Linshang Chemical
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3,5-Dichloroisocyanatobenzene
Linshang Chemical
|
HS Code |
900343 |
| Chemical Formula | C7H3Cl2NO |
| Molecular Weight | 188.01 g/mol |
| Appearance | Solid |
| Color | Off - white to light yellow |
| Odor | Pungent |
| Melting Point | 93 - 95 °C |
| Boiling Point | 263 - 265 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in many organic solvents like dichloromethane, toluene |
As an accredited 3,5-Dichloroisocyanatobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 3,5 - dichloroisocyanatobenzene packaged in a sealed, chemical - resistant container. |
| Storage | 3,5 - dichloroisocyanatobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, ignition sources, and incompatible substances such as strong acids, bases, and amines. Store it in a tightly sealed container to prevent moisture absorption and degradation. Avoid storing in areas prone to flooding or high humidity. |
| Shipping | 3,5 - dichloroisocyanatobenzene should be shipped in well - sealed, corrosion - resistant containers. Ensure compliance with hazardous chemical shipping regulations. Ship with proper labeling indicating its nature and handle with care to prevent spills. |
Competitive 3,5-Dichloroisocyanatobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 3,5-Dichloroisocyanatobenzene in China?
As a trusted 3,5-Dichloroisocyanatobenzene manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 3,5-Dichloroisocyanatobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 3,5-dichloroisocyanate phenyl ester?
3,2,5-Benzyl difluoroisonicotinate is a crucial compound in the field of organic synthesis. It has a wide range of uses and is often used as a key intermediate in the field of medicinal chemistry. The development and preparation of many new drugs rely on it as a starting material, which is converted into substances with specific pharmacological activities through a series of chemical reactions. For example, in the synthesis path of some antibacterial and antiviral drugs, 3,2,5-benzyl difluoroisonicotinate can be cleverly reacted with other reagents to build complex molecular structures to achieve the desired therapeutic effect.
In the field of materials science, this compound also shows unique value. It can participate in the synthesis of special polymer materials, endowing materials with special properties such as excellent stability and corrosion resistance. Due to the introduction of fluorine atoms in its molecular structure, it can significantly change the physical and chemical properties of the material, making it play a unique role in specific environments. For example, high-performance materials used in the aerospace field, or component materials that require special properties in electronic devices, can be synthesized with the participation of benzyl 3,2,5-difluoroisonicotinate.
Furthermore, in the fine chemical industry, it can be used to prepare high-end fragrances, pigments and other fine chemicals. By modifying and converting its functional groups, products with unique aromas or colors can be obtained to meet the diverse needs of fine chemicals in different fields. In conclusion, benzyl 3,2,5-difluoroisonicotinate plays an indispensable role in many fields due to its unique chemical structure, promoting the development and progress of related industries.
In the field of materials science, this compound also shows unique value. It can participate in the synthesis of special polymer materials, endowing materials with special properties such as excellent stability and corrosion resistance. Due to the introduction of fluorine atoms in its molecular structure, it can significantly change the physical and chemical properties of the material, making it play a unique role in specific environments. For example, high-performance materials used in the aerospace field, or component materials that require special properties in electronic devices, can be synthesized with the participation of benzyl 3,2,5-difluoroisonicotinate.
Furthermore, in the fine chemical industry, it can be used to prepare high-end fragrances, pigments and other fine chemicals. By modifying and converting its functional groups, products with unique aromas or colors can be obtained to meet the diverse needs of fine chemicals in different fields. In conclusion, benzyl 3,2,5-difluoroisonicotinate plays an indispensable role in many fields due to its unique chemical structure, promoting the development and progress of related industries.
What are the synthesis methods of 3,5-dichloroisocyanate phenyl ester?
The synthesis of benzyl 3,5-dihydroxyisonicotinate is an important topic in the field of organic synthesis. There are several common ways to prepare this compound.
First, isonicotinic acid is used as the starting material. First, isonicotinic acid is properly protected to keep the carboxyl group in a stable state. Then, with the help of a specific electrophilic substitution reaction, the hydroxyl group is introduced at the 3,5 position of the pyridine ring. This step requires precise control of the reaction conditions, such as reaction temperature, reactant ratio, and catalyst dosage, to ensure that the hydroxyl group can be selectively introduced into the target position. After the hydroxyl group is successfully introduced, the carboxyl group is activated, and a suitable acylating agent can be selected to convert it into an active acyl intermediate. Finally, benzyl dihydroxyisonicotinate can be obtained by esterification reaction with benzyl alcohol. The advantage of this route is that the starting material is easy to obtain, and the reaction steps are relatively clear; however, the disadvantages are also obvious. The multi-step reaction involves protection and deprotection processes, which are complicated to operate, and the total yield may be affected.
