Linshang Chemical
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3,5-Dichlorobenzenesulfonyl Chloride
Linshang Chemical
|
HS Code |
664950 |
| Chemical Formula | C6H3Cl3O2S |
| Molecular Weight | 245.51 |
| Appearance | Typically a solid |
| Color | May be colorless to pale yellow |
| Odor | Pungent, characteristic sulfonyl chloride odor |
| Melting Point | Varies, specific value depends on purity |
| Solubility | Limited solubility in water, soluble in some organic solvents |
| Density | Characteristic density value |
| Reactivity | Reactive towards nucleophiles, reacts with alcohols, amines etc. |
As an accredited 3,5-Dichlorobenzenesulfonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 3,5 - dichlorobenzenesulfonyl chloride packaged in a sealed glass bottle. |
| Storage | 3,5 - dichlorobenzenesulfonyl chloride should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and incompatible substances such as bases, oxidizing agents, and reducing agents. Store it in a tightly - sealed container to prevent moisture absorption and leakage, which could lead to decomposition or reactivity issues. |
| Shipping | 3,5 - Dichlorobenzenesulfonyl Chloride is a hazardous chemical. It should be shipped in tightly - sealed, corrosion - resistant containers, following all relevant regulations for hazardous substances, ensuring safe transportation. |
Competitive 3,5-Dichlorobenzenesulfonyl Chloride prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
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As a leading 3,5-Dichlorobenzenesulfonyl Chloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the physical properties of 3,5-dichlorobenzenesulfonyl chloride?
3,2,5-Difluorobenzoyl chloride is an organic compound. Its physical properties are quite characteristic. Looking at its shape, under room temperature and pressure, it is a colorless to light yellow liquid, with a clear appearance and a specific color.
When it comes to odor, this substance emits a pungent and corrosive odor. This odor is strong and can significantly stimulate the sense of smell, causing discomfort.
Its boiling point is fixed, about a certain temperature range, and this boiling point characteristic is closely related to its molecular structure and intermolecular forces. The existence of the boiling point determines the change from liquid to gas at a specific temperature. The melting point of
is also one of its important physical properties, and the specific melting point defines the critical temperature for the transition between solid and liquid states.
In terms of density, there is a specific value, which reflects the mass per unit volume. This property has an important impact on many physical processes involving the substance, such as mixing and separation.
In terms of solubility, in organic solvents, it shows a certain solubility and can be soluble with some organic solvents, but in water its solubility is quite limited. This difference in solubility is based on the polarity of its molecules and the interaction with water and organic solvent molecules.
These physical properties play a key role in the application, storage, and transportation of 3,2,5-difluorobenzoyl chloride in many fields such as chemical engineering and medicine, and are related to the safety of operation, the feasibility of reaction, and many other aspects.
When it comes to odor, this substance emits a pungent and corrosive odor. This odor is strong and can significantly stimulate the sense of smell, causing discomfort.
Its boiling point is fixed, about a certain temperature range, and this boiling point characteristic is closely related to its molecular structure and intermolecular forces. The existence of the boiling point determines the change from liquid to gas at a specific temperature. The melting point of
is also one of its important physical properties, and the specific melting point defines the critical temperature for the transition between solid and liquid states.
In terms of density, there is a specific value, which reflects the mass per unit volume. This property has an important impact on many physical processes involving the substance, such as mixing and separation.
In terms of solubility, in organic solvents, it shows a certain solubility and can be soluble with some organic solvents, but in water its solubility is quite limited. This difference in solubility is based on the polarity of its molecules and the interaction with water and organic solvent molecules.
These physical properties play a key role in the application, storage, and transportation of 3,2,5-difluorobenzoyl chloride in many fields such as chemical engineering and medicine, and are related to the safety of operation, the feasibility of reaction, and many other aspects.
What are the chemical properties of 3,5-dichlorobenzenesulfonyl chloride?
Ethyl 3,5-difluorobenzoate is an organic compound with the following chemical properties:
First, hydrolysis. This compound contains an ester group and can undergo hydrolysis in an acid or base-catalyzed environment. When exposed to acid, it slowly hydrolyzes to produce 3,5-difluorobenzoic acid and ethanol, just like "esters encounter acid, water acts as a medium, and acids and alcohols gradually grow"; when exposed to alkali, hydrolysis is more rapid, resulting in 3,5-difluorobenzoate and ethanol. This process "alkali promotes hydrolysis, and ester bonds are broken quickly".
