Linshang Chemical
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3-Bromo-1-Chloro-4-Fluorobenzene
Linshang Chemical
|
HS Code |
527971 |
| Chemical Formula | C6H3BrClF |
| Appearance | Liquid (usually) |
| Boiling Point | Around 190 - 195 °C |
| Density | Approx. 1.7 - 1.8 g/cm³ |
| Solubility In Water | Low, considered insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, toluene |
| Odor | Typical aromatic - halogenated smell |
As an accredited 3-Bromo-1-Chloro-4-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 3 - bromo - 1 - chloro - 4 - fluorobenzene in a sealed, chemical - resistant bottle. |
| Storage | Store 3 - bromo - 1 - chloro - 4 - fluorobenzene in a cool, well - ventilated area away from heat sources and ignition sources. Keep it in a tightly closed container made of corrosion - resistant material, as it may react with certain substances. Store it separately from oxidizing agents and incompatible chemicals to prevent potential reactions. |
| Shipping | 3 - bromo - 1 - chloro - 4 - fluorobenzene is shipped in well - sealed, corrosion - resistant containers. It adheres to strict chemical shipping regulations, ensuring proper labeling and secure packaging to prevent leaks during transit. |
Competitive 3-Bromo-1-Chloro-4-Fluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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What is the Chinese name of 3-bromo-1-chloro-4-fluorobenzene?
3-Bromo-1-chloro-4-fluorobenzene is a kind of organic compound. Its naming follows the chemical naming rules, and different halogen atoms are arranged in specific positions above the benzene ring. "3-bromo" means that there are bromine atoms attached to the third carbon of the benzene ring; "1-chlorine" indicates the first carbon-linked chlorine atom; "4-fluorine" refers to the fourth carbon-linked fluorine atom.
Chemical nomenclature aims to accurately describe the structure of a compound. This nomenclature allows chemists to clarify the atomic composition and arrangement of the compound. The position difference of different halogen atoms in the benzene ring affects the chemical and physical properties of the compound. Properties such as reactivity, solubility, boiling point, etc. vary depending on the position and type of halogen atom.
3-Bromo-1-chloro-4-fluorobenzene has many applications in the field of organic synthesis. It can be used as an intermediate to participate in various organic reactions to prepare more complex organic compounds. The uniqueness of its structure gives it specific reactivity and selectivity, which is valued by organic synthesis chemists.
Chemical nomenclature aims to accurately describe the structure of a compound. This nomenclature allows chemists to clarify the atomic composition and arrangement of the compound. The position difference of different halogen atoms in the benzene ring affects the chemical and physical properties of the compound. Properties such as reactivity, solubility, boiling point, etc. vary depending on the position and type of halogen atom.
3-Bromo-1-chloro-4-fluorobenzene has many applications in the field of organic synthesis. It can be used as an intermediate to participate in various organic reactions to prepare more complex organic compounds. The uniqueness of its structure gives it specific reactivity and selectivity, which is valued by organic synthesis chemists.
What are the physical properties of 3-bromo-1-chloro-4-fluorobenzene?
3-Bromo-1-chloro-4-fluorobenzene is one of the organohalogenated aromatic hydrocarbons. Its physical properties are unique, let me explain in detail.
First of all, its phase state and odor. Under normal temperature and pressure, this substance is mostly a colorless to light yellow liquid, but its smell is specific, irritating, and uncomfortable to smell. The significant smell of this odor is due to the chemical activity endowed by the halogen atom, which makes the molecule volatile to a certain extent, so it can be diffused in the air, which is felt by our sense of smell.
Second, its melting point is quite low, about -40 ° C, due to the weak intermolecular forces. The boiling point is relatively high, probably between 190 ° C and 200 ° C. The reason for this phenomenon is that although there is only a weak van der Waals force between molecules, the polarity of the molecule increased by the halogen atom increases the attractive force between molecules. To make it boil, more energy is required to overcome the intermolecular force, so the boiling point is higher.
Furthermore, look at its solubility. In water, 3-bromo-1-chloro-4-fluorobenzene is extremely difficult to dissolve. Due to the strong hydrogen bond between water molecules, and the substance is a non-polar or weakly polar molecule, which is very different from water in polarity. According to the principle of "similar miscibility", it is difficult to dissolve in water. However, it has good solubility in organic solvents, such as ethanol, ether, and dichloromethane. Because the force between the molecules of the organic solvent and the substance is similar, it can be interspersed and mixed with each other, so it is soluble.
