Linshang Chemical
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3,4-Dichlorobenzenesulfonyl Chloride
Linshang Chemical
|
HS Code |
281143 |
| Chemical Formula | C6H3Cl3O2S |
| Molar Mass | 245.51 g/mol |
| Appearance | White to off - white solid |
| Boiling Point | Approximately 180 - 182°C at 1.5 mmHg |
| Melting Point | 54 - 56°C |
| Solubility In Water | Reacts with water |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, toluene |
| Density | 1.66 g/cm³ |
| Vapor Pressure | Low vapor pressure |
| Acidity Basicity | Acidic due to the sulfonyl chloride group |
As an accredited 3,4-Dichlorobenzenesulfonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 kg of 3,4 - dichlorobenzenesulfonyl chloride in sealed, corrosion - resistant container. |
| Storage | 3,4 - dichlorobenzenesulfonyl chloride should be stored in a cool, dry, well - ventilated area. Keep it away from heat, flames, and oxidizing agents. Store in a tightly - sealed container to prevent moisture ingress, as it may react with water. Separate it from incompatible substances like bases. This storage approach helps maintain its stability and reduces the risk of hazardous reactions. |
| Shipping | 3,4 - dichlorobenzenesulfonyl chloride is a hazardous chemical. It must be shipped in accordance with strict regulations. Use appropriate packaging to prevent leakage, and label clearly for safe and compliant transportation. |
Competitive 3,4-Dichlorobenzenesulfonyl Chloride prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 3,4-Dichlorobenzenesulfonyl Chloride in China?
As a trusted 3,4-Dichlorobenzenesulfonyl Chloride manufacturer, we deliver:
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Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 3,4-Dichlorobenzenesulfonyl Chloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 3,4-dichlorobenzenesulfonyl chloride?
3,4-Difluorobenzoyl chloride is a crucial raw material in organic synthesis and has a wide range of uses in medicine, pesticides, materials and other fields.
In the field of medicine, it is often used to prepare a variety of drugs. For example, in the synthesis of many fluorinated drugs, 3,4-difluorobenzoyl chloride can be used as a key intermediate to react with specific amines, alcohols and other compounds to construct molecular structures with specific pharmacological activities. Because the fluorine atoms introduced by it can significantly change the lipophilicity, stability and interaction with receptors of drug molecules, thereby enhancing the efficacy of drugs, prolonging the action time and reducing side effects.
In the field of pesticides, 3,4-difluorobenzoyl chloride is also an important synthetic raw material. It can be used to synthesize highly efficient, low-toxic and environmentally friendly fluorinated pesticides. By combining with various active groups, pesticides, fungicides and herbicides with unique mechanisms of action are created to meet the needs of modern agriculture for pest control and weed control, while reducing the adverse impact on the environment.
In the field of materials, it can participate in the preparation of high-performance fluoropolymer materials. Such materials often have excellent heat resistance, chemical corrosion resistance and electrical properties, and are widely used in high-end fields such as aerospace and electronic information. Such as the preparation of special engineering plastics, high-performance coatings, etc., can significantly improve the comprehensive properties of materials and meet the requirements of special environments and high-end technologies.
In short, 3,4-difluorobenzoyl chloride plays an indispensable role in many important fields due to its unique chemical properties, promoting the technological progress and development of related industries.
In the field of medicine, it is often used to prepare a variety of drugs. For example, in the synthesis of many fluorinated drugs, 3,4-difluorobenzoyl chloride can be used as a key intermediate to react with specific amines, alcohols and other compounds to construct molecular structures with specific pharmacological activities. Because the fluorine atoms introduced by it can significantly change the lipophilicity, stability and interaction with receptors of drug molecules, thereby enhancing the efficacy of drugs, prolonging the action time and reducing side effects.
In the field of pesticides, 3,4-difluorobenzoyl chloride is also an important synthetic raw material. It can be used to synthesize highly efficient, low-toxic and environmentally friendly fluorinated pesticides. By combining with various active groups, pesticides, fungicides and herbicides with unique mechanisms of action are created to meet the needs of modern agriculture for pest control and weed control, while reducing the adverse impact on the environment.
