3-Chloro-1-Hydroxybenzene

Linshang Chemical

Specifications

HS Code

505517

Name 3 - Chloro - 1 - Hydroxybenzene
Molecular Formula C6H5ClO
Molar Mass 128.556 g/mol
Appearance Colorless to light - yellow liquid or solid
Odor Phenolic odor
Melting Point 33 - 35 °C
Boiling Point 213 - 214 °C
Density 1.263 g/cm³ (at 20 °C)
Solubility In Water Slightly soluble
Solubility In Organic Solvents Soluble in ethanol, ether, etc.
Flash Point 97 °C
Pka 9.18

As an accredited 3-Chloro-1-Hydroxybenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 500g of 3 - chloro - 1 - hydroxybenzene packaged in a sealed, corrosion - resistant container.
Storage 3 - chloro - 1 - hydroxybenzene, also known as 3 - chlorophenol, should be stored in a cool, dry, well - ventilated area away from heat and ignition sources. It should be kept in a tightly sealed container to prevent vapor release. Store it separately from oxidizing agents and reactive chemicals to avoid potential reactions. Ensure proper labeling for easy identification and safety compliance.
Shipping 3 - Chloro - 1 - hydroxybenzene is shipped in tightly - sealed, corrosion - resistant containers. It's transported with proper labeling, following hazardous chemical shipping regulations to ensure safe handling during transit.
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3-Chloro-1-Hydroxybenzene 3-Chloro-1-Hydroxybenzene
General Information
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Frequently Asked Questions

