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3-Chloro-2-Fluorobenzenesulphonyl Chloride
Linshang Chemical
|
HS Code |
286504 |
| Name | 3-Chloro-2-Fluorobenzenesulphonyl Chloride |
| Chemical Formula | C6H3Cl2FO2S |
| Molar Mass | 231.05 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | Around 270 - 275 °C |
| Density | Approx. 1.64 g/cm³ |
| Solubility | Reacts with water, soluble in some organic solvents |
| Pungency | Pungent odor |
| Reactivity | Reactive towards nucleophiles |
As an accredited 3-Chloro-2-Fluorobenzenesulphonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 3 - chloro - 2 - fluorobenzenesulphonyl Chloride packaged in a sealed glass bottle. |
| Storage | 3 - Chloro - 2 - fluorobenzenesulphonyl chloride should be stored in a cool, dry, well - ventilated area, away from sources of heat, ignition, and direct sunlight. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials. Store it separately from incompatible substances like bases, reducing agents, and moisture - sensitive compounds to prevent reactions. |
| Shipping | 3 - Chloro - 2 - fluorobenzenesulphonyl chloride is a chemical that requires careful shipping. It should be in well - sealed, corrosion - resistant containers, shipped as hazardous goods following strict regulations to prevent leakage and ensure safety during transit. |
Competitive 3-Chloro-2-Fluorobenzenesulphonyl Chloride prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 3-Chloro-2-Fluorobenzenesulphonyl Chloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the physical properties of 3-chloro-2-fluorobenzenesulphonyl Chloride?
3-Chloro-2-fluorobenzenesulfonyl chloride, this material has unique physical properties. If its shape is colorless to slightly yellow oily liquid, it can exist stably at room temperature and pressure.
Looking at its color, pure is colorless, but it is common to be slightly yellowish, like light waves in the morning sun, shimmering with light. Its smell is pungent, and it smells like a spike, straight into the nasal cavity, which is uncomfortable. This strong smell is a warning sign, and precautions must be taken during operation.
When it comes to boiling point, it is about a specific temperature range, just like the boiling point of water is 100 degrees. At a certain temperature, the thermal motion of the molecules intensifies, breaking free from the shackles of the liquid phase and rising into the gas phase. The exact value of the boiling point is related to its state transition under a specific environment, which is a key indicator in operations such as distillation.
As for the melting point, it is another important property. When the temperature drops to a certain point, the movement of molecules slows down, close to each other, arranged in a regular manner, and condensed from liquid to solid. The value of the melting point defines the conversion limit between its solid state and liquid state, and also affects its morphological stability during storage and transportation.
The density cannot be ignored. Its unit volume mass is specific, and the density difference is an important basis for the mixing and separation of substances. Just like sand and water, the density is different, and it is naturally layered in a container. The density of 3-chloro-2-fluorobenzenesulfonyl chloride gives it a unique position in the liquid system, either floating on the top or sinking on the bottom, depending on the density relationship with other substances.
In terms of solubility, it has a certain solubility in organic solvents, such as alcohols and ethers. Just like salts dissolve in water, the molecules interact and disperse uniformly. However, in water, the solubility is not good, because its molecular structure is incompatible with the polarity of water molecules, such as oil and water, it is difficult to blend. This difference in solubility is an important consideration in the selection of solvents in the chemical synthesis and purification steps, and is related to whether the reaction can proceed smoothly and whether the product can be separated efficiently.
Looking at its color, pure is colorless, but it is common to be slightly yellowish, like light waves in the morning sun, shimmering with light. Its smell is pungent, and it smells like a spike, straight into the nasal cavity, which is uncomfortable. This strong smell is a warning sign, and precautions must be taken during operation.
When it comes to boiling point, it is about a specific temperature range, just like the boiling point of water is 100 degrees. At a certain temperature, the thermal motion of the molecules intensifies, breaking free from the shackles of the liquid phase and rising into the gas phase. The exact value of the boiling point is related to its state transition under a specific environment, which is a key indicator in operations such as distillation.
As for the melting point, it is another important property. When the temperature drops to a certain point, the movement of molecules slows down, close to each other, arranged in a regular manner, and condensed from liquid to solid. The value of the melting point defines the conversion limit between its solid state and liquid state, and also affects its morphological stability during storage and transportation.
