Linshang Chemical
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3-Chloro-1,2-Dihydroxybenzene
Linshang Chemical
|
HS Code |
999047 |
| Chemical Formula | C6H5ClO2 |
| Molar Mass | 144.555 g/mol |
| Appearance | Solid |
| Solubility In Water | Limited solubility, as it has polar -OH groups but also a non - polar benzene ring |
| Pka Of Phenolic Oh | Typical phenolic pKa around 9 - 10, exact value for this compound may vary |
As an accredited 3-Chloro-1,2-Dihydroxybenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 - gram pack of 3 - chloro - 1,2 - dihydroxybenzene in a sealed chemical - resistant container. |
| Storage | 3 - Chloro - 1,2 - dihydroxybenzene should be stored in a cool, dry, well - ventilated area away from heat sources and ignition sources. Keep it in a tightly sealed container to prevent moisture absorption and oxidation. Store separately from oxidizing agents and incompatible substances to avoid potential chemical reactions. Label the storage container clearly for easy identification. |
| Shipping | 3 - Chloro - 1,2 - dihydroxybenzene should be shipped in tightly sealed, corrosion - resistant containers. It must be labeled clearly as a chemical. Transport should follow regulations to prevent spills and ensure safety during transit. |
Competitive 3-Chloro-1,2-Dihydroxybenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 3-Chloro-1,2-Dihydroxybenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 3-chloro-1,2-dihydroxybenzene?
3-Chloro-1,2-dihydroxybenzene, which has unique chemical properties. It contains chlorine atoms and dihydroxyl groups, which are significantly active in chemical reactions. Hydroxyl groups are highly reactive groups and can participate in many reactions. First, esterification can occur. Under appropriate conditions, hydrogen in the hydroxyl group is replaced by an acyl group in an organic acid or an inorganic acid to form a corresponding ester. This reaction is often the way to prepare ester compounds in organic synthesis.
Furthermore, due to the presence of hydroxyl groups, it is easy to be oxidized. Under the action of oxidants, hydroxyl groups can be converted into higher oxidation state functional groups such as carbonyl groups, and this oxidation reaction is of great significance for the construction of complex organic structures. Although the chlorine atom is relatively stable, the nucleophilic substitution reaction can occur under specific nucleophilic reagents and reaction conditions. The nucleophilic reagent will attack the carbon atom connected to the chlorine, and the chlorine atom will leave to form a new organic compound, which provides the possibility of introducing other functional groups.
In addition, the conjugated structure of the benzene ring in this compound gives the molecule a certain stability and special electronic effect. The substituents on the benzene ring interact with each other, and the hydroxyl group is the power supply group, which will increase the electron cloud density of the benzene ring, especially in the ortho and para-positions of the hydroxyl group, which will affect the activity and check point selectivity of the electrophilic substitution reaction. In the electrophilic substitution reaction, the electrophilic reagent is more likely to attack the ortho and para-sites of the hydroxyl group, which is very important when designing the reaction route in organic synthesis. Therefore, other functional groups can be selectively introduced at specific positions of the benzene ring to prepare the target compound.
Furthermore, due to the presence of hydroxyl groups, it is easy to be oxidized. Under the action of oxidants, hydroxyl groups can be converted into higher oxidation state functional groups such as carbonyl groups, and this oxidation reaction is of great significance for the construction of complex organic structures. Although the chlorine atom is relatively stable, the nucleophilic substitution reaction can occur under specific nucleophilic reagents and reaction conditions. The nucleophilic reagent will attack the carbon atom connected to the chlorine, and the chlorine atom will leave to form a new organic compound, which provides the possibility of introducing other functional groups.
In addition, the conjugated structure of the benzene ring in this compound gives the molecule a certain stability and special electronic effect. The substituents on the benzene ring interact with each other, and the hydroxyl group is the power supply group, which will increase the electron cloud density of the benzene ring, especially in the ortho and para-positions of the hydroxyl group, which will affect the activity and check point selectivity of the electrophilic substitution reaction. In the electrophilic substitution reaction, the electrophilic reagent is more likely to attack the ortho and para-sites of the hydroxyl group, which is very important when designing the reaction route in organic synthesis. Therefore, other functional groups can be selectively introduced at specific positions of the benzene ring to prepare the target compound.
