Linshang Chemical
PRODUCTS
3-Bromo-4-Chloronitrobenzene
Linshang Chemical
|
HS Code |
562519 |
| Chemical Formula | C6H3BrClNO2 |
| Molar Mass | 240.45 g/mol |
| Appearance | Yellow solid |
| Melting Point | 58 - 62 °C |
| Boiling Point | 263 - 265 °C |
| Density | 1.85 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in many organic solvents like ethanol, benzene |
| Flash Point | 113.1 °C |
| Stability | Stable under normal conditions, but reacts with strong oxidizing agents |
As an accredited 3-Bromo-4-Chloronitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 3 - bromo - 4 - chloronitrobenzene packaged in a sealed chemical - grade bottle. |
| Storage | 3 - Bromo - 4 - chloronitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat and ignition sources. It is a hazardous chemical, so keep it in a locked storage cabinet, separated from incompatible substances like oxidizing agents, reducing agents, and bases. Use appropriate secondary containment to prevent spills. Clearly label the storage container with its name, hazards, and handling instructions. |
| Shipping | 3 - bromo - 4 - chloronitrobenzene is shipped in sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations to prevent leakage, ensuring safe transportation due to its potential risks. |
Competitive 3-Bromo-4-Chloronitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 3-Bromo-4-Chloronitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 3 - bromo - 4 - chloronitrobenzene?
3-Bromo-4-chloronitrobenzene is also an organic compound. It has the dual characteristics of halogenated aromatics and nitro compounds.
In this compound, bromine (Br) and chlorine (Cl) are halogen atoms, and nitro (-NO -2) has strong electron-absorbing properties. Due to the presence of nitro groups, the electron cloud density of the benzene ring decreases, resulting in lower electrophilic substitution activity than that of benzene.
As for the electrophilic substitution reaction, due to the electron-absorbing and conjugation effects of nitro groups, the electron cloud density of the ortho-and para-potential of the benzene ring decreases more than that of the meta-position, so the electrophilic reagents are more likely to attack the meta-position. However, due to the fact that bromine and chlorine are also ortho and para-localized groups, their activation is weaker than that of nitro groups, so the overall reactivity is still low.
Its halogen atoms can participate in nucleophilic substitution reactions. Under suitable conditions, such as strong bases, high temperatures or catalysts, bromine or chlorine can be replaced by nucleophilic reagents. For example, when treated with nucleophilic reagents such as sodium alcohol, the halogen atoms can be replaced by alkoxy groups to obtain corresponding ether compounds.
And because it contains nitro groups, it can participate in reduction reactions. In reduction systems such as iron and hydrochloric acid, nitro groups can be gradually reduced to amino groups to obtain products such as 3-bromo-4-chloroaniline. This product is widely used in organic synthesis and can be used as an intermediate for the preparation of dyes, medicines, etc.
In addition, the physical properties of 3-bromo-4-chloronitrobenzene also need to be paid attention to. It is a solid with a certain melting point and boiling point, and has a certain solubility in organic solvents due to molecular polarity, but very little solubility in water.
In this compound, bromine (Br) and chlorine (Cl) are halogen atoms, and nitro (-NO -2) has strong electron-absorbing properties. Due to the presence of nitro groups, the electron cloud density of the benzene ring decreases, resulting in lower electrophilic substitution activity than that of benzene.
As for the electrophilic substitution reaction, due to the electron-absorbing and conjugation effects of nitro groups, the electron cloud density of the ortho-and para-potential of the benzene ring decreases more than that of the meta-position, so the electrophilic reagents are more likely to attack the meta-position. However, due to the fact that bromine and chlorine are also ortho and para-localized groups, their activation is weaker than that of nitro groups, so the overall reactivity is still low.
Its halogen atoms can participate in nucleophilic substitution reactions. Under suitable conditions, such as strong bases, high temperatures or catalysts, bromine or chlorine can be replaced by nucleophilic reagents. For example, when treated with nucleophilic reagents such as sodium alcohol, the halogen atoms can be replaced by alkoxy groups to obtain corresponding ether compounds.
And because it contains nitro groups, it can participate in reduction reactions. In reduction systems such as iron and hydrochloric acid, nitro groups can be gradually reduced to amino groups to obtain products such as 3-bromo-4-chloroaniline. This product is widely used in organic synthesis and can be used as an intermediate for the preparation of dyes, medicines, etc.
In addition, the physical properties of 3-bromo-4-chloronitrobenzene also need to be paid attention to. It is a solid with a certain melting point and boiling point, and has a certain solubility in organic solvents due to molecular polarity, but very little solubility in water.
