Linshang Chemical
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3-Chloro-2,4-Difluoronitrobenzene
Linshang Chemical
|
HS Code |
185187 |
| Chemical Formula | C6H2ClF2NO2 |
| Molar Mass | 195.536 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | Around 205 - 207 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Odor | Characteristic aromatic odor |
| Stability | Stable under normal conditions, but reactive with strong oxidizing agents |
As an accredited 3-Chloro-2,4-Difluoronitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 3 - chloro - 2,4 - difluoronitrobenzene packaged in a sealed glass bottle. |
| Storage | 3 - Chloro - 2,4 - difluoronitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. It should be stored in a tightly sealed container to prevent leakage and exposure to air or moisture. Keep it separate from oxidizing agents, reducing agents, and bases to avoid potential chemical reactions. |
| Shipping | 3 - Chloro - 2,4 - difluoronitrobenzene is shipped in sealed, corrosion - resistant containers. Transport follows strict chemical regulations, ensuring proper handling to prevent spills and maintain safety during transit. |
Competitive 3-Chloro-2,4-Difluoronitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 3-Chloro-2,4-Difluoronitrobenzene in China?
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 3-Chloro-2,4-Difluoronitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the main use of 3-chloro-2, 4-difluoronitrobenzene
3-Chloro-2,4-difluoronitrobenzene is also an important substance in organic synthesis. Its use is widely used in various fields and is of great importance to the industry.
The primary use is as a raw material for pharmaceutical synthesis. When creating new drugs, this compound is often used as a key intermediate. With its special structure, it can introduce specific functional groups through various chemical reactions to build molecular structures with specific pharmacological activities. For example, in the process of developing antibacterial and antiviral drugs, 3-chloro-2,4-difluoronitrobenzene can be finely transformed to participate in the construction of the drug core skeleton, which has a profound impact on the interaction and biological activity of drugs and targets.
Furthermore, it is also very useful in the field of pesticides. The creation of pesticides is related to the yield and quality of grain. This compound can be chemically modified to convert into pesticide components with high insecticidal, bactericidal or herbicidal properties. Its fluorine, chlorine and other atoms give the prepared pesticides unique physical and chemical properties and biological activities, such as enhancing fat solubility, making it easier for drugs to penetrate biofilms and improve drug efficacy.
In addition, in the field of materials science, it has also emerged. It can be used as a starting material for the synthesis of special polymer materials. After polymerization, its structural units are introduced into the polymer main chain or side chain, giving the material special electrical, optical or thermal properties. For example, the synthesis of polymers with special fluorescent properties has potential applications in optical displays, sensors and other fields.
In summary, 3-chloro-2,4-difluoronitrobenzene, with its unique chemical structure, is an indispensable key substance in the fields of medicine, pesticides and materials science, promoting technological innovation and development in various fields.
The primary use is as a raw material for pharmaceutical synthesis. When creating new drugs, this compound is often used as a key intermediate. With its special structure, it can introduce specific functional groups through various chemical reactions to build molecular structures with specific pharmacological activities. For example, in the process of developing antibacterial and antiviral drugs, 3-chloro-2,4-difluoronitrobenzene can be finely transformed to participate in the construction of the drug core skeleton, which has a profound impact on the interaction and biological activity of drugs and targets.
Furthermore, it is also very useful in the field of pesticides. The creation of pesticides is related to the yield and quality of grain. This compound can be chemically modified to convert into pesticide components with high insecticidal, bactericidal or herbicidal properties. Its fluorine, chlorine and other atoms give the prepared pesticides unique physical and chemical properties and biological activities, such as enhancing fat solubility, making it easier for drugs to penetrate biofilms and improve drug efficacy.
In addition, in the field of materials science, it has also emerged. It can be used as a starting material for the synthesis of special polymer materials. After polymerization, its structural units are introduced into the polymer main chain or side chain, giving the material special electrical, optical or thermal properties. For example, the synthesis of polymers with special fluorescent properties has potential applications in optical displays, sensors and other fields.
In summary, 3-chloro-2,4-difluoronitrobenzene, with its unique chemical structure, is an indispensable key substance in the fields of medicine, pesticides and materials science, promoting technological innovation and development in various fields.
3-Chloro-2, what are the physical properties of 4-difluoronitrobenzene
3-Chloro-2,4-difluoronitrobenzene is also an organic compound. It has specific physical properties and is closely related to the chemical industry and scientific research.
