Linshang Chemical
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3-Bromo-4-Chlorofluorobenzene
Linshang Chemical
|
HS Code |
413531 |
| Name | 3-Bromo-4-Chlorofluorobenzene |
| Chemical Formula | C6H3BrClF |
| Molar Mass | 225.44 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | 197 - 198 °C |
| Density | 1.82 g/cm³ (approximate, as density can vary with temperature) |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether, etc. |
As an accredited 3-Bromo-4-Chlorofluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 3 - bromo - 4 - chlorofluorobenzene packaged in a sealed glass bottle. |
| Storage | 3 - Bromo - 4 - chlorofluorobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly - sealed container, preferably made of corrosion - resistant materials like glass or certain plastics. Store it separately from oxidizing agents, reducing agents, and reactive chemicals to prevent potential chemical reactions. |
| Shipping | 3 - bromo - 4 - chlorofluorobenzene is shipped in well - sealed, corrosion - resistant containers. It adheres to strict hazardous chemical shipping regulations, ensuring proper labeling and secure handling during transit to prevent leakage and potential hazards. |
Competitive 3-Bromo-4-Chlorofluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 3-Bromo-4-Chlorofluorobenzene in China?
As a trusted 3-Bromo-4-Chlorofluorobenzene manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 3-Bromo-4-Chlorofluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 3-bromo-4-chlorofluorobenzene?
3-Bromo-4-fluoroanisole is an organic compound, its chemical properties are particularly important, and it plays an extraordinary role in the field of organic synthesis.
In this compound, both bromine and fluorine atoms are halogen atoms, and halogen atoms have certain electronegativity, which can change the density distribution of benzene ring electron clouds. Bromine atoms are large in size, and their existence can affect the molecular spatial structure and reactivity. In nucleophilic substitution reactions, bromine atoms can be used as leaving groups and are replaced by nucleophiles. For example, they react with nucleophiles containing hydroxyl groups and amino groups to generate corresponding substitution products, thereby introducing diverse functional groups to expand the structure and function of the compound.
The fluorine atom is extremely electronegative, and its introduction will significantly affect the benzene ring electron cloud, causing the benzene ring electron cloud to shift towards the fluorine atom, and changing the electrophilic substitution reaction activity on the benzene ring. Due to the special electronic effects of fluorine atoms, fluorine-containing organic compounds often exhibit unique physical, chemical and biological activities. For example, in pharmaceutical chemistry, fluorine-containing compounds often have higher lipid solubility and are easier to penetrate biofilms, enhancing the bioavailability and efficacy of drugs.
The methoxy group is connected to the benzene ring, which is the power supply sub-group, which can increase the density of the benzene ring electron cloud, making the benzene ring more prone to electrophilic substitution reactions, and its localization effect makes the electrophilic In 3-bromo-4-fluoroanisole, the methoxy group interacts with the bromine and fluorine atoms to jointly determine the molecular reactivity and selectivity.
In summary, 3-bromo-4-fluoroanisole exhibits unique chemical properties due to the characteristics of bromine, fluorine atoms and methoxy groups, and has important applications in many fields such as organic synthesis and drug development. It can be used to construct various organic compounds through its chemical properties to meet the needs of different fields.
In this compound, both bromine and fluorine atoms are halogen atoms, and halogen atoms have certain electronegativity, which can change the density distribution of benzene ring electron clouds. Bromine atoms are large in size, and their existence can affect the molecular spatial structure and reactivity. In nucleophilic substitution reactions, bromine atoms can be used as leaving groups and are replaced by nucleophiles. For example, they react with nucleophiles containing hydroxyl groups and amino groups to generate corresponding substitution products, thereby introducing diverse functional groups to expand the structure and function of the compound.
The fluorine atom is extremely electronegative, and its introduction will significantly affect the benzene ring electron cloud, causing the benzene ring electron cloud to shift towards the fluorine atom, and changing the electrophilic substitution reaction activity on the benzene ring. Due to the special electronic effects of fluorine atoms, fluorine-containing organic compounds often exhibit unique physical, chemical and biological activities. For example, in pharmaceutical chemistry, fluorine-containing compounds often have higher lipid solubility and are easier to penetrate biofilms, enhancing the bioavailability and efficacy of drugs.