The density cannot be ignored. Its unit volume mass is specific, and the density difference is an important basis for the mixing and separation of substances. Just like sand and water, the density is different, and it is naturally layered in a container. The density of 3-chloro-2-fluorobenzenesulfonyl chloride gives it a unique position in the liquid system, either floating on the top or sinking on the bottom, depending on the density relationship with other substances.
In terms of solubility, it has a certain solubility in organic solvents, such as alcohols and ethers. Just like salts dissolve in water, the molecules interact and disperse uniformly. However, in water, the solubility is not good, because its molecular structure is incompatible with the polarity of water molecules, such as oil and water, it is difficult to blend. This difference in solubility is an important consideration in the selection of solvents in the chemical synthesis and purification steps, and is related to whether the reaction can proceed smoothly and whether the product can be separated efficiently.
What are the chemical properties of 3-chloro-2-fluorobenzenesulphonyl Chloride?
3-Chloro-2-fluorobenzenesulfonyl chloride, this is an organic compound whose chemical properties are particularly important and are related to many organic synthesis reactions.
Looking at its structure, the chlorine atom and fluorine atom are connected to the benzene ring and the sulfonyl chloride group. Due to its unique structure, it exhibits specific chemical properties.
The sulfonyl chloride group (-SO ² Cl) is abnormally active. It is very easy to hydrolyze in contact with water. When hydrolyzed, the sulfonyl chloride bond breaks to form 3-chloro-2-fluorobenzenesulfonic acid and hydrogen chloride. This hydrolysis reaction is quite violent. In humid air, it can be seen as "smoking", which is caused by the generation of hydrogen chloride gas in contact with water vapor.
Sulfonyl chloride can also react with alcohols. This reaction is called alcoholysis. The hydroxyl group of the alcohol attacks the sulfur atom of the sulfonyl chloride, and the chlorine leaves the atom to form a sulfonate. This reaction condition is usually mild and the yield is quite high. It is often used in organic synthesis to prepare sulfonate compounds, which are widely used in medicine, materials and other fields.
Furthermore, on the benzene ring of 3-chloro-2-fluorobenzenesulfonyl chloride, the electron cloud density of the benzene ring changes due to the presence of chlorine and fluorine atoms. The electron-absorbing effect of fluorine atoms decreases the electron cloud density of the benzene ring, so the electrophilic substitution reaction is more difficult than that of benzene. However, if the conditions are suitable, electrophilic substitution can still occur, and the substitution position is affected by the positioning effect of chlorine and fluorine atoms. Generally speaking, chlorine and fluorine atoms are ortho-para-sites, but the positioning effect of fluorine atoms is slightly stronger, so electrophilic reagents are more inclined to attack the ortho-sites of fluorine atoms.
And because fluorine atoms are extremely electronegative and have high carbon-fluorine bond energies, some reactivity of this compound is different from that of those containing other halogen atoms. The reactions in which it participates often require specific conditions or catalysts to proceed smoothly.
In addition, 3-chloro-2-fluorobenzenesulfonyl chloride can undergo ammonolysis with amines to form sulfonamides. The nitrogen atom of the amine nucleophilic attacks the sulfur atom of the sulfonyl chloride, and the chlorine atom leaves to form a sulfonamide bond. Sulfonamide compounds have diverse biological activities and are of great significance in the field of drug research and development.
In summary, 3-chloro-2-fluorobenzenesulfonyl chloride has a unique performance due to its special structure, hydrolysis, alcoholysis, aminolysis, and electrophilic substitution of benzene rings, which occupy an important position in the field of organic synthetic chemistry.
Looking at its structure, the chlorine atom and fluorine atom are connected to the benzene ring and the sulfonyl chloride group. Due to its unique structure, it exhibits specific chemical properties.
The sulfonyl chloride group (-SO ² Cl) is abnormally active. It is very easy to hydrolyze in contact with water. When hydrolyzed, the sulfonyl chloride bond breaks to form 3-chloro-2-fluorobenzenesulfonic acid and hydrogen chloride. This hydrolysis reaction is quite violent. In humid air, it can be seen as "smoking", which is caused by the generation of hydrogen chloride gas in contact with water vapor.
Sulfonyl chloride can also react with alcohols. This reaction is called alcoholysis. The hydroxyl group of the alcohol attacks the sulfur atom of the sulfonyl chloride, and the chlorine leaves the atom to form a sulfonate. This reaction condition is usually mild and the yield is quite high. It is often used in organic synthesis to prepare sulfonate compounds, which are widely used in medicine, materials and other fields.
