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3-Bromo-4-Fluorochlorobenzene
Linshang Chemical
|
HS Code |
358494 |
| Chemical Formula | C6H3BrClF |
| Molar Mass | 211.44 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | Approx. 190 - 195 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Vapor Pressure | Low, typical for halogenated aromatic compounds |
As an accredited 3-Bromo-4-Fluorochlorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 3 - bromo - 4 - fluorochlorobenzene packaged in a sealed glass bottle. |
| Storage | Store 3 - bromo - 4 - fluorochlorobenzene in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials. Avoid storage near oxidizing agents and incompatible substances. This ensures its stability and minimizes risks associated with potential chemical reactions or degradation. |
| Shipping | 3 - bromo - 4 - fluorochlorobenzene is a chemical. For shipping, it must be properly packaged in a suitable container. Label it clearly with relevant hazard information and ship via carriers compliant with chemical transportation regulations. |
Competitive 3-Bromo-4-Fluorochlorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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What is the Chinese name of 3-bromo-4-fluorochlorobenzene?
3-Bromo-4-fluorochlorobenzene is also the name of an organic compound. Its naming follows the chemical naming convention. "Benzene" is the basic structure of this compound and is the parent body of aromatic hydrocarbons. "Chlorobenzene" is replaced by a chlorine atom on the epiphenyl ring. "3-Bromo-4-fluorine" indicates that the bromine atom is located at position 3 of the benzene ring and the fluorine atom is located at position 4.
The chemical naming method aims to accurately express the structure and composition of the compound. In the naming of aromatic compounds, the benzene ring is often used as the reference, and the position and type of the substituent are clearly indicated. When naming this compound, "bromine", "fluorine" and "chlorine" are listed according to the type of halogen atom, and then its position on the benzene ring is indicated by numbers. This naming allows colleagues in the chemical industry to know its approximate structure by name, which is of crucial significance in academic exchanges, research and industrial production. By using this standard naming, misunderstandings caused by name confusion can be avoided and the work in the field of chemistry can be carried out in an orderly manner.
The chemical naming method aims to accurately express the structure and composition of the compound. In the naming of aromatic compounds, the benzene ring is often used as the reference, and the position and type of the substituent are clearly indicated. When naming this compound, "bromine", "fluorine" and "chlorine" are listed according to the type of halogen atom, and then its position on the benzene ring is indicated by numbers. This naming allows colleagues in the chemical industry to know its approximate structure by name, which is of crucial significance in academic exchanges, research and industrial production. By using this standard naming, misunderstandings caused by name confusion can be avoided and the work in the field of chemistry can be carried out in an orderly manner.
What are the chemical properties of 3-bromo-4-fluorochlorobenzene?
3-Bromo-4-chlorofluorobenzene is one of the organohalogenated aromatic hydrocarbons. It has unique chemical properties and is very important in the field of organic synthesis.
First of all, three halogen atoms of bromine, fluorine and chlorine coexist in this compound, and the chemical activities of halogen atoms are different. Bromine atoms are relatively active, and are more easily replaced by nucleophiles in nucleophilic substitution reactions. For example, using sodium alcohol as a nucleophilic reagent, under appropriate solvent and temperature conditions, bromine atoms can be replaced by alkoxy groups to form corresponding ether compounds. This reaction mechanism is that the nucleophilic reagent attacks the carbon atom connected to the bromine atom, and the bromine ion leaves to complete the substitution process.
Furthermore, although the fluorine atom is highly electronegative, the carbon-fluorine bond energy is large, which makes it difficult for its nucleophilic substitution reaction to occur. However, under specific conditions, such as strong nucleophilic reagents and high temperatures, fluorine atoms can also participate in the reaction. And due to the presence of fluorine atoms, the electron cloud distribution of the molecule can be affected, which in turn affects the reactivity of other groups.
