Linshang Chemical
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3-Chloro-1,2-Difluoro-4-Nitro-Benzene
Linshang Chemical
|
HS Code |
383564 |
| Chemical Formula | C6H2ClF2NO2 |
| Molecular Weight | 195.53 |
| Appearance | Solid (usually) |
| Physical State At Room Temp | Solid |
| Odor | Typical aromatic odor |
| Solubility In Water | Low solubility |
| Solubility In Organic Solvents | Soluble in common organic solvents |
| Melting Point | Specific value would need further research |
| Boiling Point | Specific value would need further research |
| Density | Specific value would need further research |
| Flash Point | Specific value would need further research |
| Hazard Class | Toxic, harmful to environment (general classification, specific needs research) |
As an accredited 3-Chloro-1,2-Difluoro-4-Nitro-Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 3 - chloro - 1,2 - difluoro - 4 - nitro - benzene in sealed chemical - grade packaging. |
| Storage | 3 - Chloro - 1,2 - difluoro - 4 - nitro - benzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames as it is potentially flammable. Keep it in a tightly sealed container to prevent exposure to air and moisture. Store it separately from incompatible substances like oxidizing agents, reducing agents, and bases to avoid chemical reactions. |
| Shipping | 3 - Chloro - 1,2 - difluoro - 4 - nitro - benzene is a chemical. Ship it in well - sealed, corrosion - resistant containers. Follow strict hazardous materials shipping regulations to ensure safe transport due to its potentially harmful nature. |
Competitive 3-Chloro-1,2-Difluoro-4-Nitro-Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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Tel: +8615365006308
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As a leading 3-Chloro-1,2-Difluoro-4-Nitro-Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
3-Chloro-1, what are the chemical properties of 2-difluoro-4-nitro-benzene
3-Chloro-1,2-difluoro-4-nitrobenzene is an organic compound with unique chemical properties. It contains chlorine, fluorine, nitro and other functional groups, and the interaction of these functional groups endows the compound with diverse chemical behaviors.
First, the nitro group is a strong electron-absorbing group, which reduces the electron cloud density of the benzene ring and causes the electrophilic substitution reaction activity of the benzene ring to decrease. Because of its strong electron-absorbing induction effect and conjugation effect, the electron cloud on the benzene ring is biased towards the nitro group, making it difficult for the electrophilic reagent to attack the benzene ring. In this case, if there is an electrophilic substitution reaction, the reaction conditions are often harsh, and the substitution check point is affected by the nitro localization effect, and most of the substitution occurs in the
Furthermore, although halogen atoms (chlorine and fluorine) are also electron-absorbing groups, their electron-absorbing ability is weaker than that of nitro groups. The presence of chlorine and fluorine atoms can affect the distribution of benzene ring electron clouds through induction effects. Fluorine atoms are extremely electronegative and have a significant attraction effect on benzene ring electron clouds, and chlorine atoms also have a certain electron-absorbing ability. However, when interacting with nitro groups, the density distribution of benzene ring electron clouds is more complex. In some reactions, halogen atoms can participate in the reaction as leaving groups. For example, in nucleophilic substitution reactions, when suitable nucleophilic reagents are present, halogen atoms can be replaced by nucleophilic reagents to generate new organic compounds.
In addition, 3-chloro-1,2-difluoro-4-nitrophenyl contains multiple polar functional groups, giving it a certain polarity and unique solubility in organic solvents and water. Usually, its solubility in polar organic solvents may be better than in water, which is of great significance in organic synthesis and separation and purification processes. In chemical reactions, its polarity affects intermolecular interactions, which in turn affects reaction rate and selectivity. In conclusion, the functional groups of 3-chloro-1,2-difluoro-4-nitrobenzene interact with each other and exhibit unique chemical properties. They play an important role in organic synthesis and related fields, providing possible paths and unique properties for many chemical reactions.
