Linshang Chemical
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3-Chloro-2-Fluoro-1-Nitrobenzene
Linshang Chemical
|
HS Code |
849573 |
| Chemical Formula | C6H3ClFNO2 |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | Around 212 - 214 °C |
| Density | Approx. 1.48 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in many organic solvents like ethanol, ether |
| Flash Point | Approx. 90 °C |
| Vapor Pressure | Low vapor pressure at room temperature |
| Odor | Characteristic aromatic odor |
As an accredited 3-Chloro-2-Fluoro-1-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 3 - chloro - 2 - fluoro - 1 - nitrobenzene packaged in a sealed, corrosion - resistant container. |
| Storage | 3 - Chloro - 2 - fluoro - 1 - nitrobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly - sealed container, preferably made of corrosion - resistant materials, as it may react with certain substances. Store separately from incompatible chemicals like oxidizers, reducing agents, and bases to prevent hazardous reactions. |
| Shipping | 3 - Chloro - 2 - fluoro - 1 - nitrobenzene is shipped in sealed, corrosion - resistant containers. It's classified as a hazardous chemical, so shipping follows strict regulations to ensure safety during transit. |
Competitive 3-Chloro-2-Fluoro-1-Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 3-Chloro-2-Fluoro-1-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 3-chloro-2-fluoro-1-nitrobenzene?
3-Alkane-2-ene-1-alcohol benzene, also known as allyl phenyl alcohol, has important uses in many fields.
In the field of medicinal chemistry, it is a key intermediate in organic synthesis. It can be integrated into complex drug molecular structures through a series of chemical reactions. For example, in the total synthesis of some natural products with specific physiological activities, 3-alkane-2-ene-1-alcohol benzene can be used as a starting material. Through ingenious functional group transformation and carbon-carbon bond construction reactions, compounds with complex structures and medicinal value can be synthesized, providing a rich material basis for the development of new drugs.
In the field of fragrance industry, due to its unique molecular structure, it can emit a special aroma. It can be used as a fragrance component to prepare various unique flavors. When blending floral and herb flavors, adding an appropriate amount of this compound can give flavors a richer sense of hierarchy and unique flavor, and improve the quality and market competitiveness of fragrance products.
In the field of materials science, 3-alkane-2-ene-1-alcohol benzene also shows potential application value. It can participate in polymerization reactions to prepare polymer materials with special properties. For example, copolymerization with other monomers can endow polymers with specific functions, such as improving the solubility, thermal stability, or mechanical properties of materials, thus meeting the needs of different fields for specific properties of materials and promoting the further development of materials science.
In the field of medicinal chemistry, it is a key intermediate in organic synthesis. It can be integrated into complex drug molecular structures through a series of chemical reactions. For example, in the total synthesis of some natural products with specific physiological activities, 3-alkane-2-ene-1-alcohol benzene can be used as a starting material. Through ingenious functional group transformation and carbon-carbon bond construction reactions, compounds with complex structures and medicinal value can be synthesized, providing a rich material basis for the development of new drugs.
In the field of fragrance industry, due to its unique molecular structure, it can emit a special aroma. It can be used as a fragrance component to prepare various unique flavors. When blending floral and herb flavors, adding an appropriate amount of this compound can give flavors a richer sense of hierarchy and unique flavor, and improve the quality and market competitiveness of fragrance products.
In the field of materials science, 3-alkane-2-ene-1-alcohol benzene also shows potential application value. It can participate in polymerization reactions to prepare polymer materials with special properties. For example, copolymerization with other monomers can endow polymers with specific functions, such as improving the solubility, thermal stability, or mechanical properties of materials, thus meeting the needs of different fields for specific properties of materials and promoting the further development of materials science.
What are the physical properties of 3-chloro-2-fluoro-1-nitrobenzene?
3-Chloro-2-fluoro-1-methoxybenzene is a kind of organic compound. Its physical properties are as follows:
Looking at its appearance, under room temperature and pressure, it is mostly a colorless to light yellow transparent liquid. This form is more common in many organic synthesis reactions, because its liquid state is easy to mix and participate in the reaction.
When it comes to odor, it has a special organic odor. This odor is often present in this class of halogenated and alkoxy compounds. However, the identification of its odor is quite high, which can help experienced people to initially identify it.
When it comes to boiling point, it has been experimentally determined and related literature records, and it is about a certain temperature range. The value of the boiling point is closely related to the intermolecular force of the compound. The presence of chlorine, fluorine atoms and methoxy groups in the 3-chloro-2-fluoro-1-methoxybenzene molecule affects the intermolecular force, which in turn determines its boiling point characteristics. This boiling point value is a key parameter in the distillation operation of separating and purifying the compound.
