Linshang Chemical
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3-Chloro-2-Fluoronitrobenzene
Linshang Chemical
|
HS Code |
732336 |
| Chemical Formula | C6H3ClFNO2 |
| Molar Mass | 177.545 g/mol |
| Appearance | Yellow - brown liquid or solid |
| Boiling Point | Approximately 243 - 245 °C |
| Melting Point | 16 - 18 °C |
| Density | 1.498 g/cm³ (estimated for liquid state) |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in many organic solvents like ethanol, ether |
| Flash Point | 100 °C (closed cup, estimated) |
| Vapor Pressure | Low, due to relatively high boiling point |
As an accredited 3-Chloro-2-Fluoronitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 3 - chloro - 2 - fluoronitrobenzene packaged in a sealed, corrosion - resistant container. |
| Storage | 3 - Chloro - 2 - fluoronitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition points. It must be stored separately from oxidizing agents, reducing agents, and bases due to potential chemical reactions. Keep it in tightly sealed containers to prevent leakage and vapor release, and ensure storage areas comply with safety regulations. |
| Shipping | 3 - Chloro - 2 - fluoronitrobenzene is a chemical. It should be shipped in well - sealed, corrosion - resistant containers. Follow proper hazardous material shipping regulations, with appropriate labeling for its toxic and reactive nature. |
Competitive 3-Chloro-2-Fluoronitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 3-Chloro-2-Fluoronitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 3-chloro-2-fluoronitrobenzene?
3-Chloro-2-fluoronitrobenzene is an important intermediate in organic synthesis. It has a wide range of uses and plays a key role in many fields.
First, in the field of pharmaceutical synthesis, it is often used as a raw material for the preparation of various specific drugs. Due to its unique chemical structure, it can participate in a variety of reactions to build a drug activity skeleton. For example, in the synthesis of some antibacterial and antiviral drugs, 3-chloro-2-fluoronitrobenzene can introduce key functional groups through specific chemical reactions, and then shape the effective structure of the drug, so that it has good pharmacological activity and contributes greatly to human health.
Second, it is also indispensable in the creation of pesticides. Using it as the starting material, it can synthesize a variety of high-efficiency, low-toxicity and environmentally friendly pesticides. With precise chemical modification, pesticides are endowed with excellent insecticidal, bactericidal or weeding properties, ensuring the thriving growth of crops, improving agricultural production efficiency, and safeguarding food security.
Third, in the field of materials science, 3-chloro-2-fluoronitrobenzene also has outstanding performance. It can be used to prepare high-performance polymer materials. After clever polymerization, its structural units are integrated into the polymer chain to improve the thermal stability, mechanical properties and other characteristics of the material, so as to meet the strict requirements of special materials in high-end fields such as aerospace and electronics.
Furthermore, in the dye industry, it also plays an important role. As a precursor to synthesizing new dyes, it can build a rich and diverse hair color system through a series of chemical transformations, endowing dyes with excellent color fastness, vividness and other characteristics, and is widely used in textile, printing and dyeing industries to add gorgeous colors to people's lives.
In summary, 3-chloro-2-fluoronitrobenzene occupies an important position in many industries such as medicine, pesticides, materials and dyes due to its special chemical structure and reactivity, promoting technological innovation and development in various fields.
First, in the field of pharmaceutical synthesis, it is often used as a raw material for the preparation of various specific drugs. Due to its unique chemical structure, it can participate in a variety of reactions to build a drug activity skeleton. For example, in the synthesis of some antibacterial and antiviral drugs, 3-chloro-2-fluoronitrobenzene can introduce key functional groups through specific chemical reactions, and then shape the effective structure of the drug, so that it has good pharmacological activity and contributes greatly to human health.
Second, it is also indispensable in the creation of pesticides. Using it as the starting material, it can synthesize a variety of high-efficiency, low-toxicity and environmentally friendly pesticides. With precise chemical modification, pesticides are endowed with excellent insecticidal, bactericidal or weeding properties, ensuring the thriving growth of crops, improving agricultural production efficiency, and safeguarding food security.
Third, in the field of materials science, 3-chloro-2-fluoronitrobenzene also has outstanding performance. It can be used to prepare high-performance polymer materials. After clever polymerization, its structural units are integrated into the polymer chain to improve the thermal stability, mechanical properties and other characteristics of the material, so as to meet the strict requirements of special materials in high-end fields such as aerospace and electronics.
Furthermore, in the dye industry, it also plays an important role. As a precursor to synthesizing new dyes, it can build a rich and diverse hair color system through a series of chemical transformations, endowing dyes with excellent color fastness, vividness and other characteristics, and is widely used in textile, printing and dyeing industries to add gorgeous colors to people's lives.
