Linshang Chemical
PRODUCTS
3-Chloro-2-Fluorobromobenzene
Linshang Chemical
|
HS Code |
782412 |
| Chemical Formula | C6H3BrClF |
| Appearance | liquid (usually) |
| Solubility In Water | insoluble (organic compound, likely) |
| Solubility In Organic Solvents | soluble (common in organic solvents) |
| Hazard Class | flammable liquid (organic halide, potential) |
| Odor | characteristic, likely pungent |
As an accredited 3-Chloro-2-Fluorobromobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 - gram bottle packaging for 3 - chloro - 2 - fluorobromobenzene chemical. |
| Storage | Store 3 - chloro - 2 - fluorobromobenzene in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly closed container made of suitable materials like glass or metal to prevent leakage. It should be separated from oxidizing agents, acids, and bases to avoid potential reactions. Ensure proper labeling for easy identification and handling. |
| Shipping | 3 - Chloro - 2 - fluorobromobenzene is shipped in well - sealed, corrosion - resistant containers. It's handled with care during transport, following strict regulations for hazardous chemicals to prevent spills and ensure safety. |
Competitive 3-Chloro-2-Fluorobromobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 3-Chloro-2-Fluorobromobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemistry of 3-chloro-2-fluorobromobenzene?
3-Chloro-2-fluorobromobenzene is also an organic compound. Its molecule contains chlorine, fluorine, and bromine halogen atoms, and this structure gives it unique chemical properties.
On its chemical activity, due to the existence of halogen atoms, it can participate in a variety of reactions. Such as nucleophilic substitution reaction, halogen atoms can be replaced by nucleophilic reagents. Due to the strong electronegativity of fluorine atoms, the carbon-fluorine bond energy is large, and it is difficult to be replaced; while the carbon-halogen bond connected to chlorine and bromine is relatively active, nucleophilic reagents such as sodium alcohol and amines can react with it to form new carbon-oxygen and carbon-nitrogen bonds.
can also undergo metallization reaction and interact with metal reagents such as magnesium and lithium to form organometallic compounds. Such compounds can further react with electrophilic reagents such as carbonyl compounds to construct complex organic structures.
In the aromatic electrophilic substitution reaction, the halogen atom is an ortho-and para-localization group, which can change the electron cloud density on the benzene ring and affect the selectivity of the reaction check point. Due to the combined effect of electron-absorbing induction and electron-giving conjugation effects of fluorine, chlorine and bromine, the electrophilic reagents mostly attack the ortho-and para-sites of halogen atoms. However, due to the combined effect of steric hindrance and electronic effects, the ortho-and para-site reactivity of different halogen atoms
and 3-chloro-2-fluorobromobenzene contains multiple halogen atoms, which can undergo elimination reactions under some conditions, dehalide hydrogen, form unsaturated bonds, and then participate in subsequent rearrangements, addition and other reactions. It has important uses in the field of organic synthesis and can be used as a key intermediate to prepare a variety of complex organic molecules through a series of reactions.
On its chemical activity, due to the existence of halogen atoms, it can participate in a variety of reactions. Such as nucleophilic substitution reaction, halogen atoms can be replaced by nucleophilic reagents. Due to the strong electronegativity of fluorine atoms, the carbon-fluorine bond energy is large, and it is difficult to be replaced; while the carbon-halogen bond connected to chlorine and bromine is relatively active, nucleophilic reagents such as sodium alcohol and amines can react with it to form new carbon-oxygen and carbon-nitrogen bonds.
can also undergo metallization reaction and interact with metal reagents such as magnesium and lithium to form organometallic compounds. Such compounds can further react with electrophilic reagents such as carbonyl compounds to construct complex organic structures.
