Linshang Chemical
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3,5-Dichloro-4-Fluoro-1-Nitrobenzene
Linshang Chemical
|
HS Code |
690958 |
| Chemical Formula | C6H2Cl2FNO2 |
| Molar Mass | 209.99 g/mol |
| Appearance | Solid (Typically) |
| Melting Point | Data needed |
| Boiling Point | Data needed |
| Density | Data needed |
| Solubility In Water | Low (Expected, due to non - polar nature) |
| Solubility In Organic Solvents | Soluble in common organic solvents like benzene, toluene |
| Vapor Pressure | Data needed |
| Flash Point | Data needed |
| Odor | Data needed |
| Stability | Stable under normal conditions, but may react with strong reducing agents, bases |
As an accredited 3,5-Dichloro-4-Fluoro-1-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 3,5 - dichloro - 4 - fluoro - 1 - nitrobenzene packaged in sealed plastic bags. |
| Storage | 3,5 - dichloro - 4 - fluoro - 1 - nitrobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat, ignition sources, and incompatible substances like strong oxidizers and reducing agents. Store in a tightly sealed container, preferably made of corrosion - resistant materials, to prevent leakage and exposure to air or moisture. |
| Shipping | 3,5 - dichloro - 4 - fluoro - 1 - nitrobenzene is shipped in sealed, corrosion - resistant containers. Special care is taken to prevent leakage. It follows strict hazardous chemical shipping regulations to ensure safety during transit. |
Competitive 3,5-Dichloro-4-Fluoro-1-Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 3,5-Dichloro-4-Fluoro-1-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 3,5-dichloro-4-fluoro-1-nitrobenzene?
3,2,5-Difluoro-4-ethoxy-1-formylbenzene, which is widely used in the field of pharmaceutical and chemical industry.
In the process of pharmaceutical research and development, it is a key organic synthesis intermediate. Taking the creation of new antidepressant drugs as an example, researchers integrate them into the target molecular structure through exquisite chemical reactions. Due to its unique fluorine atom and ethoxy structure, it can efficiently regulate the lipid solubility and electron cloud distribution of drug molecules, greatly optimize the affinity and selectivity of drugs and biological targets, and then improve the efficacy and safety of drugs.
In the field of pesticide creation, it is also indispensable. With the development of green agriculture, there is an increasing demand for high-efficiency, low-toxicity and environmentally friendly pesticides. 3,2,5-Difluoro-4-ethoxy-1-formylbenzene can be converted into an effective ingredient with excellent insecticidal and bactericidal activities. Due to its special structure, it can precisely act on specific physiological links of pests or pathogens, interfere with their normal physiological metabolism, achieve the purpose of efficient control, and have little toxicity to non-target organisms, which is in line with the concept of sustainable development of modern agriculture.
In the field of materials science, this compound has emerged. With the rapid development of the electronic information industry, the demand for high-performance organic optoelectronic materials has surged. The unique electronic structure and optical properties of 3,2,5-difluoro-4-ethoxy-1-formylbenzene can be used as a building unit to prepare key materials for optoelectronic devices such as organic Light Emitting Diodes (OLEDs) and organic solar cells, and contribute to the progress of materials science.
In the process of pharmaceutical research and development, it is a key organic synthesis intermediate. Taking the creation of new antidepressant drugs as an example, researchers integrate them into the target molecular structure through exquisite chemical reactions. Due to its unique fluorine atom and ethoxy structure, it can efficiently regulate the lipid solubility and electron cloud distribution of drug molecules, greatly optimize the affinity and selectivity of drugs and biological targets, and then improve the efficacy and safety of drugs.
In the field of pesticide creation, it is also indispensable. With the development of green agriculture, there is an increasing demand for high-efficiency, low-toxicity and environmentally friendly pesticides. 3,2,5-Difluoro-4-ethoxy-1-formylbenzene can be converted into an effective ingredient with excellent insecticidal and bactericidal activities. Due to its special structure, it can precisely act on specific physiological links of pests or pathogens, interfere with their normal physiological metabolism, achieve the purpose of efficient control, and have little toxicity to non-target organisms, which is in line with the concept of sustainable development of modern agriculture.
In the field of materials science, this compound has emerged. With the rapid development of the electronic information industry, the demand for high-performance organic optoelectronic materials has surged. The unique electronic structure and optical properties of 3,2,5-difluoro-4-ethoxy-1-formylbenzene can be used as a building unit to prepare key materials for optoelectronic devices such as organic Light Emitting Diodes (OLEDs) and organic solar cells, and contribute to the progress of materials science.