Furthermore, on the benzene ring of 3-chloro-2-fluorobenzenesulfonyl chloride, the electron cloud density of the benzene ring changes due to the presence of chlorine and fluorine atoms. The electron-absorbing effect of fluorine atoms decreases the electron cloud density of the benzene ring, so the electrophilic substitution reaction is more difficult than that of benzene. However, if the conditions are suitable, electrophilic substitution can still occur, and the substitution position is affected by the positioning effect of chlorine and fluorine atoms. Generally speaking, chlorine and fluorine atoms are ortho-para-sites, but the positioning effect of fluorine atoms is slightly stronger, so electrophilic reagents are more inclined to attack the ortho-sites of fluorine atoms.
And because fluorine atoms are extremely electronegative and have high carbon-fluorine bond energies, some reactivity of this compound is different from that of those containing other halogen atoms. The reactions in which it participates often require specific conditions or catalysts to proceed smoothly.
In addition, 3-chloro-2-fluorobenzenesulfonyl chloride can undergo ammonolysis with amines to form sulfonamides. The nitrogen atom of the amine nucleophilic attacks the sulfur atom of the sulfonyl chloride, and the chlorine atom leaves to form a sulfonamide bond. Sulfonamide compounds have diverse biological activities and are of great significance in the field of drug research and development.
In summary, 3-chloro-2-fluorobenzenesulfonyl chloride has a unique performance due to its special structure, hydrolysis, alcoholysis, aminolysis, and electrophilic substitution of benzene rings, which occupy an important position in the field of organic synthetic chemistry.
What are the common synthesis methods of 3-chloro-2-fluorobenzenesulphonyl Chloride?
The common synthesis method of 3-chloro-2-fluorobenzenesulfonyl chloride is a key technology in the field of chemistry. Its synthesis path can be achieved by various strategies. The following common methods are described in detail.
First, 3-chloro-2-fluorobenzene is used as the starting material. First, 3-chloro-2-fluorobenzene is co-heated with fuming sulfuric acid and sulfur trioxide. This step aims to introduce a sulfonic acid group to generate 3-chloro-2-fluorobenzene sulfonic acid. The reaction mechanism is the electrophilic substitution of the benzene ring, and the sulfonic acid group replaces the hydrogen atom on the benzene ring. The reaction temperature and reaction time need to be controlled to ensure the high efficiency and selectivity of the reaction. Subsequently, the resulting 3-chloro-2-fluorobenzenesulfonic acid is reacted with phosphorus pentachloride or thionyl chloride. This step can convert the sulfonic acid group into a sulfonyl chloride group to obtain 3-chloro-2-fluorobenzenesulfonyl chloride. Taking phosphorus pentachloride as an example, during the reaction process, the chlorine atom of phosphorus pentachloride replaces the hydroxyl group in the sulfonate group to form the target product and by-products such as phosphorus oxychloride. This reaction needs to be carried out in an anhydrous environment to prevent hydrolysis of sulfonyl chloride.
Second, halogenated aromatics can also be used as the starting material to introduce lithium First, halogenated aromatics are reacted with reagents such as lithium butyl at low temperature to form aryl lithium intermediates. This intermediate is highly active and can react with sulfur dioxide to form lithium aryl sulfonate salts. After that, after acidification treatment, the lithium salt is converted into sulfonic acid, and then reacted with phosphorus pentachloride or sulfinyl chloride as described above to convert into sulfonyl chloride. This method requires precise control of the reaction temperature and the amount of reagents. Due to the high activity of lithium halogen exchange reaction, the conditions are harsh.
Furthermore, the reaction path catalyzed by transition metals can also be used. For example, using halogenated benzene derivatives as raw materials, in the presence of transition metal catalysts and ligands such as palladium and copper, it reacts with sulfur dioxide sources and chlorine sources to directly construct a sulfonyl chloride structure. This method has the advantages of high atomic economy and relatively mild reaction conditions, but the selection and optimization of catalysts are crucial, and factors such as catalyst activity, selectivity and cost need to be considered.
All these synthetic methods have their own advantages and disadvantages. In practical application, it is necessary to comprehensively consider factors such as raw material availability, cost, reaction conditions and purity of target products, and make careful choices to achieve the best synthetic effect.
