chemical reactions, chlorine atoms can be used as leaving groups to participate in nucleophilic substitution and other reactions.
Nitro is a strong electron-absorbing group, which has a great influence on the electron cloud density of the benzene ring, which can greatly reduce the electron cloud density of the ortho and para-site of the benzene ring, making the electrophilic substitution reaction more likely to occur in the meta-site. At the same time, the presence of nitro groups enhances the polarity of molecules and affects their physical properties, such as boiling point and solubility.
2-fluoro-4-chloronitrobenzene has active chemical properties and can undergo a variety of reactions. In the nucleophilic substitution reaction, fluorine and chlorine atoms can be replaced by nucleophilic reagents. Due to the strong binding force between fluorine atoms and benzene rings, the substitution reaction conditions may be harsh; while chlorine atoms are relatively easy to be replaced. In addition, its nitro groups can Under suitable conditions, other reactions on benzene ring, such as halogenation and sulfonation, can also occur, but the reaction activity has changed significantly due to the influence of fluorine, chlorine and nitro groups compared with benzene.
What are 2-fluoro-4-chloronitrobenzene synthesis methods?
The common methods for synthesizing 2-fluoro-4-chloronitrobenzene are as follows.
One is the halogenation reaction path. A suitable nitrobenzene derivative is used as the starting material, and chlorine atoms are first introduced under specific reaction conditions. Appropriate chlorination reagents, such as chlorine gas or chlorine-containing compounds, can be selected under the action of catalysts to realize the chlorination reaction at a specific position on the benzene ring. Then, fluorine atoms are introduced. The fluorination reaction often requires a specific fluorine source, such as potassium fluoride, and is carried out under a suitable organic solvent and reaction temperature, which prompts fluorine atoms to replace other atoms in the corresponding positions, and finally obtains 2-fluoro-4-chloronitrobenzene. In this pathway, factors such as the choice of halogenating reagents, the type and amount of catalysts, reaction temperature and time all have a great influence on the reaction process and product yield.
The second is to construct the target product through nucleophilic substitution. First prepare benzene ring compounds containing suitable substituents, so that the benzene ring has a check point that can be attacked by nucleophiles. Introduce fluorine or chlorine atoms with nucleophiles, depending on the specific reaction design. The activity of nucleophiles, the structure of reaction substrates, and the properties of reaction solvents will affect the efficiency and selectivity of nucleophilic substitution reactions, which in turn will affect the synthesis efficiency of 2-fluoro-4-chloronitrobenzene.
The third is to start with other benzene series compounds and gradually build the target molecular structure through multi-step reactions. For example, the benzene ring is modified first, and a specific functional group is introduced. After a series of functional group conversion reactions, such as oxidation, reduction, substitution, etc., the specific positions of nitro, chlorine atoms and fluorine atoms on the benzene ring are constructed in sequence. This strategy requires fine planning of the reaction steps, consideration of the compatibility of each step and the feasibility of the overall synthesis route, in order to efficiently synthesize 2-fluoro-4-chloronitrobenzene.
One is the halogenation reaction path. A suitable nitrobenzene derivative is used as the starting material, and chlorine atoms are first introduced under specific reaction conditions. Appropriate chlorination reagents, such as chlorine gas or chlorine-containing compounds, can be selected under the action of catalysts to realize the chlorination reaction at a specific position on the benzene ring. Then, fluorine atoms are introduced. The fluorination reaction often requires a specific fluorine source, such as potassium fluoride, and is carried out under a suitable organic solvent and reaction temperature, which prompts fluorine atoms to replace other atoms in the corresponding positions, and finally obtains 2-fluoro-4-chloronitrobenzene. In this pathway, factors such as the choice of halogenating reagents, the type and amount of catalysts, reaction temperature and time all have a great influence on the reaction process and product yield.