In addition, the density of the substance also needs to be paid attention to. Its density is greater than that of water, about 1.8 g/cm ³. This is because the relative weight of the halogen atom is large, resulting in an increase in molecular weight, and the molecular volume is not correspondingly greatly expanded, so the density is higher than that of water. This property is of great significance in operations such as separation and purification. If it is mixed with water, it will sink to the bottom of the water, and the separation can be performed according to this difference.
In summary, the physical properties of 3-bromo-1-chloro-4-fluorobenzene, such as phase state, odor, melting boiling point, solubility and density, are determined by its molecular structure, and have far-reaching influence in the fields of organic synthesis and chemical production. It is related to the choice of reaction conditions and the means of product separation.
First of all, its phase state and odor. Under normal temperature and pressure, this substance is mostly a colorless to light yellow liquid, but its smell is specific, irritating, and uncomfortable to smell. The significant smell of this odor is due to the chemical activity endowed by the halogen atom, which makes the molecule volatile to a certain extent, so it can be diffused in the air, which is felt by our sense of smell.
Second, its melting point is quite low, about -40 ° C, due to the weak intermolecular forces. The boiling point is relatively high, probably between 190 ° C and 200 ° C. The reason for this phenomenon is that although there is only a weak van der Waals force between molecules, the polarity of the molecule increased by the halogen atom increases the attractive force between molecules. To make it boil, more energy is required to overcome the intermolecular force, so the boiling point is higher.
Furthermore, look at its solubility. In water, 3-bromo-1-chloro-4-fluorobenzene is extremely difficult to dissolve. Due to the strong hydrogen bond between water molecules, and the substance is a non-polar or weakly polar molecule, which is very different from water in polarity. According to the principle of "similar miscibility", it is difficult to dissolve in water. However, it has good solubility in organic solvents, such as ethanol, ether, and dichloromethane. Because the force between the molecules of the organic solvent and the substance is similar, it can be interspersed and mixed with each other, so it is soluble.
In addition, the density of the substance also needs to be paid attention to. Its density is greater than that of water, about 1.8 g/cm ³. This is because the relative weight of the halogen atom is large, resulting in an increase in molecular weight, and the molecular volume is not correspondingly greatly expanded, so the density is higher than that of water. This property is of great significance in operations such as separation and purification. If it is mixed with water, it will sink to the bottom of the water, and the separation can be performed according to this difference.
In summary, the physical properties of 3-bromo-1-chloro-4-fluorobenzene, such as phase state, odor, melting boiling point, solubility and density, are determined by its molecular structure, and have far-reaching influence in the fields of organic synthesis and chemical production. It is related to the choice of reaction conditions and the means of product separation.
What are the chemical properties of 3-bromo-1-chloro-4-fluorobenzene?
3-Bromo-1-chloro-4-fluorobenzene is also an organic compound. It has the properties of halogenated aromatics, which is especially critical in chemical reactions.
First of all, its chemical activity. On the benzene ring, the presence of halogen atoms of bromine, chlorine and fluorine causes the electron cloud density to change, making the reactivity of the benzene ring different from that of benzene. Because the halogen atom has an electron-absorbing induction effect, the electron cloud density of the benzene ring decreases, and the electrophilic substitution reaction is more difficult than that of benzene. However, under certain conditions, the electrophilic substitution can still occur, and the substitution position is subject to the localization effect of the halogen atom. Bromine, chlorine, and fluorine are all ortho-para sites. Although their electron-withdrawing reactivity decreases, the ortho-para site is still the preferred entry site of electrophilic reagents.
And then nucleophilic substitution reaction. Halogen atoms can be replaced by nucleophilic reagents, and their activity is related to the type of halogen atoms. Usually, the carbon-fluorine bond is extremely stable, and it is difficult to replace fluorine; while the carbon-bromine bond is relatively weak, bromine is easily replaced by nucleophilic reagents. In case of strong nucleophilic reagents, bromine may be replaced to produce new organic compounds.
