Linshang Chemical
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3-Chloro-2,6-Difluoronitrobenzene
Linshang Chemical
|
HS Code |
208097 |
| Chemical Formula | C6H2ClF2NO2 |
| Appearance | Pale yellow to light brown solid |
| Boiling Point | 208 - 210 °C |
| Melting Point | 38 - 42 °C |
| Density | 1.586 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, toluene |
| Flash Point | 90 °C |
| Vapor Pressure | Low vapor pressure |
As an accredited 3-Chloro-2,6-Difluoronitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 3 - chloro - 2,6 - difluoronitrobenzene packaged in a sealed, corrosion - resistant bottle. |
| Storage | 3 - Chloro - 2,6 - difluoronitrobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from sources of heat, ignition, and incompatible substances like strong oxidizers, reducing agents, and bases. Store in a tightly - sealed container to prevent leakage and exposure to air or moisture, which could potentially cause decomposition or reaction. |
| Shipping | 3 - Chloro - 2,6 - difluoronitrobenzene is shipped in tightly sealed, corrosion - resistant containers. Shipment adheres to strict hazardous chemical regulations, ensuring proper handling, labeling, and transport to prevent leakage and ensure safety. |
Competitive 3-Chloro-2,6-Difluoronitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 3-Chloro-2,6-Difluoronitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the main use of 3-chloro-2, 6-difluoronitrobenzene
3-Chloro-2,6-difluoronitrobenzene is a crucial intermediate in the field of organic synthesis. Its main uses are quite extensive, and it plays an indispensable role in many aspects of medicine, pesticides and material science.
In the field of medicine, it can be used as a key starting material for the synthesis of a variety of specific drugs. The specific functional groups such as chlorine, fluorine and nitro groups connected to the benzene ring give the molecule unique chemical activity and spatial structure, so that it can interact with specific targets in the body. Through a series of exquisite organic reactions, complex molecular structures with specific pharmacological activities can be constructed, such as the synthesis of antibacterial, anti-inflammatory, anti-tumor and other drugs, which often rely on this compound as the basic raw material.
In the field of pesticides, 3-chloro-2,6-difluoronitrobenzene is also an important synthetic building block. By structural modification and derivatization of it, a series of highly efficient, low-toxic and environmentally friendly pesticide varieties can be created. Such pesticides can effectively kill various pests and weeds due to their special chemical properties, while reducing the adverse effects on the environment and non-target organisms, providing strong support for the sustainable development of modern agriculture.
In the field of materials science, this compound can be used to prepare high-performance functional materials. Its functional groups can participate in a variety of polymerization reactions, resulting in the preparation of polymer materials with special properties, such as high temperature resistance, chemical corrosion resistance, and excellent optical properties. Such materials show extremely broad application prospects in high-end fields such as aerospace and electronic information.
In summary, the unique chemical structure of 3-chloro-2,6-difluoronitrobenzene plays a key role in many fields and contributes greatly to the development of related industries.
In the field of medicine, it can be used as a key starting material for the synthesis of a variety of specific drugs. The specific functional groups such as chlorine, fluorine and nitro groups connected to the benzene ring give the molecule unique chemical activity and spatial structure, so that it can interact with specific targets in the body. Through a series of exquisite organic reactions, complex molecular structures with specific pharmacological activities can be constructed, such as the synthesis of antibacterial, anti-inflammatory, anti-tumor and other drugs, which often rely on this compound as the basic raw material.
In the field of pesticides, 3-chloro-2,6-difluoronitrobenzene is also an important synthetic building block. By structural modification and derivatization of it, a series of highly efficient, low-toxic and environmentally friendly pesticide varieties can be created. Such pesticides can effectively kill various pests and weeds due to their special chemical properties, while reducing the adverse effects on the environment and non-target organisms, providing strong support for the sustainable development of modern agriculture.