Looking at its properties, it is mostly a colorless to light yellow liquid under normal conditions. The sign of this color can help to identify it at the beginning. Smell it, it often has a special smell, but this smell is not pleasant, or pungent and irritating. When handling this substance, you need to pay attention to protection to avoid damage to the sense of smell and respiratory tract.
When it comes to the melting point, the melting point is about [specific value] ℃, and the boiling point is around [specific value] ℃. The state of the melting point, the substance changes from a solid state to a liquid state; when the boiling point, it liquefies into a gaseous state. These two points are crucial for the control of separation, purification and reaction conditions. For example, the method of distillation, depending on the boiling point, can separate the components in the mixture to obtain pure 3-chloro-2,4-difluoronitrobenzene.
Furthermore, its density is about [specific value] g/cm ³, which is heavier than water, placed in water, and sank at the bottom. This density characteristic can be separated according to the difference between its density and other liquids during liquid-liquid separation operations.
In terms of solubility, it is slightly soluble in water, but soluble in many organic solvents, such as ethanol, ether, acetone, etc. This difference in solubility is due to the difference between its molecular structure and the forces between water molecules and organic solvent molecules. In organic synthesis reactions, a suitable solvent is often selected according to its solubility to facilitate the reaction or to make the product easy to separate.
In addition, the physical properties such as vapor pressure and refractive index of 3-chloro-2,4-difluoronitrobenzene are also characterized. Vapor pressure is related to the difficulty of volatilization, and refractive index has important reference value in purity identification. The determination of these two can provide key data for their quality control and application.
In summary, the physical properties of 3-chloro-2,4-difluoronitrobenzene, its production, use, storage, and other aspects are of indispensable significance, which can help practitioners carry out related work safely and efficiently.
Looking at its properties, it is mostly a colorless to light yellow liquid under normal conditions. The sign of this color can help to identify it at the beginning. Smell it, it often has a special smell, but this smell is not pleasant, or pungent and irritating. When handling this substance, you need to pay attention to protection to avoid damage to the sense of smell and respiratory tract.
When it comes to the melting point, the melting point is about [specific value] ℃, and the boiling point is around [specific value] ℃. The state of the melting point, the substance changes from a solid state to a liquid state; when the boiling point, it liquefies into a gaseous state. These two points are crucial for the control of separation, purification and reaction conditions. For example, the method of distillation, depending on the boiling point, can separate the components in the mixture to obtain pure 3-chloro-2,4-difluoronitrobenzene.
Furthermore, its density is about [specific value] g/cm ³, which is heavier than water, placed in water, and sank at the bottom. This density characteristic can be separated according to the difference between its density and other liquids during liquid-liquid separation operations.
In terms of solubility, it is slightly soluble in water, but soluble in many organic solvents, such as ethanol, ether, acetone, etc. This difference in solubility is due to the difference between its molecular structure and the forces between water molecules and organic solvent molecules. In organic synthesis reactions, a suitable solvent is often selected according to its solubility to facilitate the reaction or to make the product easy to separate.
In addition, the physical properties such as vapor pressure and refractive index of 3-chloro-2,4-difluoronitrobenzene are also characterized. Vapor pressure is related to the difficulty of volatilization, and refractive index has important reference value in purity identification. The determination of these two can provide key data for their quality control and application.
In summary, the physical properties of 3-chloro-2,4-difluoronitrobenzene, its production, use, storage, and other aspects are of indispensable significance, which can help practitioners carry out related work safely and efficiently.
Is 3-chloro-2, 4-difluoronitrobenzene chemically stable?
The chemical properties of 3-chloro-2,4-difluoronitrobenzene are usually quite stable. Due to its unique molecular structure, chlorine, fluorine, and nitro substituents interact with each other on the benzene ring, resulting in the same properties.
The benzene ring has a conjugated electronic system, which is very stable. The chlorine atom and the fluorine atom, due to their high electronegativity, can produce an electron-sucking induction effect on the benzene ring. The nitro group has a more powerful electron-sucking conjugation effect and induction effect. The synergy of these numbers significantly reduces the electron cloud density of the benzene ring.
Such a structure changes its reactivity to external reagents. For example, in the nucleophilic substitution reaction, due to its low electron cloud density of benzene ring, nucleophilic reagents are difficult to attack. However, if the conditions are suitable, it can also be done. Under the common reaction environment such as oxidation and reduction, if there is no special catalyst or intense reaction conditions, its chemical structure is not easy to change.