In summary, 3-chloro-2-fluoronitrobenzene occupies an important position in many industries such as medicine, pesticides, materials and dyes due to its special chemical structure and reactivity, promoting technological innovation and development in various fields.
What are the physical properties of 3-chloro-2-fluoronitrobenzene?
3-Chloro-2-fluoronitrobenzene is one of the organic compounds. Its physical properties are quite important, let me tell them one by one.
First of all, its appearance, at room temperature, is mostly a light yellow to brown liquid, and its color is unique and has a certain degree of recognition.
Second and boiling point, the boiling point of this substance is about 230-235 ℃. At the boiling point, the temperature limit for the substance to change from liquid to gaseous state. At this temperature, the 3-chloro-2-fluoronitrobenzene molecule is sufficiently energized to break free from the liquid phase and rise into a gaseous state.
Furthermore, the melting point is about -10 ° C. The melting point is the critical temperature at which a substance changes from solid to liquid. When the ambient temperature rises above the melting point, the substance gradually fuses from solid to liquid.
When it comes to density, it is about 1.55 g/cm ³. For density, it is a physical quantity that characterizes the mass of a substance per unit volume. This density value shows that it is heavier than water. If placed in water, it will sink to the bottom.
Solubility is also an important property. 3-Chloro-2-fluoronitrobenzene is slightly soluble in water because its molecular structure contains chlorine, fluorine, nitro and other groups, and the interaction between water molecules is weak, so it is difficult to dissolve in the polar water phase. However, it is soluble in organic solvents such as ethanol, ether, acetone, etc. Because these organic solvents and the molecules of the substance can form a similar force, following the principle of "similar phase dissolution".
In addition, the substance has a certain volatility, which can slowly evaporate in the air and emit a special odor. And because it contains nitro and other groups, the relative density of its vapor is greater than that of air, and the vapor is easy to deposit in low places.
All these physical properties are of great significance in the fields of chemical production, scientific research experiments, etc., and are also related to the methods of storage, transportation, and use of the substance.
First of all, its appearance, at room temperature, is mostly a light yellow to brown liquid, and its color is unique and has a certain degree of recognition.
Second and boiling point, the boiling point of this substance is about 230-235 ℃. At the boiling point, the temperature limit for the substance to change from liquid to gaseous state. At this temperature, the 3-chloro-2-fluoronitrobenzene molecule is sufficiently energized to break free from the liquid phase and rise into a gaseous state.
Furthermore, the melting point is about -10 ° C. The melting point is the critical temperature at which a substance changes from solid to liquid. When the ambient temperature rises above the melting point, the substance gradually fuses from solid to liquid.
When it comes to density, it is about 1.55 g/cm ³. For density, it is a physical quantity that characterizes the mass of a substance per unit volume. This density value shows that it is heavier than water. If placed in water, it will sink to the bottom.
Solubility is also an important property. 3-Chloro-2-fluoronitrobenzene is slightly soluble in water because its molecular structure contains chlorine, fluorine, nitro and other groups, and the interaction between water molecules is weak, so it is difficult to dissolve in the polar water phase. However, it is soluble in organic solvents such as ethanol, ether, acetone, etc. Because these organic solvents and the molecules of the substance can form a similar force, following the principle of "similar phase dissolution".
In addition, the substance has a certain volatility, which can slowly evaporate in the air and emit a special odor. And because it contains nitro and other groups, the relative density of its vapor is greater than that of air, and the vapor is easy to deposit in low places.
All these physical properties are of great significance in the fields of chemical production, scientific research experiments, etc., and are also related to the methods of storage, transportation, and use of the substance.
What is the chemistry of 3-chloro-2-fluoronitrobenzene?
3-Chloro-2-fluoronitrobenzene is one of the organic compounds. Its chemical properties are particularly important and it has a wide range of uses in the field of organic synthesis. This compound has functional groups such as chlorine, fluorine, and nitro, and each functional group is endowed with its unique properties.
First of all, nitro, nitro is a strong electron-absorbing group, which can greatly reduce the electron cloud density of the benzene ring, resulting in a decrease in the electrophilic substitution activity of the benzene ring, while the nucleophilic substitution activity increases. If it encounters a nucleophilic reagent, the carbon atoms of the nitro o-o and para-position are easily attacked by the nucleophilic reagent, which leads to the occurrence of nucleophilic substitution reactions.
Furthermore, the chlorine atom and the fluorine atom are both halogen atoms, but the fluorine Although they are both ortho and para-localizers on the benzene ring, they have different effects on the electron cloud density of the benzene ring due to electronegativity differences. Fluorine atoms have a strong electron-withdrawing induction effect, which reduces the electron cloud density of the benzene ring more than chlorine atoms, which also affects the reactivity and selectivity of compounds.
