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3-Chloro-2-Methylbenzenesulfonyl Chloride
Linshang Chemical
|
HS Code |
422339 |
| Name | 3-Chloro-2-Methylbenzenesulfonyl Chloride |
| Chemical Formula | C7H6Cl2O2S |
| Molar Mass | 225.09 g/mol |
| Appearance | A colorless to light yellow liquid |
| Boiling Point | Around 278 - 280 °C |
| Density | Typically around 1.4 - 1.5 g/cm³ |
| Solubility | Soluble in organic solvents like dichloromethane, less soluble in water |
| Flash Point | Relatively high, due to its structure and boiling point |
| Hazard Class | Corrosive, can cause burns to skin and eyes |
As an accredited 3-Chloro-2-Methylbenzenesulfonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 kg of 3 - chloro - 2 - methylbenzenesulfonyl chloride packaged in a sealed, corrosion - resistant container. |
| Storage | 3 - Chloro - 2 - methylbenzenesulfonyl chloride should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. It must be kept in a tightly - sealed container, preferably made of corrosion - resistant materials, as it is reactive and can hydrolyze in the presence of moisture. Store it separately from incompatible substances like bases, amines, and water - containing materials to prevent dangerous reactions. |
| Shipping | 3 - Chloro - 2 - methylbenzenesulfonyl chloride, a hazardous chemical, is shipped in tightly sealed, corrosion - resistant containers. It's transported under regulated conditions, following safety protocols to prevent spills and ensure safe transit. |
Competitive 3-Chloro-2-Methylbenzenesulfonyl Chloride prices that fit your budget—flexible terms and customized quotes for every order.
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What are the main uses of 3-chloro-2-methylbenzenesulfonyl Chloride?
3-Chloro-2-methylbenzenesulfonyl chloride is an important chemical raw material in organic synthesis. It has a wide range of uses and has significant applications in many fields.
First, in the field of pharmaceutical chemistry, it is often a key intermediate. The structure of benzenesulfonyl chloride has unique reactivity, and it can be substituted with various nitrogenous and oxygen-containing nucleophiles through many chemical reactions to construct complex drug molecular structures. For example, it can react with specific amine compounds to form sulfonamide derivatives. Some sulfonamide compounds have pharmacological activities such as antibacterial and anti-inflammatory, which are of great significance in the preparation of drug research and development.
Second, it also plays an important role in the field of materials science. It can participate in the synthesis of polymer materials. For example, when reacting with polymer monomers containing hydroxyl or amino groups, benzenesulfonyl chloride groups are introduced through polymerization to improve the properties of polymer materials, such as improving the heat resistance and chemical stability of materials. At the same time, the coating materials formed by its derivatives can exhibit good anti-corrosion and wear resistance under certain special environments, and are widely used in metal protection, machinery manufacturing and other industries.
Furthermore, in the field of pesticide chemistry, 3-chloro-2-methylbenzenesulfonyl chloride is also a commonly used synthetic raw material. Through a reasonable reaction design, it can be converted into pesticide ingredients with biological activities such as insecticides and weeds. Its special chemical structure enables the synthesized pesticides to have efficient inhibition or killing effects on specific pests or weeds, and some products have good environmental compatibility, which meets the development needs of modern green pesticides.
In summary, 3-chloro-2-methylbenzenesulfonyl chloride, with its unique chemical properties, is an indispensable and important raw material in many fields such as medicine, materials, and pesticides, and has made great contributions to promoting the development of related industries.
First, in the field of pharmaceutical chemistry, it is often a key intermediate. The structure of benzenesulfonyl chloride has unique reactivity, and it can be substituted with various nitrogenous and oxygen-containing nucleophiles through many chemical reactions to construct complex drug molecular structures. For example, it can react with specific amine compounds to form sulfonamide derivatives. Some sulfonamide compounds have pharmacological activities such as antibacterial and anti-inflammatory, which are of great significance in the preparation of drug research and development.