In the field of materials, it can participate in the preparation of high-performance fluoropolymer materials. Such materials often have excellent heat resistance, chemical corrosion resistance and electrical properties, and are widely used in high-end fields such as aerospace and electronic information. Such as the preparation of special engineering plastics, high-performance coatings, etc., can significantly improve the comprehensive properties of materials and meet the requirements of special environments and high-end technologies.
In short, 3,4-difluorobenzoyl chloride plays an indispensable role in many important fields due to its unique chemical properties, promoting the technological progress and development of related industries.
What are the physical properties of 3,4-dichlorobenzenesulfonyl chloride?
3,2,4-Difluorobenzoyl chloride is a key raw material in organic synthesis. Its physical properties are unique, allowing you to take a closer look.
Looking at its properties, this substance is a colorless to light yellow liquid under normal conditions, with a clear texture. It has a pungent smell, just like a sharp and sharp light hidden in the dark. A little careless contact will cause irritation to the respiratory tract, eyes and skin of the human body, so when using it, you must pay great attention to protection.
When it comes to melting point, the melting point of 3,2,4-difluorobenzoyl chloride is about -40 ° C. Such a low melting point allows it to remain liquid in a relatively low temperature environment, making it easier to operate and mix in specific synthetic reactions.
In terms of boiling point, it is about 190 ° C - 195 ° C. This boiling point characteristic is crucial in the separation and purification process. By precisely controlling the temperature, it can be effectively separated from other substances.
In terms of solubility, 3,2,4-difluorobenzoyl chloride is soluble in many organic solvents, such as ether and dichloromethane. This solubility property provides convenient conditions for its integration in the organic synthesis reaction system. It can fully contact and react with different reactants to help synthesize the target product.
The density is about 1.45 - 1.50g/cm ³, which is slightly higher than that of water. When it comes to liquid-liquid separation and other operations, this density characteristic helps to judge its distribution in the mixed system and provides an important basis for experimental operations.
In summary, the physical properties of 3,2,4-difluorobenzoyl chloride play an extraordinary role in the field of organic synthesis. Only by accurately grasping these characteristics can synthesizers strategize and achieve efficient synthesis of the target product.
Looking at its properties, this substance is a colorless to light yellow liquid under normal conditions, with a clear texture. It has a pungent smell, just like a sharp and sharp light hidden in the dark. A little careless contact will cause irritation to the respiratory tract, eyes and skin of the human body, so when using it, you must pay great attention to protection.
When it comes to melting point, the melting point of 3,2,4-difluorobenzoyl chloride is about -40 ° C. Such a low melting point allows it to remain liquid in a relatively low temperature environment, making it easier to operate and mix in specific synthetic reactions.
In terms of boiling point, it is about 190 ° C - 195 ° C. This boiling point characteristic is crucial in the separation and purification process. By precisely controlling the temperature, it can be effectively separated from other substances.
In terms of solubility, 3,2,4-difluorobenzoyl chloride is soluble in many organic solvents, such as ether and dichloromethane. This solubility property provides convenient conditions for its integration in the organic synthesis reaction system. It can fully contact and react with different reactants to help synthesize the target product.
The density is about 1.45 - 1.50g/cm ³, which is slightly higher than that of water. When it comes to liquid-liquid separation and other operations, this density characteristic helps to judge its distribution in the mixed system and provides an important basis for experimental operations.
In summary, the physical properties of 3,2,4-difluorobenzoyl chloride play an extraordinary role in the field of organic synthesis. Only by accurately grasping these characteristics can synthesizers strategize and achieve efficient synthesis of the target product.
Is the chemical properties of 3,4-dichlorobenzenesulfonyl chloride stable?
The chemical properties of 3,4-difluorobenzoyl chloride are not stable. This is an organic compound, containing fluorine, chlorine and other halogen elements, and has the active functional group of acid chloride.
The activity of acid chloride is quite strong, and it is easy to react violently in contact with water, and hydrolysis produces corresponding acid and hydrogen chloride gas. If 3,4-difluorobenzoyl chloride encounters water, 3,4-difluorobenzoyl chloride produces 3,4-difluorobenzoic acid and hydrogen chloride. The reaction formula can be expressed as: RCOCl + H2O → RCOOH + HCl (here R is 3,4-difluorophenyl). This hydrolysis reaction is rapid, or causes the pressure in the container to rise sharply, which is potentially dangerous.