First, 3-chloro-2-fluorobenzene is used as the starting material. First, 3-chloro-2-fluorobenzene is co-heated with fuming sulfuric acid and sulfur trioxide. This step aims to introduce a sulfonic acid group to generate 3-chloro-2-fluorobenzene sulfonic acid. The reaction mechanism is the electrophilic substitution of the benzene ring, and the sulfonic acid group replaces the hydrogen atom on the benzene ring. The reaction temperature and reaction time need to be controlled to ensure the high efficiency and selectivity of the reaction. Subsequently, the resulting 3-chloro-2-fluorobenzenesulfonic acid is reacted with phosphorus pentachloride or thionyl chloride. This step can convert the sulfonic acid group into a sulfonyl chloride group to obtain 3-chloro-2-fluorobenzenesulfonyl chloride. Taking phosphorus pentachloride as an example, during the reaction process, the chlorine atom of phosphorus pentachloride replaces the hydroxyl group in the sulfonate group to form the target product and by-products such as phosphorus oxychloride. This reaction needs to be carried out in an anhydrous environment to prevent hydrolysis of sulfonyl chloride.
Second, halogenated aromatics can also be used as the starting material to introduce lithium First, halogenated aromatics are reacted with reagents such as lithium butyl at low temperature to form aryl lithium intermediates. This intermediate is highly active and can react with sulfur dioxide to form lithium aryl sulfonate salts. After that, after acidification treatment, the lithium salt is converted into sulfonic acid, and then reacted with phosphorus pentachloride or sulfinyl chloride as described above to convert into sulfonyl chloride. This method requires precise control of the reaction temperature and the amount of reagents. Due to the high activity of lithium halogen exchange reaction, the conditions are harsh.
Furthermore, the reaction path catalyzed by transition metals can also be used. For example, using halogenated benzene derivatives as raw materials, in the presence of transition metal catalysts and ligands such as palladium and copper, it reacts with sulfur dioxide sources and chlorine sources to directly construct a sulfonyl chloride structure. This method has the advantages of high atomic economy and relatively mild reaction conditions, but the selection and optimization of catalysts are crucial, and factors such as catalyst activity, selectivity and cost need to be considered.
All these synthetic methods have their own advantages and disadvantages. In practical application, it is necessary to comprehensively consider factors such as raw material availability, cost, reaction conditions and purity of target products, and make careful choices to achieve the best synthetic effect.
3-chloro-2-fluorobenzenesulphonyl Chloride is used in what areas
3-Chloro-2-fluorobenzenesulfonyl chloride is useful in various fields. In the field of pharmaceutical and chemical industry, it can be used as a key intermediate. In pharmaceuticals, with its special chemical structure, it can participate in a variety of organic synthesis reactions, helping to build molecular structures with specific physiological activities, so as to prepare various drugs, such as antibacterial and anti-inflammatory drugs.
In the field of materials science, it may contribute to the synthesis of special materials. By reacting with other compounds, it can endow materials with unique properties, such as enhancing the stability and corrosion resistance of materials, which is of great value in the development and manufacture of high-end materials.
In the field of pesticides, 3-chloro-2-fluorobenzenesulfonyl chloride is also useful. It can be used to synthesize high-efficiency pesticides, or enhance the pesticide's lethality to pests, or improve the stability and durability of pesticides in the environment, and improve the overall efficacy of pesticides.
In the fine chemical industry, it can participate in the synthesis of many fine chemicals. These fine chemicals are widely used in coatings, dyes, fragrances and other industries, giving unique properties and quality to products, and is of great significance to the upgrading and innovation of fine chemical products. Therefore, 3-chloro-2-fluorobenzenesulfonyl chloride plays an indispensable role in many important industrial fields.
In the field of materials science, it may contribute to the synthesis of special materials. By reacting with other compounds, it can endow materials with unique properties, such as enhancing the stability and corrosion resistance of materials, which is of great value in the development and manufacture of high-end materials.
In the field of pesticides, 3-chloro-2-fluorobenzenesulfonyl chloride is also useful. It can be used to synthesize high-efficiency pesticides, or enhance the pesticide's lethality to pests, or improve the stability and durability of pesticides in the environment, and improve the overall efficacy of pesticides.
In the fine chemical industry, it can participate in the synthesis of many fine chemicals. These fine chemicals are widely used in coatings, dyes, fragrances and other industries, giving unique properties and quality to products, and is of great significance to the upgrading and innovation of fine chemical products. Therefore, 3-chloro-2-fluorobenzenesulfonyl chloride plays an indispensable role in many important industrial fields.