Second, esterification reaction. In the inverse process of hydrolysis, under specific conditions, 3,5-difluorobenzoic acid and ethanol can be esterified by means of a catalyst such as concentrated sulfuric acid and heated to obtain ethyl 3,5-difluorobenzoate, which is "catalyzed by acid and alcohol, and the ester is reborn in heat".
Third, substitution reaction. Hydrogen atoms on the benzene ring can undergo electrophilic substitution reactions due to the influence of fluorine atoms and ester groups. For example, when reacting with halogen elementals catalyzed by iron halides, halogen atoms can replace hydrogen atoms on the benzene ring, "benzene ring hydrogen is disturbed, halogen electrophilic".
Fourth, reduction reaction. The ester group can be reduced to an alcohol under the action of a specific reducing agent, such as lithium aluminum hydride, that is, 3,5-difluorobenzyl alcohol and ethanol, "strong reduction power, ester group to alcohol group".
Fifth, fluorination reaction characteristics. Because it already contains fluorine atoms, under certain conditions, it can further participate in reactions involving fluorine atoms, or perform reactions such as fluorine atom position adjustment, "fluorine atoms exist, and the reaction adds variables".
First, hydrolysis. This compound contains an ester group and can undergo hydrolysis in an acid or base-catalyzed environment. When exposed to acid, it slowly hydrolyzes to produce 3,5-difluorobenzoic acid and ethanol, just like "esters encounter acid, water acts as a medium, and acids and alcohols gradually grow"; when exposed to alkali, hydrolysis is more rapid, resulting in 3,5-difluorobenzoate and ethanol. This process "alkali promotes hydrolysis, and ester bonds are broken quickly".
Second, esterification reaction. In the inverse process of hydrolysis, under specific conditions, 3,5-difluorobenzoic acid and ethanol can be esterified by means of a catalyst such as concentrated sulfuric acid and heated to obtain ethyl 3,5-difluorobenzoate, which is "catalyzed by acid and alcohol, and the ester is reborn in heat".
Third, substitution reaction. Hydrogen atoms on the benzene ring can undergo electrophilic substitution reactions due to the influence of fluorine atoms and ester groups. For example, when reacting with halogen elementals catalyzed by iron halides, halogen atoms can replace hydrogen atoms on the benzene ring, "benzene ring hydrogen is disturbed, halogen electrophilic".
Fourth, reduction reaction. The ester group can be reduced to an alcohol under the action of a specific reducing agent, such as lithium aluminum hydride, that is, 3,5-difluorobenzyl alcohol and ethanol, "strong reduction power, ester group to alcohol group".
Fifth, fluorination reaction characteristics. Because it already contains fluorine atoms, under certain conditions, it can further participate in reactions involving fluorine atoms, or perform reactions such as fluorine atom position adjustment, "fluorine atoms exist, and the reaction adds variables".
What are the common uses of 3,5-dichlorobenzenesulfonyl chloride?
3,5-Dioxane heptanone, also known as 1,3-dioxane-2-one, is commonly used as follows:
This is an important intermediate in organic synthesis and is widely used in the field of medicinal chemistry. It can be used as a starting material for the synthesis of many complex drug molecules. For example, when developing drugs for the treatment of cardiovascular diseases, with the help of its special structure, key pharmacophores are constructed to interact with specific targets in the body, regulate physiological processes, and achieve therapeutic purposes.
It also has important applications in materials science. Polymer materials with unique properties can be prepared through polymerization. The prepared polyester polymer has good biocompatibility and degradability, and is very popular in the field of biomedical materials. For example, it can be used to prepare sutures, which can be gradually degraded in the body after surgery without removing the stitches, relieving the pain of patients; it can also be used as a drug sustained-release carrier to wrap the drug in it to achieve slow release of the drug, prolong the action time of the drug, and improve the therapeutic effect.
