Linshang Chemical
PRODUCTS
2-Fluoro-5-Chlorobromobenzene
Linshang Chemical
|
HS Code |
280254 |
| Chemical Formula | C6H3BrClF |
| Molar Mass | 225.44 g/mol |
| Appearance | Liquid (usually) |
| Boiling Point | Approx. 190 - 200 °C |
| Density | Approx. 1.8 - 2.0 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Odor | Typical aromatic halogenated compound odor |
As an accredited 2-Fluoro-5-Chlorobromobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 2 - fluoro - 5 - chlorobromobenzene packaged in a sealed glass bottle. |
| Storage | 2 - fluoro - 5 - chlorobromobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and strong oxidizing agents. Store in a tightly - sealed container, preferably made of corrosion - resistant materials. This helps prevent leakage, degradation due to moisture or air, and potential reactions that could pose safety risks. |
| Shipping | 2 - fluoro - 5 - chlorobromobenzene is shipped in sealed, corrosion - resistant containers. It's carefully packaged to prevent leakage. Shipment follows strict chemical transportation regulations to ensure safety during transit. |
Competitive 2-Fluoro-5-Chlorobromobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 2-Fluoro-5-Chlorobromobenzene in China?
As a trusted 2-Fluoro-5-Chlorobromobenzene manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 2-Fluoro-5-Chlorobromobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 2-fluoro-5-chlorobromobenzene?
2-Fluoro-5-chlorobrombenzene is one of the organic compounds. Its chemical properties are unique and worth studying.
As for its substitution reaction, the compound is quite active due to the presence of halogen atoms. Bromine atoms, chlorine atoms and fluorine atoms can all be replaced by other functional groups under suitable conditions. For example, in the case of nucleophilic reagents, bromine atoms can be replaced by nucleophilic groups to undergo nucleophilic substitution reactions. This is because the benzene ring carbon atom connected to the bromine atom, the electron cloud density decreases due to the electron-withdrawing effect of the halogen atom, making the carbon atom more vulnerable to attack by nucleophilic reagents.
In addition to its addition reaction, although the benzene ring is aromatic and more difficult to add than unsaturated hydrocarbons such as olefins, it can also be added under special conditions and the action of strong reagents. In case of active metal-organic reagents, or addition reactions can occur with the benzene ring, changing the electron cloud distribution and structure of the benzene ring.
And its redox properties. The halogen atom in 2-fluoro-5-chlorobrombenzene is relatively stable and is not easily affected by common weak oxidants or reducing agents. However, when encountering strong oxidants, such as acidic potassium permanganate, if the side chain of the benzene ring has oxidizable groups, oxidation reactions may occur; if treated with strong reducing agents, halogen atoms may be reduced and removed.
In addition, the physical properties of 2-fluoro-5-chlorobromobenzene, such as melting point, boiling point, solubility, etc., are also closely related to its chemical structure. The type and location of its halogen atoms affect the intermolecular forces, which in turn affect the melting and boiling points; and because it is a halogenated aromatic hydrocarbon, its solubility in organic solvents is usually better than that of water. This property is of great application in the separation and purification steps of organic synthesis. In short, the chemical properties of 2-fluoro-5-chlorobromobenzene are rich and diverse, and have important research and application significance in organic synthesis, pharmaceutical chemistry and other fields.
As for its substitution reaction, the compound is quite active due to the presence of halogen atoms. Bromine atoms, chlorine atoms and fluorine atoms can all be replaced by other functional groups under suitable conditions. For example, in the case of nucleophilic reagents, bromine atoms can be replaced by nucleophilic groups to undergo nucleophilic substitution reactions. This is because the benzene ring carbon atom connected to the bromine atom, the electron cloud density decreases due to the electron-withdrawing effect of the halogen atom, making the carbon atom more vulnerable to attack by nucleophilic reagents.
In addition to its addition reaction, although the benzene ring is aromatic and more difficult to add than unsaturated hydrocarbons such as olefins, it can also be added under special conditions and the action of strong reagents. In case of active metal-organic reagents, or addition reactions can occur with the benzene ring, changing the electron cloud distribution and structure of the benzene ring.
And its redox properties. The halogen atom in 2-fluoro-5-chlorobrombenzene is relatively stable and is not easily affected by common weak oxidants or reducing agents. However, when encountering strong oxidants, such as acidic potassium permanganate, if the side chain of the benzene ring has oxidizable groups, oxidation reactions may occur; if treated with strong reducing agents, halogen atoms may be reduced and removed.
