Linshang Chemical
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3-Amino-4-Chlorotrifluoromethylbenzene
Linshang Chemical
|
HS Code |
992219 |
| Chemical Formula | C7H5ClF3N |
| Molecular Weight | 195.57 |
| Appearance | A colorless to light yellow liquid |
| Boiling Point | Around 200 - 210 °C |
| Density | Approx. 1.4 g/cm³ |
| Solubility In Water | Poorly soluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Purity | Typically sold in high purity, e.g., 98%+ |
As an accredited 3-Amino-4-Chlorotrifluoromethylbenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 3 - amino - 4 - chlorotrifluoromethylbenzene in sealed, chemical - resistant containers. |
| Storage | 3 - amino - 4 - chlorotrifluoromethylbenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition sources. It should be kept in a tightly closed container to prevent moisture and air exposure, which could potentially lead to degradation. Store it separately from oxidizing agents and incompatible substances to avoid chemical reactions. |
| Shipping | 3 - amino - 4 - chlorotrifluoromethylbenzene is shipped in well - sealed containers. It must be transported in accordance with chemical regulations, ensuring protection from heat, moisture, and incompatible substances during transit. |
Competitive 3-Amino-4-Chlorotrifluoromethylbenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 3-Amino-4-Chlorotrifluoromethylbenzene in China?
As a trusted 3-Amino-4-Chlorotrifluoromethylbenzene manufacturer, we deliver:
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 3-Amino-4-Chlorotrifluoromethylbenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 3-amino-4-chlorotrifluoromethylbenzene?
3-Amino-4-chlorotrifluoromethylbenzene, this substance has a wide range of uses. In the field of pharmaceutical synthesis, it is a key intermediate. It can be converted into a variety of drugs with unique curative effects through specific reaction steps. For some difficult diseases, it can lay the foundation for the development of new therapeutic drugs. By participating in the construction of drug molecules, it gives the drug the ability to accurately act on specific targets, thereby improving the therapeutic effect.
It also plays an important role in the creation of pesticides. Using it as a starting material, a series of highly efficient, low-toxic and environmentally friendly pesticides can be synthesized. Such pesticides can precisely act on pests, inhibit their growth and reproduction, ensure the healthy growth of crops, and reduce the negative impact on the environment, which is in line with the current needs of green agriculture development.
Furthermore, in the field of materials science, it can be used as a synthetic building block of functional materials. Through chemical modification and polymerization reactions, materials with special properties can be prepared, such as sensing materials with high sensitivity to specific gases, which play an important role in environmental monitoring and other fields; or high-performance polymer materials can be prepared, which can be used in high-end fields such as aerospace and electronic devices to improve the comprehensive properties of materials.
It also plays an important role in the creation of pesticides. Using it as a starting material, a series of highly efficient, low-toxic and environmentally friendly pesticides can be synthesized. Such pesticides can precisely act on pests, inhibit their growth and reproduction, ensure the healthy growth of crops, and reduce the negative impact on the environment, which is in line with the current needs of green agriculture development.
Furthermore, in the field of materials science, it can be used as a synthetic building block of functional materials. Through chemical modification and polymerization reactions, materials with special properties can be prepared, such as sensing materials with high sensitivity to specific gases, which play an important role in environmental monitoring and other fields; or high-performance polymer materials can be prepared, which can be used in high-end fields such as aerospace and electronic devices to improve the comprehensive properties of materials.
What are the physical properties of 3-amino-4-chlorotrifluoromethylbenzene?
The physical properties of 3-hydroxy-4-methoxytrimethoxybenzoylbenzene are as follows:
This substance is white to pale yellow crystalline powder at room temperature. Looking at its shape, the powder is fine and uniform in texture. Smell it, no significant odor is emitted, and there is no pungent or special smell.
Its melting point is in a specific range, roughly between [X] ° C - [X] ° C. The melting point is an important characteristic of the substance. In this temperature range, the substance gradually melts from a solid state to a liquid state. This temperature range is relatively stable and can be used as a basis for identification and purity judgment.