Second, start from 3,5-dihydroxypyridine. First, the hydroxyl group of the pyridine ring is protected to prevent unnecessary side reactions in the subsequent reaction. Then, the carboxyl group is introduced into the fourth position of the pyridine ring. This process can be achieved by means of Grignard reaction, nucleophilic substitution, etc. After the carboxyl group is successfully introduced, the carboxyl group is also activated, and then esterified with benzyl alcohol to obtain the target product. The advantage of this route is that the carboxyl group can be directly constructed and esterified on the pyridine derivative with the target hydroxyl group position, and the steps may be relatively simple; however, the cost of 3,5-dihydroxypyridine raw materials may be relatively high, and the introduction of carboxyl groups requires fine regulation.
Third, the one-pot synthesis strategy can also be adopted. Select suitable starting materials, and through ingenious design of reaction sequence and conditions, in the same reaction vessel, through a series of continuous reactions, directly generate 3,5-dihydroxyisonicotinate benzyl ester. Although this method can theoretically avoid multi-step separation operations, improve efficiency and reduce costs, it requires extremely high control of reaction conditions, and requires in-depth understanding of reaction kinetics and thermodynamics in each step to achieve efficient synthesis of one-pot method.
First, isonicotinic acid is used as the starting material. First, isonicotinic acid is properly protected to keep the carboxyl group in a stable state. Then, with the help of a specific electrophilic substitution reaction, the hydroxyl group is introduced at the 3,5 position of the pyridine ring. This step requires precise control of the reaction conditions, such as reaction temperature, reactant ratio, and catalyst dosage, to ensure that the hydroxyl group can be selectively introduced into the target position. After the hydroxyl group is successfully introduced, the carboxyl group is activated, and a suitable acylating agent can be selected to convert it into an active acyl intermediate. Finally, benzyl dihydroxyisonicotinate can be obtained by esterification reaction with benzyl alcohol. The advantage of this route is that the starting material is easy to obtain, and the reaction steps are relatively clear; however, the disadvantages are also obvious. The multi-step reaction involves protection and deprotection processes, which are complicated to operate, and the total yield may be affected.
Second, start from 3,5-dihydroxypyridine. First, the hydroxyl group of the pyridine ring is protected to prevent unnecessary side reactions in the subsequent reaction. Then, the carboxyl group is introduced into the fourth position of the pyridine ring. This process can be achieved by means of Grignard reaction, nucleophilic substitution, etc. After the carboxyl group is successfully introduced, the carboxyl group is also activated, and then esterified with benzyl alcohol to obtain the target product. The advantage of this route is that the carboxyl group can be directly constructed and esterified on the pyridine derivative with the target hydroxyl group position, and the steps may be relatively simple; however, the cost of 3,5-dihydroxypyridine raw materials may be relatively high, and the introduction of carboxyl groups requires fine regulation.
Third, the one-pot synthesis strategy can also be adopted. Select suitable starting materials, and through ingenious design of reaction sequence and conditions, in the same reaction vessel, through a series of continuous reactions, directly generate 3,5-dihydroxyisonicotinate benzyl ester. Although this method can theoretically avoid multi-step separation operations, improve efficiency and reduce costs, it requires extremely high control of reaction conditions, and requires in-depth understanding of reaction kinetics and thermodynamics in each step to achieve efficient synthesis of one-pot method.
What are the precautions for 3,5-dichloroisocyanate during storage and transportation?
3% 2C5-dihydroxyisobutyrate naphthyl ester is a special chemical substance. When storing and transporting, there are many precautions to keep in mind.
First words storage. Must choose a cool, dry and well-ventilated place to store. Due to its nature or susceptibility to temperature and humidity, if it is placed in a high temperature and humid place, it may deteriorate. And it should be placed separately from oxidizing agents, acids, alkalis, etc., to cover the contact of these substances with them, or to cause chemical reactions, which will damage their quality. Storage also requires perfect fire and explosion-proof facilities to prevent accidents.