If at room temperature and pressure, and there is no special catalyst or strengthening agent, 3-chloro-2,4-difluoronitrobenzene can maintain its chemical structure intact for a long time, and rarely react with common substances around it. However, in case of high temperature, strong acid-base or specific catalytic conditions, its stability may be affected, and then various chemical reactions occur, which are all under special circumstances.
The benzene ring has a conjugated electronic system, which is very stable. The chlorine atom and the fluorine atom, due to their high electronegativity, can produce an electron-sucking induction effect on the benzene ring. The nitro group has a more powerful electron-sucking conjugation effect and induction effect. The synergy of these numbers significantly reduces the electron cloud density of the benzene ring.
Such a structure changes its reactivity to external reagents. For example, in the nucleophilic substitution reaction, due to its low electron cloud density of benzene ring, nucleophilic reagents are difficult to attack. However, if the conditions are suitable, it can also be done. Under the common reaction environment such as oxidation and reduction, if there is no special catalyst or intense reaction conditions, its chemical structure is not easy to change.
If at room temperature and pressure, and there is no special catalyst or strengthening agent, 3-chloro-2,4-difluoronitrobenzene can maintain its chemical structure intact for a long time, and rarely react with common substances around it. However, in case of high temperature, strong acid-base or specific catalytic conditions, its stability may be affected, and then various chemical reactions occur, which are all under special circumstances.
What are the preparation methods of 3-chloro-2,4-difluoronitrobenzene
There are several common methods for preparing 3-chloro-2,4-difluoronitrobenzene.
One is the halogenation reaction path. 2,4-difluoronitrobenzene is used as the starting material, and chlorine atoms are introduced under suitable reaction conditions. In this process, suitable halogenating reagents, such as chlorine gas and sulfoxide chloride, need to be selected. Taking chlorine as an example, in the presence of a catalyst, chlorine gas can be substituted with 2,4-difluoronitrobenzene. The catalyst often uses Lewis acid, such as ferric trichloride, etc. The reaction temperature and time need to be precisely controlled. If the temperature is too high or the time is too long, it may cause the formation of polyhalogenated by-products; if the temperature is too low or the time is too short, the reaction will not be complete. In general, the reaction temperature can be controlled between tens of degrees Celsius and hundreds of degrees Celsius, and the reaction time depends on the specific situation, about several hours to ten hours.
The second can be started from the perspective of nitro introduction. First prepare chlorine and fluorine-containing benzene ring compounds, and then introduce nitro groups through nitrification reaction. For example, 1-chloro-2,4-difluorobenzene is used as raw material, and mixed acid (a mixture of concentrated sulfuric acid and concentrated nitric acid) is used for nitrification. In this reaction, concentrated sulfuric acid not only acts as a dehydrating agent, but also helps to generate nitroyl positive ions, which promotes the nitrification reaction. The reaction temperature is also critical, and the reaction needs to be initiated at a low temperature to prevent the side reaction of polynitroylation. Generally, the initial temperature can be controlled at 0 ° C to 10 ° C, and then gradually heated to room temperature or slightly higher than room temperature. The reaction time also needs to be adjusted according to the experimental situation, ranging from several hours.
Third, a nucleophilic substitution reaction strategy can be used. Take benzene derivatives containing appropriate leaving groups as substrates and react with chlorine and fluorine-related nucleophiles. For example, if the substrate benzene ring is connected with suitable leaving groups such as sulfonate groups, fluorine atoms can be introduced into the reaction with fluoride nucleophiles, and then chlorine atoms and nitro groups can be introduced through subsequent reactions. The reaction conditions at each step in this process need to be carefully adjusted to ensure the selectivity and yield of the reaction. When preparing 3-chloro-2,4-difluoronitrobenzene, no matter what method is used, the reaction conditions must be carefully considered to achieve higher product purity and yield.
One is the halogenation reaction path. 2,4-difluoronitrobenzene is used as the starting material, and chlorine atoms are introduced under suitable reaction conditions. In this process, suitable halogenating reagents, such as chlorine gas and sulfoxide chloride, need to be selected. Taking chlorine as an example, in the presence of a catalyst, chlorine gas can be substituted with 2,4-difluoronitrobenzene. The catalyst often uses Lewis acid, such as ferric trichloride, etc. The reaction temperature and time need to be precisely controlled. If the temperature is too high or the time is too long, it may cause the formation of polyhalogenated by-products; if the temperature is too low or the time is too short, the reaction will not be complete. In general, the reaction temperature can be controlled between tens of degrees Celsius and hundreds of degrees Celsius, and the reaction time depends on the specific situation, about several hours to ten hours.