The second is to construct the target product through nucleophilic substitution. First prepare benzene ring compounds containing suitable substituents, so that the benzene ring has a check point that can be attacked by nucleophiles. Introduce fluorine or chlorine atoms with nucleophiles, depending on the specific reaction design. The activity of nucleophiles, the structure of reaction substrates, and the properties of reaction solvents will affect the efficiency and selectivity of nucleophilic substitution reactions, which in turn will affect the synthesis efficiency of 2-fluoro-4-chloronitrobenzene.
The third is to start with other benzene series compounds and gradually build the target molecular structure through multi-step reactions. For example, the benzene ring is modified first, and a specific functional group is introduced. After a series of functional group conversion reactions, such as oxidation, reduction, substitution, etc., the specific positions of nitro, chlorine atoms and fluorine atoms on the benzene ring are constructed in sequence. This strategy requires fine planning of the reaction steps, consideration of the compatibility of each step and the feasibility of the overall synthesis route, in order to efficiently synthesize 2-fluoro-4-chloronitrobenzene.
2-fluoro-4-chloronitrobenzene need to pay attention to when storing and transporting
2-Fluoro-4-chloronitrobenzene is also an organic compound. During storage and transportation, many matters need to be paid attention to.
When storing, choose the first environment. It should be placed in a cool and ventilated warehouse, away from fires and heat sources. Cover because of its flammability, in case of open flame, hot topic can cause the risk of combustion and explosion. Warehouse temperature should not exceed 30 ° C, relative humidity should not exceed 80%.
Furthermore, this substance should be stored separately from oxidants, reducing agents, acids, bases, etc., and should not be mixed. Due to its active chemical properties, it can react violently with various substances, causing danger. And should be equipped with the corresponding variety and quantity of fire fighting equipment. The storage area should be equipped with suitable materials to contain leaks.
As for the time of transportation, make sure that the container is sealed before transportation, and the loading should be secure. During transportation, make sure that the container does not leak, collapse, fall, or damage. The tank (tank) car used during transportation should have a grounding chain, and holes can be set in the tank baffle to reduce shock and generate static electricity. It is strictly forbidden to mix and transport with oxidizing agents, reducing agents, acids, alkalis, edible chemicals, etc. During transportation, it should be protected from exposure to sunlight, rain, and high temperature. During stopovers, it should be kept away from fire, heat sources, and high temperature areas. The exhaust pipe of the vehicle must have a fire retardant device, and it is forbidden to use machinery and tools that are prone to sparks for loading and unloading. Road transportation should follow the prescribed route, do not stop in residential areas and densely populated areas. It is forbidden to slip during railway transportation. It is strictly forbidden to transport in bulk by wooden boats and cement ships. In this way, the safety of storage and transportation can be guaranteed.
When storing, choose the first environment. It should be placed in a cool and ventilated warehouse, away from fires and heat sources. Cover because of its flammability, in case of open flame, hot topic can cause the risk of combustion and explosion. Warehouse temperature should not exceed 30 ° C, relative humidity should not exceed 80%.
Furthermore, this substance should be stored separately from oxidants, reducing agents, acids, bases, etc., and should not be mixed. Due to its active chemical properties, it can react violently with various substances, causing danger. And should be equipped with the corresponding variety and quantity of fire fighting equipment. The storage area should be equipped with suitable materials to contain leaks.
As for the time of transportation, make sure that the container is sealed before transportation, and the loading should be secure. During transportation, make sure that the container does not leak, collapse, fall, or damage. The tank (tank) car used during transportation should have a grounding chain, and holes can be set in the tank baffle to reduce shock and generate static electricity. It is strictly forbidden to mix and transport with oxidizing agents, reducing agents, acids, alkalis, edible chemicals, etc. During transportation, it should be protected from exposure to sunlight, rain, and high temperature. During stopovers, it should be kept away from fire, heat sources, and high temperature areas. The exhaust pipe of the vehicle must have a fire retardant device, and it is forbidden to use machinery and tools that are prone to sparks for loading and unloading. Road transportation should follow the prescribed route, do not stop in residential areas and densely populated areas. It is forbidden to slip during railway transportation. It is strictly forbidden to transport in bulk by wooden boats and cement ships. In this way, the safety of storage and transportation can be guaranteed.
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