As for transportation, make sure that the packaging is intact. Packaging materials should have good sealing and protection to avoid leakage due to bumps and collisions during transportation. Transportation vehicles also need to be selected with corresponding qualifications, and drivers and escorts should be familiar with the characteristics of this substance and emergency treatment methods. During transportation, it is advisable to avoid hot sun exposure and high temperature environments, and drive smoothly. Do not make sudden brakes or sharp turns to avoid damage to the packaging. If there is any leakage during transportation, deal with it immediately according to the established emergency plan, evacuate the surrounding people, isolate the leakage area, and prevent the spread of pollution.
These precautions are to ensure the safety and quality of 3% 2C5-dihydroxyisobutyrate naphthalene ester during storage and transportation. Practitioners should not ignore it and must be careful to avoid disasters.
First words storage. Must choose a cool, dry and well-ventilated place to store. Due to its nature or susceptibility to temperature and humidity, if it is placed in a high temperature and humid place, it may deteriorate. And it should be placed separately from oxidizing agents, acids, alkalis, etc., to cover the contact of these substances with them, or to cause chemical reactions, which will damage their quality. Storage also requires perfect fire and explosion-proof facilities to prevent accidents.
As for transportation, make sure that the packaging is intact. Packaging materials should have good sealing and protection to avoid leakage due to bumps and collisions during transportation. Transportation vehicles also need to be selected with corresponding qualifications, and drivers and escorts should be familiar with the characteristics of this substance and emergency treatment methods. During transportation, it is advisable to avoid hot sun exposure and high temperature environments, and drive smoothly. Do not make sudden brakes or sharp turns to avoid damage to the packaging. If there is any leakage during transportation, deal with it immediately according to the established emergency plan, evacuate the surrounding people, isolate the leakage area, and prevent the spread of pollution.
These precautions are to ensure the safety and quality of 3% 2C5-dihydroxyisobutyrate naphthalene ester during storage and transportation. Practitioners should not ignore it and must be careful to avoid disasters.
What are the physical and chemical properties of 3,5-dichloroisocyanate phenyl ester?
3,5-Benzyl difluoroisonicotinate is one of the organic compounds. Its physical and chemical properties have many characteristics, which are described as follows:
Under normal conditions, it is mostly white to light yellow crystalline powder. This appearance characteristic makes it traceable when it is initially identified. The state of the powder makes its surface area relatively large, and when participating in the chemical reaction, it can be more fully contacted with other substances, which in turn affects the reaction rate and effect.
When it comes to the melting point, the melting point of this compound is in a specific range, about [X] ° C. The important thing about the melting point is that it is not only an important indicator of the purity of the material, but also a key parameter for judging the transformation of its physical state. When the temperature reaches this melting point, 3,5-benzyl difluoroisonicotinate gradually melts from a solid state to a liquid state. During this process, the intermolecular forces change, which affects its subsequent reactivity and solubility in the liquid phase.
In terms of solubility, 3,5-benzyl difluoroisonicotinate exhibits good solubility in organic solvents such as ethanol and dichloromethane. This property makes it possible to achieve uniform dispersion with the help of these organic solvents in the process of organic synthesis and drug preparation, which is conducive to the reaction. In water, its solubility is poor, because its molecular structure lacks groups that form strong interactions with water molecules, and most of them are hydrophobic parts, resulting in poor solubility with water.
Its chemical stability is also worthy of attention. Under conventional environmental conditions, benzyl 3,5-difluoroisonicotinate has a certain stability, but when it encounters extreme conditions such as strong acid, strong base or high temperature, its molecular structure may change. For example, in a strong acid environment, its ester group may undergo hydrolysis to form 3,5-difluoroisonicotinic acid and benzyl alcohol; under strong base conditions, the reaction process may be more complicated. In addition to the hydrolysis of the ester group, it may trigger the reaction of other groups, thereby changing the original chemical properties and functions of the molecule.
In addition, the physical properties such as the density and boiling point of benzyl 3,5-difluoroisonicotinate also affect its behavior in practical applications to a certain extent. The density determines its distribution position in the mixture, and the boiling point is related to its condition control in distillation, separation, and other operations.
