Linshang Chemical
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2-Methoxy-4-Nitrochlorobenzene
Linshang Chemical
|
HS Code |
516613 |
| Chemical Formula | C7H6ClNO3 |
| Molar Mass | 187.58 g/mol |
| Appearance | Yellow solid |
| Boiling Point | Approximately 272 - 274 °C |
| Melting Point | 67 - 70 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, acetone, benzene |
| Odor | Characteristic aromatic odor |
| Stability | Stable under normal conditions but can react with strong oxidizing and reducing agents |
As an accredited 2-Methoxy-4-Nitrochlorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 250 - gram bottle of 2 - methoxy - 4 - nitrochlorobenzene, securely sealed for safe storage. |
| Storage | 2 - methoxy - 4 - nitrochlorobenzene should be stored in a cool, dry, well - ventilated area, away from sources of heat and ignition. Keep it in a tightly closed container to prevent leakage and exposure to air and moisture. Store it separately from oxidizing agents, reducing agents, and bases to avoid chemical reactions. Follow proper safety regulations during storage. |
| Shipping | 2 - methoxy - 4 - nitrochlorobenzene, a chemical, should be shipped in tightly sealed, corrosion - resistant containers. Ensure compliance with regulations for hazardous chemicals, with proper labeling indicating its nature during transportation. |
Competitive 2-Methoxy-4-Nitrochlorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 2-Methoxy-4-Nitrochlorobenzene in China?
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 2-Methoxy-4-Nitrochlorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the use of 2-methoxy-4-nitrochlorobenzene?
2-% methoxy-4-acetylbenzaldehyde is an important organic compound that has a wide range of uses in many fields.
In the field of medicinal chemistry, it is often a key intermediate for the synthesis of drugs. For example, in some drug molecular architectures with specific biological activities, the structural units of this compound can be cleverly derived and transformed, which can endow drugs with specific pharmacological properties. With its unique chemical structure, it can precisely bind to specific targets in the body and exert therapeutic effects. For example, when developing anti-tumor and antibacterial drugs, 2-% methoxy-4-acetylbenzaldehyde is often used as the starting material to construct complex drug molecules through multi-step reactions, making significant contributions to human health.
In the field of materials science, it also has extraordinary value. It can be used as a raw material for the preparation of special functional materials. After specific reactions and modifications, it can be introduced into polymer materials, thereby changing the physical and chemical properties of the materials. For example, it can improve the optical properties of the materials, so that the materials have specific light absorption and emission characteristics, and are used in cutting-edge fields such as photoelectric display and optical storage; or enhance the stability and durability of the materials to meet the needs of high-end materials in special environments.
In the fragrance industry, 2-% methoxy-4-acetylbenzaldehyde can be used as an important intermediate for fragrance composition or fragrance synthesis. Due to its unique chemical structure, it can produce a special aroma. After blending and synthesizing, it can prepare unique flavor fragrance products, which are widely used in perfumes, cosmetics, food additives and other industries to add fascinating aroma to products, improve product quality and market competitiveness.
In summary, 2-% methoxy-4-acetylbenzaldehyde, with its unique chemical structure, has shown an irreplaceable role in many fields such as medicine, materials, and fragrances, promoting the continuous development of various fields.
In the field of medicinal chemistry, it is often a key intermediate for the synthesis of drugs. For example, in some drug molecular architectures with specific biological activities, the structural units of this compound can be cleverly derived and transformed, which can endow drugs with specific pharmacological properties. With its unique chemical structure, it can precisely bind to specific targets in the body and exert therapeutic effects. For example, when developing anti-tumor and antibacterial drugs, 2-% methoxy-4-acetylbenzaldehyde is often used as the starting material to construct complex drug molecules through multi-step reactions, making significant contributions to human health.
In the field of materials science, it also has extraordinary value. It can be used as a raw material for the preparation of special functional materials. After specific reactions and modifications, it can be introduced into polymer materials, thereby changing the physical and chemical properties of the materials. For example, it can improve the optical properties of the materials, so that the materials have specific light absorption and emission characteristics, and are used in cutting-edge fields such as photoelectric display and optical storage; or enhance the stability and durability of the materials to meet the needs of high-end materials in special environments.
In the fragrance industry, 2-% methoxy-4-acetylbenzaldehyde can be used as an important intermediate for fragrance composition or fragrance synthesis. Due to its unique chemical structure, it can produce a special aroma. After blending and synthesizing, it can prepare unique flavor fragrance products, which are widely used in perfumes, cosmetics, food additives and other industries to add fascinating aroma to products, improve product quality and market competitiveness.