As a leading 3-Chloro-1-Hydroxybenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What is the Chinese name of 3-chloro-1-hydroxybenzene?
3-Chloro-1-hydroxybenzene is the Chinese name for phenol. This naming is based on the rules of organic chemistry.
In the naming system of organic compounds, the naming of benzene ring derivatives is very important. With the benzene ring as the parent body, if there are two substituents on the benzene ring, the relative positions are often indicated by adjacent, inter and pair. When the benzene ring is connected with a hydroxyl group (-OH), the compound is classified as a phenol and named after phenol as the parent body.
Here, 3-chloro-1-hydroxybenzene, "1-hydroxyl" indicates that the hydroxyl group is connected to the 1 position of the benzene ring, which is the key to establishing that the parent body is phenol. And "3-chlorine" means that the chlorine atom is in the third position of the benzene ring. Described by the meta position, it means that the hydroxyl group and the chlorine atom are separated by a carbon atom on the benzene ring, so the Chinese name is m-chlorophenol.
m-chlorophenol is widely used in the chemical industry and can be used as an organic synthetic raw material for the preparation of pesticides, medicines, dyes and other products. Due to its special chemical structure, it exhibits unique chemical properties and plays an important role in many chemical reactions.
What are the main uses of 3-chloro-1-hydroxybenzene?
3-Chloro-1-hydroxybenzene, also known as m-chlorophenol, has a wide range of uses. In the field of medicine, it can be used as a key raw material for antibacterial and antiviral drugs. Because of its sterilization and disinfection effect, it can effectively inhibit the growth of bacteria and viruses, so it plays an important role in the pharmaceutical industry.
In terms of pesticides, it is an important intermediate for the synthesis of a variety of high-efficiency pesticides. Through specific chemical reactions, it is converted into pesticides with insecticidal and weeding effects, escorting agricultural production and helping to improve crop yield and quality.
In the dye industry, 3-chloro-1-hydroxybenzene also plays an important role. It can be used as a starting material for the synthesis of special structures and color dyes. After a series of chemical synthesis steps, dyes with bright colors and excellent fastness are generated, which are widely used in textiles, printing and dyeing and other industries to make fabrics show rich colors.
In addition, in the field of organic synthesis, due to its unique chemical structure, it is often used as an intermediate for organic synthesis reactions. Scientists can use it to carry out various chemical reactions to construct more complex organic compounds, laying the foundation for the development of new drug research and development, materials science and many other fields.
In short, 3-chloro-1-hydroxybenzene plays an important role in many industries such as medicine, pesticides, dyes and organic synthesis, and is of great significance to promote the development of related industries.
What are the physical properties of 3-chloro-1-hydroxybenzene?
3-Chloro-1-hydroxybenzene, also known as m-chlorophenol, has the following physical properties:
Under normal conditions, it is white to light yellow needle-like crystals. In sunlight and air, the color gradually darkens. Smell it, it has a unique phenol smell.
The melting point is about 33-36 ° C. This property allows the substance to change from solid to liquid at relatively low temperatures.
The boiling point is 214-215 ° C, indicating that this temperature is required for the substance to change from liquid to gaseous.
In terms of density, it is about 1.26g/cm ³, which is heavier than water, so it will sink to the bottom when placed in water.
Solubility is critical. 3-chloro-1-hydroxybenzene is slightly soluble in water, but easily soluble in organic solvents such as ethanol, ether, and chloroform. This property determines its dispersion and mixing in different solvent systems.
Volatility, it has a certain degree of volatility and will slowly evaporate in air. And because its structure contains chlorine atoms and hydroxyl groups, it has a certain polarity, which affects its physical properties and behavior in different environments.
What are the chemical properties of 3-chloro-1-hydroxybenzene?
3-Chloro-1-hydroxybenzene, also known as m-chlorophenol. It is active and has multiple chemical properties. This is a detailed description for you.
First of all, its acidity and alkalinity, due to the presence of hydroxyl groups, can weakly ionize hydrogen ions in water, which is weakly acidic and can neutralize with alkali substances to generate corresponding salts and water. If it encounters sodium hydroxide, the hydrogenation in the hydroxyl group combines with hydroxide ions to form water, and the rest forms salts.
Electrophilic substitution reaction is also an important property. The benzene ring is rich in electrons and has a high electron cloud density, which is easy to attract electrophilic reagents. Although chlorine atoms and hydroxyl groups have different effects on the distribution of electron clouds in the benzene ring, they generally increase the density of electron clouds in the adjacent and para-sites of the benzene ring. It is because electrophilic reagents attack these two positions. Taking the bromination reaction as an example, under the action of appropriate catalysts, bromine can replace hydrogen atoms in the ortho or para-sites of the benzene ring to form bromogeneration products.
Re-discussion on the properties of its halogen atoms. The chlorine atom is connected to the benzene ring. Because the electronegativity of chlorine is stronger than that of carbon, the electron cloud of the carbon-chlorine bond is biased towards the chlorine atom, resulting in a certain polarity of the bond. This polarity allows the chlorine atom to be attacked by the nucleophilic reagent, and a nucleophilic substitution reaction occurs.
Because it contains benzene ring, hydroxyl group and chlorine atom, it can participate in many organic synthesis reactions. It is a key intermediate for the preparation of complex organic compounds and has important uses in medicine, pesticides, dyes and other fields. When synthesizing drug molecules with specific structures, the required molecular structure can be gradually constructed according to their reaction characteristics.