In addition to density, its density is also a specific value. Density is an important physical property of a substance and is related to its distribution in the mixed system. For example, in operations such as liquid-liquid extraction, effective separation can be achieved according to the difference in density between it and other solvents.
In terms of solubility, 3-chloro-2-fluoro-1-methoxybenzene is insoluble in water, because water is a polar solvent, while this compound is an organic compound, and the molecular polarity is relatively weak. It follows the principle of "similar phase solubility", so it is insoluble in water. However, in common organic solvents such as ethanol, ether, dichloromethane, etc., it shows good solubility. This property provides a basis for the selection of suitable reaction solvents in organic synthesis reactions, so that the reactants can be fully mixed and the reaction efficiency can be improved.
Looking at its appearance, under room temperature and pressure, it is mostly a colorless to light yellow transparent liquid. This form is more common in many organic synthesis reactions, because its liquid state is easy to mix and participate in the reaction.
When it comes to odor, it has a special organic odor. This odor is often present in this class of halogenated and alkoxy compounds. However, the identification of its odor is quite high, which can help experienced people to initially identify it.
When it comes to boiling point, it has been experimentally determined and related literature records, and it is about a certain temperature range. The value of the boiling point is closely related to the intermolecular force of the compound. The presence of chlorine, fluorine atoms and methoxy groups in the 3-chloro-2-fluoro-1-methoxybenzene molecule affects the intermolecular force, which in turn determines its boiling point characteristics. This boiling point value is a key parameter in the distillation operation of separating and purifying the compound.
In addition to density, its density is also a specific value. Density is an important physical property of a substance and is related to its distribution in the mixed system. For example, in operations such as liquid-liquid extraction, effective separation can be achieved according to the difference in density between it and other solvents.
In terms of solubility, 3-chloro-2-fluoro-1-methoxybenzene is insoluble in water, because water is a polar solvent, while this compound is an organic compound, and the molecular polarity is relatively weak. It follows the principle of "similar phase solubility", so it is insoluble in water. However, in common organic solvents such as ethanol, ether, dichloromethane, etc., it shows good solubility. This property provides a basis for the selection of suitable reaction solvents in organic synthesis reactions, so that the reactants can be fully mixed and the reaction efficiency can be improved.
What are the chemical properties of 3-chloro-2-fluoro-1-nitrobenzene?
3-Chloro-2-fluoro-1-methoxybenzene is an organic compound with interesting chemical properties. This substance contains functional groups such as chlorine, fluorine and methoxy, and each functional group endows it with unique chemical activities.
The chlorine atom above the benzene ring has a certain electronegativity, which can change the electron cloud density distribution of the benzene ring. Due to its electron-absorbing induction effect, the electron cloud density of the adjacent and para-potential of the benzene ring is relatively reduced, so during the electrophilic substitution reaction, the new substituent is more inclined to enter the meso-site. For example, if the nitration reaction is carried out, the nitro group is more likely to be introduced in the intersite of the chlorine atom.
The fluorine atom is extremely electronegative and produces a significant electron It not only affects the electron cloud of the benzene ring, but also has a significant impact on the physical and chemical properties of the whole molecule. Due to the small radius of the fluorine atom and the large electronegativity, it can enhance the stability of the molecule, and sometimes the reactivity is different from that of the analogs containing other halogen atoms. For example, in some nucleophilic substitution reactions, the reactivity of fluorine-containing compounds may be different from those containing chlorine and bromine.
Methoxy group acts as the power supply subgroup and interacts with the electron-withdrawing effect of chlorine and fluorine. It provides electrons to the benzene ring through the conjugation effect, increasing the electron cloud density of the benzene ring, especially the electron This is contrary to the effect of chlorine and fluorine, so the reactivity of 3-chloro-2-fluoro-1-methoxybenzene needs to comprehensively consider the synergy effect of each functional group. In the electrophilic substitution reaction, the electron-sucking interaction of the methoxy group competes with the electron-sucking interaction of chlorine and fluorine, which ultimately determines the reaction check point and reactivity.
In addition, 3-chloro-2-fluoro-1-methoxybenzene can participate in a variety of organic reactions, such as nucleophilic substitution reactions with nucleophilic reagents, chlorine or fluorine atoms can be replaced by suitable nucleophilic reagents; It can also participate in metal-catalyzed reactions, such as palladium-catalyzed coupling reactions, etc. It is widely used in the field of organic synthesis and can be used as a key intermediate for the synthesis of complex organic molecules.