In addition, the physical properties of 2-fluoro-5-chlorobromobenzene, such as melting point, boiling point, solubility, etc., are also closely related to its chemical structure. The type and location of its halogen atoms affect the intermolecular forces, which in turn affect the melting and boiling points; and because it is a halogenated aromatic hydrocarbon, its solubility in organic solvents is usually better than that of water. This property is of great application in the separation and purification steps of organic synthesis. In short, the chemical properties of 2-fluoro-5-chlorobromobenzene are rich and diverse, and have important research and application significance in organic synthesis, pharmaceutical chemistry and other fields.
What is 2-fluoro-5-chlorobromobenzene synthesis method?
The method of preparing 2-fluoro-5-chlorobrombenzene can follow the conventional route of organic synthesis. The starting material can be selected from suitable aromatic compounds, such as benzene derivatives.
One method can start with benzene, and introduce chlorine atoms into the benzene ring through chlorination reaction. The chlorination reaction is usually carried out with chlorine gas and benzene under the action of a catalyst such as iron trichloride. During the reaction, the chlorine atom replaces the hydrogen atom on the benzene ring to form chlorobenzene.
Then, the chlorobenzene is fluorinated. In this step, a suitable fluorination reagent, such as potassium fluoride, can be used to replace the hydrogen atom at a specific position on the chlorobenzene under specific reaction conditions to obtain a benzene derivative containing fluorine and chlorine.
In the last step, the derivative is brominated. Generally, bromine is used. Under the action of the catalyst, the bromine atom replaces the hydrogen atom at a specific position on the benzene ring. This position needs to be precisely controlled to obtain the target product 2-fluoro-5-chlorobromobenzene. The catalyst for the bromination reaction is usually iron powder or iron tribromide.
Each step of the reaction requires detailed regulation of the reaction conditions, such as temperature, pressure, reaction time and proportion of reactants. Too high or too low temperature may affect the reaction rate and product selectivity. Improper ratio of reactants will also increase side reactions and reduce the yield of the target product. After each step of the reaction, it needs to be separated and purified to remove impurities and ensure the purity of the product, so that 2-fluoro-5-chlorobromobenzene can be efficiently prepared.
One method can start with benzene, and introduce chlorine atoms into the benzene ring through chlorination reaction. The chlorination reaction is usually carried out with chlorine gas and benzene under the action of a catalyst such as iron trichloride. During the reaction, the chlorine atom replaces the hydrogen atom on the benzene ring to form chlorobenzene.
Then, the chlorobenzene is fluorinated. In this step, a suitable fluorination reagent, such as potassium fluoride, can be used to replace the hydrogen atom at a specific position on the chlorobenzene under specific reaction conditions to obtain a benzene derivative containing fluorine and chlorine.
In the last step, the derivative is brominated. Generally, bromine is used. Under the action of the catalyst, the bromine atom replaces the hydrogen atom at a specific position on the benzene ring. This position needs to be precisely controlled to obtain the target product 2-fluoro-5-chlorobromobenzene. The catalyst for the bromination reaction is usually iron powder or iron tribromide.
Each step of the reaction requires detailed regulation of the reaction conditions, such as temperature, pressure, reaction time and proportion of reactants. Too high or too low temperature may affect the reaction rate and product selectivity. Improper ratio of reactants will also increase side reactions and reduce the yield of the target product. After each step of the reaction, it needs to be separated and purified to remove impurities and ensure the purity of the product, so that 2-fluoro-5-chlorobromobenzene can be efficiently prepared.
In what areas is 2-fluoro-5-chlorobromobenzene applied?
2-Fluoro-5-chlorobromobenzene, an organic compound, is used in many fields.
In the field of medicine, organohalogenated aromatics are often key intermediates. The fluorine, chlorine and bromine atoms in 2-fluoro-5-chlorobromobenzene may affect the interaction between drug molecules and targets due to unique electronic and spatial effects. By introducing such halogen atoms, lipid solubility, metabolic stability and biological activity of drug molecules can be optimized. For example, in the development of some antibacterial and antiviral drugs, halobenzene structural fragments may enhance the effect of drugs on pathogens and improve efficacy.
In the field of materials science, it can be used to prepare functional materials. Halogen-containing compounds may impart special photoelectric properties to materials. For example, when preparing organic Light Emitting Diode (OLED) materials, 2-fluoro-5-chlorobromobenzene participates in the reaction, or can adjust the energy level structure of the material, improve luminous efficiency and color purity. In liquid crystal materials, the structure of such halobenzene may affect the molecular arrangement and phase transition temperature, and optimize the performance of liquid crystal display.
It also has its own influence in the field of pesticides. Halogenated aromatics are often used as active ingredients of pesticides. 2-fluoro-5-chlorobromobenzene is chemically modified, or has high activity and selectivity to specific pests and pathogens. Some halogenated benzene ring insecticides can effectively inhibit the nervous system of pests or interfere with their physiological metabolism to achieve pest control.