And its physical properties. This compound may be liquid or solid at room temperature, depending on its purity and environmental conditions. Due to the halogen atom, its polarity is increased compared with benzene, and it has good solubility in organic solvents, but limited solubility in water. Its melting and boiling point is also affected by halogen atoms, which are higher than benzene, and the intermolecular force is increased due to halogen atoms.
3-Bromo-1-chloro-4-fluorobenzene has a wide range of uses in the field of organic synthesis due to its special chemical properties. It can be used as an intermediate and can be used to produce complex organic molecules through various reactions. It is of great value in the pharmaceutical, pesticide, material and other industries.
First of all, its chemical activity. On the benzene ring, the presence of halogen atoms of bromine, chlorine and fluorine causes the electron cloud density to change, making the reactivity of the benzene ring different from that of benzene. Because the halogen atom has an electron-absorbing induction effect, the electron cloud density of the benzene ring decreases, and the electrophilic substitution reaction is more difficult than that of benzene. However, under certain conditions, the electrophilic substitution can still occur, and the substitution position is subject to the localization effect of the halogen atom. Bromine, chlorine, and fluorine are all ortho-para sites. Although their electron-withdrawing reactivity decreases, the ortho-para site is still the preferred entry site of electrophilic reagents.
And then nucleophilic substitution reaction. Halogen atoms can be replaced by nucleophilic reagents, and their activity is related to the type of halogen atoms. Usually, the carbon-fluorine bond is extremely stable, and it is difficult to replace fluorine; while the carbon-bromine bond is relatively weak, bromine is easily replaced by nucleophilic reagents. In case of strong nucleophilic reagents, bromine may be replaced to produce new organic compounds.
And its physical properties. This compound may be liquid or solid at room temperature, depending on its purity and environmental conditions. Due to the halogen atom, its polarity is increased compared with benzene, and it has good solubility in organic solvents, but limited solubility in water. Its melting and boiling point is also affected by halogen atoms, which are higher than benzene, and the intermolecular force is increased due to halogen atoms.
3-Bromo-1-chloro-4-fluorobenzene has a wide range of uses in the field of organic synthesis due to its special chemical properties. It can be used as an intermediate and can be used to produce complex organic molecules through various reactions. It is of great value in the pharmaceutical, pesticide, material and other industries.
What are the main uses of 3-bromo-1-chloro-4-fluorobenzene?
3-Bromo-1-chloro-4-fluorobenzene, that is, 3-bromo-1-chloro-4-fluorobenzene, has a wide range of uses. In the field of pharmaceutical synthesis, its status is crucial. The presence of halogen atoms on the benzene ring gives it unique chemical activity, which can be used as key intermediates and participate in the construction of many drug molecules. For example, in the development of antibacterial drugs, by virtue of their structural characteristics, they can be combined with specific biological targets, chemically modified and reacted, and converted into active ingredients with antibacterial effects, helping to resist the invasion of pathogens and protect human health.
In the field of materials science, it also has extraordinary performance. Due to its special structure, it can be used as a raw material to prepare polymer materials with special properties. For example, the introduction of fluorine, chlorine, and bromine groups can effectively adjust the electrical, optical, and thermal properties of the material. When preparing organic optoelectronic materials, the carrier transport properties and luminous efficiency of the materials can be optimized, providing excellent basic materials for the manufacture of high-performance Light Emitting Diodes, solar cells, and other optoelectronic devices, promoting the vigorous development of the optoelectronics industry.
Furthermore, in the field of organic synthetic chemistry, 3-bromo-1-chloro-4-fluorobenzene is an extremely important synthetic building block. Its halogen atoms can be modified by various classical organic reactions, such as nucleophilic substitution reactions, metal catalytic coupling reactions, etc., to realize the diversification of functional groups on the benzene ring, and then synthesize organic compounds with complex structures and specific functions, which greatly enriches the types of organic compounds and opens up a broad space for organic chemistry research.
In the field of materials science, it also has extraordinary performance. Due to its special structure, it can be used as a raw material to prepare polymer materials with special properties. For example, the introduction of fluorine, chlorine, and bromine groups can effectively adjust the electrical, optical, and thermal properties of the material. When preparing organic optoelectronic materials, the carrier transport properties and luminous efficiency of the materials can be optimized, providing excellent basic materials for the manufacture of high-performance Light Emitting Diodes, solar cells, and other optoelectronic devices, promoting the vigorous development of the optoelectronics industry.