The chlorine atom above the benzene ring has a certain electronegativity, which can change the electron cloud density distribution of the benzene ring. Due to its electron-absorbing induction effect, the electron cloud density of the adjacent and para-potential of the benzene ring is relatively reduced, so during the electrophilic substitution reaction, the new substituent is more inclined to enter the meso-site. For example, if the nitration reaction is carried out, the nitro group is more likely to be introduced in the intersite of the chlorine atom.
The fluorine atom is extremely electronegative and produces a significant electron It not only affects the electron cloud of the benzene ring, but also has a significant impact on the physical and chemical properties of the whole molecule. Due to the small radius of the fluorine atom and the large electronegativity, it can enhance the stability of the molecule, and sometimes the reactivity is different from that of the analogs containing other halogen atoms. For example, in some nucleophilic substitution reactions, the reactivity of fluorine-containing compounds may be different from those containing chlorine and bromine.
Methoxy group acts as the power supply subgroup and interacts with the electron-withdrawing effect of chlorine and fluorine. It provides electrons to the benzene ring through the conjugation effect, increasing the electron cloud density of the benzene ring, especially the electron This is contrary to the effect of chlorine and fluorine, so the reactivity of 3-chloro-2-fluoro-1-methoxybenzene needs to comprehensively consider the synergy effect of each functional group. In the electrophilic substitution reaction, the electron-sucking interaction of the methoxy group competes with the electron-sucking interaction of chlorine and fluorine, which ultimately determines the reaction check point and reactivity.
In addition, 3-chloro-2-fluoro-1-methoxybenzene can participate in a variety of organic reactions, such as nucleophilic substitution reactions with nucleophilic reagents, chlorine or fluorine atoms can be replaced by suitable nucleophilic reagents; It can also participate in metal-catalyzed reactions, such as palladium-catalyzed coupling reactions, etc. It is widely used in the field of organic synthesis and can be used as a key intermediate for the synthesis of complex organic molecules.
What are the synthesis methods of 3-chloro-2-fluoro-1-nitrobenzene?
There are many ways to synthesize 3-bromo-2-chloro-1-aminobenzene, the following are common ones:
First, o-chloroaniline is used as the starting material. First, the bromination reaction of o-chloroaniline and bromine occurs. In this process, because the amino group is the o-para-site group, the bromine atom will mainly replace the amino o-o-site to obtain 2-chloro-4-bromoaniline. This step requires the selection of a suitable solvent, such as glacial acetic acid, etc., and the reaction temperature and the amount of bromine are precisely controlled to prevent excessive bromination. Afterwards, the diazotization reaction of 2-chloro-4-bromoaniline is carried out, and the diazonium salt is generally formed in a low temperature environment with sodium nitrite and hydrochloric acid as reagents. Finally, through the Sandmeier reaction, the diazonium group is replaced with a chlorine atom to achieve the synthesis of 3-bromo-2-chloro-1-aminobenzene.
Second, start from o-bromoaniline. First, the o-bromoaniline is chlorinated with chlorine, and the chlorine atom will mainly enter the amino ortho-position due to the amino positioning effect to obtain 2-bromo-4-chloroaniline. The control of the chlorination reaction conditions is very critical, including the reaction temperature, chlorine gas penetration rate, etc. Subsequent to the diazotization reaction and Sandmeier reaction, the diazo group is converted into bromine atoms, and the final product is synthesized.
Third, m-dihalobenzene is used as the raw material. For example, m-bromochlorobenzene, the nitro group is first introduced through nitration reaction. Because the halogen atom is an ortho-para-site group, the nitro group mainly enters the ortho-para-site of the halogen atom. After precise control of the reaction conditions, the nitro group can be mainly in a specific position. After that, the nitro group is reduced to an amino group. Common reduction methods include iron powder reduction method, catalytic hydrogenation reduction method, etc., and then 3-bromo-2-
All synthesis methods have their own advantages and disadvantages. The steps of using o-chloroaniline or o-bromoaniline as the starting material are relatively clear, but the diazotization reaction needs to be strictly controlled to prevent side reactions. In the method of using m-dihalobenzene as the raw material, although the starting material selection is different, the nitrification and reduction steps also need to be carefully operated to achieve high yield and purity. During the synthesis process, the control of the reaction conditions, the separation and purification of the intermediate are all the keys to obtaining high purity 3-bromo-2-chloro-1-aminobenzene.
First, o-chloroaniline is used as the starting material. First, the bromination reaction of o-chloroaniline and bromine occurs. In this process, because the amino group is the o-para-site group, the bromine atom will mainly replace the amino o-o-site to obtain 2-chloro-4-bromoaniline. This step requires the selection of a suitable solvent, such as glacial acetic acid, etc., and the reaction temperature and the amount of bromine are precisely controlled to prevent excessive bromination. Afterwards, the diazotization reaction of 2-chloro-4-bromoaniline is carried out, and the diazonium salt is generally formed in a low temperature environment with sodium nitrite and hydrochloric acid as reagents. Finally, through the Sandmeier reaction, the diazonium group is replaced with a chlorine atom to achieve the synthesis of 3-bromo-2-chloro-1-aminobenzene.