In summary, 2-% methoxy-4-acetylbenzaldehyde, with its unique chemical structure, has shown an irreplaceable role in many fields such as medicine, materials, and fragrances, promoting the continuous development of various fields.
What are the physical properties of 2-methoxy-4-nitrochlorobenzene?
2-% methoxy-4-pyridylbromobenzene is an important compound in organic chemistry. Its physical properties are unique and related to many chemical applications.
Looking at its properties, 2-% methoxy-4-pyridylbromobenzene is mostly in a solid state at room temperature, due to intermolecular forces. The atoms in the molecule are arranged in an orderly manner to form a stable structure, resulting in a high lattice energy at room temperature and maintaining a solid state.
When it comes to melting point, the melting point of 2-% methoxy-4-pyridylbromobenzene is within a certain range, which is determined by its molecular structure. Intermolecular interactions, such as van der Waals forces, hydrogen bonds, etc., jointly affect the melting point. In its molecules, methoxy interacts with pyridyl and bromophenyl groups to form a specific spatial structure, which determines the melting point value. This melting point characteristic is crucial for the purification and identification of compounds, and its purity can be determined by melting point measurement.
In addition to solubility, 2-% methoxy-4-pyridyl bromobenzene exhibits different solubility in organic solvents. In polar organic solvents, such as ethanol and acetone, because their molecules have a certain polarity, they can form intermolecular forces with polar solvents, such as dipole-dipole interactions, so they have a certain solubility. However, in non-polar solvents, such as n-hexane, due to the large difference in molecular polarity and polar non-solvents, the interaction is weak, and the solubility is very small. This difference in solubility can be exploited in the separation and purification steps of chemical synthesis to achieve the separation of the compound from other impurities with different solvents.
As for density, the density of 2-% methoxy-4-pyridyl bromobenzene is also an important physical property. The density is determined by the molecular mass and the degree of molecular packing compactness. The molecular mass and spatial structure of the compound give it a specific density value. In chemical production and experimental operations, density data can assist in determining the relationship between dosage and volume, which is of great significance for accurate preparation of solutions or measurement of reaction materials.
Looking at its properties, 2-% methoxy-4-pyridylbromobenzene is mostly in a solid state at room temperature, due to intermolecular forces. The atoms in the molecule are arranged in an orderly manner to form a stable structure, resulting in a high lattice energy at room temperature and maintaining a solid state.
When it comes to melting point, the melting point of 2-% methoxy-4-pyridylbromobenzene is within a certain range, which is determined by its molecular structure. Intermolecular interactions, such as van der Waals forces, hydrogen bonds, etc., jointly affect the melting point. In its molecules, methoxy interacts with pyridyl and bromophenyl groups to form a specific spatial structure, which determines the melting point value. This melting point characteristic is crucial for the purification and identification of compounds, and its purity can be determined by melting point measurement.
In addition to solubility, 2-% methoxy-4-pyridyl bromobenzene exhibits different solubility in organic solvents. In polar organic solvents, such as ethanol and acetone, because their molecules have a certain polarity, they can form intermolecular forces with polar solvents, such as dipole-dipole interactions, so they have a certain solubility. However, in non-polar solvents, such as n-hexane, due to the large difference in molecular polarity and polar non-solvents, the interaction is weak, and the solubility is very small. This difference in solubility can be exploited in the separation and purification steps of chemical synthesis to achieve the separation of the compound from other impurities with different solvents.
As for density, the density of 2-% methoxy-4-pyridyl bromobenzene is also an important physical property. The density is determined by the molecular mass and the degree of molecular packing compactness. The molecular mass and spatial structure of the compound give it a specific density value. In chemical production and experimental operations, density data can assist in determining the relationship between dosage and volume, which is of great significance for accurate preparation of solutions or measurement of reaction materials.
What are the chemical properties of 2-methoxy-4-nitrochlorobenzene?
The chemical properties of 2-% methoxy-4-carbonyl thiobenzene are complex and interesting. In this compound, the presence of methoxy gives it certain lipophilic properties. Methyl is a common group in organic compounds, with relative stability, which can affect the spatial structure of molecules and the distribution of electron clouds. The oxygen group is connected to the methyl group, which makes the electron cloud shift, which in turn affects the polarity of the molecule as a whole.
As for the 4-carbonyl part, this is a strongly polar group, and the carbon-oxygen double bond in the carbonyl group has significant electronegativity differences. Oxygen atoms strongly attract electrons, making carbonyl carbons partially positively charged and vulnerable to attack by nucleophiles. This property allows the compound to participate in many nucleophilic addition reactions, such as reacting with nucleophiles such as alcohols and amines to generate corresponding acetals, amides and other derivatives.