In the field of organic synthesis, 2-fluoro-5-chlorobromobenzene, as an important intermediate, can participate in many reactions due to the activity of halogen atoms, such as nucleophilic substitution, metal catalytic coupling reaction, etc. With this, complex organic compounds can be constructed, providing rich choices for organic synthesis chemists to prepare various organic products.
In the field of medicine, organohalogenated aromatics are often key intermediates. The fluorine, chlorine and bromine atoms in 2-fluoro-5-chlorobromobenzene may affect the interaction between drug molecules and targets due to unique electronic and spatial effects. By introducing such halogen atoms, lipid solubility, metabolic stability and biological activity of drug molecules can be optimized. For example, in the development of some antibacterial and antiviral drugs, halobenzene structural fragments may enhance the effect of drugs on pathogens and improve efficacy.
In the field of materials science, it can be used to prepare functional materials. Halogen-containing compounds may impart special photoelectric properties to materials. For example, when preparing organic Light Emitting Diode (OLED) materials, 2-fluoro-5-chlorobromobenzene participates in the reaction, or can adjust the energy level structure of the material, improve luminous efficiency and color purity. In liquid crystal materials, the structure of such halobenzene may affect the molecular arrangement and phase transition temperature, and optimize the performance of liquid crystal display.
It also has its own influence in the field of pesticides. Halogenated aromatics are often used as active ingredients of pesticides. 2-fluoro-5-chlorobromobenzene is chemically modified, or has high activity and selectivity to specific pests and pathogens. Some halogenated benzene ring insecticides can effectively inhibit the nervous system of pests or interfere with their physiological metabolism to achieve pest control.
In the field of organic synthesis, 2-fluoro-5-chlorobromobenzene, as an important intermediate, can participate in many reactions due to the activity of halogen atoms, such as nucleophilic substitution, metal catalytic coupling reaction, etc. With this, complex organic compounds can be constructed, providing rich choices for organic synthesis chemists to prepare various organic products.
What are the physical properties of 2-fluoro-5-chlorobromobenzene?
2-Fluoro-5-chlorobromobenzene is also an organic compound. Its physical properties are very important, and it is related to the properties and behavior of this substance in various situations.
First of all, under normal temperature and pressure, 2-fluoro-5-chlorobromobenzene is often in a liquid state. Due to the nature of the intermolecular force, the intermolecular force of this compound allows the molecules to move relatively freely, but it does not disperse like a gaseous state. Looking at its color, it is mostly a colorless to light yellow transparent liquid. The pure color state reflects the relative stability and purity of its chemical structure.
When it comes to boiling point, 2-fluoro-5-chlorobromobenzene has a high boiling point. Due to the large number of halogen atoms in the molecule, the existence of fluorine, chlorine and bromine atoms enhances the van der Waals force between molecules. To make the molecule break free from the liquid phase and turn into the gas phase, more energy needs to be input, so the boiling point rises. This boiling point characteristic is crucial in the separation and purification process. 2-fluoro-5-chlorobromobenzene can be separated from the mixture by distillation according to the difference in boiling points.
Its melting point is also affected by halogen atoms. Halogen atoms make the molecular arrangement more regular, increase the interaction between molecules, and cause the melting point to rise. This melting point property has important guiding significance in setting the crystallization and solid storage conditions of substances.
2-Fluoro-5-chlorobrobenzene has a higher density than water. Due to the large relative atomic weight of halogen atoms, the molecular weight is increased, and the spatial arrangement is tight, resulting in a unit volume mass greater than that of water. In the liquid-liquid separation step of chemical production, this density characteristic can help distinguish 2-fluoro-5-chlorobrobenzene from the aqueous phase in order to obtain a pure product.
As for solubility, 2-fluoro-5-chlorobrobenzene is a non-polar or weakly polar compound, so it has good solubility in organic solvents such as ethanol, ether, and dichloromethane. Due to the principle of "similar miscibility", the force between the organic solvent and 2-fluoro-5-chlorobromobenzene molecules is similar and can be mixed with each other. However, the solubility in water is very small, and water is a strongly polar molecule, and the force difference between the molecules and 2-fluoro-5-chlorobromobenzene is large, and it is not easy to dissolve each other. This solubility property is of great value in the selection of reaction solvents and the extraction and separation of products.
First of all, under normal temperature and pressure, 2-fluoro-5-chlorobromobenzene is often in a liquid state. Due to the nature of the intermolecular force, the intermolecular force of this compound allows the molecules to move relatively freely, but it does not disperse like a gaseous state. Looking at its color, it is mostly a colorless to light yellow transparent liquid. The pure color state reflects the relative stability and purity of its chemical structure.
