Linshang Chemical
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3-Chloro-2-Fluorobenzenesulfonyl Chloride
Linshang Chemical
|
HS Code |
212278 |
| Chemical Formula | C6H3Cl2FO2S |
| Molecular Weight | 231.05 |
| Appearance | Typically a colorless to light - colored liquid |
| Odor | Pungent, characteristic sulfonyl chloride odor |
| Density | Data specific to this compound needed (but sulfonyl chlorides generally have relatively high densities) |
| Boiling Point | Data specific to this compound required (sulfonyl chlorides usually boil at elevated temperatures) |
| Melting Point | Data specific to this compound needed |
| Solubility | Soluble in many organic solvents like dichloromethane, chloroform; insoluble in water |
| Reactivity | Highly reactive, reacts with nucleophiles such as amines, alcohols |
| Hazard | Corrosive, can cause severe skin and eye burns; harmful if inhaled or ingested |
As an accredited 3-Chloro-2-Fluorobenzenesulfonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 3 - chloro - 2 - fluorobenzenesulfonyl chloride in a sealed, corrosion - resistant bottle. |
| Storage | 3 - Chloro - 2 - fluorobenzenesulfonyl chloride should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials due to its reactive nature. Store it separately from incompatible substances like bases, reducing agents, and water to prevent hazardous reactions. |
| Shipping | 3 - chloro - 2 - fluorobenzenesulfonyl chloride is a chemical. For shipping, it must be in a well - sealed, corrosion - resistant container, following hazardous chemical regulations, and properly labeled to ensure safe transportation. |
Competitive 3-Chloro-2-Fluorobenzenesulfonyl Chloride prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
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As a leading 3-Chloro-2-Fluorobenzenesulfonyl Chloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemistry of 3-chloro-2-fluorobenzenesulfonyl Chloride?
3-Chloro-2-fluorobenzenesulfonyl chloride is an important compound in organic chemistry. Looking at its chemical properties, it has a sulfonyl chloride group and a halogen atom, and its activity is quite strong.
Let's talk about the sulfonyl chloride group first. This group has high chemical activity and is often an electrophilic reagent. It is easy to hydrolyze in contact with water. During hydrolysis, the sulfonyl chloride bond (S-Cl) breaks and reacts with water to form the corresponding sulfonic acid and hydrogen chloride. The reaction is violent, as shown in the following formula: $R - SO_2Cl + H_2O\ longrightarrow R - SO_3H + HCl $, where $R $is 3-chloro-2-fluorophenyl. This hydrolysis reaction releases hydrogen chloride gas, which has a pungent odor and can form an acid mist in the air.
Furthermore, the compound can react with alcohols to form sulfonates. The chlorine atom of the sulfonyl chloride is attacked by the alcoholic hydroxyl group. After the nucleophilic substitution reaction, the chlorine atom is replaced by the alcoholic group to form a sulfonate. If it reacts with ethanol, 3-chloro-2-fluorobenzenesulfonate ethyl ester is formed, and the reaction formula is: $R - SO_2Cl + C_2H_5OH\ longrightarrow R - SO_2OC_2H_5 + HCl $.
Its halogen atoms (chlorine and fluorine) also have unique properties. Fluorine atoms have strong electronegativity, which reduces the electron cloud density of the benzene ring, which in turn affects the activity and localization of electrophilic substitution reactions on the benzene ring. Usually, fluorine atoms reduce the electron cloud density of the benzene ring o and para-site less than the meta-site, and electrophilic substitution reactions are more likely to occur in the meta-site. Although chlorine atoms are also electron-withdrawing groups, their electron-withdrawing ability is weaker than that of fluorine. The combined effect of the two makes the 3-Chloro-2-fluorobenzenesulfonyl chloride is widely used in the field of organic synthesis due to its special chemical properties. It can be used as a key intermediate to prepare a variety of compounds containing sulfonyl groups or halogenated benzene structures. It is an important research object in organic synthesis chemistry.
Let's talk about the sulfonyl chloride group first. This group has high chemical activity and is often an electrophilic reagent. It is easy to hydrolyze in contact with water. During hydrolysis, the sulfonyl chloride bond (S-Cl) breaks and reacts with water to form the corresponding sulfonic acid and hydrogen chloride. The reaction is violent, as shown in the following formula: $R - SO_2Cl + H_2O\ longrightarrow R - SO_3H + HCl $, where $R $is 3-chloro-2-fluorophenyl. This hydrolysis reaction releases hydrogen chloride gas, which has a pungent odor and can form an acid mist in the air.