And thiophenyl is also the key structure. The introduction of sulfur atoms changes the electron cloud density and spatial configuration of the molecule. The electronegativity of sulfur atoms is slightly smaller than that of oxygen atoms, but its radius is larger, which can form special bond lengths and bond angles. Thiophenyl can enhance the conjugation system of molecules, increasing the electron delocalization of compounds, thereby affecting their spectral properties and chemical activities.
Due to its unique combination of structures, 2-% methoxy-4-carbonyl thiobenzene is of great value in the field of organic synthesis. It can be used as a key intermediate to participate in the construction of complex organic molecules. The synergy of different functional groups provides organic chemists with a variety of reaction pathways and strategies to achieve the synthesis of specific target compounds.
As for the 4-carbonyl part, this is a strongly polar group, and the carbon-oxygen double bond in the carbonyl group has significant electronegativity differences. Oxygen atoms strongly attract electrons, making carbonyl carbons partially positively charged and vulnerable to attack by nucleophiles. This property allows the compound to participate in many nucleophilic addition reactions, such as reacting with nucleophiles such as alcohols and amines to generate corresponding acetals, amides and other derivatives.
And thiophenyl is also the key structure. The introduction of sulfur atoms changes the electron cloud density and spatial configuration of the molecule. The electronegativity of sulfur atoms is slightly smaller than that of oxygen atoms, but its radius is larger, which can form special bond lengths and bond angles. Thiophenyl can enhance the conjugation system of molecules, increasing the electron delocalization of compounds, thereby affecting their spectral properties and chemical activities.
Due to its unique combination of structures, 2-% methoxy-4-carbonyl thiobenzene is of great value in the field of organic synthesis. It can be used as a key intermediate to participate in the construction of complex organic molecules. The synergy of different functional groups provides organic chemists with a variety of reaction pathways and strategies to achieve the synthesis of specific target compounds.
What is the synthesis method of 2-methoxy-4-nitrochlorobenzene?
To prepare 2-methyl-4-nitrophenethyl ether, the method is as follows:
First take an appropriate amount of phenol, place it in the reaction kettle, and use an appropriate alkali solution, such as sodium hydroxide solution, to convert the phenolic hydroxyl group into sodium phenol. This is because the hydrogen of the phenolic hydroxyl group has a certain acidity, which can neutralize with the base to form a salt of sodium phenol to enhance its nucleophilicity.
Then, take halogenated ethane, such as bromoethane, and slowly add the above reaction system containing sodium phenol. In the presence of appropriate temperature and catalyst, the oxygen anion of sodium phenol acts as a nucleophilic reagent to attack the α-carbon atom of bromoethane, and the bromine ion leaves as a leaving group, and a nucleophilic substitution reaction occurs to form phenethyl ether. This step requires strict control of the reaction conditions. The temperature should not be too high or too low. If it is too high, it may lead to side reactions. If it is too low, the reaction rate is too slow.
After phenethyl ether is formed, the nitrification reaction is carried out. Concentrated sulfuric acid and concentrated nitric acid are prepared into a mixed acid in a certain proportion, and slowly added dropwise to the reaction system containing phenethyl ether. The phenyl ring of phenyl ether is affected by ethoxy groups, and the density of o and para-position electron clouds is relatively high, which is The nitro-positive ion produced by the mixed acid is used as an electrophilic reagent to attack the para-position of the benzene ring and generate 2-methyl-4-nitrophenyl ether. The reaction process needs to be closely monitored during the reaction process, and the reaction endpoint should be determined by thin-layer chromatography and other means. After the reaction, a series of post-processing operations, such as liquid separation, washing, drying, distillation, etc., are used to purify the product to obtain high-purity 2-methyl-4-nitrophenyl ether.
First take an appropriate amount of phenol, place it in the reaction kettle, and use an appropriate alkali solution, such as sodium hydroxide solution, to convert the phenolic hydroxyl group into sodium phenol. This is because the hydrogen of the phenolic hydroxyl group has a certain acidity, which can neutralize with the base to form a salt of sodium phenol to enhance its nucleophilicity.
Then, take halogenated ethane, such as bromoethane, and slowly add the above reaction system containing sodium phenol. In the presence of appropriate temperature and catalyst, the oxygen anion of sodium phenol acts as a nucleophilic reagent to attack the α-carbon atom of bromoethane, and the bromine ion leaves as a leaving group, and a nucleophilic substitution reaction occurs to form phenethyl ether. This step requires strict control of the reaction conditions. The temperature should not be too high or too low. If it is too high, it may lead to side reactions. If it is too low, the reaction rate is too slow.