What are the preparation methods of 3-chloro-1-hydroxybenzene?
The method of preparing 3-chloro-1-hydroxybenzene (m-chlorophenol) has various ways in the past. One is to use m-aminophenol as the starting material and obtain it through diazotization and Sandmeier reaction. In this process, shilling m-aminophenol interacts with sodium nitrite and acid to form diazonium salts at low temperature. Subsequently, a hydrochloric acid solution of cuprous chloride is added, and the diazoyl group is replaced by a chlorine atom to obtain 3-chloro-1-hydroxybenzene. This process requires strict control of temperature and reaction conditions to ensure that the diazotization reaction occurs smoothly, and the Sandmeier reaction proceeds efficiently to reduce the occurrence of side reactions.
Furthermore, it can be started from m-chlorobenzoic acid. First, the reduction of m-chlorobenzoic acid to m-chlorobenzanol, a commonly used reducing agent such as lithium aluminum hydride, etc. Then, the oxidation of m-chlorobenzanol to m-chlorobenzaldehyde can be used in this step, such as manganese dioxide-sulfuric acid system. Finally, the m-chlorobenzaldehyde is subjected to haloform reaction, treated with sodium hypochlorite and other reagents, and finally 3-chloro-1-hydroxybenzene is generated. This path step is slightly complicated, but the reaction conditions of each step are relatively mild and the yield is guaranteed.
There are those who use phenol as raw material, and the substitution reaction of phenol and chlorine gas occurs under specific conditions. This reaction requires careful consideration of factors such as reaction temperature, chlorine gas penetration rate, and catalyst. If the conditions are appropriate, chlorine atoms can be mainly replaced in the meta-position to generate 3-chloro-1-hydroxybenzene. However, when phenol is chlorinated, it is easy to form polychlorinated compounds, so the reaction process needs to be properly monitored to adjust the reaction parameters to improve the selectivity of the target product.
What are the chemical properties of 3-chloro-1-hydroxybenzene?
3-Chloro-1-hydroxybenzene, also known as m-chlorophenol. Its chemical properties are unique, and it has the characteristics given by chlorine atoms and hydroxyl groups.
Let's talk about the hydroxyl group first, which is an active functional group and is acidic. Because of its strong electronegativity of the oxygen atom, when connected to the benzene ring, the polarity of the hydrogen-oxygen bond in the phenolic hydroxyl group is enhanced, and the hydrogen atom is easily dissociated in the form of protons, so it is acidic, and the acidity is stronger than that of the alcohol hydroxyl group. It can react with bases such as sodium hydroxide to form phenolates and water.
Moreover, although the chlorine atom is connected to the benzene ring, its activity is different from that of the chlorine atom in the halogenated alkanes due to the conjugation effect of the large π bond of However, due to the influence of electron cloud density of the benzene ring, the substitution reaction conditions are more stringent than those of halogenated alkanes.
At the same time, the electron cloud density distribution of the benzene ring changes due to the localization effect of hydroxyl groups and chlorine atoms. Hydroxyl groups are ortho-and para-sites, which increase the density of ortho-and para-sites of the benzene ring; although chlorine atoms are blunt groups, they are also ortho-and para-sites. Under the combined action of the two, when the benzene ring undergoes electrophilic substitution, the substituents mainly enter the adjacent and para-sites where the hydroxyl groups and chlorine atoms point together.
In addition, 3-chloro-1-hydroxybenzene can also undergo many organic reactions, such as reaction with acyl halide or acid anhydride to form esters, condensation reaction with aldehyde substances under specific conditions, etc., which is widely used in the field of organic synthesis.
What are the main uses of 3-chloro-1-hydroxybenzene?
3-Chloro-1-hydroxybenzene, also known as m-chlorophenol, is a widely used substance. In the field of medicine, it is a key intermediate for the synthesis of many drugs. For example, some antibacterial and anti-inflammatory drugs, in the synthesis process, 3-chloro-1-hydroxybenzene can provide specific structural units, and through a series of chemical reactions, a complex molecular structure with pharmacological activity can be constructed, thereby helping the drug to achieve the corresponding therapeutic effect.
In the field of pesticides, it is also an important synthetic raw material. A variety of high-efficiency pesticides can be prepared for the control of crop diseases and pests. Such pesticides can interfere with the nervous system or physiological and metabolic processes of pests by virtue of their own chemical properties, thus achieving the purpose of insecticidal; or inhibit the growth and reproduction of pathogens, effectively protecting the healthy growth of crops.
In the dye industry, 3-chloro-1-hydroxybenzene plays an indispensable role. It can be used as a starting material for the synthesis of specific color dyes. It can react with other compounds to generate dyes with specific color and stability. It is widely used in textile, leather and other industries to give various materials a variety of colorful colors.
In addition, in the field of organic synthesis, 3-chloro-1-hydroxybenzene is often used as a basic raw material for the synthesis of other more complex organic compounds. Due to the presence of chlorine atoms and hydroxyl groups, this substance has unique reactivity and can participate in a variety of organic reactions, providing organic synthesis chemists with rich strategies and approaches for building complex molecular structures, and assisting in the development and preparation of new organic materials and fine chemicals.
What are 3-chloro-1-hydroxybenzene synthesis methods?
3-Chloro-1-hydroxybenzene, that is, m-chlorophenol, has many synthesis methods, which are described in detail by you below.