3-chloro-2-fluorobenzenesulphonyl the precautions when using Chloride
3-Chloro-2-fluorobenzenesulfonyl chloride, when using, many things need to be paid attention to. This is a commonly used reagent in organic synthesis, which is active, corrosive and irritating, so when operating, the protection must be comprehensive.
First personal protection. In front of protective clothing, this clothing needs to be resistant to chemical corrosion to prevent its damage to the body. Wear protective gloves, the material should be selected to effectively block the reagent, such as nitrile rubber gloves, which can keep the hands and skin safe. Goggles are also indispensable, which can prevent the reagent from splashing into the eyes and avoid eye injuries.
Furthermore, the operating environment is crucial. It should be used in a well-ventilated place, and it is best to operate in a fume hood. In this way, volatile harmful gases can be quickly discharged, and the concentration in the air can be reduced, so as to prevent the operator from inhaling poisoning. At the same time, ensure that the operating table is clean, dry and flat, free of debris and water stains, in order to prevent the experiment from being affected, and to avoid accidents caused by the reaction of reagents with it.
When taking it, the action should be stable and accurate. Use clean and dry utensils to measure, and take it accurately according to the needs of the experiment. Do not take too much waste, and prevent the difficulty of handling the remaining reagents. If it is accidentally spilled, do not panic, and deal with it quickly according to the established procedures. If a small amount is spilled, it can be covered with inert adsorption materials such as sand and vermiculite, and then If a large amount of spills, it is necessary to evacuate the personnel, seal the scene, and notify the professionals to deal with it.
Storage is also exquisite. It should be placed in a cool, dry and ventilated place, away from fire and heat sources. Because it is easy to decompose when heated, it is dangerous. And it needs to be stored separately from oxidants and alkalis to avoid reactions between mixed storage. At the same time, the storage place should be equipped with suitable materials to contain leaks.
Furthermore, after use, the utensils must be cleaned in time. Rinse with a suitable organic solvent first to remove residual reagents, then rinse thoroughly with water and dry for later use. The waste generated by the experiment should not be discarded at will. It should be collected by classification and handed over to professional institutions for treatment. Follow environmental protection and safety regulations. Therefore, when using 3-chloro-2-fluorobenzenesulfonyl chloride, the personnel are safe, the experiment is smooth, and the environment is not damaged.
First personal protection. In front of protective clothing, this clothing needs to be resistant to chemical corrosion to prevent its damage to the body. Wear protective gloves, the material should be selected to effectively block the reagent, such as nitrile rubber gloves, which can keep the hands and skin safe. Goggles are also indispensable, which can prevent the reagent from splashing into the eyes and avoid eye injuries.
Furthermore, the operating environment is crucial. It should be used in a well-ventilated place, and it is best to operate in a fume hood. In this way, volatile harmful gases can be quickly discharged, and the concentration in the air can be reduced, so as to prevent the operator from inhaling poisoning. At the same time, ensure that the operating table is clean, dry and flat, free of debris and water stains, in order to prevent the experiment from being affected, and to avoid accidents caused by the reaction of reagents with it.
When taking it, the action should be stable and accurate. Use clean and dry utensils to measure, and take it accurately according to the needs of the experiment. Do not take too much waste, and prevent the difficulty of handling the remaining reagents. If it is accidentally spilled, do not panic, and deal with it quickly according to the established procedures. If a small amount is spilled, it can be covered with inert adsorption materials such as sand and vermiculite, and then If a large amount of spills, it is necessary to evacuate the personnel, seal the scene, and notify the professionals to deal with it.
Storage is also exquisite. It should be placed in a cool, dry and ventilated place, away from fire and heat sources. Because it is easy to decompose when heated, it is dangerous. And it needs to be stored separately from oxidants and alkalis to avoid reactions between mixed storage. At the same time, the storage place should be equipped with suitable materials to contain leaks.
Furthermore, after use, the utensils must be cleaned in time. Rinse with a suitable organic solvent first to remove residual reagents, then rinse thoroughly with water and dry for later use. The waste generated by the experiment should not be discarded at will. It should be collected by classification and handed over to professional institutions for treatment. Follow environmental protection and safety regulations. Therefore, when using 3-chloro-2-fluorobenzenesulfonyl chloride, the personnel are safe, the experiment is smooth, and the environment is not damaged.
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