The activity of chlorine atoms is between bromine and fluorine. In some reactions, such as when reacting with metal magnesium to form Grignard reagents, chlorine atoms can participate in the reaction to form magnesium-containing organometallic compounds. This Grignard reagent is extremely active and can undergo addition reactions with a variety of carbonyl compounds to form new carbon-carbon bonds, which is a key step in organic synthesis.
In addition, the benzene ring of 3-bromo-4-fluorochlorobenzene also has unique properties. The electron cloud density of the benzene ring is affected by the induction and conjugation effects of halogen atoms. Halogen atoms are electron-withdrawing groups, which reduce the electron cloud density of the benzene ring and reduce the activity of electrophilic substitution reactions. However, due to their localization effect, electrophilic reagents have specific positional selectivity when attacking the benzene ring. For example, bromine and chlorine are ortho and para-localization groups, while fluorine also has a certain influence on the localization of electrophilic substitution reactions due to its special electronic In the electrophilic substitution reaction, the newly introduced group mostly enters the adjacent and para-position of the bromine and chlorine atoms, and is affected by the fluorine atom, the selectivity of the specific position will be more complicated, and the electronic and spatial effects of each halogen atom need to be comprehensively considered.
In short, the chemical properties of 3-bromo-4-fluorochlorobenzene are determined by the interaction between its halogen atom and benzene ring. It can be used as an important intermediate in the field of organic synthesis. Through rational design of reaction conditions, the synthesis of various organic compounds can be realized.
First of all, three halogen atoms of bromine, fluorine and chlorine coexist in this compound, and the chemical activities of halogen atoms are different. Bromine atoms are relatively active, and are more easily replaced by nucleophiles in nucleophilic substitution reactions. For example, using sodium alcohol as a nucleophilic reagent, under appropriate solvent and temperature conditions, bromine atoms can be replaced by alkoxy groups to form corresponding ether compounds. This reaction mechanism is that the nucleophilic reagent attacks the carbon atom connected to the bromine atom, and the bromine ion leaves to complete the substitution process.
Furthermore, although the fluorine atom is highly electronegative, the carbon-fluorine bond energy is large, which makes it difficult for its nucleophilic substitution reaction to occur. However, under specific conditions, such as strong nucleophilic reagents and high temperatures, fluorine atoms can also participate in the reaction. And due to the presence of fluorine atoms, the electron cloud distribution of the molecule can be affected, which in turn affects the reactivity of other groups.
The activity of chlorine atoms is between bromine and fluorine. In some reactions, such as when reacting with metal magnesium to form Grignard reagents, chlorine atoms can participate in the reaction to form magnesium-containing organometallic compounds. This Grignard reagent is extremely active and can undergo addition reactions with a variety of carbonyl compounds to form new carbon-carbon bonds, which is a key step in organic synthesis.
In addition, the benzene ring of 3-bromo-4-fluorochlorobenzene also has unique properties. The electron cloud density of the benzene ring is affected by the induction and conjugation effects of halogen atoms. Halogen atoms are electron-withdrawing groups, which reduce the electron cloud density of the benzene ring and reduce the activity of electrophilic substitution reactions. However, due to their localization effect, electrophilic reagents have specific positional selectivity when attacking the benzene ring. For example, bromine and chlorine are ortho and para-localization groups, while fluorine also has a certain influence on the localization of electrophilic substitution reactions due to its special electronic In the electrophilic substitution reaction, the newly introduced group mostly enters the adjacent and para-position of the bromine and chlorine atoms, and is affected by the fluorine atom, the selectivity of the specific position will be more complicated, and the electronic and spatial effects of each halogen atom need to be comprehensively considered.
In short, the chemical properties of 3-bromo-4-fluorochlorobenzene are determined by the interaction between its halogen atom and benzene ring. It can be used as an important intermediate in the field of organic synthesis. Through rational design of reaction conditions, the synthesis of various organic compounds can be realized.
What are the physical properties of 3-bromo-4-fluorochlorobenzene?