When it comes to boiling point, 2-fluoro-5-chlorobromobenzene has a high boiling point. Due to the large number of halogen atoms in the molecule, the existence of fluorine, chlorine and bromine atoms enhances the van der Waals force between molecules. To make the molecule break free from the liquid phase and turn into the gas phase, more energy needs to be input, so the boiling point rises. This boiling point characteristic is crucial in the separation and purification process. 2-fluoro-5-chlorobromobenzene can be separated from the mixture by distillation according to the difference in boiling points.
Its melting point is also affected by halogen atoms. Halogen atoms make the molecular arrangement more regular, increase the interaction between molecules, and cause the melting point to rise. This melting point property has important guiding significance in setting the crystallization and solid storage conditions of substances.
2-Fluoro-5-chlorobrobenzene has a higher density than water. Due to the large relative atomic weight of halogen atoms, the molecular weight is increased, and the spatial arrangement is tight, resulting in a unit volume mass greater than that of water. In the liquid-liquid separation step of chemical production, this density characteristic can help distinguish 2-fluoro-5-chlorobrobenzene from the aqueous phase in order to obtain a pure product.
As for solubility, 2-fluoro-5-chlorobrobenzene is a non-polar or weakly polar compound, so it has good solubility in organic solvents such as ethanol, ether, and dichloromethane. Due to the principle of "similar miscibility", the force between the organic solvent and 2-fluoro-5-chlorobromobenzene molecules is similar and can be mixed with each other. However, the solubility in water is very small, and water is a strongly polar molecule, and the force difference between the molecules and 2-fluoro-5-chlorobromobenzene is large, and it is not easy to dissolve each other. This solubility property is of great value in the selection of reaction solvents and the extraction and separation of products.
What is the market outlook for 2-fluoro-5-chlorobromobenzene?
2-Fluoro-5-chlorobromobenzene, an organic chemical, has a unique appearance in the current market prospect.
In terms of its scientific research field, it is a key building block for organic synthesis. In the process of many new drug research and development, molecules with specific structures need to be constructed. 2-fluoro-5-chlorobromobenzene, due to its unique substituent distribution, can lay the foundation for the synthesis of complex structure drug molecules through nucleophilic substitution and coupling reactions. With the global demand for innovative drugs rising, R & D investment is increasing day by day, and the demand for this compound in the pharmaceutical research raw material market is on the rise.
At the industrial production level, it has emerged in the field of materials science. The preparation of some high-performance polymer materials requires the introduction of halogen atomic structures such as fluorine, chlorine, and bromine to improve material properties, such as improving heat resistance and chemical stability. 2-Fluoro-5-chlorobromobenzene can be used as a key monomer for the synthesis of such functional polymer materials. With the development of the materials industry, the demand for high-performance materials expands, and it will also usher in a wider world in the industrial raw material market.
Furthermore, with the popularization of green chemistry concepts, the development of more environmentally friendly and efficient methods for synthesizing 2-fluoro-5-chlorobrobenzene is also a major trend. If a new synthesis process is born to increase productivity, reduce energy consumption and pollution, it will be able to further expand its market application scope, attract more companies to participate in the production and application development of related products, and brighten its market prospects.
In terms of its scientific research field, it is a key building block for organic synthesis. In the process of many new drug research and development, molecules with specific structures need to be constructed. 2-fluoro-5-chlorobromobenzene, due to its unique substituent distribution, can lay the foundation for the synthesis of complex structure drug molecules through nucleophilic substitution and coupling reactions. With the global demand for innovative drugs rising, R & D investment is increasing day by day, and the demand for this compound in the pharmaceutical research raw material market is on the rise.
At the industrial production level, it has emerged in the field of materials science. The preparation of some high-performance polymer materials requires the introduction of halogen atomic structures such as fluorine, chlorine, and bromine to improve material properties, such as improving heat resistance and chemical stability. 2-Fluoro-5-chlorobromobenzene can be used as a key monomer for the synthesis of such functional polymer materials. With the development of the materials industry, the demand for high-performance materials expands, and it will also usher in a wider world in the industrial raw material market.
Furthermore, with the popularization of green chemistry concepts, the development of more environmentally friendly and efficient methods for synthesizing 2-fluoro-5-chlorobrobenzene is also a major trend. If a new synthesis process is born to increase productivity, reduce energy consumption and pollution, it will be able to further expand its market application scope, attract more companies to participate in the production and application development of related products, and brighten its market prospects.
Scan to WhatsApp