Second, start from o-bromoaniline. First, the o-bromoaniline is chlorinated with chlorine, and the chlorine atom will mainly enter the amino ortho-position due to the amino positioning effect to obtain 2-bromo-4-chloroaniline. The control of the chlorination reaction conditions is very critical, including the reaction temperature, chlorine gas penetration rate, etc. Subsequent to the diazotization reaction and Sandmeier reaction, the diazo group is converted into bromine atoms, and the final product is synthesized.
Third, m-dihalobenzene is used as the raw material. For example, m-bromochlorobenzene, the nitro group is first introduced through nitration reaction. Because the halogen atom is an ortho-para-site group, the nitro group mainly enters the ortho-para-site of the halogen atom. After precise control of the reaction conditions, the nitro group can be mainly in a specific position. After that, the nitro group is reduced to an amino group. Common reduction methods include iron powder reduction method, catalytic hydrogenation reduction method, etc., and then 3-bromo-2-
All synthesis methods have their own advantages and disadvantages. The steps of using o-chloroaniline or o-bromoaniline as the starting material are relatively clear, but the diazotization reaction needs to be strictly controlled to prevent side reactions. In the method of using m-dihalobenzene as the raw material, although the starting material selection is different, the nitrification and reduction steps also need to be carefully operated to achieve high yield and purity. During the synthesis process, the control of the reaction conditions, the separation and purification of the intermediate are all the keys to obtaining high purity 3-bromo-2-chloro-1-aminobenzene.
What are the precautions for storing and transporting 3-chloro-2-fluoro-1-nitrobenzene?
For 3-bromo-2-chloro-1-fluorobenzene, pay attention to everything during storage and transportation.
The first thing to do is to be careful with its packaging. This compound has a certain chemical activity, and the packaging must be tight to prevent leakage. The packaging material used must be resistant to its corrosion. If it is packed in a glass container, it should be checked for cracks and other damages to ensure a good seal. If using plastic material, it should be compatible with it, no chemical reaction occurs, and the wall thickness is moderate to withstand pressure changes during transportation.
Times and storage environment. It should be placed in a cool, dry and well-ventilated place. Avoid direct sunlight, due to light or cause photochemical reactions to occur, resulting in changes in composition. Temperature also needs to be controlled. Too high temperature may accelerate its volatilization and decomposition, and too low temperature may cause it to solidify, affecting access. At the same time, away from fire sources, heat sources and oxidizing substances, this compound may cause combustion and explosion in case of open flame, hot topic or contact with oxidants.
Furthermore, when transporting, follow relevant laws and regulations. A professional transportation team needs to be selected, and its personnel should be familiar with the characteristics of this chemical and emergency treatment methods. Transportation vehicles need to be equipped with corresponding fire equipment and leakage emergency treatment equipment. Avoid bumps and vibrations on the way to prevent package damage.
In the process of handling, storing and transporting 3-bromo-2-chloro-1-fluorobenzene, all aspects should not be ignored, and caution should be taken to ensure safety.
The first thing to do is to be careful with its packaging. This compound has a certain chemical activity, and the packaging must be tight to prevent leakage. The packaging material used must be resistant to its corrosion. If it is packed in a glass container, it should be checked for cracks and other damages to ensure a good seal. If using plastic material, it should be compatible with it, no chemical reaction occurs, and the wall thickness is moderate to withstand pressure changes during transportation.
Times and storage environment. It should be placed in a cool, dry and well-ventilated place. Avoid direct sunlight, due to light or cause photochemical reactions to occur, resulting in changes in composition. Temperature also needs to be controlled. Too high temperature may accelerate its volatilization and decomposition, and too low temperature may cause it to solidify, affecting access. At the same time, away from fire sources, heat sources and oxidizing substances, this compound may cause combustion and explosion in case of open flame, hot topic or contact with oxidants.
Furthermore, when transporting, follow relevant laws and regulations. A professional transportation team needs to be selected, and its personnel should be familiar with the characteristics of this chemical and emergency treatment methods. Transportation vehicles need to be equipped with corresponding fire equipment and leakage emergency treatment equipment. Avoid bumps and vibrations on the way to prevent package damage.
In the process of handling, storing and transporting 3-bromo-2-chloro-1-fluorobenzene, all aspects should not be ignored, and caution should be taken to ensure safety.
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