The methoxy group is connected to the benzene ring, which is the power supply sub-group, which can increase the density of the benzene ring electron cloud, making the benzene ring more prone to electrophilic substitution reactions, and its localization effect makes the electrophilic In 3-bromo-4-fluoroanisole, the methoxy group interacts with the bromine and fluorine atoms to jointly determine the molecular reactivity and selectivity.
In summary, 3-bromo-4-fluoroanisole exhibits unique chemical properties due to the characteristics of bromine, fluorine atoms and methoxy groups, and has important applications in many fields such as organic synthesis and drug development. It can be used to construct various organic compounds through its chemical properties to meet the needs of different fields.
What are the physical properties of 3-bromo-4-chlorofluorobenzene?
3-Bromo-4-fluoroanisole is an organic compound with unique physical properties. Looking at its properties, at room temperature, this is a colorless to light yellow liquid with clear texture and good fluidity. It is like a smart stream, flowing naturally in the container.
Smell its smell, exuding a special aromatic smell. This smell is not rich and pungent, but it also has unique recognition and can be clearly perceived in a specific space.
Observe its solubility. The substance is insoluble in water, just like the incompatibility of oil and water. Due to its molecular structure, the force between it and water molecules is weak and cannot be evenly dispersed in water. However, in organic solvents such as ethanol and ether, it can exhibit good solubility, quickly fusing with organic solvents like a fish entering water, and dispersing uniformly.
Looking at its boiling point, it is about a specific temperature range. At this temperature, the liquid 3-bromo-4-fluoroanisole absorbs enough energy, and the molecular thermal motion intensifies, breaking free from the liquid binding and turning into a gaseous state. The characteristics of the boiling point determine its performance in separation operations such as distillation.
When the temperature drops to a certain level, the molecular thermal motion slows down, and the arrangement of each other becomes orderly, and the substance changes from a liquid state to a solid state. Its melting point is also its own inherent physical property, which is of great significance for the choice of its storage and application ambient temperature.
In terms of density, 3-bromo-4-fluoroanisole has a specific density value compared to water, which determines the distribution of the upper and lower layers when it mixes with water. If the density is greater than that of water, it will sink to the bottom of the water, and vice versa. These many physical properties are intertwined to build a unique physical "portrait" of 3-bromo-4-fluoroanisole, laying the foundation for its application in chemical, pharmaceutical and other fields.
Smell its smell, exuding a special aromatic smell. This smell is not rich and pungent, but it also has unique recognition and can be clearly perceived in a specific space.
Observe its solubility. The substance is insoluble in water, just like the incompatibility of oil and water. Due to its molecular structure, the force between it and water molecules is weak and cannot be evenly dispersed in water. However, in organic solvents such as ethanol and ether, it can exhibit good solubility, quickly fusing with organic solvents like a fish entering water, and dispersing uniformly.
Looking at its boiling point, it is about a specific temperature range. At this temperature, the liquid 3-bromo-4-fluoroanisole absorbs enough energy, and the molecular thermal motion intensifies, breaking free from the liquid binding and turning into a gaseous state. The characteristics of the boiling point determine its performance in separation operations such as distillation.
When the temperature drops to a certain level, the molecular thermal motion slows down, and the arrangement of each other becomes orderly, and the substance changes from a liquid state to a solid state. Its melting point is also its own inherent physical property, which is of great significance for the choice of its storage and application ambient temperature.
In terms of density, 3-bromo-4-fluoroanisole has a specific density value compared to water, which determines the distribution of the upper and lower layers when it mixes with water. If the density is greater than that of water, it will sink to the bottom of the water, and vice versa. These many physical properties are intertwined to build a unique physical "portrait" of 3-bromo-4-fluoroanisole, laying the foundation for its application in chemical, pharmaceutical and other fields.
What are the main uses of 3-bromo-4-chlorofluorobenzene?