What are the synthesis methods of 3 - bromo - 4 - chloronitrobenzene?
There are several ways to make 3-bromo-4-chloronitrobenzene.
First, it can be started from chlorobenzene. The reaction of nitrification of chlorobenzene is carried out. The mixed acid of sulfuric acid and nitric acid is used as a reagent. Under suitable temperature conditions, the hydrogen atom on the chlorobenzene ring is replaced by a nitro group, and p-chloronitrobenzene can be obtained. This step of reaction requires precise temperature control. Due to the temperature, the selectivity of the product is related. The obtained p-chloronitrobenzene is brominated with bromine in the presence of a catalyst such as iron powder or iron tribromide. The bromine atom can selectively enter the ortho position of the nitro group to obtain 3-bromo-4-chloronitrobenzene. In this path, the conditions of the nitration reaction, such as the proportion of mixed acids, the reaction temperature, the amount of catalyst used for the bromination reaction, the reaction time, etc., all have a significant impact on the yield and purity of the product.
Second, bromobenzene can also be started from bromobenzene. Similarly, it is nitrified first to obtain p-bromonitrobenzene. Then chlorine reagents, such as chlorine gas, are used under specific conditions under the action of catalysts, and chlorine atoms can be introduced into the ortho-position of bromine atoms to obtain 3-bromo-4-chloronitrobenzene. In this process, the nitration step needs to pay attention to the positional selectivity of nitro introduction, while the chlorination reaction needs to pay attention to the optimization of reaction conditions, such as reaction temperature, pressure, and catalyst activity, in order to improve the yield and quality of the target product.
Another way is to use nitrobenzene as a raw material. The halogenation reaction of nitrobenzene is carried out first, and chlorine atoms can be introduced first, and then bromine atoms can be introduced, or vice versa. However, because the nitro group is a strong electron-absorbing group, the electron cloud density of the benzene ring will be reduced, and the halogenation reaction is relatively difficult to carry out. More severe reaction conditions are often required, and the selective control of the product is also quite challenging. In this situation, the selection of efficient catalysts and suitable reaction solvents is crucial to promote the reaction and improve the selectivity of products.
All synthesis methods have their own advantages and disadvantages. In actual synthesis work, it is necessary to weigh and choose the optimal synthesis path according to many factors such as the availability of raw materials, reaction conditions, product purity and yield requirements.
First, it can be started from chlorobenzene. The reaction of nitrification of chlorobenzene is carried out. The mixed acid of sulfuric acid and nitric acid is used as a reagent. Under suitable temperature conditions, the hydrogen atom on the chlorobenzene ring is replaced by a nitro group, and p-chloronitrobenzene can be obtained. This step of reaction requires precise temperature control. Due to the temperature, the selectivity of the product is related. The obtained p-chloronitrobenzene is brominated with bromine in the presence of a catalyst such as iron powder or iron tribromide. The bromine atom can selectively enter the ortho position of the nitro group to obtain 3-bromo-4-chloronitrobenzene. In this path, the conditions of the nitration reaction, such as the proportion of mixed acids, the reaction temperature, the amount of catalyst used for the bromination reaction, the reaction time, etc., all have a significant impact on the yield and purity of the product.
Second, bromobenzene can also be started from bromobenzene. Similarly, it is nitrified first to obtain p-bromonitrobenzene. Then chlorine reagents, such as chlorine gas, are used under specific conditions under the action of catalysts, and chlorine atoms can be introduced into the ortho-position of bromine atoms to obtain 3-bromo-4-chloronitrobenzene. In this process, the nitration step needs to pay attention to the positional selectivity of nitro introduction, while the chlorination reaction needs to pay attention to the optimization of reaction conditions, such as reaction temperature, pressure, and catalyst activity, in order to improve the yield and quality of the target product.
Another way is to use nitrobenzene as a raw material. The halogenation reaction of nitrobenzene is carried out first, and chlorine atoms can be introduced first, and then bromine atoms can be introduced, or vice versa. However, because the nitro group is a strong electron-absorbing group, the electron cloud density of the benzene ring will be reduced, and the halogenation reaction is relatively difficult to carry out. More severe reaction conditions are often required, and the selective control of the product is also quite challenging. In this situation, the selection of efficient catalysts and suitable reaction solvents is crucial to promote the reaction and improve the selectivity of products.
All synthesis methods have their own advantages and disadvantages. In actual synthesis work, it is necessary to weigh and choose the optimal synthesis path according to many factors such as the availability of raw materials, reaction conditions, product purity and yield requirements.
Where is 3 - bromo - 4 - chloronitrobenzene used?