What are the physical properties of 3-chloro-1,2-dihydroxybenzene?
3-Chloro-1,2-dihydroxybenzene, this substance has unique physical properties. Its properties are mostly crystalline solids at room temperature, and if it is finely crushed crystals, it is more brittle. The color is often white to light yellow, and the color changes according to the purity. If the purity is high, the color is nearly white, and it gradually turns light yellow after containing impurities or long-standing.
The melting point is quite critical, and it has been experimentally determined to be within a specific temperature range. This melting point characteristic is of great significance for its separation, purification and identification. It can be determined by melting point to judge the purity. For example, in chemical preparation, if the melting point of the product is consistent with the theoretical value, it usually indicates good purity; if it deviates, it contains impurities and needs to be further purified.
The solubility is also worthy of attention. In organic solvents, such as ethanol, ether, etc., it shows a certain solubility. Due to the principle of similar miscibility, its molecular structure characteristics make it interact with organic solvent molecules and can dissolve well. The solubility in water is limited. Although the hydroxyl group in the molecule can form a hydrogen bond with water, the chlorine atom is affected, resulting in weak overall hydrophilicity. This difference in solubility is widely used in chemical separation and extraction operations, and it can be separated from the mixture by taking advantage of the difference in solubility of different solvents.
In addition, its density also has a specific value. Although it is not often a key consideration of properties, it is of great significance in some studies involving accurate measurement or density. For example, in specific phase separation experiments or studies involving heterogeneous systems, density data can help to understand its distribution and behavior in the system. In short, the physical properties of 3-chloro-1,2-dihydroxybenzene lay the foundation for its application in chemical research, industrial production and other fields.
The melting point is quite critical, and it has been experimentally determined to be within a specific temperature range. This melting point characteristic is of great significance for its separation, purification and identification. It can be determined by melting point to judge the purity. For example, in chemical preparation, if the melting point of the product is consistent with the theoretical value, it usually indicates good purity; if it deviates, it contains impurities and needs to be further purified.
The solubility is also worthy of attention. In organic solvents, such as ethanol, ether, etc., it shows a certain solubility. Due to the principle of similar miscibility, its molecular structure characteristics make it interact with organic solvent molecules and can dissolve well. The solubility in water is limited. Although the hydroxyl group in the molecule can form a hydrogen bond with water, the chlorine atom is affected, resulting in weak overall hydrophilicity. This difference in solubility is widely used in chemical separation and extraction operations, and it can be separated from the mixture by taking advantage of the difference in solubility of different solvents.
In addition, its density also has a specific value. Although it is not often a key consideration of properties, it is of great significance in some studies involving accurate measurement or density. For example, in specific phase separation experiments or studies involving heterogeneous systems, density data can help to understand its distribution and behavior in the system. In short, the physical properties of 3-chloro-1,2-dihydroxybenzene lay the foundation for its application in chemical research, industrial production and other fields.
Where is 3-chloro-1,2-dihydroxybenzene used?
3-Chloro-1,2-dihydroxybenzene, this compound has wonderful uses in many fields.
In the field of medicine, it can be used as a raw material for drug synthesis. Because it contains special functional groups, it can construct molecular structures with specific biological activities through specific chemical reactions, or it can be used to create antibacterial and anti-inflammatory drugs. If it is synthesized through fine chemistry, the compound can be converted into drug components that can precisely act on the metabolic pathways of pathogens, inhibit the growth and reproduction of pathogens, and thus contribute to the development of medicine.
In the field of materials science, it also has unique features. With the hydroxyl groups and chlorine atoms it contains, it can participate in the reaction of material surface modification. By chemical means, grafting it on the surface of the material can change the hydrophobicity and biocompatibility of the material surface. For example, surface modification of biomedical materials can help cell adhesion and proliferation, promote tissue repair and regeneration; used in electronic materials, it may improve the electrical properties and stability of materials.