After phenethyl ether is formed, the nitrification reaction is carried out. Concentrated sulfuric acid and concentrated nitric acid are prepared into a mixed acid in a certain proportion, and slowly added dropwise to the reaction system containing phenethyl ether. The phenyl ring of phenyl ether is affected by ethoxy groups, and the density of o and para-position electron clouds is relatively high, which is The nitro-positive ion produced by the mixed acid is used as an electrophilic reagent to attack the para-position of the benzene ring and generate 2-methyl-4-nitrophenyl ether. The reaction process needs to be closely monitored during the reaction process, and the reaction endpoint should be determined by thin-layer chromatography and other means. After the reaction, a series of post-processing operations, such as liquid separation, washing, drying, distillation, etc., are used to purify the product to obtain high-purity 2-methyl-4-nitrophenyl ether.
What are the precautions for storing and transporting 2-methoxy-4-nitrochlorobenzene?
When storing and transporting 2-% methoxy-4-carbonyl chlorobenzene, many key matters need to be paid attention to.
When storing, the first environmental conditions. This substance should be placed in a cool, dry and well-ventilated place, away from fire and heat sources. Because it may have certain volatility and chemical activity, high temperature is prone to increased volatilization, which increases safety risks, and humid environment may cause chemical reactions, which affects quality. For example, if stored in a high temperature and humid warehouse, or its composition changes, the use efficiency will be reduced.
Furthermore, storage needs to be classified. Do not mix with oxidants, acids, bases, etc. 2-% methoxy-4-carbonyl chlorobenzene has unique chemical properties. It can mix with the above substances, or cause violent chemical reactions, such as combustion and explosion. Just like placing it in the same place as a strong oxidizer, a little carelessness can trigger a dangerous reaction.
Packaging is also crucial. Make sure that the packaging is well sealed and suitable packaging materials are used. High-quality sealed packaging can prevent its volatilization and leakage, and can block external factors. Suitable packaging materials can withstand its chemical properties and do not react with it. If the packaging is not good, leakage will not only waste resources, but also may pollute the environment and endanger the safety of personnel.
When transporting, strictly abide by relevant regulations and standards. Transportation vehicles need to have corresponding qualifications and safety equipment, such as fire protection, explosion-proof devices, etc. Escorts should be familiar with the characteristics of the substance and emergency treatment methods, and pay close attention to the status of the goods on the way. If there is an emergency during transportation, they can quickly take correct measures to deal with it.
The loading and unloading process also needs to be cautious. Handle with care to avoid collisions and falls to prevent package damage. Once the package is damaged, the material leaks, which is quite difficult to deal with, and the leaked material may cause harm to surrounding personnel and the environment. In short, 2-% methoxy-4-carbonyl chlorobenzene cannot be ignored in all aspects of storage and transportation, so as to ensure safety and quality.
When storing, the first environmental conditions. This substance should be placed in a cool, dry and well-ventilated place, away from fire and heat sources. Because it may have certain volatility and chemical activity, high temperature is prone to increased volatilization, which increases safety risks, and humid environment may cause chemical reactions, which affects quality. For example, if stored in a high temperature and humid warehouse, or its composition changes, the use efficiency will be reduced.
Furthermore, storage needs to be classified. Do not mix with oxidants, acids, bases, etc. 2-% methoxy-4-carbonyl chlorobenzene has unique chemical properties. It can mix with the above substances, or cause violent chemical reactions, such as combustion and explosion. Just like placing it in the same place as a strong oxidizer, a little carelessness can trigger a dangerous reaction.
Packaging is also crucial. Make sure that the packaging is well sealed and suitable packaging materials are used. High-quality sealed packaging can prevent its volatilization and leakage, and can block external factors. Suitable packaging materials can withstand its chemical properties and do not react with it. If the packaging is not good, leakage will not only waste resources, but also may pollute the environment and endanger the safety of personnel.
When transporting, strictly abide by relevant regulations and standards. Transportation vehicles need to have corresponding qualifications and safety equipment, such as fire protection, explosion-proof devices, etc. Escorts should be familiar with the characteristics of the substance and emergency treatment methods, and pay close attention to the status of the goods on the way. If there is an emergency during transportation, they can quickly take correct measures to deal with it.
The loading and unloading process also needs to be cautious. Handle with care to avoid collisions and falls to prevent package damage. Once the package is damaged, the material leaks, which is quite difficult to deal with, and the leaked material may cause harm to surrounding personnel and the environment. In short, 2-% methoxy-4-carbonyl chlorobenzene cannot be ignored in all aspects of storage and transportation, so as to ensure safety and quality.
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