Furthermore, the compound can react with alcohols to form sulfonates. The chlorine atom of the sulfonyl chloride is attacked by the alcoholic hydroxyl group. After the nucleophilic substitution reaction, the chlorine atom is replaced by the alcoholic group to form a sulfonate. If it reacts with ethanol, 3-chloro-2-fluorobenzenesulfonate ethyl ester is formed, and the reaction formula is: $R - SO_2Cl + C_2H_5OH\ longrightarrow R - SO_2OC_2H_5 + HCl $.
Its halogen atoms (chlorine and fluorine) also have unique properties. Fluorine atoms have strong electronegativity, which reduces the electron cloud density of the benzene ring, which in turn affects the activity and localization of electrophilic substitution reactions on the benzene ring. Usually, fluorine atoms reduce the electron cloud density of the benzene ring o and para-site less than the meta-site, and electrophilic substitution reactions are more likely to occur in the meta-site. Although chlorine atoms are also electron-withdrawing groups, their electron-withdrawing ability is weaker than that of fluorine. The combined effect of the two makes the 3-Chloro-2-fluorobenzenesulfonyl chloride is widely used in the field of organic synthesis due to its special chemical properties. It can be used as a key intermediate to prepare a variety of compounds containing sulfonyl groups or halogenated benzene structures. It is an important research object in organic synthesis chemistry.
What are the preparation methods of 3-chloro-2-fluorobenzenesulfonyl Chloride?
There are several methods for preparing 3-chloro-2-fluorobenzenesulfonyl chloride. One method is to use 3-chloro-2-fluorobenzene as the starting material. First, 3-chloro-2-fluorobenzene is heated with fuming sulfuric acid to perform a sulfonation reaction. In this process, the sulfate radical (\ (SO_ {3} H\)) replaces the hydrogen atom on the benzene ring to generate 3-chloro-2-fluorobenzenesulfonic acid. This reaction needs to be carefully controlled because too high or too low temperature can affect the yield and selectivity of the reaction.
After the sulfonation reaction is completed, the product is cooled, and then phosphorus pentachloride (\ (PCl_ {5}\)) is slowly added. Phosphorus pentachloride reacts with the sulfonic acid group (\ (SO_ {3} H\)) in 3-chloro-2-fluorobenzenesulfonic acid, and the hydroxyl group (\ (-OH\)) of the sulfonic acid group is replaced by a chlorine atom, resulting in 3-chloro-2-fluorobenzenesulfonyl chloride. In this step of the reaction, it is also necessary to pay attention to the reaction conditions, such as the reaction temperature, the amount of phosphorus pentachloride, etc. If the amount of phosphorus pentachloride is insufficient, the reaction
Another method can be started from 3-chloro-2-fluoroaniline. First, 3-chloro-2-fluoroaniline is reacted with sodium nitrite and hydrochloric acid at low temperature to form a diazonium salt. After that, the diazonium salt is reacted with sodium sulfite to convert to 3-chloro-2-fluorobenzenesulfonate. Then 3-chloro-2-fluorobenzenesulfonate is acidified with hydrochloric acid to obtain 3-chloro-2-fluorobenzenesulfonate. Finally, the target product 3-chloro-2-fluorobenzenesulfonyl chloride was obtained by treating with phosphorus pentachloride as before.
The process of preparing 3-chloro-2-fluorobenzenesulfonyl chloride requires fine operation in any method, and strict control of reaction conditions, such as temperature, reactant dosage, reaction time, etc., to obtain products with higher yield and purity.
After the sulfonation reaction is completed, the product is cooled, and then phosphorus pentachloride (\ (PCl_ {5}\)) is slowly added. Phosphorus pentachloride reacts with the sulfonic acid group (\ (SO_ {3} H\)) in 3-chloro-2-fluorobenzenesulfonic acid, and the hydroxyl group (\ (-OH\)) of the sulfonic acid group is replaced by a chlorine atom, resulting in 3-chloro-2-fluorobenzenesulfonyl chloride. In this step of the reaction, it is also necessary to pay attention to the reaction conditions, such as the reaction temperature, the amount of phosphorus pentachloride, etc. If the amount of phosphorus pentachloride is insufficient, the reaction
Another method can be started from 3-chloro-2-fluoroaniline. First, 3-chloro-2-fluoroaniline is reacted with sodium nitrite and hydrochloric acid at low temperature to form a diazonium salt. After that, the diazonium salt is reacted with sodium sulfite to convert to 3-chloro-2-fluorobenzenesulfonate. Then 3-chloro-2-fluorobenzenesulfonate is acidified with hydrochloric acid to obtain 3-chloro-2-fluorobenzenesulfonate. Finally, the target product 3-chloro-2-fluorobenzenesulfonyl chloride was obtained by treating with phosphorus pentachloride as before.