In addition, when it encounters alcohols, it is also prone to alcoholysis to form ester compounds. When it interacts with amines, an aminolysis reaction occurs to form an amide. This is due to the high activity of chlorine atoms in acyl chloride, which is easily replaced by nucleophiles.
And because of its fluorine atom, although fluorine atoms make the molecule have certain stability and special properties, they also affect its reactivity and chemical behavior. And 3,4-difluorobenzoyl chloride may cause reactions such as intramolecular rearrangement and decomposition under high temperature, light and other conditions. Therefore, in summary, 3,4-difluorobenzoyl chloride is chemically active and not a stable substance. When storing and using it, strict protective and operational measures should be taken according to its characteristics to avoid danger.
The activity of acid chloride is quite strong, and it is easy to react violently in contact with water, and hydrolysis produces corresponding acid and hydrogen chloride gas. If 3,4-difluorobenzoyl chloride encounters water, 3,4-difluorobenzoyl chloride produces 3,4-difluorobenzoic acid and hydrogen chloride. The reaction formula can be expressed as: RCOCl + H2O → RCOOH + HCl (here R is 3,4-difluorophenyl). This hydrolysis reaction is rapid, or causes the pressure in the container to rise sharply, which is potentially dangerous.
In addition, when it encounters alcohols, it is also prone to alcoholysis to form ester compounds. When it interacts with amines, an aminolysis reaction occurs to form an amide. This is due to the high activity of chlorine atoms in acyl chloride, which is easily replaced by nucleophiles.
And because of its fluorine atom, although fluorine atoms make the molecule have certain stability and special properties, they also affect its reactivity and chemical behavior. And 3,4-difluorobenzoyl chloride may cause reactions such as intramolecular rearrangement and decomposition under high temperature, light and other conditions. Therefore, in summary, 3,4-difluorobenzoyl chloride is chemically active and not a stable substance. When storing and using it, strict protective and operational measures should be taken according to its characteristics to avoid danger.
What is the preparation method of 3,4-dichlorobenzenesulfonyl chloride?
3,4-Difluorobenzoyl chloride is a key intermediate in organic synthesis. The preparation method is as follows:
First, 3,4-difluorobenzoic acid is used as the starting material. Place an appropriate amount of 3,4-difluorobenzoic acid in a clean and dry reaction vessel. This reaction vessel should be a reactor with good sealing properties and a stirring device, so as to ensure the stability of the reaction process and the full mixing of materials.
Then, slowly add an appropriate amount of chlorination reagent to the reactor. Commonly used chlorination reagents include sulfoxide chloride (SOCl ²), phosphorus trichloride (PCl ²), etc. If thionyl chloride is used, the product is easy to separate and purify due to its advantages of high reactivity, few side reactions and easy escape of the gases (sulfur dioxide and hydrogen chloride) generated after the reaction.
The reaction process requires strict control of the reaction temperature and reaction time. Generally speaking, when thionyl chloride is used as a chlorination reagent, the temperature of the reaction system is maintained at a low level, about 20-30 ° C, and stirred for a period of time to make the reactants initially contact and react. Then, slowly heat up to 50-80 ° C, and continue to stir for 3-5 hours. This heating process needs to be carried out smoothly to prevent the reaction from being too violent and causing accidents.
After the reaction is over, the reaction system is first distilled under reduced pressure. The excess sulfoxide chloride and the low boiling point by-products generated by the reaction can be effectively separated by vacuum distillation. Subsequently, the remaining products are rectified to collect fractions within a specific boiling point range, which is pure 3,4-difluorobenzoyl chloride.
The whole preparation process needs to be carried out in a well-ventilated environment. Due to the corrosive and irritating properties of sulfoxide chloride and other reagents involved in the reaction, operators must also strictly follow relevant safety procedures and take protective measures to ensure their own safety and the smooth progress of the experiment.
First, 3,4-difluorobenzoic acid is used as the starting material. Place an appropriate amount of 3,4-difluorobenzoic acid in a clean and dry reaction vessel. This reaction vessel should be a reactor with good sealing properties and a stirring device, so as to ensure the stability of the reaction process and the full mixing of materials.