3-Bromo-4-chloronitrobenzene is also a good material for chemical processing. In the field of organic synthesis, it has a wide range of uses.
It is often used as an essential agent in the synthesis of medicine. It can be used as a precursor to make specific drugs. For example, some antibacterial and anti-inflammatory drugs, the combination of these compounds depends on this compound as the basis. After several delicate reactions, the required structure can be obtained to achieve the effect of curing diseases and saving people.
In the field of pesticide creation, it also has its own function. It can be used as a raw material to create efficient insecticides and herbicides. Such pesticides can precisely eliminate pests, grow agricultural protection products, and ensure the abundance of grains. They make great contributions to the prosperity of agriculture.
In the realm of dye preparation, 3-bromo-4-chloronitrobenzene is also indispensable. From it, dyes with brilliant color and good fastness can be made. For fabric printing and dyeing, make cloth colorful, never fade for a long time, increase the beauty of clothing and add color to life.
In the field of material science, it can also be seen. Or as monomers, participate in polymerization reactions to make materials with special functions. These materials may have excellent electrical and optical properties, and are used in electronic and optical devices to promote the progress of science and technology and promote the new era.
In summary, 3-bromo-4-chloronitrobenzene has important applications in many fields such as medicine, pesticides, dyes, materials, etc. It is a treasure of the chemical industry, promoting the development of all industries, and benefiting all people.
It is often used as an essential agent in the synthesis of medicine. It can be used as a precursor to make specific drugs. For example, some antibacterial and anti-inflammatory drugs, the combination of these compounds depends on this compound as the basis. After several delicate reactions, the required structure can be obtained to achieve the effect of curing diseases and saving people.
In the field of pesticide creation, it also has its own function. It can be used as a raw material to create efficient insecticides and herbicides. Such pesticides can precisely eliminate pests, grow agricultural protection products, and ensure the abundance of grains. They make great contributions to the prosperity of agriculture.
In the realm of dye preparation, 3-bromo-4-chloronitrobenzene is also indispensable. From it, dyes with brilliant color and good fastness can be made. For fabric printing and dyeing, make cloth colorful, never fade for a long time, increase the beauty of clothing and add color to life.
In the field of material science, it can also be seen. Or as monomers, participate in polymerization reactions to make materials with special functions. These materials may have excellent electrical and optical properties, and are used in electronic and optical devices to promote the progress of science and technology and promote the new era.
In summary, 3-bromo-4-chloronitrobenzene has important applications in many fields such as medicine, pesticides, dyes, materials, etc. It is a treasure of the chemical industry, promoting the development of all industries, and benefiting all people.
What are the physical properties of 3 - bromo - 4 - chloronitrobenzene?
3-Bromo-4-chloronitrobenzene is also an organic compound. Its physical properties are particularly important and are related to the application of chemical industries.
Looking at its properties, it is mostly light yellow crystalline under normal conditions, and the quality is stable and easy to identify. As for the melting point, the melting point is about 48-50 degrees Celsius, and the boiling point is about 287 degrees Celsius. The characteristics of this melting point are crucial in chemical operations such as separation and purification. The cover can be separated by conventional heating and condensation because of its moderate melting point, which is neither too high refractory nor too low.
In terms of solubility, 3-bromo-4-chloronitrobenzene has good solubility in organic solvents such as ethanol, ether, benzene, etc. This property makes it fully miscible with many organic reagents in the reaction system of organic synthesis, promoting the reaction. However, in water, its solubility is very small. Due to the existence of groups such as nitro, bromine atom, and chlorine atom in the molecular structure, the polarity of the molecule is quite different from that of water. It follows the principle of similar compatibility, so it is difficult to dissolve in water.
Density is also one of its important physical properties, which is heavier than water, about 1.88 g/cm ³. This property is of great significance in experiments or industrial processes involving liquid-liquid separation. If it is co-located with water, it must sink at the bottom of the water due to its high density. It can be easily separated by means of liquid separation.
In addition, 3-bromo-4-chloronitrobenzene has a low vapor pressure and low volatility. It is not easy to volatilize into gas at room temperature and pressure. This property is not only conducive to storage, but also reduces the loss and danger caused by volatilization. It is also beneficial to the operating environment and reduces the pollution of steam to the air and the harm to the human body.
Looking at its properties, it is mostly light yellow crystalline under normal conditions, and the quality is stable and easy to identify. As for the melting point, the melting point is about 48-50 degrees Celsius, and the boiling point is about 287 degrees Celsius. The characteristics of this melting point are crucial in chemical operations such as separation and purification. The cover can be separated by conventional heating and condensation because of its moderate melting point, which is neither too high refractory nor too low.