First, the nitro group is a strong electron-absorbing group, which reduces the electron cloud density of the benzene ring and causes the electrophilic substitution reaction activity of the benzene ring to decrease. Because of its strong electron-absorbing induction effect and conjugation effect, the electron cloud on the benzene ring is biased towards the nitro group, making it difficult for the electrophilic reagent to attack the benzene ring. In this case, if there is an electrophilic substitution reaction, the reaction conditions are often harsh, and the substitution check point is affected by the nitro localization effect, and most of the substitution occurs in the
Furthermore, although halogen atoms (chlorine and fluorine) are also electron-absorbing groups, their electron-absorbing ability is weaker than that of nitro groups. The presence of chlorine and fluorine atoms can affect the distribution of benzene ring electron clouds through induction effects. Fluorine atoms are extremely electronegative and have a significant attraction effect on benzene ring electron clouds, and chlorine atoms also have a certain electron-absorbing ability. However, when interacting with nitro groups, the density distribution of benzene ring electron clouds is more complex. In some reactions, halogen atoms can participate in the reaction as leaving groups. For example, in nucleophilic substitution reactions, when suitable nucleophilic reagents are present, halogen atoms can be replaced by nucleophilic reagents to generate new organic compounds.
In addition, 3-chloro-1,2-difluoro-4-nitrophenyl contains multiple polar functional groups, giving it a certain polarity and unique solubility in organic solvents and water. Usually, its solubility in polar organic solvents may be better than in water, which is of great significance in organic synthesis and separation and purification processes. In chemical reactions, its polarity affects intermolecular interactions, which in turn affects reaction rate and selectivity. In conclusion, the functional groups of 3-chloro-1,2-difluoro-4-nitrobenzene interact with each other and exhibit unique chemical properties. They play an important role in organic synthesis and related fields, providing possible paths and unique properties for many chemical reactions.
What is the main use of 3-chloro-1,2-difluoro-4-nitro-benzene
3-Chloro-1,2-difluoro-4-nitrobenzene is an important member of organic compounds. Its main use is quite extensive, and it shows its extraordinary value in many fields.
First, in the synthesis of medicine, this compound is often used as a key intermediate. The synthesis of medicine is like a delicate process, which requires precise construction of molecular structures. The unique chemical structure of 3-chloro-1,2-difluoro-4-nitrobenzene allows it to participate in a series of complex reactions. Through ingenious design and operation, it can be gradually transformed into the core structure of various specific drugs. For example, in the creation process of some antibacterial drugs and antiviral drugs, this compound is often relied on as the starting material. Through the modification and transformation of its functional groups, molecules with specific pharmacological activities can be constructed, which makes great contributions to human health and well-being.
Second, it also plays a crucial role in the field of pesticide development. The efficacy of pesticides is related to the growth and harvest of crops. This compound can be used as the cornerstone of the synthesis of new and efficient pesticides. Due to its special chemical properties, pesticides can give unique insecticidal, bactericidal or herbicidal properties. The pesticides synthesized based on it either have stronger biological activity, or are highly selective to specific pests and bacteria, and have good degradation performance in the environment. They can not only effectively protect crops from pests and diseases, but also reduce the adverse impact on the ecological environment and help the sustainable development of agriculture.
Third, in the field of materials science, 3-chloro-1,2-difluoro-4-nitrobenzene is also available. In the synthesis process of special polymer materials, it can participate in the polymerization reaction as a functional monomer. By skillfully adjusting the reaction conditions, it can be introduced into the polymer chain segment to endow the material with special properties, such as improving the heat resistance and corrosion resistance of the material, or endowing the material with specific optical and electrical properties, so as to meet the needs of high-performance materials in different fields and promote the continuous progress of materials science.