Then, slowly add an appropriate amount of chlorination reagent to the reactor. Commonly used chlorination reagents include sulfoxide chloride (SOCl ²), phosphorus trichloride (PCl ²), etc. If thionyl chloride is used, the product is easy to separate and purify due to its advantages of high reactivity, few side reactions and easy escape of the gases (sulfur dioxide and hydrogen chloride) generated after the reaction.
The reaction process requires strict control of the reaction temperature and reaction time. Generally speaking, when thionyl chloride is used as a chlorination reagent, the temperature of the reaction system is maintained at a low level, about 20-30 ° C, and stirred for a period of time to make the reactants initially contact and react. Then, slowly heat up to 50-80 ° C, and continue to stir for 3-5 hours. This heating process needs to be carried out smoothly to prevent the reaction from being too violent and causing accidents.
After the reaction is over, the reaction system is first distilled under reduced pressure. The excess sulfoxide chloride and the low boiling point by-products generated by the reaction can be effectively separated by vacuum distillation. Subsequently, the remaining products are rectified to collect fractions within a specific boiling point range, which is pure 3,4-difluorobenzoyl chloride.
The whole preparation process needs to be carried out in a well-ventilated environment. Due to the corrosive and irritating properties of sulfoxide chloride and other reagents involved in the reaction, operators must also strictly follow relevant safety procedures and take protective measures to ensure their own safety and the smooth progress of the experiment.
What are the precautions for storing and transporting 3,4-dichlorobenzenesulfonyl chloride?
3,4-Difluorobenzoyl chloride is also a chemical substance. When storing and transporting, there are several ends that should be paid attention to.
First words storage. This material is lively, corrosive, and should be stored in a cool, dry and well-ventilated place. Keep away from fire and heat sources to prevent it from being dangerous due to heat. Because it is sensitive to humidity, the storage place should be protected from moisture to prevent moisture degradation. And it should be stored separately from oxidizing agents, alkalis, etc., and must not be mixed. The lid is prone to chemical reactions with them, causing accidents. In addition, the storage container must also be strictly selected, and corrosion-resistant materials should be used to ensure that it is well sealed to prevent leakage.
Times and transportation. Before transportation, the container must be carefully checked to ensure that there is no damage or risk of leakage. During transportation, the container must be fixed securely to prevent damage caused by bumps and collisions. In view of its corrosive nature, transporters must wear professional protective equipment, such as protective clothing, protective gloves and goggles, to ensure safety. At the same time, transportation vehicles should also be equipped with emergency treatment equipment and suitable containment materials, so that in the event of leakage, they can be dealt with in time. And the planning of transportation routes should avoid sensitive areas such as densely populated areas and water source reserves to prevent major hazards from leakage.
All of these are for the storage and transportation of 3,4-difluorobenzoyl chloride. Only with caution can the process be safe and secure.
First words storage. This material is lively, corrosive, and should be stored in a cool, dry and well-ventilated place. Keep away from fire and heat sources to prevent it from being dangerous due to heat. Because it is sensitive to humidity, the storage place should be protected from moisture to prevent moisture degradation. And it should be stored separately from oxidizing agents, alkalis, etc., and must not be mixed. The lid is prone to chemical reactions with them, causing accidents. In addition, the storage container must also be strictly selected, and corrosion-resistant materials should be used to ensure that it is well sealed to prevent leakage.
Times and transportation. Before transportation, the container must be carefully checked to ensure that there is no damage or risk of leakage. During transportation, the container must be fixed securely to prevent damage caused by bumps and collisions. In view of its corrosive nature, transporters must wear professional protective equipment, such as protective clothing, protective gloves and goggles, to ensure safety. At the same time, transportation vehicles should also be equipped with emergency treatment equipment and suitable containment materials, so that in the event of leakage, they can be dealt with in time. And the planning of transportation routes should avoid sensitive areas such as densely populated areas and water source reserves to prevent major hazards from leakage.
All of these are for the storage and transportation of 3,4-difluorobenzoyl chloride. Only with caution can the process be safe and secure.
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