In the aromatic electrophilic substitution reaction, the halogen atom is an ortho-and para-localization group, which can change the electron cloud density on the benzene ring and affect the selectivity of the reaction check point. Due to the combined effect of electron-absorbing induction and electron-giving conjugation effects of fluorine, chlorine and bromine, the electrophilic reagents mostly attack the ortho-and para-sites of halogen atoms. However, due to the combined effect of steric hindrance and electronic effects, the ortho-and para-site reactivity of different halogen atoms
and 3-chloro-2-fluorobromobenzene contains multiple halogen atoms, which can undergo elimination reactions under some conditions, dehalide hydrogen, form unsaturated bonds, and then participate in subsequent rearrangements, addition and other reactions. It has important uses in the field of organic synthesis and can be used as a key intermediate to prepare a variety of complex organic molecules through a series of reactions.
What are the physical properties of 3-chloro-2-fluorobromobenzene?
3-Chloro-2-fluorobromobenzene is one of the organic compounds. Its physical properties are particularly important and related to chemical things.
Looking at its properties, under normal circumstances, 3-chloro-2-fluorobrobenzene is a colorless to light yellow liquid. Under sunlight, it is slightly glowing, like morning dew attached to the tip of grass, crystal clear and has a unique color. This color is not gaudy, but it shows the uniqueness of its molecular structure, which is also one of the key characteristics to distinguish this substance.
As for its smell, it has a special fragrance, not a fragrant aroma, but it has a unique charm and seems to be mixed with a faint bitterness. This smell originates from its complex combination of chlorine, fluorine, bromine atoms and benzene ring. Like the ancient secret fragrance, it is unique.
Its boiling point is quite worth exploring. After various experiments, it is determined that at a certain temperature range, this temperature makes the intermolecular force reach a critical point, causing it to gradually change from liquid to gaseous state. The value of the boiling point is like a key to open the method of separation and purification of this substance in the chemical process.
Melting point is also a key physical property. When the temperature drops to a certain value, the self-flowing state of 3-chloro-2-fluorobrobenzene gradually condenses into a solid state, and the molecular arrangement changes from disorder to order, like a soldier's array, in an orderly manner. The data of this melting point is an important basis for ensuring the stability of its morphology during storage and transportation.
The density of 3-chloro-2-fluorobrobenzene is heavier than that of water. If it is placed in one place with water, it will be like a stone sinking in water and slowly settling. This characteristic can be used to separate substances in operations such as extraction.
In terms of solubility, it can quite blend in organic solvents such as ethanol and ether, just like fish entering water, free. However, in water, it is insoluble, such as oil floating in water, and the boundaries are clear. This difference in solubility is an important consideration for the selection of suitable solvents in the process of chemical synthesis and product separation.
The physical properties of 3-chloro-2-fluorobromobenzene play a crucial role in the synthesis, separation, storage, transportation and other links of the chemical industry, such as silk veins, which run through the whole process of chemical production.
Looking at its properties, under normal circumstances, 3-chloro-2-fluorobrobenzene is a colorless to light yellow liquid. Under sunlight, it is slightly glowing, like morning dew attached to the tip of grass, crystal clear and has a unique color. This color is not gaudy, but it shows the uniqueness of its molecular structure, which is also one of the key characteristics to distinguish this substance.
As for its smell, it has a special fragrance, not a fragrant aroma, but it has a unique charm and seems to be mixed with a faint bitterness. This smell originates from its complex combination of chlorine, fluorine, bromine atoms and benzene ring. Like the ancient secret fragrance, it is unique.
Its boiling point is quite worth exploring. After various experiments, it is determined that at a certain temperature range, this temperature makes the intermolecular force reach a critical point, causing it to gradually change from liquid to gaseous state. The value of the boiling point is like a key to open the method of separation and purification of this substance in the chemical process.
Melting point is also a key physical property. When the temperature drops to a certain value, the self-flowing state of 3-chloro-2-fluorobrobenzene gradually condenses into a solid state, and the molecular arrangement changes from disorder to order, like a soldier's array, in an orderly manner. The data of this melting point is an important basis for ensuring the stability of its morphology during storage and transportation.