In the field of materials science, this compound can be used to prepare high-performance functional materials. Its functional groups can participate in a variety of polymerization reactions, resulting in the preparation of polymer materials with special properties, such as high temperature resistance, chemical corrosion resistance, and excellent optical properties. Such materials show extremely broad application prospects in high-end fields such as aerospace and electronic information.
In summary, the unique chemical structure of 3-chloro-2,6-difluoronitrobenzene plays a key role in many fields and contributes greatly to the development of related industries.
3-Chloro-2, what are the physical properties of 6-difluoronitrobenzene
3-Chloro-2,6-difluoronitrobenzene is a class of organic compounds. Its physical properties are quite important and are related to many practical applications.
Looking at its properties, under room temperature and pressure, it often appears colorless to light yellow liquid. The characterization of this color state is one of the key clues for identifying this substance. And its appearance characteristics also reflect the role of molecular structure and composition on light absorption and scattering.
When it comes to melting points, they are usually in a low range, and the specific values may fluctuate slightly due to factors such as impurities, but their intervals can be roughly found. The characteristics of melting points reveal the strength of intermolecular forces, molecular arrangement and other structural information.
The boiling point is also an important physical property. Under certain pressure conditions, it reaches a certain temperature and is evaporated by boiling. The boiling point value is closely related to the attractive force between molecules and the relative molecular mass. In this compound, the boiling point characteristics determine its behavior in chemical operations such as distillation and separation.
In terms of solubility, 3-chloro-2,6-difluoronitrobenzene has a certain solubility in organic solvents such as ethanol and ether, but very little solubility in water. This difference in solubility is due to the polar characteristics of molecules. Due to its molecular structure containing chlorine, fluorine, nitro and other functional groups, the overall polarity is biased, which is incompatible with the strong polar intermolecular forces of water, but can interact with the weaker polar or non-polar molecules of organic solvents and dissolve.
Density is also a property that cannot be ignored. Its density has a specific value relative to water. This density characteristic is of great significance in practical operations such as liquid-liquid separation and material metering. The determination of density helps to accurately grasp the distribution and behavior of substances in the mixed system.
In addition, its vapor pressure also has characteristics. At different temperatures, the vapor pressure varies. The vapor pressure reflects the tendency of substances to evaporate, and provides key data support for preventing leakage and controlling environmental impact during storage, transportation, etc.
In summary, the physical properties of 3-chloro-2,6-difluoronitrobenzene, such as color state, melting boiling point, solubility, density, vapor pressure, etc., are related to each other, and together describe the physical properties of this substance, laying the foundation for its application and research in the fields of chemical industry and scientific research.
Looking at its properties, under room temperature and pressure, it often appears colorless to light yellow liquid. The characterization of this color state is one of the key clues for identifying this substance. And its appearance characteristics also reflect the role of molecular structure and composition on light absorption and scattering.
When it comes to melting points, they are usually in a low range, and the specific values may fluctuate slightly due to factors such as impurities, but their intervals can be roughly found. The characteristics of melting points reveal the strength of intermolecular forces, molecular arrangement and other structural information.
The boiling point is also an important physical property. Under certain pressure conditions, it reaches a certain temperature and is evaporated by boiling. The boiling point value is closely related to the attractive force between molecules and the relative molecular mass. In this compound, the boiling point characteristics determine its behavior in chemical operations such as distillation and separation.
In terms of solubility, 3-chloro-2,6-difluoronitrobenzene has a certain solubility in organic solvents such as ethanol and ether, but very little solubility in water. This difference in solubility is due to the polar characteristics of molecules. Due to its molecular structure containing chlorine, fluorine, nitro and other functional groups, the overall polarity is biased, which is incompatible with the strong polar intermolecular forces of water, but can interact with the weaker polar or non-polar molecules of organic solvents and dissolve.
Density is also a property that cannot be ignored. Its density has a specific value relative to water. This density characteristic is of great significance in practical operations such as liquid-liquid separation and material metering. The determination of density helps to accurately grasp the distribution and behavior of substances in the mixed system.