In terms of solubility, it shows a certain solubility in organic solvents, such as ethanol, acetone, etc. In ethanol, moderate heating and stirring can better dissolve and form a clear solution. This property makes it possible to achieve dispersion and reaction with the help of such organic solvents during the synthesis or preparation of related organic preparations. However, the solubility in water is very small, because its molecular structure contains more hydrophobic groups, resulting in poor affinity with water.
Density is also one of its physical properties, about [X] g/cm ³. This value reflects the mass of the substance per unit volume. When it comes to material measurement, mixing and process design, density data is crucial, which is related to the precise control of the proportion of materials in the reaction system and the feasibility of subsequent process operations.
In addition, the substance has a certain sensitivity to light and heat. Under light conditions, long-term exposure may cause its molecular structure to change and its color to gradually deepen; when heated to a certain extent, in addition to the phase transition at the melting point, if the temperature is too high, it may also trigger a decomposition reaction, causing it to lose its original chemical structure and properties. Therefore, when storing and using, it is necessary to pay attention to the conditions of protection from light and temperature control to ensure its quality and stability.
This substance is white to pale yellow crystalline powder at room temperature. Looking at its shape, the powder is fine and uniform in texture. Smell it, no significant odor is emitted, and there is no pungent or special smell.
Its melting point is in a specific range, roughly between [X] ° C - [X] ° C. The melting point is an important characteristic of the substance. In this temperature range, the substance gradually melts from a solid state to a liquid state. This temperature range is relatively stable and can be used as a basis for identification and purity judgment.
In terms of solubility, it shows a certain solubility in organic solvents, such as ethanol, acetone, etc. In ethanol, moderate heating and stirring can better dissolve and form a clear solution. This property makes it possible to achieve dispersion and reaction with the help of such organic solvents during the synthesis or preparation of related organic preparations. However, the solubility in water is very small, because its molecular structure contains more hydrophobic groups, resulting in poor affinity with water.
Density is also one of its physical properties, about [X] g/cm ³. This value reflects the mass of the substance per unit volume. When it comes to material measurement, mixing and process design, density data is crucial, which is related to the precise control of the proportion of materials in the reaction system and the feasibility of subsequent process operations.
In addition, the substance has a certain sensitivity to light and heat. Under light conditions, long-term exposure may cause its molecular structure to change and its color to gradually deepen; when heated to a certain extent, in addition to the phase transition at the melting point, if the temperature is too high, it may also trigger a decomposition reaction, causing it to lose its original chemical structure and properties. Therefore, when storing and using, it is necessary to pay attention to the conditions of protection from light and temperature control to ensure its quality and stability.
What are the chemical properties of 3-amino-4-chlorotrifluoromethylbenzene?
3-Hydroxy-4-methoxytriphenylmethyl ether, the physical properties are as follows:
Its shape is mostly white to off-white crystalline powder, with certain stability. At room temperature and pressure, if there is no external interference such as open flame and hot topic, it can exist more stably.
When it comes to solubility, it is soluble in common organic solvents such as dichloromethane and chloroform. In the two, the solubility is quite good, and the solution is clear and transparent. However, in water, the solubility is poor and almost insoluble. Because the molecular structure of the compound contains many hydrophobic groups, the polarity difference with water is large, making it difficult to form effective interactions with water molecules. The melting point of
is in a specific range. It has been experimentally determined to be in the range of [X] ° C - [X] ° C. This characteristic is of great significance for identification and purity judgment.
In terms of chemical activity, its hydroxyl groups have certain reactivity. In case of acylation reagents, hydroxyl hydrogen can be replaced by acyl groups, and acylation reactions occur to form corresponding ester derivatives. Under basic conditions, nucleophilic substitution reactions can occur with halogenated hydrocarbons. Hydroxyl oxygen attacks the carbon atoms connected to halogenated hydrocarbons, and the halogenated atoms leave to form new ether bonds. Methoxy groups are relatively stable and do not react easily under general conditions, but under extreme conditions such as strong acidity and high temperature, reactions such as methyl departure may occur.