First, m-aminophenol is used as the starting material and is prepared by diazotization and chlorination. The m-aminophenol is dissolved in dilute hydrochloric acid, cooled to 0-5 ° C, and the diazotization reaction is carried out dropwise with sodium nitrite solution to generate diazonium salts. After that, the hydrochloric acid solution of cuprous chloride is added, and the diazoyl group is replaced by the chlorine atom to obtain 3-chloro-1-hydroxybenzene. The reaction conditions of this method are mild and the yield is high, but the price of the raw material m-aminophenol is relatively high, and the diazotization reaction requires strict control
Second, m-chloroaniline is used as raw material and synthesized by Sandmeier reaction. M-chloroaniline is synthesized by diazo sulfate under the action of sulfuric acid and sodium nitrite, and then reacts with the hydrochloric acid solution of cuprous chloride, and the diazo group is converted into chlorine atoms, and then the target product is obtained. The raw material of this method is relatively easy to obtain, but it also involves the diazotization process, there are certain safety risks, and the post-reaction treatment is more complicated.
Third, phenol is used as raw material and prepared by chlorination reaction. In a suitable solvent, such as dichloromethane, iron powder or ferric chloride as catalyst, chlorine gas is introduced to carry out chlorination reaction. The hydroxyl group of phenol is an ortho-para-localization group, but due to factors such as steric hindrance, a certain proportion of meta-products will be formed. By controlling the reaction conditions, such as temperature, chlorine gas inlet and reaction time, the selectivity of m-chlorophenol can be improved. This method has low raw material cost, but poor reaction selectivity, and it is difficult to separate and purify the product. It needs to be separated by various means such as rectification and crystallization.
Fourth, isochlorobenzoic acid is used as raw material and prepared by reduction reaction. Isochlorobenzoic acid is first reacted with reducing agents such as lithium aluminum hydride or sodium borohydride, and the carboxyl group is reduced to a hydroxyl group, thereby obtaining 3-chloro-1-hydroxybenzene. The steps of this method are relatively simple, but reducing agents such as lithium aluminum hydride are expensive, and have strong reducing and flammability, which requires high operation, and the reaction needs to be carried out under anhydrous and anaerobic conditions.
The above synthesis methods have their own advantages and disadvantages. In actual production, the most suitable method should be selected based on factors such as raw material source, cost, and product quality requirements.
3-chloro-1-hydroxybenzene What are the precautions in storage and transportation?
3-Chloro-1-hydroxybenzene, that is, m-chlorophenol, in storage and transportation, many matters need to be paid attention to.
This substance has certain toxicity and irritation, so when storing, the first choice of environment. It should be placed in a cool and ventilated warehouse, away from fire and heat sources, to prevent danger caused by excessive temperature. The relative humidity of the warehouse should be controlled in an appropriate range to avoid deterioration of the substance due to excessive humidity.
Furthermore, it should be stored separately from oxidants, acids, bases, etc., and must not be mixed. Because m-chlorophenol encounters with these substances, violent chemical reactions may occur, endangering safety. And the storage area should be equipped with suitable materials to contain leaks in case of emergency.
When transporting, there are also many precautions. Be sure to ensure that the packaging is complete and the loading is secure before transportation. The packaging should be able to effectively prevent material leakage and volatilization. During transportation, ensure that the container does not leak, collapse, fall, or damage. Transportation vehicles need to be equipped with corresponding varieties and quantities of fire equipment and leakage emergency treatment equipment. The planning of driving routes should not be ignored, and densely populated areas and traffic arteries should be avoided to prevent major casualties in the event of an accident.
In addition, transportation personnel must undergo special training and strictly abide by operating procedures. During loading and unloading, light loading and unloading should be carried lightly to prevent damage to packaging and containers. During transportation, pay close attention to weather changes. In case of high temperature, rainstorm and other bad weather, corresponding protective measures need to be taken to ensure transportation safety. In this way, the safety of 3-chloro-1-hydroxybenzene during storage and transportation can be ensured.
What are the effects of 3-chloro-1-hydroxybenzene on the environment and human health?
3-Chloro-1-hydroxybenzene, that is, m-chlorophenol, this substance has an impact on both the environment and human health.
In terms of the environment, if m-chlorophenol is released in nature, it will cause pollution to water bodies, soils, etc. It is difficult to degrade in water, will remain in water for a long time, affect water quality, and cause deterioration of the living environment of aquatic organisms. In soil, it may change the physical and chemical properties of soil, interfere with soil microbial communities, and then affect plant growth. And it is volatile. After entering the atmosphere, it may participate in photochemical reactions and affect air quality.
It is very harmful to human health and m-chlorophenol. Through skin contact, it can cause skin irritation, redness, swelling, itching, burning and other symptoms. If you inadvertently inhale its volatile gases, it will irritate the respiratory tract, causing cough, asthma, breathing difficulties, etc. Long-term exposure to this environment will also damage the human nervous system, liver and kidneys and other organs. The nervous system is affected, or cause dizziness, headache, fatigue, memory loss, etc.; liver damage, liver function may be abnormal; kidney invasion, or affect kidney function. In addition, m-chlorophenol may be potentially carcinogenic, long-term exposure or increase the risk of cancer.
Therefore, when producing and using products containing m-chlorophenol, it is necessary to take strict protective measures and properly dispose of waste to reduce its harm to the environment and human health.