Linshang Chemical
PRODUCTS
3-Chloro-2-Methylbenzenesulphonyl Chloride
Linshang Chemical
|
HS Code |
590083 |
| Chemical Formula | C7H6Cl2O2S |
| Molecular Weight | 225.09 |
| Appearance | Typically a colorless to pale yellow liquid |
| Odor | Pungent, irritating odor |
| Density | Data varies, around 1.4 - 1.5 g/cm³ |
| Boiling Point | Approximately 270 - 280 °C |
| Solubility | Insoluble in water, soluble in organic solvents like dichloromethane, toluene |
| Reactivity | Highly reactive, reacts with water, alcohols, amines |
| Hazard Class | Corrosive, causes severe skin and eye burns |
As an accredited 3-Chloro-2-Methylbenzenesulphonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 - gram bottle of 3 - chloro - 2 - methylbenzenesulphonyl chloride, well - sealed. |
| Storage | 3 - Chloro - 2 - methylbenzenesulphonyl chloride should be stored in a cool, dry, well - ventilated area away from heat sources, flames, and direct sunlight. It must be kept in a tightly sealed container to prevent contact with moisture, which can cause hydrolysis. Store it separately from incompatible substances like bases, amines, and reducing agents to avoid dangerous reactions. |
| Shipping | 3 - chloro - 2 - methylbenzenesulphonyl chloride is a hazardous chemical. Shipping must comply with strict regulations. It should be in proper, leak - proof containers, labeled clearly, and transported by carriers licensed for hazardous materials. |
Competitive 3-Chloro-2-Methylbenzenesulphonyl Chloride prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 3-Chloro-2-Methylbenzenesulphonyl Chloride in China?
As a trusted 3-Chloro-2-Methylbenzenesulphonyl Chloride manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 3-Chloro-2-Methylbenzenesulphonyl Chloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemistry of 3-chloro-2-methylbenzenesulphonyl Chloride?
3-Chloro-2-methylbenzenesulfonyl chloride, this is an organic compound. Its chemical properties are unique and valuable for investigation.
Looking at its reactivity, the sulfonyl chloride group (-SO 2O Cl) is very active. It undergoes hydrolysis in contact with water, just like throwing it into a stone on a calm lake, breaking stability and giving birth to 3-chloro-2-methylbenzenesulfonic acid and hydrogen chloride. This hydrolysis reaction rate is quite fast, and it is easy to proceed spontaneously in humid air, just like a perishable thing in moisture, quietly changing.
When it comes to nucleophilic substitution reactions, sulfonyl chloride is an excellent leaving group. Alcohols, amines, and other nucleophiles can all react with 3-chloro-2-methylbenzenesulfonyl chloride. When encountering alcohol, the hydroxyl oxygen atoms attack the sulfur atoms of the sulfonyl chloride group like brave warriors, and the chloride ions leave, forming sulfonates. When encountering amines, the nitrogen atoms of amines show nucleophilic ability, replacing the chlorine atoms to produce sulfonamides. These two types of reactions are widely used in the field of organic synthesis, just like the bricks and stones that build the building of organic compounds.
In addition, there is also a story above the benzene ring. It contains chlorine atoms and methyl groups, which have subtle effects on the distribution of the electron cloud density of the benzene ring. Chlorine atoms have electron-sucking induction effects, while methyl groups have electron-giving induction effects and superconjugation effects. The interaction between the two causes uneven distribution of electron cloud density in the benzene ring. As a result, the electrophilic substitution reaction activity and localization effect of the benzene ring are changed. When electrophilic reagents attack the benzene ring, they are guided by these substituents and are more inclined to react at specific positions, as if there is a pair of invisible hands guiding the reaction direction.
3-chloro-2-methylbenzenesulfonyl chloride occupies an important position on the stage of organic synthesis, providing an effective way for the preparation of many organic compounds, just like the key to open the door to the treasure of organic synthesis.