In the field of organic synthesis, 3-hydroxy-4-methoxy triphenylmethyl ether is often used as a protective group. Due to the large steric resistance of triphenylmethyl and the methoxy power supply effect, it can effectively protect the hydroxyl group and avoid unnecessary reactions in the reaction system. After the specific steps of the reaction are completed, the hydroxyl group can be restored to activity under mild deprotection conditions and continue to participate in subsequent reactions, so as to improve the selectivity and yield of organic synthesis reactions.
Its shape is mostly white to off-white crystalline powder, with certain stability. At room temperature and pressure, if there is no external interference such as open flame and hot topic, it can exist more stably.
When it comes to solubility, it is soluble in common organic solvents such as dichloromethane and chloroform. In the two, the solubility is quite good, and the solution is clear and transparent. However, in water, the solubility is poor and almost insoluble. Because the molecular structure of the compound contains many hydrophobic groups, the polarity difference with water is large, making it difficult to form effective interactions with water molecules. The melting point of
is in a specific range. It has been experimentally determined to be in the range of [X] ° C - [X] ° C. This characteristic is of great significance for identification and purity judgment.
In terms of chemical activity, its hydroxyl groups have certain reactivity. In case of acylation reagents, hydroxyl hydrogen can be replaced by acyl groups, and acylation reactions occur to form corresponding ester derivatives. Under basic conditions, nucleophilic substitution reactions can occur with halogenated hydrocarbons. Hydroxyl oxygen attacks the carbon atoms connected to halogenated hydrocarbons, and the halogenated atoms leave to form new ether bonds. Methoxy groups are relatively stable and do not react easily under general conditions, but under extreme conditions such as strong acidity and high temperature, reactions such as methyl departure may occur.
In the field of organic synthesis, 3-hydroxy-4-methoxy triphenylmethyl ether is often used as a protective group. Due to the large steric resistance of triphenylmethyl and the methoxy power supply effect, it can effectively protect the hydroxyl group and avoid unnecessary reactions in the reaction system. After the specific steps of the reaction are completed, the hydroxyl group can be restored to activity under mild deprotection conditions and continue to participate in subsequent reactions, so as to improve the selectivity and yield of organic synthesis reactions.
What are the synthesis methods of 3-amino-4-chlorotrifluoromethylbenzene?
To prepare 3-hydroxy-4-methoxy trifluoromethylphenyl, there are many methods. Common ones can be started by benzene ring compounds containing corresponding substituents, and formed by various organic reactions.
First, benzene with suitable substituents is used as a raw material, and the benzene ring is introduced into a halogen atom through a halogenation reaction. This halogen atom can be bromine or chlorine. Subsequently, by a nucleophilic substitution reaction, the halogen is replaced with a methoxy negative ion to obtain a benzene derivative containing methoxy groups. After a specific oxidation step, a hydroxyl group is introduced at an appropriate position, and the reaction conditions are carefully controlled to avoid excessive oxidation or side reactions. Finally, trifluoromethyl is introduced by means of suitable trifluoromethylation reagents, such as trifluoromethyl magnesium halide, etc., to obtain the target product.
Second, the reaction of aryl boric acid or borate ester can be used. First, the aromatic boric acid or borate containing hydroxyl group and methoxy group substitution is prepared, and then it is coupled with trifluoromethyl halide under palladium catalysis and other conditions, and the trifluoromethyl group is connected to the benzene ring to obtain the target 3-hydroxy-4-methoxy trifluoromethylphenyl group. In this process, the choice and dosage of palladium catalyst, the type of reaction solvent and the type of base all have a great impact on the reaction efficiency.
Or, starting from the benzene series containing trifluoromethyl, gradually introduce hydroxyl and methoxy groups. First, methoxy groups are introduced through the guidance of positioning effect, and then hydroxyl groups are generated at suitable positions through oxidation or other functional group conversion reactions. This approach requires a deep understanding of the localization effect of functional groups on the benzene ring, and precise control of the reaction check point to achieve the purpose of efficient synthesis.
Synthesis methods have advantages and disadvantages. It is necessary to carefully choose the synthesis path according to the availability of raw materials, the difficulty of reaction conditions, cost considerations, and the purity requirements of the target product.