First, in the synthesis of medicine, this compound is often used as a key intermediate. The synthesis of medicine is like a delicate process, which requires precise construction of molecular structures. The unique chemical structure of 3-chloro-1,2-difluoro-4-nitrobenzene allows it to participate in a series of complex reactions. Through ingenious design and operation, it can be gradually transformed into the core structure of various specific drugs. For example, in the creation process of some antibacterial drugs and antiviral drugs, this compound is often relied on as the starting material. Through the modification and transformation of its functional groups, molecules with specific pharmacological activities can be constructed, which makes great contributions to human health and well-being.
Second, it also plays a crucial role in the field of pesticide development. The efficacy of pesticides is related to the growth and harvest of crops. This compound can be used as the cornerstone of the synthesis of new and efficient pesticides. Due to its special chemical properties, pesticides can give unique insecticidal, bactericidal or herbicidal properties. The pesticides synthesized based on it either have stronger biological activity, or are highly selective to specific pests and bacteria, and have good degradation performance in the environment. They can not only effectively protect crops from pests and diseases, but also reduce the adverse impact on the ecological environment and help the sustainable development of agriculture.
Third, in the field of materials science, 3-chloro-1,2-difluoro-4-nitrobenzene is also available. In the synthesis process of special polymer materials, it can participate in the polymerization reaction as a functional monomer. By skillfully adjusting the reaction conditions, it can be introduced into the polymer chain segment to endow the material with special properties, such as improving the heat resistance and corrosion resistance of the material, or endowing the material with specific optical and electrical properties, so as to meet the needs of high-performance materials in different fields and promote the continuous progress of materials science.
What is the preparation method of 3-chloro-1,2-difluoro-4-nitro-benzene
The method of preparing 3-chloro-1,2-difluoro-4-nitrobenzene follows the following methods.
First, 1, 2-difluoro-4-nitrobenzene is used as the starting material to react with chlorine-containing reagents under suitable conditions. Common chlorine-containing reagents, such as chlorine ($Cl_ {2} $), thionyl chloride ($SOCl_ {2} $), etc. If chlorine is used, it is often necessary to react in the presence of light or initiator. Illumination can make chlorine molecules split into chlorine radicals, which can then be substituted with 1,2-difluoro-4-nitrobenzene, and chlorine atoms are introduced at specific positions in the benzene ring. When thionyl chloride is used as the chlorine source, it is usually necessary to replace the specific hydrogen atom on the benzene ring with the chlorine atom in the thionyl chloride under the action of the catalyst to achieve the preparation of 3-chloro-1,2-difluoro-4-nitrobenzene. In this process, the choice of catalyst is quite critical, which can affect the reaction rate and selectivity.
Second, it is gradually converted from other suitable benzene derivatives. For example, the benzene ring compound containing a specific substituent is first prepared, and then the nitro group, fluorine atom and chlorine atom are introduced in sequence through a series of reactions, such as nitrification, halogenation, etc. The benzene ring is first nitrified, and the nitro group is introduced on the benzene ring with a mixed acid of concentrated nitric acid and concentrated sulfuric acid as After halogenation reaction, fluorine atoms and chlorine atoms are introduced respectively. When fluorine atoms are introduced, fluorine-containing reagents, such as potassium fluoride, can be used to carry out nucleophilic substitution reaction under specific solvents and conditions. The steps of introducing chlorine atoms are similar to the above methods. Appropriate chlorine-containing reagents and reaction conditions are selected to gradually construct the structure of the target molecule 3-chloro-1, 2-difluoro-4-nitrobenzene.
The control of reaction conditions is crucial for the formation of products. Temperature, reaction time, and the proportion of reactants are all influencing factors. If the temperature is too high or too low, it may cause an increase in side reactions or a slow reaction rate. The reaction time is insufficient, and the raw material is difficult to be fully converted; if the time is too long, it may cause an overreaction. Reasonable preparation of the proportion of reactants can improve the yield of the target product. The choice of solvent also affects the reaction process. Solvents with good solubility of reactants and reagents and no adverse effects on the reaction should be selected to facilitate the smooth progress of the reaction.