What are the physical properties of 3,5-dichloro-4-fluoro-1-nitrobenzene?
3,5-Dihydroxy-4-methoxy-1-naphthylbenzene, this material property is complex and delicate. Its color, or light brown, shines faintly under the light, just like the accumulation of ancient wood. Its quality is as stable as a rock at room temperature, and when it encounters a hot topic, it is like melting ice, gradually disappearing and formless. Its taste is almost undetectable, but it is like a faint fragrance hidden in fine taste, similar to the clear air of forest leaves through rain.
On its solubility, it melts seamlessly in alcoholic solvents, such as alcohol and water; in water, it is like oil floating on water, distinct and difficult to form a whole. Its melting point, like the needle of the sea, is about a specific temperature, and the state of solid and liquid is instantaneous at that time.
Furthermore, its chemical activity is like a smart dance. In acid, it is like a warrior meeting a drum, reacting enthusiastically, and a new compound is born; in lye, it is not a silent person. According to its conditions, it can deduce wonderful changes, whether static or dynamic.
Its spectral characteristics, like the stars in the sky, each have their own position. The infrared spectrum, the peaks and valleys are scattered, just like the ups and downs of mountains and rivers, showing the structural characteristics of its molecules; the nuclear magnetic spectrum, the signal flickers, like stars in the sky, indicating the location of hydrogen and carbon.
Such physical properties are determined by its molecular structure. Atoms are connected, the strength and length of bonds, and the arrangement of space are all the sources of physical properties. In research and application, knowing physical properties well, it can be used like a craftsman, and it can be used properly in the fields of medicine and chemical industry.
On its solubility, it melts seamlessly in alcoholic solvents, such as alcohol and water; in water, it is like oil floating on water, distinct and difficult to form a whole. Its melting point, like the needle of the sea, is about a specific temperature, and the state of solid and liquid is instantaneous at that time.
Furthermore, its chemical activity is like a smart dance. In acid, it is like a warrior meeting a drum, reacting enthusiastically, and a new compound is born; in lye, it is not a silent person. According to its conditions, it can deduce wonderful changes, whether static or dynamic.
Its spectral characteristics, like the stars in the sky, each have their own position. The infrared spectrum, the peaks and valleys are scattered, just like the ups and downs of mountains and rivers, showing the structural characteristics of its molecules; the nuclear magnetic spectrum, the signal flickers, like stars in the sky, indicating the location of hydrogen and carbon.
Such physical properties are determined by its molecular structure. Atoms are connected, the strength and length of bonds, and the arrangement of space are all the sources of physical properties. In research and application, knowing physical properties well, it can be used like a craftsman, and it can be used properly in the fields of medicine and chemical industry.
What are the chemical properties of 3,5-dichloro-4-fluoro-1-nitrobenzene?
3,5-Difluoro-4-ethyl-1-naphthylboronic acid is a crucial reagent in the field of organic synthesis. This compound has many unique chemical properties and plays a key role in organic synthesis reactions.
In terms of reactivity, its boric acid groups are active and can participate in a variety of classical organic reactions. For example, in the Suzuki coupling reaction, 3,5-difluoro-4-ethyl-1-naphthylboronic acid can be coupled with halogenated aromatics or olefins under palladium catalysis to achieve the formation of carbon-carbon bonds. The reaction conditions are mild and the selectivity is very high. It can efficiently synthesize a series of complex organic compounds containing naphthyl groups, which are widely used in the fields of medicinal chemistry and materials science.
From the perspective of electronic effects, the presence of fluorine atoms in the molecule significantly affects the distribution of its electron cloud. Fluorine atoms are extremely electronegative and have a strong electron-absorbing induction effect, which can reduce the density of the molecular electron cloud and make the carbon atoms connected to them more positively charged. In this way, it not only affects the polarity of the molecule, but also affects the reactivity and selectivity. In the nucleophilic substitution reaction, the electron-absorbing effect of fluorine atoms can enhance the electrophilicity of the substrate, making it easier to attract nucleophilic reagents to attack.
In terms of spatial structure, the rigid planar structure of naphthyl groups imparts a certain steric resistance to molecules. This steric resistance has a significant impact on the reaction selectivity. In some reactions, a large steric resistance will limit the proximity of reagents, so that the reaction selectivity tends to proceed in the direction of smaller steric resistance.
In terms of stability, 3,5-difluoro-4-ethyl-1-naphthylboronic acid is relatively stable under conventional conditions, but is more sensitive to humidity. Because boric acid groups can react with water, it is necessary to pay attention to moisture protection when storing and using, usually under the protection of dry inert gas. In conclusion, 3,5-difluoro-4-ethyl-1-naphthyl boronic acid occupies an important position in the field of modern organic synthetic chemistry due to its unique reactivity, electronic effect, spatial structure and stability characteristics, providing an effective way for the synthesis of many complex organic compounds.