The process of preparing 3-chloro-2-fluorobenzenesulfonyl chloride requires fine operation in any method, and strict control of reaction conditions, such as temperature, reactant dosage, reaction time, etc., to obtain products with higher yield and purity.
What are the main uses of 3-chloro-2-fluorobenzenesulfonyl Chloride?
3-Chloro-2-fluorobenzenesulfonyl chloride has a wide range of uses. In the field of organic synthesis, its position is pivotal.
First, it is often a key raw material for the preparation of multi-element organic compounds containing sulfur, chlorine, and fluorine. Because of its active sulfonyl chloride group in the molecule, it is easy to react with many nucleophiles. For example, when it meets alcohols, it can give rise to sulfonate compounds. This sulfonate can act as a good leaving group in organic synthesis, helping to build various carbon-carbon bonds and carbon-heteroatomic bonds, so as to achieve the synthesis of complex organic molecules.
Second, it also plays an important role in the field of medicinal chemistry. In view of the special properties of fluorine atoms, such as increasing the fat solubility of compounds and improving metabolic stability, fluorinated drugs have attracted much attention. 3-Chloro-2-fluorobenzenesulfonyl chloride can be used as a reagent for introducing fluorosulfonyl groups, laying the foundation for the development of new drugs with unique pharmacological activities. By combining with a specific drug skeleton, it may endow drugs with better bioavailability and higher target affinity, thereby enhancing the efficacy of drugs.
Third, it also has its uses in the field of materials science. Some functional materials involved in the synthesis may have unique physicochemical properties. For example, if synthesized polymer materials contain such structural units, they may exhibit excellent thermal stability, chemical stability, and special electrical and optical properties, which holds great potential for the preparation of high-performance materials.
In short, 3-chloro-2-fluorobenzenesulfonyl chloride is an indispensable chemical reagent in many fields such as organic synthesis, drug development, and material preparation due to its unique structure and active reactivity. It is of great significance to promote the development of related fields.
First, it is often a key raw material for the preparation of multi-element organic compounds containing sulfur, chlorine, and fluorine. Because of its active sulfonyl chloride group in the molecule, it is easy to react with many nucleophiles. For example, when it meets alcohols, it can give rise to sulfonate compounds. This sulfonate can act as a good leaving group in organic synthesis, helping to build various carbon-carbon bonds and carbon-heteroatomic bonds, so as to achieve the synthesis of complex organic molecules.
Second, it also plays an important role in the field of medicinal chemistry. In view of the special properties of fluorine atoms, such as increasing the fat solubility of compounds and improving metabolic stability, fluorinated drugs have attracted much attention. 3-Chloro-2-fluorobenzenesulfonyl chloride can be used as a reagent for introducing fluorosulfonyl groups, laying the foundation for the development of new drugs with unique pharmacological activities. By combining with a specific drug skeleton, it may endow drugs with better bioavailability and higher target affinity, thereby enhancing the efficacy of drugs.
Third, it also has its uses in the field of materials science. Some functional materials involved in the synthesis may have unique physicochemical properties. For example, if synthesized polymer materials contain such structural units, they may exhibit excellent thermal stability, chemical stability, and special electrical and optical properties, which holds great potential for the preparation of high-performance materials.
In short, 3-chloro-2-fluorobenzenesulfonyl chloride is an indispensable chemical reagent in many fields such as organic synthesis, drug development, and material preparation due to its unique structure and active reactivity. It is of great significance to promote the development of related fields.
What are the precautions for 3-chloro-2-fluorobenzenesulfonyl Chloride during storage and transportation?
3-Chloro-2-fluorobenzenesulfonyl chloride is a chemical substance. When storing and transporting, many matters need to be paid careful attention.
When storing, the first environment. It should be placed in a cool, dry and well-ventilated place. Due to its nature or affected by temperature, humidity and air, if it is in a high temperature and humid place, it may cause chemical reactions and cause it to deteriorate. And it needs to be kept away from fires and heat sources to prevent fires. Because of its flammability, it may be dangerous in case of open flames and hot topics.
Furthermore, storage must be separated from different types of chemicals. Such as oxidants, alkalis, etc., should not be mixed with them. Due to its severe reaction with oxidants, it can also chemically react with alkalis, causing changes in properties and increasing danger.
Packaging should not be ignored. It is necessary to ensure that the package is complete and sealed. If the package is damaged, it is easy to come into contact with external substances, or evaporate and leak, which not only damages itself, but also endangers the surrounding environment and personal safety.
There are also many key points in the transportation process. Transportation vehicles must have corresponding qualifications. Drivers and escorts need to be professionally trained and familiar with their characteristics and emergency treatment methods.
During driving, the speed should not be too fast, avoid sudden braking and bumps. Leakage due to excessive vibration or damage to the package. When transporting, keep away from densely populated areas and important places, such as residential areas, schools, hospitals, etc. In the event of a leak, the harm to the crowd can be reduced.