In organic synthesis, it is often used as a carbonylation agent to participate in the reaction. Due to the high reactivity of the carbonyl group in the molecule, it can react with a variety of nucleophiles, introduce specific functional groups, realize the structural modification and functional group transformation of organic compounds, and help synthesize a variety of organic compounds, expanding the methods and strategies of organic synthesis.
In addition, it also has certain applications in the fragrance industry. Due to its unique chemical structure, it can endow fragrances with a special aroma and stability, providing the possibility to formulate unique flavor fragrances for use in food, cosmetics and other industries to enhance the sensory quality of products.
This is an important intermediate in organic synthesis and is widely used in the field of medicinal chemistry. It can be used as a starting material for the synthesis of many complex drug molecules. For example, when developing drugs for the treatment of cardiovascular diseases, with the help of its special structure, key pharmacophores are constructed to interact with specific targets in the body, regulate physiological processes, and achieve therapeutic purposes.
It also has important applications in materials science. Polymer materials with unique properties can be prepared through polymerization. The prepared polyester polymer has good biocompatibility and degradability, and is very popular in the field of biomedical materials. For example, it can be used to prepare sutures, which can be gradually degraded in the body after surgery without removing the stitches, relieving the pain of patients; it can also be used as a drug sustained-release carrier to wrap the drug in it to achieve slow release of the drug, prolong the action time of the drug, and improve the therapeutic effect.
In organic synthesis, it is often used as a carbonylation agent to participate in the reaction. Due to the high reactivity of the carbonyl group in the molecule, it can react with a variety of nucleophiles, introduce specific functional groups, realize the structural modification and functional group transformation of organic compounds, and help synthesize a variety of organic compounds, expanding the methods and strategies of organic synthesis.
In addition, it also has certain applications in the fragrance industry. Due to its unique chemical structure, it can endow fragrances with a special aroma and stability, providing the possibility to formulate unique flavor fragrances for use in food, cosmetics and other industries to enhance the sensory quality of products.
What is the synthesis method of 3,5-dichlorobenzenesulfonyl chloride?
3,5-Difluorobenzoyl chloride is an important intermediate in organic synthesis. The synthesis method is as follows:
The starting material is 3,5-difluorobenzoic acid. The 3,5-difluorobenzoic acid is placed in the reactor, and an appropriate amount of chlorination reagent, such as dichlorosulfoxide (SOCl), is added. This chlorination reagent reacts with 3,5-difluorobenzoic acid to convert the carboxyl group into an acyl chloride group.
When reacting, pay attention to the reaction conditions. Heat the reactor to maintain the temperature within a certain range, usually between about 60-80 ° C. At this temperature, the dichlorosulfoxide reacts fully with 3,5-difluorobenzoic acid. The boiling point of dichlorosulfoxide is low, and the reaction system can maintain a moderate reflux state during heating, so as to promote the reaction to form 3,5-difluorobenzoyl chloride.
During the reaction process, the reaction of dichlorosulfoxide with 3,5-difluorobenzoic acid will generate 3,5-difluorobenzoyl chloride, sulfur dioxide (SO 2) and hydrogen chloride (HCl) gases. Because both sulfur dioxide and hydrogen chloride are gases, they can escape from the reaction system, which is conducive to the forward reaction.
When the reaction is completed, the main component in the reaction solution is 3,5-difluorobenzoyl chloride. In order to obtain pure products, subsequent separation and purification operations are required. The unreacted chlorinated reagent dichlorosulfoxide can be removed by vacuum distillation. Due to its relatively low boiling point, it is more volatile to remove under reduced pressure. Subsequently, the distillation operation can be carried out to further purify 3,5-difluorobenzoyl chloride to obtain high-purity target products.
In this way, by selecting suitable starting materials, controlling appropriate reaction conditions, and performing effective separation and purification, 3,5-difluorobenzoyl chloride can be successfully synthesized.
The starting material is 3,5-difluorobenzoic acid. The 3,5-difluorobenzoic acid is placed in the reactor, and an appropriate amount of chlorination reagent, such as dichlorosulfoxide (SOCl), is added. This chlorination reagent reacts with 3,5-difluorobenzoic acid to convert the carboxyl group into an acyl chloride group.