The second can be started from the perspective of nitro introduction. First prepare chlorine and fluorine-containing benzene ring compounds, and then introduce nitro groups through nitrification reaction. For example, 1-chloro-2,4-difluorobenzene is used as raw material, and mixed acid (a mixture of concentrated sulfuric acid and concentrated nitric acid) is used for nitrification. In this reaction, concentrated sulfuric acid not only acts as a dehydrating agent, but also helps to generate nitroyl positive ions, which promotes the nitrification reaction. The reaction temperature is also critical, and the reaction needs to be initiated at a low temperature to prevent the side reaction of polynitroylation. Generally, the initial temperature can be controlled at 0 ° C to 10 ° C, and then gradually heated to room temperature or slightly higher than room temperature. The reaction time also needs to be adjusted according to the experimental situation, ranging from several hours.
Third, a nucleophilic substitution reaction strategy can be used. Take benzene derivatives containing appropriate leaving groups as substrates and react with chlorine and fluorine-related nucleophiles. For example, if the substrate benzene ring is connected with suitable leaving groups such as sulfonate groups, fluorine atoms can be introduced into the reaction with fluoride nucleophiles, and then chlorine atoms and nitro groups can be introduced through subsequent reactions. The reaction conditions at each step in this process need to be carefully adjusted to ensure the selectivity and yield of the reaction. When preparing 3-chloro-2,4-difluoronitrobenzene, no matter what method is used, the reaction conditions must be carefully considered to achieve higher product purity and yield.
3-Chloro-2, 4-difluoronitrobenzene what are the precautions in storage and transportation
3-Chloro-2,4-difluoronitrobenzene is a chemical commonly used in organic synthesis. When storing and transporting, care must be taken, and many matters should not be ignored.
First words storage. This substance should be placed in a cool, dry and well-ventilated place. The cover is lively because of its nature, and it is easy to react when heated, which may cause safety risks. If it is in a humid environment or in contact with water, it may cause adverse reactions such as hydrolysis and damage its quality. And it should be stored separately from oxidants, reducing agents, alkalis and other substances to avoid interaction and danger. Special personnel need to be set up to manage, regularly check its storage status, record temperature, humidity and other environmental parameters to ensure that storage conditions are always suitable.
Next talk about transportation. Before transportation, the packaging must be strictly inspected to ensure that the packaging is intact and free of leakage. The packaging materials used must have good sealing and corrosion resistance to resist the vibration, collision and environmental changes that may be encountered during transportation. During transportation, temperature control should also be strictly carried out to avoid high temperature. At the same time, the transportation vehicle should be equipped with corresponding emergency treatment equipment and protective equipment for emergencies. Escort personnel must be familiar with the characteristics of the chemical and emergency treatment methods, and transportation route planning should also avoid densely populated areas and environmentally sensitive areas to prevent major hazards in the event of accidents.
In short, the storage and transportation of 3-chloro-2,4-difluoronitrobenzene is related to safety and quality, and all aspects need to be strictly operated according to the specifications to ensure safety.
First words storage. This substance should be placed in a cool, dry and well-ventilated place. The cover is lively because of its nature, and it is easy to react when heated, which may cause safety risks. If it is in a humid environment or in contact with water, it may cause adverse reactions such as hydrolysis and damage its quality. And it should be stored separately from oxidants, reducing agents, alkalis and other substances to avoid interaction and danger. Special personnel need to be set up to manage, regularly check its storage status, record temperature, humidity and other environmental parameters to ensure that storage conditions are always suitable.
Next talk about transportation. Before transportation, the packaging must be strictly inspected to ensure that the packaging is intact and free of leakage. The packaging materials used must have good sealing and corrosion resistance to resist the vibration, collision and environmental changes that may be encountered during transportation. During transportation, temperature control should also be strictly carried out to avoid high temperature. At the same time, the transportation vehicle should be equipped with corresponding emergency treatment equipment and protective equipment for emergencies. Escort personnel must be familiar with the characteristics of the chemical and emergency treatment methods, and transportation route planning should also avoid densely populated areas and environmentally sensitive areas to prevent major hazards in the event of accidents.
In short, the storage and transportation of 3-chloro-2,4-difluoronitrobenzene is related to safety and quality, and all aspects need to be strictly operated according to the specifications to ensure safety.
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