Second, it also plays an important role in the field of materials science. It can participate in the synthesis of polymer materials. For example, when reacting with polymer monomers containing hydroxyl or amino groups, benzenesulfonyl chloride groups are introduced through polymerization to improve the properties of polymer materials, such as improving the heat resistance and chemical stability of materials. At the same time, the coating materials formed by its derivatives can exhibit good anti-corrosion and wear resistance under certain special environments, and are widely used in metal protection, machinery manufacturing and other industries.
Furthermore, in the field of pesticide chemistry, 3-chloro-2-methylbenzenesulfonyl chloride is also a commonly used synthetic raw material. Through a reasonable reaction design, it can be converted into pesticide ingredients with biological activities such as insecticides and weeds. Its special chemical structure enables the synthesized pesticides to have efficient inhibition or killing effects on specific pests or weeds, and some products have good environmental compatibility, which meets the development needs of modern green pesticides.
In summary, 3-chloro-2-methylbenzenesulfonyl chloride, with its unique chemical properties, is an indispensable and important raw material in many fields such as medicine, materials, and pesticides, and has made great contributions to promoting the development of related industries.
What are the physical properties of 3-chloro-2-methylbenzenesulfonyl Chloride?
3-Chloro-2-methylbenzenesulfonyl chloride, this is an organic compound with unique physical properties. Its appearance is usually colorless to light yellow liquid, with a clear texture and certain fluidity.
Looking at its color, colorless to light yellow state reflects the light absorption and scattering characteristics of the molecular structure. The compound is liquid at room temperature and pressure, indicating that the intermolecular forces are in a specific range, allowing the molecules to move relatively freely.
Smell, has a pungent odor, which is derived from the chlorine atoms and sulfonyl chloride groups it contains. These groups are highly chemically active and easily interact with olfactory receptors in the nasal cavity, causing irritating odors.
When it comes to volatility, there is a certain degree of volatility at room temperature, and the molecules are constantly moving. Some molecules break free from the liquid phase and enter the gas phase. This property requires caution when storing and using, because it evaporates in the air, or affects the environment and human health.
Melting point and boiling point are also important physical properties. The melting point determines the temperature at which it changes from a solid state to a liquid state, and the boiling point is the temperature at which the liquid state converts to a gas state. The melting point and boiling point of this compound are determined by intermolecular forces, such as van der Waals forces and hydrogen bonds. The specific melting point and boiling point values need to be accurately determined by experiments. However, generally speaking, the boiling point of compounds containing such groups is relatively high. Due to the strong intermolecular forces, more energy is required to overcome them, so that the molecules can be separated and converted into a gaseous state. In terms of solubility, it is generally insoluble in water. Due to its molecular structure, the benzene ring is a hydrophobic group, and the sulfonyl chloride group has a certain polarity, but the overall interaction with water molecules is weak, and it is difficult to form stable hydrogen bonds or other strong interactions with water, so the solubility in water is low. But it is soluble in some organic solvents, such as dichloromethane, chloroform, ether, etc. These organic solvents and 3-chloro-2-methylbenzenesulfonyl chloride molecules can form similar intermolecular forces, such as van der Waals forces, to achieve mutual solubility.
density is another physical property. Compared with water, the density is greater than that of water. If accidentally mixed with water, it will sink to the bottom of the water. This property is of great significance when treating wastewater containing this compound or conducting related experimental operations.
Looking at its color, colorless to light yellow state reflects the light absorption and scattering characteristics of the molecular structure. The compound is liquid at room temperature and pressure, indicating that the intermolecular forces are in a specific range, allowing the molecules to move relatively freely.
Smell, has a pungent odor, which is derived from the chlorine atoms and sulfonyl chloride groups it contains. These groups are highly chemically active and easily interact with olfactory receptors in the nasal cavity, causing irritating odors.
When it comes to volatility, there is a certain degree of volatility at room temperature, and the molecules are constantly moving. Some molecules break free from the liquid phase and enter the gas phase. This property requires caution when storing and using, because it evaporates in the air, or affects the environment and human health.