The density of 3-chloro-2-fluorobrobenzene is heavier than that of water. If it is placed in one place with water, it will be like a stone sinking in water and slowly settling. This characteristic can be used to separate substances in operations such as extraction.
In terms of solubility, it can quite blend in organic solvents such as ethanol and ether, just like fish entering water, free. However, in water, it is insoluble, such as oil floating in water, and the boundaries are clear. This difference in solubility is an important consideration for the selection of suitable solvents in the process of chemical synthesis and product separation.
The physical properties of 3-chloro-2-fluorobromobenzene play a crucial role in the synthesis, separation, storage, transportation and other links of the chemical industry, such as silk veins, which run through the whole process of chemical production.
What is 3-chloro-2-fluorobromobenzene synthesis method?
The synthesis of 3-chloro-2-fluorobromobenzene is a key issue in organic synthetic chemistry. To make this compound, several paths are often followed.
First, benzene is used as the starting material, and chlorine, fluorine and bromine atoms are introduced in sequence through halogenation reaction. First, benzene and chlorine under the action of ferric chloride and other catalysts undergo an electrophilic substitution reaction to obtain chlorobenzene. In this reaction, chlorine gas is polarized by the catalyst to generate chlorine positive ions, which attack the benzene ring electron cloud and are converted into chlorobenzene through intermediates.
Then, chlorobenzene is reacted with fluorine reagents. The fluorination reaction conditions are relatively harsh, and special catalysts and solvents are often required. For example, using fluorine-containing compounds, under a specific temperature and pressure, the chlorine atom is replaced by the fluorine atom to obtain 2-fluorochlorobenzene.
Finally, 2-fluorochlorobenzene reacts with a bromine reagent under suitable conditions. A brominating agent, such as N-bromosuccinimide (NBS), can be used to replace the hydrogen atom at a specific position on the benzene ring under the action of light or an initiator to generate the target product 3-chloro-2-fluorobromobenzene. This process involves a free radical reaction mechanism. The light or initiator prompts the brominating agent to produce a bromine free radical, attack the benzene ring, and complete the substitution through a series of steps.
Another strategy is to start with benzene derivatives containing specific substituents. If the starting material benzene ring already has some desired substituents, the target can be achieved by functional group conversion and further halogenation. For example, selecting suitable phenolic derivatives, first converting the hydroxyl group into a suitable leaving group, and then introducing chlorine, fluorine and bromine atoms through halogenation reaction. After multi-step reaction, the reaction conditions and reagents are finely adjusted to obtain high-purity 3-chloro-2-fluorobromobenzene. This method requires a deep understanding of functional group conversion chemistry and precise control of the selectivity and yield of each step.
First, benzene is used as the starting material, and chlorine, fluorine and bromine atoms are introduced in sequence through halogenation reaction. First, benzene and chlorine under the action of ferric chloride and other catalysts undergo an electrophilic substitution reaction to obtain chlorobenzene. In this reaction, chlorine gas is polarized by the catalyst to generate chlorine positive ions, which attack the benzene ring electron cloud and are converted into chlorobenzene through intermediates.
Then, chlorobenzene is reacted with fluorine reagents. The fluorination reaction conditions are relatively harsh, and special catalysts and solvents are often required. For example, using fluorine-containing compounds, under a specific temperature and pressure, the chlorine atom is replaced by the fluorine atom to obtain 2-fluorochlorobenzene.
Finally, 2-fluorochlorobenzene reacts with a bromine reagent under suitable conditions. A brominating agent, such as N-bromosuccinimide (NBS), can be used to replace the hydrogen atom at a specific position on the benzene ring under the action of light or an initiator to generate the target product 3-chloro-2-fluorobromobenzene. This process involves a free radical reaction mechanism. The light or initiator prompts the brominating agent to produce a bromine free radical, attack the benzene ring, and complete the substitution through a series of steps.