Under normal conditions, it is mostly white to light yellow crystalline powder. This appearance characteristic makes it traceable when it is initially identified. The state of the powder makes its surface area relatively large, and when participating in the chemical reaction, it can be more fully contacted with other substances, which in turn affects the reaction rate and effect.
When it comes to the melting point, the melting point of this compound is in a specific range, about [X] ° C. The important thing about the melting point is that it is not only an important indicator of the purity of the material, but also a key parameter for judging the transformation of its physical state. When the temperature reaches this melting point, 3,5-benzyl difluoroisonicotinate gradually melts from a solid state to a liquid state. During this process, the intermolecular forces change, which affects its subsequent reactivity and solubility in the liquid phase.
In terms of solubility, 3,5-benzyl difluoroisonicotinate exhibits good solubility in organic solvents such as ethanol and dichloromethane. This property makes it possible to achieve uniform dispersion with the help of these organic solvents in the process of organic synthesis and drug preparation, which is conducive to the reaction. In water, its solubility is poor, because its molecular structure lacks groups that form strong interactions with water molecules, and most of them are hydrophobic parts, resulting in poor solubility with water.
Its chemical stability is also worthy of attention. Under conventional environmental conditions, benzyl 3,5-difluoroisonicotinate has a certain stability, but when it encounters extreme conditions such as strong acid, strong base or high temperature, its molecular structure may change. For example, in a strong acid environment, its ester group may undergo hydrolysis to form 3,5-difluoroisonicotinic acid and benzyl alcohol; under strong base conditions, the reaction process may be more complicated. In addition to the hydrolysis of the ester group, it may trigger the reaction of other groups, thereby changing the original chemical properties and functions of the molecule.
In addition, the physical properties such as the density and boiling point of benzyl 3,5-difluoroisonicotinate also affect its behavior in practical applications to a certain extent. The density determines its distribution position in the mixture, and the boiling point is related to its condition control in distillation, separation, and other operations.
What are the effects of 3,5-dichloroisocyanate on the environment and human body?
3,5-Dihydroxyisovalerate coumarin is an organic compound. At the environmental level, it may have diverse effects on the ecosystem. In soil, if this compound is secreted by plant roots or decomposed by plant residues, it may affect the structure and function of soil microbial communities. Some coumarins can inhibit the growth of specific soil microorganisms, thereby interfering with the soil nutrient cycle and the decomposition process of organic matter. In the aquatic environment, if it enters through surface runoff and other routes, it may affect aquatic organisms. Some aquatic organisms are highly sensitive to organic compounds, which may affect their growth, reproduction and behavior.
As for the human body, coumarins have many potential effects. On the one hand, some coumarins have pharmacological activities. Studies have shown that some structurally similar coumarins may have antioxidant and anti-inflammatory effects, or can scavenge free radicals in the body, reduce inflammatory reactions, and be beneficial in preventing some chronic diseases. However, on the other hand, if excessive intake or exposure, there may be latent risks. Some coumarins may affect human coagulation function and interfere with normal physiological mechanisms.
The ancients said: "Each has advantages and disadvantages, and it is appropriate to use them." The impact of 3,5-dihydroxyisovalerate coumarin on the environment and the human body has both advantages and latent risks. In the environment, it has a subtle effect on the balance of the ecosystem; in the human body, rational use may obtain health benefits, but improper contact may cause adverse consequences. Therefore, when studying and applying this compound, careful consideration should be made to achieve the purpose of seeking advantages and avoiding disadvantages.
As for the human body, coumarins have many potential effects. On the one hand, some coumarins have pharmacological activities. Studies have shown that some structurally similar coumarins may have antioxidant and anti-inflammatory effects, or can scavenge free radicals in the body, reduce inflammatory reactions, and be beneficial in preventing some chronic diseases. However, on the other hand, if excessive intake or exposure, there may be latent risks. Some coumarins may affect human coagulation function and interfere with normal physiological mechanisms.
The ancients said: "Each has advantages and disadvantages, and it is appropriate to use them." The impact of 3,5-dihydroxyisovalerate coumarin on the environment and the human body has both advantages and latent risks. In the environment, it has a subtle effect on the balance of the ecosystem; in the human body, rational use may obtain health benefits, but improper contact may cause adverse consequences. Therefore, when studying and applying this compound, careful consideration should be made to achieve the purpose of seeking advantages and avoiding disadvantages.
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