Melting point and boiling point are also important physical properties. The melting point determines the temperature at which it changes from a solid state to a liquid state, and the boiling point is the temperature at which the liquid state converts to a gas state. The melting point and boiling point of this compound are determined by intermolecular forces, such as van der Waals forces and hydrogen bonds. The specific melting point and boiling point values need to be accurately determined by experiments. However, generally speaking, the boiling point of compounds containing such groups is relatively high. Due to the strong intermolecular forces, more energy is required to overcome them, so that the molecules can be separated and converted into a gaseous state. In terms of solubility, it is generally insoluble in water. Due to its molecular structure, the benzene ring is a hydrophobic group, and the sulfonyl chloride group has a certain polarity, but the overall interaction with water molecules is weak, and it is difficult to form stable hydrogen bonds or other strong interactions with water, so the solubility in water is low. But it is soluble in some organic solvents, such as dichloromethane, chloroform, ether, etc. These organic solvents and 3-chloro-2-methylbenzenesulfonyl chloride molecules can form similar intermolecular forces, such as van der Waals forces, to achieve mutual solubility.
density is another physical property. Compared with water, the density is greater than that of water. If accidentally mixed with water, it will sink to the bottom of the water. This property is of great significance when treating wastewater containing this compound or conducting related experimental operations.
What are the chemical properties of 3-chloro-2-methylbenzenesulfonyl Chloride?
3-Chloro-2-methylbenzenesulfonyl chloride, which has strong physical properties and unique chemical properties, has multiple significant chemical properties.
Its activity is abnormal, and the sulfonyl chloride group (-SO 2O Cl) is extremely active. When hydrolyzed, the chlorine atom in the sulfonyl chloride group is replaced by a hydroxyl group, releasing hydrogen chloride gas. This process is violent and often accompanied by heating. The reaction is as follows: R - SO 2O Cl + H 2O O → R - SO 2O OH + HCl, in 3-chloro-2-methylbenzenesulfonyl chloride, R is 3-chloro-2-methylphenyl.
In addition, the acylation ability is extraordinary, and it is a strong acylation reagent. It can react smoothly with active hydrogen-containing compounds such as alcohols and amines. It meets with alcohols and is replaced by nucleophiles to form sulfonates and hydrogen chloride. Take the reaction with ethanol as an example: 3-chloro-2-methylbenzenesulfonyl chloride + C -2 H OH → 3-chloro-2-methylbenzenesulfonate ethyl ester + HCl. The reaction with amines can produce sulfonamides, which is an important path for the preparation of specific functional materials and drugs in organic synthesis.
And because of the chlorine atoms in the benzene ring, the electron cloud density of the benzene ring is affected, resulting in different electrophilic substitution reactivity. The electron cloud density of the ortho and para-site decreases relatively, and the interpotential rises slightly. During the electrophilic substitution reaction, the proportion of the interposition substitution products may increase, which is different from the electrophilic substitution properties of the
In addition, 3-chloro-2-methylbenzenesulfonyl chloride is corrosive. Because of its hydrolysis to produce hydrogen chloride, and its own active chemistry, it has strong irritation and corrosion to the skin, eyes and respiratory tract. When operating, it must be guarded and carried out in a well-ventilated place according to specifications to prevent accidents.
In summary, 3-chloro-2-methylbenzenesulfonyl chloride has active and diverse chemical properties, and its hydrolysis, acylation and electrophilic substitution of benzene rings are unique. However, due to its corrosive nature, it must be used with caution.
Its activity is abnormal, and the sulfonyl chloride group (-SO 2O Cl) is extremely active. When hydrolyzed, the chlorine atom in the sulfonyl chloride group is replaced by a hydroxyl group, releasing hydrogen chloride gas. This process is violent and often accompanied by heating. The reaction is as follows: R - SO 2O Cl + H 2O O → R - SO 2O OH + HCl, in 3-chloro-2-methylbenzenesulfonyl chloride, R is 3-chloro-2-methylphenyl.