First, 1, 2-difluoro-4-nitrobenzene is used as the starting material to react with chlorine-containing reagents under suitable conditions. Common chlorine-containing reagents, such as chlorine ($Cl_ {2} $), thionyl chloride ($SOCl_ {2} $), etc. If chlorine is used, it is often necessary to react in the presence of light or initiator. Illumination can make chlorine molecules split into chlorine radicals, which can then be substituted with 1,2-difluoro-4-nitrobenzene, and chlorine atoms are introduced at specific positions in the benzene ring. When thionyl chloride is used as the chlorine source, it is usually necessary to replace the specific hydrogen atom on the benzene ring with the chlorine atom in the thionyl chloride under the action of the catalyst to achieve the preparation of 3-chloro-1,2-difluoro-4-nitrobenzene. In this process, the choice of catalyst is quite critical, which can affect the reaction rate and selectivity.
Second, it is gradually converted from other suitable benzene derivatives. For example, the benzene ring compound containing a specific substituent is first prepared, and then the nitro group, fluorine atom and chlorine atom are introduced in sequence through a series of reactions, such as nitrification, halogenation, etc. The benzene ring is first nitrified, and the nitro group is introduced on the benzene ring with a mixed acid of concentrated nitric acid and concentrated sulfuric acid as After halogenation reaction, fluorine atoms and chlorine atoms are introduced respectively. When fluorine atoms are introduced, fluorine-containing reagents, such as potassium fluoride, can be used to carry out nucleophilic substitution reaction under specific solvents and conditions. The steps of introducing chlorine atoms are similar to the above methods. Appropriate chlorine-containing reagents and reaction conditions are selected to gradually construct the structure of the target molecule 3-chloro-1, 2-difluoro-4-nitrobenzene.
The control of reaction conditions is crucial for the formation of products. Temperature, reaction time, and the proportion of reactants are all influencing factors. If the temperature is too high or too low, it may cause an increase in side reactions or a slow reaction rate. The reaction time is insufficient, and the raw material is difficult to be fully converted; if the time is too long, it may cause an overreaction. Reasonable preparation of the proportion of reactants can improve the yield of the target product. The choice of solvent also affects the reaction process. Solvents with good solubility of reactants and reagents and no adverse effects on the reaction should be selected to facilitate the smooth progress of the reaction.
3-Chloro-1, 2-difluoro-4-nitro-benzene what are the precautions in storage and transportation
3-Chloro-1,2-difluoro-4-nitrobenzene is an organic compound, and many matters need to be paid attention to when storing and transporting it.
First words storage, this compound should be placed in a cool, dry and well ventilated place. Because of its certain chemical activity, high temperature and humid environment, it is easy to cause its deterioration, cause changes in properties, and affect the use. Be sure to keep away from fire, heat sources, open flames or hot topics, which can cause it to catch fire or even explode, endangering safety. In addition, storage should be separated from oxidants, reducing agents, alkalis, etc. Contact with these substances can easily cause chemical reactions or cause unpredictable dangers. When storing, it is also necessary to ensure that the container is well sealed to prevent leakage. If there is a leak, it will not only waste materials, but also pollute the environment and threaten the health of personnel.
As for transportation, it is necessary to strictly follow relevant regulations and standards. Transportation vehicles should have good ventilation equipment to avoid excessive temperature and no air circulation in the car. During handling, it must be handled lightly and lightly, and should not be operated brutally to prevent material leakage caused by damage to the container. At the same time, transportation personnel should be familiar with the dangerous characteristics of this compound and emergency treatment methods. In case of accident, they can respond quickly and reduce the harm. Containers used for transportation must be sturdy and durable, can withstand certain pressure and vibration, and have good anti-leakage performance.
In conclusion, 3-chloro-1,2-difluoro-4-nitrobenzene should be treated with caution in all aspects of storage and transportation, and must not be taken lightly, so as to ensure the safety of personnel, the environment and the quality of materials.