Another strategy is to start with benzene derivatives containing specific substituents. If the starting material benzene ring already has some desired substituents, the target can be achieved by functional group conversion and further halogenation. For example, selecting suitable phenolic derivatives, first converting the hydroxyl group into a suitable leaving group, and then introducing chlorine, fluorine and bromine atoms through halogenation reaction. After multi-step reaction, the reaction conditions and reagents are finely adjusted to obtain high-purity 3-chloro-2-fluorobromobenzene. This method requires a deep understanding of functional group conversion chemistry and precise control of the selectivity and yield of each step.
What are the main uses of 3-chloro-2-fluorobromobenzene?
3-Chloro-2-fluorobromobenzene is one of the organic compounds. It has a wide range of main uses and is involved in various fields.
In the field of organic synthesis, this compound is often used as a key intermediate. The technique of organic synthesis aims to carefully construct various organic molecules. With its unique structure, 3-chloro-2-fluorobrobenzene can be derived from a variety of chemical reactions, such as nucleophilic substitution and metal-catalyzed coupling reactions. Many organic compounds with different properties and functions can be derived. For example, in the field of medicinal chemistry, chemists can create drug lead compounds with novel structures and potential biological activities by ingeniously modifying and transforming functional groups at specific locations based on this compound. After a series of reactions, various active groups, such as nitrogen-containing heterocycles, hydroxyl groups, carboxyl groups, etc. can be introduced on its benzene ring, and then its effect on specific disease targets can be explored through pharmacological tests, hoping to develop new drugs with excellent efficacy.
In the field of materials science, 3-chloro-2-fluorobromobenzene also has important functions. Materials research and development often requires organic compounds with specific structures as the cornerstone for the preparation of materials with unique properties. Polymer materials with special electrical, optical or thermal properties can be prepared from this compound as a starting material, or through polymerization. For example, by controlling the reaction conditions and introducing other comonomers, polymers with excellent photoelectric conversion properties can be synthesized, which are expected to be applied in organic solar cells and other fields, contributing to the development of renewable energy.
Furthermore, in the fine chemical industry, 3-chloro-2-fluorobromobenzene is also an important raw material for the preparation of many fine chemicals. Fine chemicals cover many categories such as fragrances, dyes, and additives. For example, in the process of dye preparation, the structural characteristics of this compound can be used to synthesize dyes with unique color and good dyeing properties through appropriate chemical modification, so as to meet the needs of high-quality dyes in textile, printing and dyeing industries. In fragrance synthesis, it may be used as a key structural fragment to react with other fragrance intermediates to prepare flavor-specific fragrance products for use in food, cosmetics and other industries to improve the sensory quality of products.
In the field of organic synthesis, this compound is often used as a key intermediate. The technique of organic synthesis aims to carefully construct various organic molecules. With its unique structure, 3-chloro-2-fluorobrobenzene can be derived from a variety of chemical reactions, such as nucleophilic substitution and metal-catalyzed coupling reactions. Many organic compounds with different properties and functions can be derived. For example, in the field of medicinal chemistry, chemists can create drug lead compounds with novel structures and potential biological activities by ingeniously modifying and transforming functional groups at specific locations based on this compound. After a series of reactions, various active groups, such as nitrogen-containing heterocycles, hydroxyl groups, carboxyl groups, etc. can be introduced on its benzene ring, and then its effect on specific disease targets can be explored through pharmacological tests, hoping to develop new drugs with excellent efficacy.
In the field of materials science, 3-chloro-2-fluorobromobenzene also has important functions. Materials research and development often requires organic compounds with specific structures as the cornerstone for the preparation of materials with unique properties. Polymer materials with special electrical, optical or thermal properties can be prepared from this compound as a starting material, or through polymerization. For example, by controlling the reaction conditions and introducing other comonomers, polymers with excellent photoelectric conversion properties can be synthesized, which are expected to be applied in organic solar cells and other fields, contributing to the development of renewable energy.