In terms of solubility, 3-bromo-4-chloronitrobenzene has good solubility in organic solvents such as ethanol, ether, benzene, etc. This property makes it fully miscible with many organic reagents in the reaction system of organic synthesis, promoting the reaction. However, in water, its solubility is very small. Due to the existence of groups such as nitro, bromine atom, and chlorine atom in the molecular structure, the polarity of the molecule is quite different from that of water. It follows the principle of similar compatibility, so it is difficult to dissolve in water.
Density is also one of its important physical properties, which is heavier than water, about 1.88 g/cm ³. This property is of great significance in experiments or industrial processes involving liquid-liquid separation. If it is co-located with water, it must sink at the bottom of the water due to its high density. It can be easily separated by means of liquid separation.
In addition, 3-bromo-4-chloronitrobenzene has a low vapor pressure and low volatility. It is not easy to volatilize into gas at room temperature and pressure. This property is not only conducive to storage, but also reduces the loss and danger caused by volatilization. It is also beneficial to the operating environment and reduces the pollution of steam to the air and the harm to the human body.
What are the precautions in the preparation of 3 - bromo - 4 - chloronitrobenzene?
When making 3-bromo-4-chloronitrobenzene, there are several points to pay attention to.
The purity of the starting material is very important. If the raw material contains impurities, or the reaction yield is reduced, the product is impure. For example, the chlorobenzene, brominating agent, nitrifying agent, etc. used, all need to be purified finely to achieve the required purity of the reaction.
The reaction conditions are also critical. The temperature needs to be precisely controlled. If the temperature is too high, or side reactions will occur, such as polybromination and polynitrification products, which will in vain reduce the yield of the target product. If the temperature is too low, the reaction rate will be slow and time-consuming. In addition, the reaction pressure also has an effect. Although this reaction can be carried out under normal pressure, in some specific cases, the pressure can be fine-tuned or optimized.
Furthermore, the choice of reaction solvent is very important. A suitable solvent can improve the solubility of the reactants, make the reaction proceed uniformly, and promote the smooth occurrence of the reaction. And different solvents have an impact on the reaction rate and selectivity, so careful selection is required according to the reaction characteristics.
Stirring rate cannot be ignored. Sufficient stirring can make the reactants evenly mixed, improve mass transfer efficiency, prevent side reactions caused by excessive local concentration, and accelerate the reaction rate, making the reaction more efficient.
Post-processing steps should also be carefully operated. The process of product separation and purification requires appropriate methods, such as extraction, distillation, recrystallization, etc., to obtain high-purity 3-bromo-4-chloronitrobenzene according to the physical and chemical properties of the product and impurities.
In addition, safety protection must not be ignored. The brominating agents and nitrifying agents used in the reaction are mostly corrosive and toxic. Safety procedures must be strictly followed during operation, wearing protective equipment, and working in good ventilation to prevent endangering the health and safety of the experimental personnel.
The purity of the starting material is very important. If the raw material contains impurities, or the reaction yield is reduced, the product is impure. For example, the chlorobenzene, brominating agent, nitrifying agent, etc. used, all need to be purified finely to achieve the required purity of the reaction.
The reaction conditions are also critical. The temperature needs to be precisely controlled. If the temperature is too high, or side reactions will occur, such as polybromination and polynitrification products, which will in vain reduce the yield of the target product. If the temperature is too low, the reaction rate will be slow and time-consuming. In addition, the reaction pressure also has an effect. Although this reaction can be carried out under normal pressure, in some specific cases, the pressure can be fine-tuned or optimized.
Furthermore, the choice of reaction solvent is very important. A suitable solvent can improve the solubility of the reactants, make the reaction proceed uniformly, and promote the smooth occurrence of the reaction. And different solvents have an impact on the reaction rate and selectivity, so careful selection is required according to the reaction characteristics.
Stirring rate cannot be ignored. Sufficient stirring can make the reactants evenly mixed, improve mass transfer efficiency, prevent side reactions caused by excessive local concentration, and accelerate the reaction rate, making the reaction more efficient.
Post-processing steps should also be carefully operated. The process of product separation and purification requires appropriate methods, such as extraction, distillation, recrystallization, etc., to obtain high-purity 3-bromo-4-chloronitrobenzene according to the physical and chemical properties of the product and impurities.
In addition, safety protection must not be ignored. The brominating agents and nitrifying agents used in the reaction are mostly corrosive and toxic. Safety procedures must be strictly followed during operation, wearing protective equipment, and working in good ventilation to prevent endangering the health and safety of the experimental personnel.
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