First, benzene with suitable substituents is used as a raw material, and the benzene ring is introduced into a halogen atom through a halogenation reaction. This halogen atom can be bromine or chlorine. Subsequently, by a nucleophilic substitution reaction, the halogen is replaced with a methoxy negative ion to obtain a benzene derivative containing methoxy groups. After a specific oxidation step, a hydroxyl group is introduced at an appropriate position, and the reaction conditions are carefully controlled to avoid excessive oxidation or side reactions. Finally, trifluoromethyl is introduced by means of suitable trifluoromethylation reagents, such as trifluoromethyl magnesium halide, etc., to obtain the target product.
Second, the reaction of aryl boric acid or borate ester can be used. First, the aromatic boric acid or borate containing hydroxyl group and methoxy group substitution is prepared, and then it is coupled with trifluoromethyl halide under palladium catalysis and other conditions, and the trifluoromethyl group is connected to the benzene ring to obtain the target 3-hydroxy-4-methoxy trifluoromethylphenyl group. In this process, the choice and dosage of palladium catalyst, the type of reaction solvent and the type of base all have a great impact on the reaction efficiency.
Or, starting from the benzene series containing trifluoromethyl, gradually introduce hydroxyl and methoxy groups. First, methoxy groups are introduced through the guidance of positioning effect, and then hydroxyl groups are generated at suitable positions through oxidation or other functional group conversion reactions. This approach requires a deep understanding of the localization effect of functional groups on the benzene ring, and precise control of the reaction check point to achieve the purpose of efficient synthesis.
Synthesis methods have advantages and disadvantages. It is necessary to carefully choose the synthesis path according to the availability of raw materials, the difficulty of reaction conditions, cost considerations, and the purity requirements of the target product.
What are the precautions for 3-amino-4-chlorotrifluoromethylbenzene during storage and transportation?
3-Amino-4-chlorotrifluorotoluene must be carefully stored and transported to avoid disasters.
When stored, first choose a cool, dry and well-ventilated place. This material is naturally active. If it is in a high temperature and humid environment, it may cause qualitative change or cause danger. It must be kept away from fires and heat sources to prevent all risks of ignition, such as open flames, hot topic equipment, etc., to prevent unexpected fires. And it should be stored separately from oxidizing agents, alkalis and other substances. Because of its chemical properties, it is easy to react with them, and there is a lot of danger in the same place. Storage places should be prepared with appropriate leakage emergency treatment equipment and containment materials for emergencies.
When shipping, do not slack off. The packaging must be tight and stable, in line with the relevant transportation regulations, to ensure that it is not damaged by vibration, collision and friction on the way. The tools used for transportation must be clean, dry, and free of impurities and foreign objects, so as not to disturb the transported objects. During transportation, the operator should pay close attention to the changes in temperature and humidity, and control it within an appropriate range. And do not mix with contraindicated objects to prevent changes on the way. When driving, avoid densely populated and traffic congestion, and choose a safe and smooth road. In case of leakage, immediately deal with it according to the established emergency plan, evacuate the surrounding people, prevent fire sources, and clean up quickly to reduce harm.
When stored, first choose a cool, dry and well-ventilated place. This material is naturally active. If it is in a high temperature and humid environment, it may cause qualitative change or cause danger. It must be kept away from fires and heat sources to prevent all risks of ignition, such as open flames, hot topic equipment, etc., to prevent unexpected fires. And it should be stored separately from oxidizing agents, alkalis and other substances. Because of its chemical properties, it is easy to react with them, and there is a lot of danger in the same place. Storage places should be prepared with appropriate leakage emergency treatment equipment and containment materials for emergencies.
When shipping, do not slack off. The packaging must be tight and stable, in line with the relevant transportation regulations, to ensure that it is not damaged by vibration, collision and friction on the way. The tools used for transportation must be clean, dry, and free of impurities and foreign objects, so as not to disturb the transported objects. During transportation, the operator should pay close attention to the changes in temperature and humidity, and control it within an appropriate range. And do not mix with contraindicated objects to prevent changes on the way. When driving, avoid densely populated and traffic congestion, and choose a safe and smooth road. In case of leakage, immediately deal with it according to the established emergency plan, evacuate the surrounding people, prevent fire sources, and clean up quickly to reduce harm.
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