In addition, the acylation ability is extraordinary, and it is a strong acylation reagent. It can react smoothly with active hydrogen-containing compounds such as alcohols and amines. It meets with alcohols and is replaced by nucleophiles to form sulfonates and hydrogen chloride. Take the reaction with ethanol as an example: 3-chloro-2-methylbenzenesulfonyl chloride + C -2 H OH → 3-chloro-2-methylbenzenesulfonate ethyl ester + HCl. The reaction with amines can produce sulfonamides, which is an important path for the preparation of specific functional materials and drugs in organic synthesis.
And because of the chlorine atoms in the benzene ring, the electron cloud density of the benzene ring is affected, resulting in different electrophilic substitution reactivity. The electron cloud density of the ortho and para-site decreases relatively, and the interpotential rises slightly. During the electrophilic substitution reaction, the proportion of the interposition substitution products may increase, which is different from the electrophilic substitution properties of the
In addition, 3-chloro-2-methylbenzenesulfonyl chloride is corrosive. Because of its hydrolysis to produce hydrogen chloride, and its own active chemistry, it has strong irritation and corrosion to the skin, eyes and respiratory tract. When operating, it must be guarded and carried out in a well-ventilated place according to specifications to prevent accidents.
In summary, 3-chloro-2-methylbenzenesulfonyl chloride has active and diverse chemical properties, and its hydrolysis, acylation and electrophilic substitution of benzene rings are unique. However, due to its corrosive nature, it must be used with caution.
What is the preparation method of 3-chloro-2-methylbenzenesulfonyl Chloride?
The method of preparing 3-chloro-2-methylbenzenesulfonyl chloride is described in many ancient books. 3-chloro-2-methylbenzene is often used as the starting material, and then obtained by sulfonation.
First take an appropriate amount of 3-chloro-2-methylbenzene, put it in a reactor, use sulfuric acid or fuming sulfuric acid as the sulfonating agent, and add it slowly. This process requires careful temperature control, usually at 50-80 ° C. Sulfuric acid interacts with 3-chloro-2-methylbenzene, and a sulfonic acid group is introduced on the benzene ring to obtain 3-chloro-2-methylbenzene sulfonic acid. In this step, the materials must be evenly mixed and the reaction time is about 2-4 hours to make the reaction sufficient.
Next, transfer the obtained 3-chloro-2-methylbenzenesulfonic acid into the chlorination reaction device. Phosphorus pentachloride, phosphorus trichloride or thionyl chloride are used as chlorination agents and added to the reaction system. If the thionyl chloride is taken as an example, it reacts with 3-chloro-2-methylbenzenesulfonic acid, and the hydroxyl group in the sulfonic acid group is replaced by a chlorine atom to form 3-chloro-2-methylbenzenesulfonyl chloride. The temperature of this chlorination reaction should be controlled at 60-100 ° C, and the reaction should be about 3-5 hours. The boiling point of thionyl chloride is low, and it can be supplemented in a timely manner during the reaction to ensure the continuation of the reaction.
After the reaction is completed, the product is refined by distillation, extraction, recrystallization, etc. During distillation, 3-chloro-2-methylbenzenesulfonyl chloride is separated according to the boiling point difference of the product; suitable organic solvents can be used for extraction, such as dichloromethane, chloroform, etc., to enrich the product; recrystallization selects suitable solvents, such as ethanol, acetone, etc., to further purify to obtain high-purity 3-chloro-2-methylbenzenesulfon
First take an appropriate amount of 3-chloro-2-methylbenzene, put it in a reactor, use sulfuric acid or fuming sulfuric acid as the sulfonating agent, and add it slowly. This process requires careful temperature control, usually at 50-80 ° C. Sulfuric acid interacts with 3-chloro-2-methylbenzene, and a sulfonic acid group is introduced on the benzene ring to obtain 3-chloro-2-methylbenzene sulfonic acid. In this step, the materials must be evenly mixed and the reaction time is about 2-4 hours to make the reaction sufficient.