3 - The "mulberry" in the mulberry field of the sea has its main uses.
3 -, used in ancient times, often involved in metallurgical fabrication. The "" is the liquid produced by the metal smelting. In ancient times, smelting and other things, this "" is also an indispensable thing in the process of smelting. Take the example of smelting, the high temperature of the stone is calcined, in which the molten liquid is used, this is the "". Craftsmen need to be good at observing the quality of the "" to judge whether the smelting is appropriate. If the heat is insufficient, the flow of the "" is not good, so that it can be fully divided; the heat is low, the gold is low or the shadow is affected. And "mulberry" can be recycled and reused, or other useful things can be proposed, which is important for both cost and source utilization.
4 - The "mulberry" in the mulberry field of the sea has a wide range of uses, and it is the first to promote mulberry colonization. Mulberry is the main food of the world. Since ancient times, mulberry has been the most important food for me. Eating mulberry and vomiting it can be made into a beautiful world. It is not only the best clothes of the people, but also the important goods of the outside world. The road is prosperous because of it. "Mulberry" also means extraordinary in terms of culture. The land of mulberries refers to the old story. Because mulberry is very important in the lives of the ancients. It is mostly planted near homes, and mulberry is like a family. In addition, the wood of mulberry is hard and can be used as utensils; mulberry is edible, has a sweet taste, and has a certain useful value, which can nourish the body. Therefore, "mulberry" plays an important role in the life, culture, and other aspects of the ancients.
What are the synthesis methods of 3-bromo-4-chlorofluorobenzene?
There are many methods for the synthesis of 3-bromo-4-fluoroacetophenone, which can be described as follows:
One is the route using acetophenone as the starting material. First, acetophenone is brominated. Under appropriate reaction conditions, such as in glacial acetic acid solvent, bromine is used as the brominating reagent, and under the action of the catalyst, the specific position of the benzene ring can be brominated to obtain bromoacetophenone-containing intermediates. Subsequently, this intermediate is used as the substrate, and through suitable fluorination means, such as the use of nucleophilic fluorination reagents, under appropriate reaction conditions, the fluorine atom is replaced at a specific position, and then 3-bromo-4-fluorophenone is obtained. The raw materials for this route are easy to obtain, and the steps are relatively clear. However, the conditions of bromination and fluorination reactions need to be precisely controlled to ensure the selectivity and yield of the reaction.
The second is to use fluorobenzene as the starting material. Fluorobenzene first reacts with acylating reagents, such as acetyl chloride or acetic anhydride, under the catalysis of Lewis acid catalysts, such as aluminum trichloride, and undergoes Fu-gram acylation. Acetyl groups are introduced into the benzene ring to obtain 4-fluoroacetophenone. Subsequently, 4-fluoroacetophenone is further brominated, and suitable brominating reagents and reaction conditions are selected to promote the substitution of bromine atoms at the target position, and finally 3-bromo-4-fluoroacetophenone is obtained This approach focuses on the orderly advancement of the acylation and bromination reactions, and the key lies in the optimization of the reaction conditions at each step to improve the purity and yield of the product.
The third is to use bromobenzene as the starting material. Bromobenzene is first metallized, such as interacting with butyl lithium and other reagents to form an active organometallic intermediate. This intermediate reacts with fluoroacylation reagents to construct the structure of acetophenone while introducing fluorine atoms. After subsequent appropriate treatment, 3-bromo-4-fluoroacetophenone can be obtained. This method involves metal-organic reactions with high reactivity, but the reaction conditions and operation requirements are strict, and a strict anhydrous and oxygen-free environment is required to ensure the smooth progress of the reaction.
One is the route using acetophenone as the starting material. First, acetophenone is brominated. Under appropriate reaction conditions, such as in glacial acetic acid solvent, bromine is used as the brominating reagent, and under the action of the catalyst, the specific position of the benzene ring can be brominated to obtain bromoacetophenone-containing intermediates. Subsequently, this intermediate is used as the substrate, and through suitable fluorination means, such as the use of nucleophilic fluorination reagents, under appropriate reaction conditions, the fluorine atom is replaced at a specific position, and then 3-bromo-4-fluorophenone is obtained. The raw materials for this route are easy to obtain, and the steps are relatively clear. However, the conditions of bromination and fluorination reactions need to be precisely controlled to ensure the selectivity and yield of the reaction.