In addition, its vapor pressure also has characteristics. At different temperatures, the vapor pressure varies. The vapor pressure reflects the tendency of substances to evaporate, and provides key data support for preventing leakage and controlling environmental impact during storage, transportation, etc.
In summary, the physical properties of 3-chloro-2,6-difluoronitrobenzene, such as color state, melting boiling point, solubility, density, vapor pressure, etc., are related to each other, and together describe the physical properties of this substance, laying the foundation for its application and research in the fields of chemical industry and scientific research.
What are the synthesis methods of 3-chloro-2, 6-difluoronitrobenzene
There are several methods for the synthesis of 3-chloro-2,6-difluoronitrobenzene.
First, 2,6-difluoronitrobenzene is used as the starting material. First, 2,6-difluoronitrobenzene is put into the reaction kettle, an appropriate amount of organic solvent, such as dichloromethane, is added, and stirred well. Then, slowly add a chlorine-containing reagent to the system, usually N-chlorosuccinimide (NCS), and add a small amount of initiator, such as benzoyl peroxide. The reaction temperature is controlled at 30-40 ° C, because this temperature range can not only ensure the reaction rate, but also avoid excessive side reactions. React under stirring for several hours, and monitor the reaction progress by thin layer chromatography (TLC). When the raw material point basically disappears, the reaction is stopped. The reaction solution is washed with water, dried, and the solvent is removed. After separation and purification by column chromatography, 3-chloro-2,6-difluoronitrobenzene can be obtained.
Second, 3-chloro-2,6-difluoroaniline is used as the raw material. Dissolve 3-chloro-2,6-difluoroaniline in an appropriate amount of dilute sulfuric acid and cool to 0-5 ° C to form a uniform solution. Slowly add sodium nitrite solution under stirring for diazotization reaction. This process must strictly control the temperature to prevent the decomposition of diazonium salts. After the diazotization reaction is completed, the reaction solution is slowly added to the mixed solution containing sodium nitrite and copper powder, and the Sandmeier reaction occurs, and the reaction temperature is maintained at 50-60 ℃. After the reaction, the target product 3-chloro-2,6-difluoronitrobenzene can also be obtained through conventional separation operations such as extraction and distillation.
Third, 2,6-difluorochlorobenzene is used as the raw material. First, 2,6-difluorochlorobenzene and mixed acid (concentrated sulfuric acid and concentrated nitric acid are mixed in a certain proportion) are placed in a reaction vessel. At low temperature, such as 0-10 ° C, the mixed acid is slowly added dropwise. After the dropwise addition is completed, the temperature is gradually raised to 50-60 ° C, and the reaction is kept warm for a period of time. In this reaction, the mixed acid nitrifies, causing nitro groups to be introduced into the benzene ring. After the reaction is completed, the reaction solution is poured into ice water, precipitated, filtered, washed, and further purified by distillation to obtain 3-chloro-2,6-difluoronitrobenzene.
The above synthesis methods have their own advantages and disadvantages. In practical application, it is necessary to comprehensively consider factors such as raw material availability, cost, reaction conditions and product purity requirements to choose the appropriate method.
First, 2,6-difluoronitrobenzene is used as the starting material. First, 2,6-difluoronitrobenzene is put into the reaction kettle, an appropriate amount of organic solvent, such as dichloromethane, is added, and stirred well. Then, slowly add a chlorine-containing reagent to the system, usually N-chlorosuccinimide (NCS), and add a small amount of initiator, such as benzoyl peroxide. The reaction temperature is controlled at 30-40 ° C, because this temperature range can not only ensure the reaction rate, but also avoid excessive side reactions. React under stirring for several hours, and monitor the reaction progress by thin layer chromatography (TLC). When the raw material point basically disappears, the reaction is stopped. The reaction solution is washed with water, dried, and the solvent is removed. After separation and purification by column chromatography, 3-chloro-2,6-difluoronitrobenzene can be obtained.