If a leak unfortunately occurs during transportation, do not panic. Surrounding people should be evacuated immediately, and fire is strictly prohibited from approaching. Emergency responders need professional protective equipment and take appropriate measures to deal with the leak according to the situation. A small amount of leakage can be adsorbed by inert materials such as sand; if a large amount of leakage, it needs to be built embankment or dug for containment, and then properly handled.
When storing, the first environment. It should be placed in a cool, dry and well-ventilated place. Due to its nature or affected by temperature, humidity and air, if it is in a high temperature and humid place, it may cause chemical reactions and cause it to deteriorate. And it needs to be kept away from fires and heat sources to prevent fires. Because of its flammability, it may be dangerous in case of open flames and hot topics.
Furthermore, storage must be separated from different types of chemicals. Such as oxidants, alkalis, etc., should not be mixed with them. Due to its severe reaction with oxidants, it can also chemically react with alkalis, causing changes in properties and increasing danger.
Packaging should not be ignored. It is necessary to ensure that the package is complete and sealed. If the package is damaged, it is easy to come into contact with external substances, or evaporate and leak, which not only damages itself, but also endangers the surrounding environment and personal safety.
There are also many key points in the transportation process. Transportation vehicles must have corresponding qualifications. Drivers and escorts need to be professionally trained and familiar with their characteristics and emergency treatment methods.
During driving, the speed should not be too fast, avoid sudden braking and bumps. Leakage due to excessive vibration or damage to the package. When transporting, keep away from densely populated areas and important places, such as residential areas, schools, hospitals, etc. In the event of a leak, the harm to the crowd can be reduced.
If a leak unfortunately occurs during transportation, do not panic. Surrounding people should be evacuated immediately, and fire is strictly prohibited from approaching. Emergency responders need professional protective equipment and take appropriate measures to deal with the leak according to the situation. A small amount of leakage can be adsorbed by inert materials such as sand; if a large amount of leakage, it needs to be built embankment or dug for containment, and then properly handled.
What is the market price range for 3-chloro-2-fluorobenzenesulfonyl Chloride?
I do not know the market price range of 3-chloro-2-fluorobenzenesulfonyl Chloride (3-chloro-2-fluorobenzenesulfonyl chloride). However, if you want to know its price, you can consult the chemical raw materials trading platform and suppliers.
On the chemical raw materials trading platform, there are many chemical products for sale, and there are also many suppliers listing prices. You can log in to a well-known chemical trading website, such as Mobell, and enter "3-chloro-2-fluorobenzenesulfonyl chloride" to see the prices quoted by different suppliers. The prices vary depending on purity, packaging, MOQ, etc.
Furthermore, you can contact the supplier directly. Through chemical industry exhibitions, industry information, online searches, etc., find suppliers who produce or distribute 3-chloro-2-fluorobenzenesulfonyl chloride, call them or send emails, inquire about their product prices, and discuss cooperation details in detail, such as delivery time, transportation methods, etc.
In addition, the price of chemical products often changes due to market supply and demand, raw material costs, policies and regulations, etc. If the market has a large demand for 3-chloro-2-fluorobenzenesulfonyl chloride, but the supply is small, the price may rise; if the price of raw materials rises, the cost will also increase, and the price will rise accordingly; if policies and regulations change, such as strict environmental protection requirements, affect production, or make prices fluctuate. Therefore, in order to know its exact price range, it is necessary to pay attention to market dynamics in real time, inquire from multiple parties, and consider comprehensively.
On the chemical raw materials trading platform, there are many chemical products for sale, and there are also many suppliers listing prices. You can log in to a well-known chemical trading website, such as Mobell, and enter "3-chloro-2-fluorobenzenesulfonyl chloride" to see the prices quoted by different suppliers. The prices vary depending on purity, packaging, MOQ, etc.
Furthermore, you can contact the supplier directly. Through chemical industry exhibitions, industry information, online searches, etc., find suppliers who produce or distribute 3-chloro-2-fluorobenzenesulfonyl chloride, call them or send emails, inquire about their product prices, and discuss cooperation details in detail, such as delivery time, transportation methods, etc.
In addition, the price of chemical products often changes due to market supply and demand, raw material costs, policies and regulations, etc. If the market has a large demand for 3-chloro-2-fluorobenzenesulfonyl chloride, but the supply is small, the price may rise; if the price of raw materials rises, the cost will also increase, and the price will rise accordingly; if policies and regulations change, such as strict environmental protection requirements, affect production, or make prices fluctuate. Therefore, in order to know its exact price range, it is necessary to pay attention to market dynamics in real time, inquire from multiple parties, and consider comprehensively.
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