Next, transfer the obtained 3-chloro-2-methylbenzenesulfonic acid into the chlorination reaction device. Phosphorus pentachloride, phosphorus trichloride or thionyl chloride are used as chlorination agents and added to the reaction system. If the thionyl chloride is taken as an example, it reacts with 3-chloro-2-methylbenzenesulfonic acid, and the hydroxyl group in the sulfonic acid group is replaced by a chlorine atom to form 3-chloro-2-methylbenzenesulfonyl chloride. The temperature of this chlorination reaction should be controlled at 60-100 ° C, and the reaction should be about 3-5 hours. The boiling point of thionyl chloride is low, and it can be supplemented in a timely manner during the reaction to ensure the continuation of the reaction.
After the reaction is completed, the product is refined by distillation, extraction, recrystallization, etc. During distillation, 3-chloro-2-methylbenzenesulfonyl chloride is separated according to the boiling point difference of the product; suitable organic solvents can be used for extraction, such as dichloromethane, chloroform, etc., to enrich the product; recrystallization selects suitable solvents, such as ethanol, acetone, etc., to further purify to obtain high-purity 3-chloro-2-methylbenzenesulfon
What are the precautions for 3-chloro-2-methylbenzenesulfonyl Chloride during use?
3-Chloro-2-methylbenzenesulfonyl chloride is an important reagent in organic synthesis. When using it, many things must be paid attention to.
First safety protection. This reagent is corrosive and irritating, and can cause serious injury to the skin, eyes and respiratory tract. When using it, appropriate protective equipment must be worn, such as protective gloves, goggles and gas masks, to prevent direct contact with the body and inhalation of its volatile gases. The operation should be carried out in a well-ventilated fume hood to ensure air circulation in the experimental environment and timely discharge of volatile harmful gases.
Secondary storage conditions. It should be stored in a cool, dry and ventilated place, away from fire and heat sources, to prevent thermal decomposition or dangerous reactions. It needs to be stored separately from oxidizing agents and alkalis, etc., and should not be mixed in storage, because it may react violently with these substances and cause safety accidents.
Furthermore, it is related to the operation process. When taking it, the action must be precise and gentle to avoid the splashing of reagents. If it is accidentally splashed on the skin or eyes, it should be rinsed with a large amount of flowing water immediately, and then seek medical treatment. When carrying out the reaction, it is necessary to strictly control the reaction conditions, such as temperature, reaction time and the proportion of reactants. Because of its high reactivity, improper temperature control can easily cause the reaction to go out of control.
In addition, after the experiment is completed, the waste containing the reagent must be properly disposed of in accordance with relevant regulations and should not be dumped at will to prevent environmental pollution.
In short, when using 3-chloro-2-methylbenzenesulfonyl chloride, safety must always be given top priority, and operations must be carried out in strict accordance with regulations to ensure the safety and smooth progress of the experiment.
First safety protection. This reagent is corrosive and irritating, and can cause serious injury to the skin, eyes and respiratory tract. When using it, appropriate protective equipment must be worn, such as protective gloves, goggles and gas masks, to prevent direct contact with the body and inhalation of its volatile gases. The operation should be carried out in a well-ventilated fume hood to ensure air circulation in the experimental environment and timely discharge of volatile harmful gases.
Secondary storage conditions. It should be stored in a cool, dry and ventilated place, away from fire and heat sources, to prevent thermal decomposition or dangerous reactions. It needs to be stored separately from oxidizing agents and alkalis, etc., and should not be mixed in storage, because it may react violently with these substances and cause safety accidents.
Furthermore, it is related to the operation process. When taking it, the action must be precise and gentle to avoid the splashing of reagents. If it is accidentally splashed on the skin or eyes, it should be rinsed with a large amount of flowing water immediately, and then seek medical treatment. When carrying out the reaction, it is necessary to strictly control the reaction conditions, such as temperature, reaction time and the proportion of reactants. Because of its high reactivity, improper temperature control can easily cause the reaction to go out of control.
In addition, after the experiment is completed, the waste containing the reagent must be properly disposed of in accordance with relevant regulations and should not be dumped at will to prevent environmental pollution.
In short, when using 3-chloro-2-methylbenzenesulfonyl chloride, safety must always be given top priority, and operations must be carried out in strict accordance with regulations to ensure the safety and smooth progress of the experiment.
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