In terms of reactivity, its boric acid groups are active and can participate in a variety of classical organic reactions. For example, in the Suzuki coupling reaction, 3,5-difluoro-4-ethyl-1-naphthylboronic acid can be coupled with halogenated aromatics or olefins under palladium catalysis to achieve the formation of carbon-carbon bonds. The reaction conditions are mild and the selectivity is very high. It can efficiently synthesize a series of complex organic compounds containing naphthyl groups, which are widely used in the fields of medicinal chemistry and materials science.
From the perspective of electronic effects, the presence of fluorine atoms in the molecule significantly affects the distribution of its electron cloud. Fluorine atoms are extremely electronegative and have a strong electron-absorbing induction effect, which can reduce the density of the molecular electron cloud and make the carbon atoms connected to them more positively charged. In this way, it not only affects the polarity of the molecule, but also affects the reactivity and selectivity. In the nucleophilic substitution reaction, the electron-absorbing effect of fluorine atoms can enhance the electrophilicity of the substrate, making it easier to attract nucleophilic reagents to attack.
In terms of spatial structure, the rigid planar structure of naphthyl groups imparts a certain steric resistance to molecules. This steric resistance has a significant impact on the reaction selectivity. In some reactions, a large steric resistance will limit the proximity of reagents, so that the reaction selectivity tends to proceed in the direction of smaller steric resistance.
In terms of stability, 3,5-difluoro-4-ethyl-1-naphthylboronic acid is relatively stable under conventional conditions, but is more sensitive to humidity. Because boric acid groups can react with water, it is necessary to pay attention to moisture protection when storing and using, usually under the protection of dry inert gas. In conclusion, 3,5-difluoro-4-ethyl-1-naphthyl boronic acid occupies an important position in the field of modern organic synthetic chemistry due to its unique reactivity, electronic effect, spatial structure and stability characteristics, providing an effective way for the synthesis of many complex organic compounds.
What is the production method of 3,5-dichloro-4-fluoro-1-nitrobenzene?
The method for preparing 3,5-difluoro-4-bromo-1-methoxybenzene can be as follows.
First take a suitable reaction vessel, wash and dry it to avoid impurities interfering with the reaction. A specific starting material is added to it, and the raw material needs to be purified in advance to ensure that its purity meets the reaction requirements.
One method also allows the basic raw material containing benzene ring to be placed in a reaction system with a suitable organic solvent. The organic solvent needs to have good solubility and stability, such as dichloromethane. In this system, slowly add halogenating reagents, such as fluorohalogenants and brominated halogenants. When adding, it is necessary to strictly control the temperature, usually in a low temperature environment, such as between 0 ° C and - 20 ° C. This is because the halogenation reaction is more active, and if the temperature is too high, it is easy to cause side reactions. At the same time, stir to make the reactants fully contact and the reaction is uniform. The stirring rate also needs to be appropriate. If it is too fast, it may damage the reaction vessel or affect the reaction process. If it is too slow, it will be unevenly mixed.
After a period of reaction, the reaction process will be monitored by means of thin layer chromatography (TLC). When the raw material point is basically eliminated and the product point reaches the expected ratio, the reaction will be regarded as basically completed. After that, the reaction mixture will be post-processed. The reaction can be quenched with an appropriate amount of water first, and then the product can be extracted with an organic solvent, such as multiple extractions with ethyl acetate, so that the product is transferred to the organic phase. The organic phase is collected and dried with a desiccant such as anhydrous sodium sulfate to remove the moisture. After drying, the desiccant is filtered to remove the desiccant, and then the organic solvent is removed by vacuum distillation to obtain a crude product.
For further purification of the crude product, column chromatography is often used. Select a suitable silica gel as the stationary phase, and use a specific proportion of eluent, such as a mixture of petroleum ether and ethyl acetate as the mobile phase, and separate it by column chromatography to collect fractions containing the target product. Finally, the collected fractions are dried and concentrated again to obtain high-purity 3,5-difluoro-4-bromo-1-methoxybenzene.
It should be noted that each step in the reaction process needs to be carefully operated, and strict control of temperature, reagent dosage, reaction time and other factors can ensure the yield and purity of the product.
First take a suitable reaction vessel, wash and dry it to avoid impurities interfering with the reaction. A specific starting material is added to it, and the raw material needs to be purified in advance to ensure that its purity meets the reaction requirements.