3-chloro-2-fluoronitrobenzene When encountering nucleophiles, halogen atoms can be replaced by nucleophiles. For example, when interacting with nucleophiles such as sodium alcohol and amines, halogen atoms can be replaced by alkoxy groups, amino groups, etc., which are widely used in the reaction of constructing carbon-heteroatomic bonds. And because of its multiple functional groups, it can selectively react with a functional group through suitable reaction conditions to achieve a specific synthesis target.
Its stability is also affected by the interaction of functional groups. The presence of nitro and halogen atoms makes the distribution of electron clouds in molecules uneven. However, under normal conditions, if there is no specific reagent or condition to initiate the reaction, it can still maintain a certain stability. However, in case of extreme conditions such as high temperature, strong alkali, and strong oxidant, violent reactions may occur.
In organic synthesis, 3-chloro-2-fluoronitrobenzene can be used as a key intermediate. After a series of reactions, many bioactive compounds and pharmaceutical intermediates can be prepared, which are of great value in many fields such as medicine, pesticides, and materials science.
First of all, nitro, nitro is a strong electron-absorbing group, which can greatly reduce the electron cloud density of the benzene ring, resulting in a decrease in the electrophilic substitution activity of the benzene ring, while the nucleophilic substitution activity increases. If it encounters a nucleophilic reagent, the carbon atoms of the nitro o-o and para-position are easily attacked by the nucleophilic reagent, which leads to the occurrence of nucleophilic substitution reactions.
Furthermore, the chlorine atom and the fluorine atom are both halogen atoms, but the fluorine Although they are both ortho and para-localizers on the benzene ring, they have different effects on the electron cloud density of the benzene ring due to electronegativity differences. Fluorine atoms have a strong electron-withdrawing induction effect, which reduces the electron cloud density of the benzene ring more than chlorine atoms, which also affects the reactivity and selectivity of compounds.
3-chloro-2-fluoronitrobenzene When encountering nucleophiles, halogen atoms can be replaced by nucleophiles. For example, when interacting with nucleophiles such as sodium alcohol and amines, halogen atoms can be replaced by alkoxy groups, amino groups, etc., which are widely used in the reaction of constructing carbon-heteroatomic bonds. And because of its multiple functional groups, it can selectively react with a functional group through suitable reaction conditions to achieve a specific synthesis target.
Its stability is also affected by the interaction of functional groups. The presence of nitro and halogen atoms makes the distribution of electron clouds in molecules uneven. However, under normal conditions, if there is no specific reagent or condition to initiate the reaction, it can still maintain a certain stability. However, in case of extreme conditions such as high temperature, strong alkali, and strong oxidant, violent reactions may occur.
In organic synthesis, 3-chloro-2-fluoronitrobenzene can be used as a key intermediate. After a series of reactions, many bioactive compounds and pharmaceutical intermediates can be prepared, which are of great value in many fields such as medicine, pesticides, and materials science.
What are 3-chloro-2-fluoronitrobenzene synthesis methods?
The synthesis of 3-chloro-2-fluoronitrobenzene follows several paths. First, it can be started from halogenated aromatics. Chlorobenzene is used as the substrate, and the nitro group is introduced into the benzene ring through nitration reaction. This step requires a mixed acid system of nitric acid and sulfuric acid to react at a suitable temperature to obtain a mixture of o-nitrochlorobenzene and p-nitrochlorobenzene. However, due to ortho-spatial resistance, p-nitrochlorobenzene is the main product. Then, by means of fractionation or crystallization, o-nitrochlorobenzene is separated. Then o-nitrochlorobenzene and fluorinated reagents, such as potassium fluoride, are reacted in polar aprotic solvents, such as dimethyl sulfoxide (DMSO), at high temperature, so that the chlorine atom is replaced by the fluorine atom, thereby obtaining 3-chloro-2-fluoronitrobenzene.
Second, using fluorobenzene as the starting material, the nitro group is also introduced through the nitrification reaction to obtain a mixture of o-nitrofluorobenzene and p-nitrofluorobenzene. Subsequent separation of o-nitrofluorobenzene is also required, and then reacts with chlorinated reagents, such as sulfoxide chloride, in the presence of appropriate catalysts, so that chlorine atoms are introduced at specific positions on the benzene ring, and the target product 3-
Third, consider using m-chloroaniline as a raw material, first through diazotization reaction, sodium nitrite and hydrochloric acid are treated with m-chloroaniline at low temperature to form diazonium salts. Subsequently, fluoroborate acid is added to form fluoroborate precipitation. After heating decomposition, a Sandmeier reaction occurs, and the diazonium group is replaced by a fluorine atom to obtain m-chlorofluorobenzene. Then the m-chlorofluorobenzene is nitrified, and the nitro group is introduced to obtain 3-chloro-2-fluoronitrobenzene. These many methods have their own advantages and disadvantages. The actual synthesis needs to be weighed according to factors such as raw material availability, cost, yield and difficulty of operation.