First words storage, this compound should be placed in a cool, dry and well ventilated place. Because of its certain chemical activity, high temperature and humid environment, it is easy to cause its deterioration, cause changes in properties, and affect the use. Be sure to keep away from fire, heat sources, open flames or hot topics, which can cause it to catch fire or even explode, endangering safety. In addition, storage should be separated from oxidants, reducing agents, alkalis, etc. Contact with these substances can easily cause chemical reactions or cause unpredictable dangers. When storing, it is also necessary to ensure that the container is well sealed to prevent leakage. If there is a leak, it will not only waste materials, but also pollute the environment and threaten the health of personnel.
As for transportation, it is necessary to strictly follow relevant regulations and standards. Transportation vehicles should have good ventilation equipment to avoid excessive temperature and no air circulation in the car. During handling, it must be handled lightly and lightly, and should not be operated brutally to prevent material leakage caused by damage to the container. At the same time, transportation personnel should be familiar with the dangerous characteristics of this compound and emergency treatment methods. In case of accident, they can respond quickly and reduce the harm. Containers used for transportation must be sturdy and durable, can withstand certain pressure and vibration, and have good anti-leakage performance.
In conclusion, 3-chloro-1,2-difluoro-4-nitrobenzene should be treated with caution in all aspects of storage and transportation, and must not be taken lightly, so as to ensure the safety of personnel, the environment and the quality of materials.
What are the effects of 3-chloro-2-difluoro-4-nitro-benzene on the environment and human health?
3-Chloro-1,2-difluoro-4-nitrobenzene is a genus of organic compounds. The impact on the environment and human health cannot be ignored.
As far as the environment is concerned, it may be persistent, difficult to degrade in the natural environment, and easy to accumulate. And its chemical structure contains chlorine, fluorine, nitro and other groups, or cause soil and water pollution. If released in the soil, it may break the ecological balance of the soil, hinder plant growth, inhibit soil microbial activities; if it enters the water body, it may harm aquatic organisms, cause disturbance of aquatic ecosystems, and affect the food chain.
As for human health, this compound may be toxic. Through respiratory tract, skin contact or accidental ingestion into the body, or damage the human body system. Or irritate the respiratory tract, causing cough, asthma and other diseases; percutaneous absorption, or cause skin allergies and inflammation. And it contains nitro, or potentially carcinogenic, long-term exposure, or increase the risk of cancer. And because of its halogen atoms, or interfere with the human endocrine system, affect hormone balance, and adversely affect physiological processes such as reproduction and development.
In summary, 3-chloro-1,2-difluoro-4-nitrobenzene has potential hazards to the environment and human health. When producing, using and disposing, appropriate measures should be taken to reduce its negative effects and protect the ecological environment and human well-being.
As far as the environment is concerned, it may be persistent, difficult to degrade in the natural environment, and easy to accumulate. And its chemical structure contains chlorine, fluorine, nitro and other groups, or cause soil and water pollution. If released in the soil, it may break the ecological balance of the soil, hinder plant growth, inhibit soil microbial activities; if it enters the water body, it may harm aquatic organisms, cause disturbance of aquatic ecosystems, and affect the food chain.
As for human health, this compound may be toxic. Through respiratory tract, skin contact or accidental ingestion into the body, or damage the human body system. Or irritate the respiratory tract, causing cough, asthma and other diseases; percutaneous absorption, or cause skin allergies and inflammation. And it contains nitro, or potentially carcinogenic, long-term exposure, or increase the risk of cancer. And because of its halogen atoms, or interfere with the human endocrine system, affect hormone balance, and adversely affect physiological processes such as reproduction and development.
In summary, 3-chloro-1,2-difluoro-4-nitrobenzene has potential hazards to the environment and human health. When producing, using and disposing, appropriate measures should be taken to reduce its negative effects and protect the ecological environment and human well-being.
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