3-Amino-5-Chloro-4-Hydroxybenzenesulphonic Acid
Linshang Chemical
HS Code |
549496 |
Chemical Formula | C6H6ClNO5S |
Molar Mass | 239.64 g/mol |
Appearance | Solid |
Solubility In Water | Soluble |
Color | Typically colorless to light - colored |
Pka Value | Relevant to its acidic groups |
Boiling Point | Decomposes before boiling |
Melting Point | High (specific value depends on purity) |
Density | Specific density data based on solid form |
Ph In Solution | Acidic |
As an accredited 3-Amino-5-Chloro-4-Hydroxybenzenesulphonic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
Packing | 500g of 3 - amino - 5 - chloro - 4 - hydroxybenzenesulphonic Acid packaged in a sealed plastic bag. |
Storage | 3 - Amino - 5 - chloro - 4 - hydroxybenzenesulphonic acid should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and incompatible substances. Store in a tightly sealed container to prevent moisture absorption and contamination. Avoid storing near strong oxidizing agents. Follow proper safety regulations for chemical storage. |
Shipping | 3 - amino - 5 - chloro - 4 - hydroxybenzenesulphonic acid should be shipped in well - sealed containers, protected from moisture and heat. Ensure compliance with hazardous chemical shipping regulations, and label clearly for safe transportation. |
Competitive 3-Amino-5-Chloro-4-Hydroxybenzenesulphonic Acid prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com


As a leading 3-Amino-5-Chloro-4-Hydroxybenzenesulphonic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
In the field of pharmaceutical chemistry, it is also of important value. With its specific chemical activity, it may participate in the synthesis of drug molecules. In the synthesis of some drugs with specific pharmacological activities, 3-amino-5-chloro-4-hydroxybenzenesulfonic acid is either used as a starting material or plays a role in key steps to help build molecular structures with precise pharmacological activities, and then provide effective drugs for the treatment of diseases.
In addition, it is also common in the preparation of some fine chemical products. The development and production of products such as special coatings and functional additives, this compound may have a significant impact on the performance of the product due to its special chemical properties. It can give coatings special adhesion, weather resistance, etc., or make additives have unique functions to meet the diverse needs of fine chemical products in different industrial fields.
The appearance of this compound is often in a solid form, mostly powdered, delicate and uniform. This form is easy to store and transport, and has significant convenience in industrial production and laboratory operations. The color is usually almost white. In the pure state, the color is pure and there is no variegation. If the color is deviated, it may suggest that there is a problem with its purity.
Melting point is also a key physical property. After experimental determination, its melting point is in a specific range, and the temperature range makes this compound realize the transition from solid to liquid under corresponding conditions. This property is of great significance for controlling the reaction conditions in the process of material processing and chemical synthesis.
In terms of solubility, it has different performances in specific solvents. In water, it has a certain solubility and can form a uniform dispersion system. This property is conducive to its participation in liquid-phase reactions in some chemical processes. In organic solvents, such as ethanol and acetone, the solubility also varies. This difference in solubility creates conditions for separation, purification and specific chemical reactions.
In addition, its density also has unique values. This value indicates that the mass of this compound per unit volume is an important parameter in terms of material measurement, reaction ratio, and product design.
These physical properties of 3-amino-5-chloro-4-hydroxybenzenesulfonic acid are an important foundation for research and application in the chemical industry, pharmaceutical fields, and materials science, and play a key role in promoting the development of related fields.
From its structural perspective, amino groups (-NH2O) are alkaline and can react with acids under specific conditions or participate in reactions such as amidation. Hydroxyl groups (-OH) are also active and can undergo esterification reactions to form esters when interacting with acids.
Although the chlorine atom (-Cl) in this compound is relatively stable, under specific reagents and reaction conditions, it may be substituted, triggering nucleophilic substitution reaction, and the chlorine atom is replaced by other groups.
Furthermore, the benzene ring endows it with certain stability and conjugated system characteristics, which have an impact on its physical and chemical properties. The conjugated system makes the distribution of molecular electron clouds more uniform, or affects its spectral properties, which is of great significance in the field of organic synthesis and analysis.
Its chemical properties make it potentially useful in dyes, medicine and other fields. In the dye industry, its structural properties can be used to introduce chromogenic groups through chemical reactions to produce dyes with specific colors and properties; in the pharmaceutical field, or because of the reactive groups contained, they can interact with biological macromolecules and have potential biological activity. It has become a starting material or key intermediate for drug development.
The starting material, take more suitable aromatic derivatives. With an aromatic hydrocarbon as the base, the method of chlorination is carried out first. In a specific reaction vessel, add aromatic hydrocarbons and an appropriate amount of chlorination reagents, such as chlorine gas or chlorine-containing compounds, complicate with a suitable catalyst, heat up and control the temperature in a specific interval, so that the chlorination reaction proceeds in an orderly manner. During the chlorination process, pay close attention to the progress of the reaction, and use a variety of analytical methods, such as chromatographic analysis, to monitor the formation of chlorinated products. When the chlorination reaction reaches the expected level, chlorine-containing aromatic derivatives are obtained.
Next, the hydroxyl group is introduced. This step is usually achieved by hydrolysis or other hydroxylation reactions. According to the selected reaction path, choose the appropriate reagent and conditions. If alkaline hydrolysis is used, a certain concentration of alkali solution needs to be prepared, and the chlorine-containing derivative is slowly added to react at a specific temperature and time. After the hydroxyl group is introduced, the molecular structure is initially formed.
Then, the step of sulfonation is performed. Take the product containing chlorine and hydroxyl groups and add a sulfonating agent, such as concentrated sulfuric acid or fuming sulfuric acid. At a suitable temperature and reaction environment, the sulfonating agent interacts with the substrate molecule, and the sulfonic acid group is connected to the benzene ring to form a 3-amino-5-chloro-4-hydroxybenzenesulfonic acid precursor.
Finally, the amination reaction is carried out. Appropriate amination reagents, such as ammonia or compounds containing amino groups, are selected in a specific reaction system to replace the groups in the corresponding positions with amino groups to obtain 3-amino-5-chloro-4-hydroxybenzenesulfonic acid. After the reaction is completed, the pure target product is obtained through separation, purification and other steps. Throughout the preparation process, the conditions of each step of the reaction are controlled to be the key, which is related to the purity and yield of the product.
The first thing to pay attention to is the temperature and humidity of the storage environment. This product should be stored in a cool and dry place to prevent moisture and deterioration. If the ambient humidity is too high, the moisture is easy to interact with it, or change its chemical properties, causing damage to the quality; if the temperature is too high, it may cause chemical reactions, and even risk safety.
Furthermore, the storage place should be well ventilated. Avoid mixing with oxidants, acids, alkalis and other substances. Due to its active chemical properties, contact with the above substances is prone to violent chemical reactions, or serious consequences such as combustion and explosion.
When transporting, the packaging must be sturdy. Make sure that the container is free of leakage to prevent the product from being scattered, lost, polluting the environment, and avoiding harm to transporters. Transportation vehicles should be selected with appropriate protective and emergency equipment.
And the transportation process should be smooth to avoid violent vibration and collision. Vibration and collision or damage to the packaging may also cause physical or chemical reactions of internal substances.
In addition, regardless of storage or transportation, relevant regulations and standards should be strictly adhered to. Operators need to undergo professional training and be familiar with product characteristics and safety precautions, so as to ensure the safety and quality of 3-amino-5-chloro-4-hydroxybenzenesulfonic acid during storage and transportation.

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