When reacting, pay attention to the reaction conditions. Heat the reactor to maintain the temperature within a certain range, usually between about 60-80 ° C. At this temperature, the dichlorosulfoxide reacts fully with 3,5-difluorobenzoic acid. The boiling point of dichlorosulfoxide is low, and the reaction system can maintain a moderate reflux state during heating, so as to promote the reaction to form 3,5-difluorobenzoyl chloride.
During the reaction process, the reaction of dichlorosulfoxide with 3,5-difluorobenzoic acid will generate 3,5-difluorobenzoyl chloride, sulfur dioxide (SO 2) and hydrogen chloride (HCl) gases. Because both sulfur dioxide and hydrogen chloride are gases, they can escape from the reaction system, which is conducive to the forward reaction.
When the reaction is completed, the main component in the reaction solution is 3,5-difluorobenzoyl chloride. In order to obtain pure products, subsequent separation and purification operations are required. The unreacted chlorinated reagent dichlorosulfoxide can be removed by vacuum distillation. Due to its relatively low boiling point, it is more volatile to remove under reduced pressure. Subsequently, the distillation operation can be carried out to further purify 3,5-difluorobenzoyl chloride to obtain high-purity target products.
In this way, by selecting suitable starting materials, controlling appropriate reaction conditions, and performing effective separation and purification, 3,5-difluorobenzoyl chloride can be successfully synthesized.
What are the precautions for using 3,5-dichlorobenzenesulfonyl chloride?
3,5-Difluorobenzoyl chloride is suitable for use when there are several ends.
First, the protection is the most heavy. This substance is corrosive and will contact the skin and eyes, causing damage. Therefore, when handling, it is necessary to wear complete protective equipment, such as corrosion-resistant gloves, protective goggles, protective clothing, etc., to prevent it from coming into contact with the body. And the workplace should have well-ventilated equipment, so that the volatile gas can be dissipated in time to avoid inhalation and damage to breathing.
Second, storage must be careful. It should be stored in a cool, dry and well-ventilated place, away from fire and heat sources. Because it is easy to decompose when heated, it is dangerous. It must also be stored separately from oxidizing agents and alkalis, and must not be mixed to prevent violent chemical reactions.
Third, when taking it, the action should be slow and careful. When pouring or measuring, beware of spills. If there is any spill, dispose of it quickly according to the corresponding method. Cut off the fire source first to avoid causing fire. Then, depending on the amount of spill, absorb it with inert materials such as sand and vermiculite, put it in a suitable container, and then properly dispose of it.
Fourth, use the finished utensils and wash them thoroughly. To prevent the residual 3,5-difluorobenzoyl chloride from corroding the utensils, and to prevent it from causing accidents in the next use.
In short, throughout the use of 3,5-difluorobenzoyl chloride, it is necessary to maintain a cautious attitude and adhere to the operating procedures, so as to ensure safety and make everything go smoothly.
First, the protection is the most heavy. This substance is corrosive and will contact the skin and eyes, causing damage. Therefore, when handling, it is necessary to wear complete protective equipment, such as corrosion-resistant gloves, protective goggles, protective clothing, etc., to prevent it from coming into contact with the body. And the workplace should have well-ventilated equipment, so that the volatile gas can be dissipated in time to avoid inhalation and damage to breathing.
Second, storage must be careful. It should be stored in a cool, dry and well-ventilated place, away from fire and heat sources. Because it is easy to decompose when heated, it is dangerous. It must also be stored separately from oxidizing agents and alkalis, and must not be mixed to prevent violent chemical reactions.
Third, when taking it, the action should be slow and careful. When pouring or measuring, beware of spills. If there is any spill, dispose of it quickly according to the corresponding method. Cut off the fire source first to avoid causing fire. Then, depending on the amount of spill, absorb it with inert materials such as sand and vermiculite, put it in a suitable container, and then properly dispose of it.
Fourth, use the finished utensils and wash them thoroughly. To prevent the residual 3,5-difluorobenzoyl chloride from corroding the utensils, and to prevent it from causing accidents in the next use.
In short, throughout the use of 3,5-difluorobenzoyl chloride, it is necessary to maintain a cautious attitude and adhere to the operating procedures, so as to ensure safety and make everything go smoothly.
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