Second, 3-chloro-2,6-difluoroaniline is used as the raw material. Dissolve 3-chloro-2,6-difluoroaniline in an appropriate amount of dilute sulfuric acid and cool to 0-5 ° C to form a uniform solution. Slowly add sodium nitrite solution under stirring for diazotization reaction. This process must strictly control the temperature to prevent the decomposition of diazonium salts. After the diazotization reaction is completed, the reaction solution is slowly added to the mixed solution containing sodium nitrite and copper powder, and the Sandmeier reaction occurs, and the reaction temperature is maintained at 50-60 ℃. After the reaction, the target product 3-chloro-2,6-difluoronitrobenzene can also be obtained through conventional separation operations such as extraction and distillation.
Third, 2,6-difluorochlorobenzene is used as the raw material. First, 2,6-difluorochlorobenzene and mixed acid (concentrated sulfuric acid and concentrated nitric acid are mixed in a certain proportion) are placed in a reaction vessel. At low temperature, such as 0-10 ° C, the mixed acid is slowly added dropwise. After the dropwise addition is completed, the temperature is gradually raised to 50-60 ° C, and the reaction is kept warm for a period of time. In this reaction, the mixed acid nitrifies, causing nitro groups to be introduced into the benzene ring. After the reaction is completed, the reaction solution is poured into ice water, precipitated, filtered, washed, and further purified by distillation to obtain 3-chloro-2,6-difluoronitrobenzene.
The above synthesis methods have their own advantages and disadvantages. In practical application, it is necessary to comprehensively consider factors such as raw material availability, cost, reaction conditions and product purity requirements to choose the appropriate method.
3-Chloro-2, 6-difluoronitrobenzene what are the precautions during storage and transportation
3-Chloro-2,6-difluoronitrobenzene is a commonly used raw material in organic synthesis. During storage and transportation, many matters need to be paid attention to.
First word storage. This substance has certain chemical activity and potential danger, and should be stored in a cool, dry and well-ventilated place. Because it is more sensitive to heat, high temperature can easily cause chemical reactions, and even cause danger, it must be kept away from heat and fire sources. In addition, the substance should be stored separately from oxidants, reducing agents, acids, bases, etc., and must not be mixed. Because contact with it can easily induce chemical reactions and damage the stability and safety of the substance. The storage place should be equipped with the corresponding variety and quantity of fire fighting equipment and leakage emergency treatment equipment for emergencies. And the storage facilities should be inspected regularly to check whether the packaging is damaged or leaked, etc., to ensure the safety of the storage environment.
Secondary transportation. Before transportation, make sure that the packaging is complete and well sealed. The packaging material must have sufficient strength and corrosion resistance to resist the vibration, collision and friction that may be encountered during transportation. During transportation, the vehicle should be equipped with a grounding device to prevent the accumulation of static electricity from causing danger. Transportation personnel also need to be professionally trained and familiar with the characteristics, hazards and emergency treatment methods of 3-chloro-2,6-difluoronitrobenzene. During driving, avoid high temperature periods and bad road conditions, and prevent packaging damage and material leakage due to excessive temperature or bumps. At the same time, transportation vehicles need to hang obvious dangerous goods signs, drive according to the designated route, and do not stop in sensitive areas such as densely populated areas and water sources. If there is an accident such as leakage during transportation, emergency measures should be taken immediately to evacuate the surrounding people, report to relevant departments in time, and properly handle the leakage to reduce the harm.
First word storage. This substance has certain chemical activity and potential danger, and should be stored in a cool, dry and well-ventilated place. Because it is more sensitive to heat, high temperature can easily cause chemical reactions, and even cause danger, it must be kept away from heat and fire sources. In addition, the substance should be stored separately from oxidants, reducing agents, acids, bases, etc., and must not be mixed. Because contact with it can easily induce chemical reactions and damage the stability and safety of the substance. The storage place should be equipped with the corresponding variety and quantity of fire fighting equipment and leakage emergency treatment equipment for emergencies. And the storage facilities should be inspected regularly to check whether the packaging is damaged or leaked, etc., to ensure the safety of the storage environment.