Second, using fluorobenzene as the starting material, the nitro group is also introduced through the nitrification reaction to obtain a mixture of o-nitrofluorobenzene and p-nitrofluorobenzene. Subsequent separation of o-nitrofluorobenzene is also required, and then reacts with chlorinated reagents, such as sulfoxide chloride, in the presence of appropriate catalysts, so that chlorine atoms are introduced at specific positions on the benzene ring, and the target product 3-
Third, consider using m-chloroaniline as a raw material, first through diazotization reaction, sodium nitrite and hydrochloric acid are treated with m-chloroaniline at low temperature to form diazonium salts. Subsequently, fluoroborate acid is added to form fluoroborate precipitation. After heating decomposition, a Sandmeier reaction occurs, and the diazonium group is replaced by a fluorine atom to obtain m-chlorofluorobenzene. Then the m-chlorofluorobenzene is nitrified, and the nitro group is introduced to obtain 3-chloro-2-fluoronitrobenzene. These many methods have their own advantages and disadvantages. The actual synthesis needs to be weighed according to factors such as raw material availability, cost, yield and difficulty of operation.
3-chloro-2-fluoronitrobenzene What are the precautions during storage and transportation?
3-Chloro-2-fluoronitrobenzene is an important raw material in organic synthesis. During storage and transportation, many key matters need to be paid attention to to in order to ensure safety and maintain its stable quality.
First words storage, this substance should be placed in a cool and well-ventilated warehouse. Due to the high temperature in the warehouse, or the acceleration of its chemical reaction rate, the stability will be reduced, and even dangerous conditions may occur. And good ventilation can effectively avoid the accumulation of volatile gases to prevent the formation of flammable and explosive mixed gases. The humidity in the warehouse also needs to be strictly controlled to avoid excessive humidity, which will affect the quality due to humid environment or adverse reactions such as hydrolysis.
Furthermore, when storing, it should be stored separately from oxidizing agents, reducing agents, alkalis, etc., and must not be mixed. Gein 3-chloro-2-fluoronitrobenzene and these substances are prone to violent chemical reactions, or cause serious accidents such as fire and explosion. The storage place should be equipped with suitable materials to contain the leakage. Once the leakage occurs, it can be dealt with in time to prevent the spread of pollution.
As for transportation, it is necessary to strictly follow the relevant regulations on the transportation of dangerous chemicals. The transportation vehicle must have corresponding safety facilities, such as fire prevention and explosion-proof devices, to prevent accidents during transportation. During transportation, ensure that the container does not leak, collapse, fall, or damage. When handling, it should be handled lightly, and it must not be loaded and unloaded brutally, so as not to cause damage to the package and cause leakage. During transportation, it should be avoided from exposure to the sun, rain, and high temperature. If the transportation time is long or the road is bumpy, it is necessary to strengthen the inspection to ensure the safety of the goods. Escorts also need to be familiar with the characteristics of 3-chloro-2-fluoronitrobenzene and emergency treatment methods. In the event of an emergency, they can be disposed of quickly and properly.
First words storage, this substance should be placed in a cool and well-ventilated warehouse. Due to the high temperature in the warehouse, or the acceleration of its chemical reaction rate, the stability will be reduced, and even dangerous conditions may occur. And good ventilation can effectively avoid the accumulation of volatile gases to prevent the formation of flammable and explosive mixed gases. The humidity in the warehouse also needs to be strictly controlled to avoid excessive humidity, which will affect the quality due to humid environment or adverse reactions such as hydrolysis.
Furthermore, when storing, it should be stored separately from oxidizing agents, reducing agents, alkalis, etc., and must not be mixed. Gein 3-chloro-2-fluoronitrobenzene and these substances are prone to violent chemical reactions, or cause serious accidents such as fire and explosion. The storage place should be equipped with suitable materials to contain the leakage. Once the leakage occurs, it can be dealt with in time to prevent the spread of pollution.
As for transportation, it is necessary to strictly follow the relevant regulations on the transportation of dangerous chemicals. The transportation vehicle must have corresponding safety facilities, such as fire prevention and explosion-proof devices, to prevent accidents during transportation. During transportation, ensure that the container does not leak, collapse, fall, or damage. When handling, it should be handled lightly, and it must not be loaded and unloaded brutally, so as not to cause damage to the package and cause leakage. During transportation, it should be avoided from exposure to the sun, rain, and high temperature. If the transportation time is long or the road is bumpy, it is necessary to strengthen the inspection to ensure the safety of the goods. Escorts also need to be familiar with the characteristics of 3-chloro-2-fluoronitrobenzene and emergency treatment methods. In the event of an emergency, they can be disposed of quickly and properly.
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