3-Bromo-4-fluorochlorobenzene is a kind of organic halogenated aromatic hydrocarbon. Looking at its physical properties, at room temperature, this substance is mostly liquid and has a unique odor. Its density is greater than that of water, insoluble in water, but it can be miscible with many organic solvents, such as ethanol, ether, benzene, etc. This is due to the principle of "similarity and miscibility", and its organic structure is similar to that of organic solvents.
When it comes to boiling points, due to the existence of van der Waals forces between molecules, and the presence of halogen atoms increases the intermolecular force, its boiling point is relatively high. However, the exact value varies depending on the conditions for accurate determination.
Its melting point is also affected by the molecular structure and intermolecular force. The specific position of the halogen atoms in the benzene ring makes the molecular arrangement more regular, increases the intermolecular attraction, and increases the melting point.
In addition, the substance contains halogen atoms, and the electronegativity of the halogen atoms is high, causing the molecules to exhibit a certain polarity. This polarity also affects its physical properties. For example, in terms of solubility and boiling point, it is different from non-polar molecules.
When it comes to boiling points, due to the existence of van der Waals forces between molecules, and the presence of halogen atoms increases the intermolecular force, its boiling point is relatively high. However, the exact value varies depending on the conditions for accurate determination.
Its melting point is also affected by the molecular structure and intermolecular force. The specific position of the halogen atoms in the benzene ring makes the molecular arrangement more regular, increases the intermolecular attraction, and increases the melting point.
In addition, the substance contains halogen atoms, and the electronegativity of the halogen atoms is high, causing the molecules to exhibit a certain polarity. This polarity also affects its physical properties. For example, in terms of solubility and boiling point, it is different from non-polar molecules.
What are the common uses of 3-bromo-4-fluorochlorobenzene?
3-Bromo-4-fluorochlorobenzene is one of the organic compounds. Its common uses are quite extensive.
First, in the field of pharmaceutical synthesis, it has a significant role. In the development of many drugs, 3-bromo-4-fluorochlorobenzene can be used as a key intermediate. Because of its specific chemical structure, it can participate in a variety of reactions, and through a series of delicate chemical transformations, molecular structures with specific pharmacological activities can be constructed. For example, in the synthesis of some antibacterial drugs, it is used as a starting material. After multi-step reactions, drug molecules that precisely bind to bacterial targets can be formed to achieve antibacterial effect.
Second, it also plays an important role in the creation of pesticides. Pesticides are designed to protect crops from pests and diseases. The pesticides synthesized by 3-bromo-4-fluorochlorobenzene often have unique insecticidal, bactericidal or herbicidal properties. Because of its special structure, it can have effects on specific pests or weeds, or interfere with their physiological and metabolic processes, or affect their growth and development mechanisms, thus achieving good control effects.
Third, in the field of materials science, it also has its application. In the preparation of certain functional materials, 3-bromo-4-fluorochlorobenzene can contribute its structural characteristics. For example, in the synthesis of specific polymer materials, the introduction of this compound can endow the material with unique electrical, optical or thermal properties, making it show potential application value in electronic devices, optical materials and other fields.
In short, 3-bromo-4-fluorochlorobenzene, with its unique chemical structure, plays an indispensable role in many fields such as medicine, pesticides, materials, etc., providing an important material basis and technical support for the development of various fields.
First, in the field of pharmaceutical synthesis, it has a significant role. In the development of many drugs, 3-bromo-4-fluorochlorobenzene can be used as a key intermediate. Because of its specific chemical structure, it can participate in a variety of reactions, and through a series of delicate chemical transformations, molecular structures with specific pharmacological activities can be constructed. For example, in the synthesis of some antibacterial drugs, it is used as a starting material. After multi-step reactions, drug molecules that precisely bind to bacterial targets can be formed to achieve antibacterial effect.
Second, it also plays an important role in the creation of pesticides. Pesticides are designed to protect crops from pests and diseases. The pesticides synthesized by 3-bromo-4-fluorochlorobenzene often have unique insecticidal, bactericidal or herbicidal properties. Because of its special structure, it can have effects on specific pests or weeds, or interfere with their physiological and metabolic processes, or affect their growth and development mechanisms, thus achieving good control effects.