Furthermore, in the field of organic synthesis chemistry, 3-chloro-1,2-dihydroxybenzene is an important intermediate. It can participate in many classical organic reactions, such as nucleophilic substitution, redox, etc. With the help of these reactions, complex organic molecular frameworks can be constructed, providing key steps for the synthesis of natural products, new functional materials, etc. For example, when synthesizing some organic conjugated molecules with special optical and electrical properties, this compound can be used as a starting material to construct the required molecular structure through multi-step reactions, promoting the progress of organic synthesis chemistry.
In the field of medicine, it can be used as a raw material for drug synthesis. Because it contains special functional groups, it can construct molecular structures with specific biological activities through specific chemical reactions, or it can be used to create antibacterial and anti-inflammatory drugs. If it is synthesized through fine chemistry, the compound can be converted into drug components that can precisely act on the metabolic pathways of pathogens, inhibit the growth and reproduction of pathogens, and thus contribute to the development of medicine.
In the field of materials science, it also has unique features. With the hydroxyl groups and chlorine atoms it contains, it can participate in the reaction of material surface modification. By chemical means, grafting it on the surface of the material can change the hydrophobicity and biocompatibility of the material surface. For example, surface modification of biomedical materials can help cell adhesion and proliferation, promote tissue repair and regeneration; used in electronic materials, it may improve the electrical properties and stability of materials.
Furthermore, in the field of organic synthesis chemistry, 3-chloro-1,2-dihydroxybenzene is an important intermediate. It can participate in many classical organic reactions, such as nucleophilic substitution, redox, etc. With the help of these reactions, complex organic molecular frameworks can be constructed, providing key steps for the synthesis of natural products, new functional materials, etc. For example, when synthesizing some organic conjugated molecules with special optical and electrical properties, this compound can be used as a starting material to construct the required molecular structure through multi-step reactions, promoting the progress of organic synthesis chemistry.
What is the preparation method of 3-chloro-1,2-dihydroxybenzene?
3-Chloro-1,2-dihydroxybenzene, also known as 3-chloro-catechol, is prepared as follows:
** Using catechol as raw material **:
Catechol is a common starting material for the preparation of 3-chloro-1,2-dihydroxybenzene. Catechol can be interacted with suitable chlorination reagents. Commonly used chlorination reagents include thionyl chloride ($SOCl_ {2} $), phosphorus trichloride ($PCl_ {3} $), etc.
Taking thionyl chloride as an example, in a suitable reaction vessel, add catechol, and then slowly drop into thionyl chloride. This reaction needs to be carried out at an appropriate temperature and reaction conditions. Generally, the reaction can be initiated at a low temperature in an inert gas (such as nitrogen) protective atmosphere, and then gradually heated to a suitable temperature to make the reaction sufficient.
During the reaction, the chlorine atom in the thionyl chloride replaces the hydrogen atom on the phthalene phenyl ring, thereby generating 3-chloro-1,2-dihydroxybenzene. After the reaction is completed, the product is purified through post-processing steps such as distillation, extraction, and recrystallization.
** Using other aromatic compounds as raw materials **:
Suitable aromatic compounds can also be used to prepare 3-chloro-1,2-dihydroxybenzene through multi-step reaction. For example, using a benzene derivative with suitable substituents as the starting material, a hydroxyl group is first introduced through a specific reaction, and then a chlorine atom is introduced through a chlorination reaction. Pay attention to the reaction conditions and the positioning effect of the group to ensure that the chlorine atom and the hydroxyl group form the desired positional relationship on the benzene ring. After a series of reactions, the pure 3-chloro-1,2-dihydroxybenzene can be obtained through separation and purification. Although this route is rather complex, it is also of practical value in some specific situations or due to factors such as the availability and cost of starting materials.
** Using catechol as raw material **:
Catechol is a common starting material for the preparation of 3-chloro-1,2-dihydroxybenzene. Catechol can be interacted with suitable chlorination reagents. Commonly used chlorination reagents include thionyl chloride ($SOCl_ {2} $), phosphorus trichloride ($PCl_ {3} $), etc.
Taking thionyl chloride as an example, in a suitable reaction vessel, add catechol, and then slowly drop into thionyl chloride. This reaction needs to be carried out at an appropriate temperature and reaction conditions. Generally, the reaction can be initiated at a low temperature in an inert gas (such as nitrogen) protective atmosphere, and then gradually heated to a suitable temperature to make the reaction sufficient.