Furthermore, in the fine chemical industry, 3-chloro-2-fluorobromobenzene is also an important raw material for the preparation of many fine chemicals. Fine chemicals cover many categories such as fragrances, dyes, and additives. For example, in the process of dye preparation, the structural characteristics of this compound can be used to synthesize dyes with unique color and good dyeing properties through appropriate chemical modification, so as to meet the needs of high-quality dyes in textile, printing and dyeing industries. In fragrance synthesis, it may be used as a key structural fragment to react with other fragrance intermediates to prepare flavor-specific fragrance products for use in food, cosmetics and other industries to improve the sensory quality of products.
What are the precautions in storage and transportation of 3-chloro-2-fluorobromobenzene?
3-Chloro-2-fluorobromobenzene is also an organic compound. When storing and transporting, pay attention to many matters to ensure its safety.
First words storage. This compound is more active and should be stored in a cool and ventilated place. The reaction will intensify due to heat, or even cause dangerous accidents. The temperature of the warehouse should not be too high, and it should be kept away from fires and heat sources. It should be stored separately from oxidizing agents and alkalis, and must not be mixed. When this compound encounters oxidizing agents or alkalis, it is easy to cause chemical reactions, or cause explosions, burns and other disasters. The storage place should also be equipped with suitable materials to contain leaks, so that it can be disposed of in time to prevent accidents.
Times and transportation. Before transportation, it is necessary to ensure that the packaging is complete and the loading is safe. The packaging must comply with relevant regulations to prevent material leakage due to damage in transit. During transportation, the speed should not be too fast, and do not brake suddenly to avoid packaging damage due to vibration and collision. Transportation vehicles should be equipped with corresponding fire equipment and leakage emergency treatment equipment, just in case. And when transporting, it is strictly forbidden to transport by car with oxidants and alkalis to avoid interaction and health risks.
Furthermore, regardless of storage or transportation, the operators should have professional knowledge and skills, familiar with the characteristics of this compound and emergency response methods. When operating, it is necessary to strictly abide by the operating procedures and wear appropriate protective equipment, such as protective glasses, gloves, etc., to protect their own safety.
In short, in the storage and transportation of 3-chloro-2-fluorobromobenzene, it is necessary to be cautious, pay attention to all details, and strictly abide by relevant regulations, so as to ensure the safety of the process and avoid disasters.
First words storage. This compound is more active and should be stored in a cool and ventilated place. The reaction will intensify due to heat, or even cause dangerous accidents. The temperature of the warehouse should not be too high, and it should be kept away from fires and heat sources. It should be stored separately from oxidizing agents and alkalis, and must not be mixed. When this compound encounters oxidizing agents or alkalis, it is easy to cause chemical reactions, or cause explosions, burns and other disasters. The storage place should also be equipped with suitable materials to contain leaks, so that it can be disposed of in time to prevent accidents.
Times and transportation. Before transportation, it is necessary to ensure that the packaging is complete and the loading is safe. The packaging must comply with relevant regulations to prevent material leakage due to damage in transit. During transportation, the speed should not be too fast, and do not brake suddenly to avoid packaging damage due to vibration and collision. Transportation vehicles should be equipped with corresponding fire equipment and leakage emergency treatment equipment, just in case. And when transporting, it is strictly forbidden to transport by car with oxidants and alkalis to avoid interaction and health risks.
Furthermore, regardless of storage or transportation, the operators should have professional knowledge and skills, familiar with the characteristics of this compound and emergency response methods. When operating, it is necessary to strictly abide by the operating procedures and wear appropriate protective equipment, such as protective glasses, gloves, etc., to protect their own safety.
In short, in the storage and transportation of 3-chloro-2-fluorobromobenzene, it is necessary to be cautious, pay attention to all details, and strictly abide by relevant regulations, so as to ensure the safety of the process and avoid disasters.
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