Furthermore, in the field of organic synthetic chemistry, 3-bromo-1-chloro-4-fluorobenzene is an extremely important synthetic building block. Its halogen atoms can be modified by various classical organic reactions, such as nucleophilic substitution reactions, metal catalytic coupling reactions, etc., to realize the diversification of functional groups on the benzene ring, and then synthesize organic compounds with complex structures and specific functions, which greatly enriches the types of organic compounds and opens up a broad space for organic chemistry research.
What are 3-bromo-1-chloro-4-fluorobenzene synthesis methods?
To prepare 3-bromo-1-chloro-4-fluorobenzene, there are two feasible methods.
First, benzene is used as the starting material. Shilling benzene and bromine are electrophilic substitution reaction under the catalysis of iron bromide to obtain bromobenzene. In this reaction, bromine ions attack the benzene ring electron cloud under the action of the catalyst, breaking its large π bond to form bromobenzene and hydrogen bromide. Subsequently, bromobenzene is reacted with chlorine under light or heating conditions. Because bromo is an ortho-para-site group, chlorine atoms mainly replace the ortho-or para-site hydrogen atoms of bromo to obtain 1-bromo-4-chlorobenzene. Then 1-bromo-4-chlorobenzene is reacted with anhydrous hydrogen fluoride and potassium fluoride and other fluorinated reagents under high temperature and pressure, and fluorine atoms replace chlorine atoms to obtain the target product 3-bromo-1-chloro-4-fluorobenzene. This process requires harsh conditions, high temperature and high pressure equipment, and the selectivity of fluorination reactions is sometimes poor.
Second, p-chloroaniline is used as the starting material. First, p-chloroaniline is mixed with hydrofluoric acid and sodium nitrite, and diazotization is carried out at low temperature to generate diazonium salts. The diazonium salt is extremely unstable, and then co-heated with cuprous bromide and hydrobromic acid, resulting in a Sandmayer reaction. The diazonium group is replaced by a bromine atom to generate 3-bromo-1-chlorobenzene. Finally, 3-bromo-1-chlorobenzene is combined with anhydrous hydrogen fluoride and potassium fluoride, etc., in the presence of suitable catalysts such as antimony pentachloride, the reaction is heated, and the fluorine atom replaces the hydrogen atom at a specific position on the benzene ring to obtain 3-bromo-1-chloro-4-fluorobenzene. There are many steps in this pathway, but the reaction conditions of each step are relatively mild, and some
First, benzene is used as the starting material. Shilling benzene and bromine are electrophilic substitution reaction under the catalysis of iron bromide to obtain bromobenzene. In this reaction, bromine ions attack the benzene ring electron cloud under the action of the catalyst, breaking its large π bond to form bromobenzene and hydrogen bromide. Subsequently, bromobenzene is reacted with chlorine under light or heating conditions. Because bromo is an ortho-para-site group, chlorine atoms mainly replace the ortho-or para-site hydrogen atoms of bromo to obtain 1-bromo-4-chlorobenzene. Then 1-bromo-4-chlorobenzene is reacted with anhydrous hydrogen fluoride and potassium fluoride and other fluorinated reagents under high temperature and pressure, and fluorine atoms replace chlorine atoms to obtain the target product 3-bromo-1-chloro-4-fluorobenzene. This process requires harsh conditions, high temperature and high pressure equipment, and the selectivity of fluorination reactions is sometimes poor.
Second, p-chloroaniline is used as the starting material. First, p-chloroaniline is mixed with hydrofluoric acid and sodium nitrite, and diazotization is carried out at low temperature to generate diazonium salts. The diazonium salt is extremely unstable, and then co-heated with cuprous bromide and hydrobromic acid, resulting in a Sandmayer reaction. The diazonium group is replaced by a bromine atom to generate 3-bromo-1-chlorobenzene. Finally, 3-bromo-1-chlorobenzene is combined with anhydrous hydrogen fluoride and potassium fluoride, etc., in the presence of suitable catalysts such as antimony pentachloride, the reaction is heated, and the fluorine atom replaces the hydrogen atom at a specific position on the benzene ring to obtain 3-bromo-1-chloro-4-fluorobenzene. There are many steps in this pathway, but the reaction conditions of each step are relatively mild, and some
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