One method also allows the basic raw material containing benzene ring to be placed in a reaction system with a suitable organic solvent. The organic solvent needs to have good solubility and stability, such as dichloromethane. In this system, slowly add halogenating reagents, such as fluorohalogenants and brominated halogenants. When adding, it is necessary to strictly control the temperature, usually in a low temperature environment, such as between 0 ° C and - 20 ° C. This is because the halogenation reaction is more active, and if the temperature is too high, it is easy to cause side reactions. At the same time, stir to make the reactants fully contact and the reaction is uniform. The stirring rate also needs to be appropriate. If it is too fast, it may damage the reaction vessel or affect the reaction process. If it is too slow, it will be unevenly mixed.
After a period of reaction, the reaction process will be monitored by means of thin layer chromatography (TLC). When the raw material point is basically eliminated and the product point reaches the expected ratio, the reaction will be regarded as basically completed. After that, the reaction mixture will be post-processed. The reaction can be quenched with an appropriate amount of water first, and then the product can be extracted with an organic solvent, such as multiple extractions with ethyl acetate, so that the product is transferred to the organic phase. The organic phase is collected and dried with a desiccant such as anhydrous sodium sulfate to remove the moisture. After drying, the desiccant is filtered to remove the desiccant, and then the organic solvent is removed by vacuum distillation to obtain a crude product.
For further purification of the crude product, column chromatography is often used. Select a suitable silica gel as the stationary phase, and use a specific proportion of eluent, such as a mixture of petroleum ether and ethyl acetate as the mobile phase, and separate it by column chromatography to collect fractions containing the target product. Finally, the collected fractions are dried and concentrated again to obtain high-purity 3,5-difluoro-4-bromo-1-methoxybenzene.
It should be noted that each step in the reaction process needs to be carefully operated, and strict control of temperature, reagent dosage, reaction time and other factors can ensure the yield and purity of the product.
What are the precautions for storing and transporting 3,5-dichloro-4-fluoro-1-nitrobenzene?
3% 2C5-dihydro-4-ene-1-naphthalene naphthalene This product requires attention to many matters during storage and transportation.
First, due to its unique chemical properties, it has strict requirements on the temperature and humidity of the storage environment. The temperature should be controlled in a specific range. If it is too high, it may cause its chemical structure to change and damage its quality; if the humidity is too high, it may also cause it to be damp and deteriorate. Therefore, it should be stored in a dry, cool and well-ventilated place.
Second, when transporting, it must be well protected. This product may have a certain sensitivity, and vibration and collision on the way may cause accidents, so it needs to be wrapped with appropriate cushioning materials to ensure stable transportation. And the means of transportation should also be clean and free from the risk of impurity contamination.
Furthermore, because it may belong to a special chemical category, storage and transportation must be carried out in accordance with relevant regulations and regulations. Relevant practitioners must be familiar with the requirements of regulations, go through complete procedures, and must not be slack in the slightest to prevent serious consequences due to violations.
In addition, the storage place should be clearly marked, indicating the name, characteristics, hazards and other key information of the object. Once there is an unexpected situation such as leakage, it is convenient to respond quickly and take appropriate measures. During transportation, it should also be monitored at any time, and if there is any abnormality, it should be disposed of immediately. Therefore, the safety of 3% 2C5-dihydro-4-ene-1-naphthalene is guaranteed during storage and transportation.
First, due to its unique chemical properties, it has strict requirements on the temperature and humidity of the storage environment. The temperature should be controlled in a specific range. If it is too high, it may cause its chemical structure to change and damage its quality; if the humidity is too high, it may also cause it to be damp and deteriorate. Therefore, it should be stored in a dry, cool and well-ventilated place.
Second, when transporting, it must be well protected. This product may have a certain sensitivity, and vibration and collision on the way may cause accidents, so it needs to be wrapped with appropriate cushioning materials to ensure stable transportation. And the means of transportation should also be clean and free from the risk of impurity contamination.
Furthermore, because it may belong to a special chemical category, storage and transportation must be carried out in accordance with relevant regulations and regulations. Relevant practitioners must be familiar with the requirements of regulations, go through complete procedures, and must not be slack in the slightest to prevent serious consequences due to violations.
In addition, the storage place should be clearly marked, indicating the name, characteristics, hazards and other key information of the object. Once there is an unexpected situation such as leakage, it is convenient to respond quickly and take appropriate measures. During transportation, it should also be monitored at any time, and if there is any abnormality, it should be disposed of immediately. Therefore, the safety of 3% 2C5-dihydro-4-ene-1-naphthalene is guaranteed during storage and transportation.
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