During the reaction, the chlorine atom in the thionyl chloride replaces the hydrogen atom on the phthalene phenyl ring, thereby generating 3-chloro-1,2-dihydroxybenzene. After the reaction is completed, the product is purified through post-processing steps such as distillation, extraction, and recrystallization.
** Using other aromatic compounds as raw materials **:
Suitable aromatic compounds can also be used to prepare 3-chloro-1,2-dihydroxybenzene through multi-step reaction. For example, using a benzene derivative with suitable substituents as the starting material, a hydroxyl group is first introduced through a specific reaction, and then a chlorine atom is introduced through a chlorination reaction. Pay attention to the reaction conditions and the positioning effect of the group to ensure that the chlorine atom and the hydroxyl group form the desired positional relationship on the benzene ring. After a series of reactions, the pure 3-chloro-1,2-dihydroxybenzene can be obtained through separation and purification. Although this route is rather complex, it is also of practical value in some specific situations or due to factors such as the availability and cost of starting materials.
What is the market outlook for 3-chloro-1,2-dihydroxybenzene?
3-Chloro-1,2-dihydroxybenzene, also known as 3-chloro-catechol, has potential applications in many fields such as chemical industry and medicine. Its market prospects are complex and influenced by multiple factors.
From the perspective of demand, with the continuous advancement of pharmaceutical research and development, the demand for specific bioactive compounds is increasing. 3-chloro-1,2-dihydroxybenzene has a unique chemical structure and can be used as a pharmaceutical intermediate. It plays a key role in the synthesis of innovative drugs, which undoubtedly opens up a broad market space for it. In addition, in the field of materials science, with the rise of functional materials research and development, it may be able to participate in the preparation of special materials and further expand the demand dimension.
However, there are also many considerations in terms of supply. The synthesis process of this compound may involve complex reaction steps and harsh reaction conditions, which requires quite high production technology and equipment. Some production processes may have environmental pollution problems. At the moment of stricter environmental regulations, enterprises need to invest more resources in pollution prevention and process optimization, which in turn drives up production costs. If the production enterprise cannot properly cope, or the supply is limited.
The market competition situation cannot be ignored. As its potential value gradually gains recognition, it may attract more enterprises to get involved in production and intensify market competition. If enterprises want to stand out, they need to rely on technological innovation to reduce costs and increase efficiency, and at the same time strengthen product quality control to win the trust of customers.
To sum up, the 3-chloro-1,2-dihydroxybenzene market prospects present both opportunities and challenges. Enterprises that can adapt to market demand, overcome technical problems, and meet environmental protection requirements are expected to emerge in the market competition and enjoy the industry development dividends.
From the perspective of demand, with the continuous advancement of pharmaceutical research and development, the demand for specific bioactive compounds is increasing. 3-chloro-1,2-dihydroxybenzene has a unique chemical structure and can be used as a pharmaceutical intermediate. It plays a key role in the synthesis of innovative drugs, which undoubtedly opens up a broad market space for it. In addition, in the field of materials science, with the rise of functional materials research and development, it may be able to participate in the preparation of special materials and further expand the demand dimension.
However, there are also many considerations in terms of supply. The synthesis process of this compound may involve complex reaction steps and harsh reaction conditions, which requires quite high production technology and equipment. Some production processes may have environmental pollution problems. At the moment of stricter environmental regulations, enterprises need to invest more resources in pollution prevention and process optimization, which in turn drives up production costs. If the production enterprise cannot properly cope, or the supply is limited.
The market competition situation cannot be ignored. As its potential value gradually gains recognition, it may attract more enterprises to get involved in production and intensify market competition. If enterprises want to stand out, they need to rely on technological innovation to reduce costs and increase efficiency, and at the same time strengthen product quality control to win the trust of customers.
To sum up, the 3-chloro-1,2-dihydroxybenzene market prospects present both opportunities and challenges. Enterprises that can adapt to market demand, overcome technical problems, and meet environmental protection requirements are expected to emerge in the market competition and enjoy the industry development dividends.
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