Third, in the field of materials science, it also has its application. In the preparation of certain functional materials, 3-bromo-4-fluorochlorobenzene can contribute its structural characteristics. For example, in the synthesis of specific polymer materials, the introduction of this compound can endow the material with unique electrical, optical or thermal properties, making it show potential application value in electronic devices, optical materials and other fields.
In short, 3-bromo-4-fluorochlorobenzene, with its unique chemical structure, plays an indispensable role in many fields such as medicine, pesticides, materials, etc., providing an important material basis and technical support for the development of various fields.
What are 3-bromo-4-fluorochlorobenzene synthesis methods?
3-Bromo-4-fluorochlorobenzene is also an organic compound. Its synthesis method has followed the classical path in the past.
First, it can be obtained by halogenation. Using chlorobenzene as the starting material, it is first brominated, and under specific conditions, the bromine atom is replaced by the hydrogen atom on the benzene ring. This bromination process requires the selection of a suitable brominating reagent, such as liquid bromine, and the addition of a suitable catalyst, such as iron filings or iron tribromide. After bromination, a chlorobenzene derivative containing bromine is obtained. Then, the fluorination reaction is carried out. At this time, it is necessary to select a fluorinating agent, such as anhydrous potassium fluoride, etc., in an appropriate solvent, heat and reflux to promote fluorine atoms to replace hydrogen atoms at specific positions on the benzene ring, and finally obtain 3-bromo-4-fluorochlorobenzene.
Second, take benzene as the initial material, and perform the chlorination reaction first. During the chlorination, the reaction conditions are controlled to introduce chlorine atoms into the benzene ring. This reaction may be carried out with chlorine gas and benzene in the presence of a catalyst such as iron trichloride. After obtaining chlorobenzene, bromination and fluorination are carried out in sequence. The conditions for bromination and fluorination are probably similar to those described above, but each step needs to be precisely controlled by temperature and time to achieve the purity and yield of the desired product.
Or with other aromatic compounds as starting materials, through multi-step conversion, such as the introduction of suitable substituents first, and then the conversion and migration of functional groups, the final synthesis of 3-bromo-4-fluorochlorobenzene. However, all these methods require familiarity with the organic reaction mechanism and fine experimental operation to obtain satisfactory results.
First, it can be obtained by halogenation. Using chlorobenzene as the starting material, it is first brominated, and under specific conditions, the bromine atom is replaced by the hydrogen atom on the benzene ring. This bromination process requires the selection of a suitable brominating reagent, such as liquid bromine, and the addition of a suitable catalyst, such as iron filings or iron tribromide. After bromination, a chlorobenzene derivative containing bromine is obtained. Then, the fluorination reaction is carried out. At this time, it is necessary to select a fluorinating agent, such as anhydrous potassium fluoride, etc., in an appropriate solvent, heat and reflux to promote fluorine atoms to replace hydrogen atoms at specific positions on the benzene ring, and finally obtain 3-bromo-4-fluorochlorobenzene.
Second, take benzene as the initial material, and perform the chlorination reaction first. During the chlorination, the reaction conditions are controlled to introduce chlorine atoms into the benzene ring. This reaction may be carried out with chlorine gas and benzene in the presence of a catalyst such as iron trichloride. After obtaining chlorobenzene, bromination and fluorination are carried out in sequence. The conditions for bromination and fluorination are probably similar to those described above, but each step needs to be precisely controlled by temperature and time to achieve the purity and yield of the desired product.
Or with other aromatic compounds as starting materials, through multi-step conversion, such as the introduction of suitable substituents first, and then the conversion and migration of functional groups, the final synthesis of 3-bromo-4-fluorochlorobenzene. However, all these methods require familiarity with the organic reaction mechanism and fine experimental operation to obtain satisfactory results.
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