Secondary transportation. Before transportation, make sure that the packaging is complete and well sealed. The packaging material must have sufficient strength and corrosion resistance to resist the vibration, collision and friction that may be encountered during transportation. During transportation, the vehicle should be equipped with a grounding device to prevent the accumulation of static electricity from causing danger. Transportation personnel also need to be professionally trained and familiar with the characteristics, hazards and emergency treatment methods of 3-chloro-2,6-difluoronitrobenzene. During driving, avoid high temperature periods and bad road conditions, and prevent packaging damage and material leakage due to excessive temperature or bumps. At the same time, transportation vehicles need to hang obvious dangerous goods signs, drive according to the designated route, and do not stop in sensitive areas such as densely populated areas and water sources. If there is an accident such as leakage during transportation, emergency measures should be taken immediately to evacuate the surrounding people, report to relevant departments in time, and properly handle the leakage to reduce the harm.
What are the effects of 3-chloro-2, 6-difluoronitrobenzene on the environment and human health?
3-Chloro-2,6-difluoronitrobenzene is an organic compound commonly used in the field of industrial synthesis. However, this substance has an impact on the environment and human health that cannot be ignored.
First talk about its impact on the environment. This compound has certain chemical stability, and if it is accidentally released into the environment, it is difficult to degrade rapidly. It flows into water bodies, or causes water pollution, endangering aquatic organisms. Because of its toxicity, it may damage the physiological functions of aquatic organisms, and hinder growth and reproduction. In the soil, it may affect the activity and community structure of soil microorganisms, causing imbalance in soil ecosystems and affecting vegetation growth. And its volatility causes some to escape into the atmosphere, or participate in photochemical reactions, causing adverse effects on the atmospheric environment.
As for the impact on human health, it is also quite serious. It can enter the human body through inhalation, skin contact or accidental ingestion. Respiratory inhalation, or irritation of respiratory mucosa, causing cough, asthma and other symptoms. Long-term exposure, or damage to lung function. Skin contact, can cause skin allergies, redness, swelling, itching, or even burns. If ingested by mistake, it can cause severe pain, vomiting, diarrhea, etc. in the digestive system, and in severe cases, it may damage important organ functions such as liver and kidney. Because of its nitro and halogen atoms, or potential carcinogenicity and mutagenicity, long-term exposure increases the risk of cancer and other diseases. Therefore, during the production, use and disposal of 3-chloro-2,6-difluoronitrobenzene, strict safety regulations and environmental protection measures should be taken to reduce its harm to the environment and human health.
First talk about its impact on the environment. This compound has certain chemical stability, and if it is accidentally released into the environment, it is difficult to degrade rapidly. It flows into water bodies, or causes water pollution, endangering aquatic organisms. Because of its toxicity, it may damage the physiological functions of aquatic organisms, and hinder growth and reproduction. In the soil, it may affect the activity and community structure of soil microorganisms, causing imbalance in soil ecosystems and affecting vegetation growth. And its volatility causes some to escape into the atmosphere, or participate in photochemical reactions, causing adverse effects on the atmospheric environment.
As for the impact on human health, it is also quite serious. It can enter the human body through inhalation, skin contact or accidental ingestion. Respiratory inhalation, or irritation of respiratory mucosa, causing cough, asthma and other symptoms. Long-term exposure, or damage to lung function. Skin contact, can cause skin allergies, redness, swelling, itching, or even burns. If ingested by mistake, it can cause severe pain, vomiting, diarrhea, etc. in the digestive system, and in severe cases, it may damage important organ functions such as liver and kidney. Because of its nitro and halogen atoms, or potential carcinogenicity and mutagenicity, long-term exposure increases the risk of cancer and other diseases. Therefore, during the production, use and disposal of 3-chloro-2,6-difluoronitrobenzene, strict safety regulations and environmental protection measures should be taken to reduce its harm to the environment and human health.
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