The second is to use fluorobenzene as the starting material. Fluorobenzene first reacts with acylating reagents, such as acetyl chloride or acetic anhydride, under the catalysis of Lewis acid catalysts, such as aluminum trichloride, and undergoes Fu-gram acylation. Acetyl groups are introduced into the benzene ring to obtain 4-fluoroacetophenone. Subsequently, 4-fluoroacetophenone is further brominated, and suitable brominating reagents and reaction conditions are selected to promote the substitution of bromine atoms at the target position, and finally 3-bromo-4-fluoroacetophenone is obtained This approach focuses on the orderly advancement of the acylation and bromination reactions, and the key lies in the optimization of the reaction conditions at each step to improve the purity and yield of the product.
The third is to use bromobenzene as the starting material. Bromobenzene is first metallized, such as interacting with butyl lithium and other reagents to form an active organometallic intermediate. This intermediate reacts with fluoroacylation reagents to construct the structure of acetophenone while introducing fluorine atoms. After subsequent appropriate treatment, 3-bromo-4-fluoroacetophenone can be obtained. This method involves metal-organic reactions with high reactivity, but the reaction conditions and operation requirements are strict, and a strict anhydrous and oxygen-free environment is required to ensure the smooth progress of the reaction.
What are the precautions for storing and transporting 3-bromo-4-chlorofluorobenzene?
3-% -4- In the process of hiding and cleaning, it is very important to pay attention to the important things and must not be neglected.
In the process of hiding, the first thing is the dryness of the environment. If these two encounter moisture, they are prone to deliquescence. When deliquescence occurs, its nature is not good, and it is effective to use it for a long time. Therefore, it must be placed in a dry place, or use a moisture-proof device to prevent invasion.
Furthermore, the degree of hiding should also be paid attention to. Do not be placed in a high place, under the height, or cause it to be reversed, so that its composition is poor. Nor should it be placed in a cold place to prevent it from being affected by the influence of the product. It is advisable to set the degree to make it safe.
If there is an external defect, it must be damaged. Use a solid tool to hold it, and use external materials, such as grass and rubber, to prevent bumps and collisions on the way, causing it to break the outside. If there is an external defect, it will not be lost by itself, and may be contaminated with the surrounding things, causing trouble.
People are also familiar with its nature, so be careful. Avoid mixing with other things, especially those that can react, such as acid and oil. Mixing is prone to danger and endangers the safety of people and materials.
Therefore, 3-% -4- should be stored in the warehouse, the environment is dry, the degree is appropriate, the package is not suitable, and the mixing is avoided. It is necessary to be careful to ensure its safety and security, and the product is not lost.
In the process of hiding, the first thing is the dryness of the environment. If these two encounter moisture, they are prone to deliquescence. When deliquescence occurs, its nature is not good, and it is effective to use it for a long time. Therefore, it must be placed in a dry place, or use a moisture-proof device to prevent invasion.
Furthermore, the degree of hiding should also be paid attention to. Do not be placed in a high place, under the height, or cause it to be reversed, so that its composition is poor. Nor should it be placed in a cold place to prevent it from being affected by the influence of the product. It is advisable to set the degree to make it safe.
If there is an external defect, it must be damaged. Use a solid tool to hold it, and use external materials, such as grass and rubber, to prevent bumps and collisions on the way, causing it to break the outside. If there is an external defect, it will not be lost by itself, and may be contaminated with the surrounding things, causing trouble.
People are also familiar with its nature, so be careful. Avoid mixing with other things, especially those that can react, such as acid and oil. Mixing is prone to danger and endangers the safety of people and materials.
Therefore, 3-% -4- should be stored in the warehouse, the environment is dry, the degree is appropriate, the package is not suitable, and the mixing is avoided. It is necessary to be careful to ensure its safety and security, and the product is not lost.
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