Looking at its reactivity, the sulfonyl chloride group (-SO 2O Cl) is very active. It undergoes hydrolysis in contact with water, just like throwing it into a stone on a calm lake, breaking stability and giving birth to 3-chloro-2-methylbenzenesulfonic acid and hydrogen chloride. This hydrolysis reaction rate is quite fast, and it is easy to proceed spontaneously in humid air, just like a perishable thing in moisture, quietly changing.
When it comes to nucleophilic substitution reactions, sulfonyl chloride is an excellent leaving group. Alcohols, amines, and other nucleophiles can all react with 3-chloro-2-methylbenzenesulfonyl chloride. When encountering alcohol, the hydroxyl oxygen atoms attack the sulfur atoms of the sulfonyl chloride group like brave warriors, and the chloride ions leave, forming sulfonates. When encountering amines, the nitrogen atoms of amines show nucleophilic ability, replacing the chlorine atoms to produce sulfonamides. These two types of reactions are widely used in the field of organic synthesis, just like the bricks and stones that build the building of organic compounds.
In addition, there is also a story above the benzene ring. It contains chlorine atoms and methyl groups, which have subtle effects on the distribution of the electron cloud density of the benzene ring. Chlorine atoms have electron-sucking induction effects, while methyl groups have electron-giving induction effects and superconjugation effects. The interaction between the two causes uneven distribution of electron cloud density in the benzene ring. As a result, the electrophilic substitution reaction activity and localization effect of the benzene ring are changed. When electrophilic reagents attack the benzene ring, they are guided by these substituents and are more inclined to react at specific positions, as if there is a pair of invisible hands guiding the reaction direction.
3-chloro-2-methylbenzenesulfonyl chloride occupies an important position on the stage of organic synthesis, providing an effective way for the preparation of many organic compounds, just like the key to open the door to the treasure of organic synthesis.
What are the common uses of 3-chloro-2-methylbenzenesulphonyl Chloride?
3-Chloro-2-methylbenzenesulfonyl chloride, which is commonly used, covers the following numbers.
First, in the field of organic synthesis, it is often a key reagent. It can react with many compounds containing active hydrogen, such as alcohols and amines. When interacted with alcohols, it can form sulfonate esters. This sulfonate has a wide range of uses in organic synthesis and can be used as a substrate for nucleophilic substitution reactions to introduce specific functional groups. When reacted with amines, sulfonamides can be prepared. Sulfonamides are of great significance in the field of medicinal chemistry. Many drug molecular structures contain this structural fragment, which has unique biological activity and pharmacological properties.
Second, it also has applications in materials science. By reacting with specific polymers, polymers can be modified. For example, by reacting with some polymers containing hydroxyl groups, sulfonic acid groups can be introduced into the main chain of the polymer. In this way, the hydrophilicity and ion exchange properties of the polymer can be improved. This modified polymer can be used to prepare ion exchange resins and play functions in water treatment, catalysis and other fields.
Third, in the field of dye chemistry, 3-chloro-2-methylbenzenesulfonyl chloride also has a place. It can be used as a precursor to synthesize specific dyes. Through a series of chemical reactions, it is converted into dye molecules with specific structures and colors. Due to the characteristics of benzene ring and sulfonyl chloride group, it is helpful to build a stable dye structure with good dyeing properties, which can endow fabrics, fibers and other materials with lasting and bright colors.
First, in the field of organic synthesis, it is often a key reagent. It can react with many compounds containing active hydrogen, such as alcohols and amines. When interacted with alcohols, it can form sulfonate esters. This sulfonate has a wide range of uses in organic synthesis and can be used as a substrate for nucleophilic substitution reactions to introduce specific functional groups. When reacted with amines, sulfonamides can be prepared. Sulfonamides are of great significance in the field of medicinal chemistry. Many drug molecular structures contain this structural fragment, which has unique biological activity and pharmacological properties.
Second, it also has applications in materials science. By reacting with specific polymers, polymers can be modified. For example, by reacting with some polymers containing hydroxyl groups, sulfonic acid groups can be introduced into the main chain of the polymer. In this way, the hydrophilicity and ion exchange properties of the polymer can be improved. This modified polymer can be used to prepare ion exchange resins and play functions in water treatment, catalysis and other fields.
Third, in the field of dye chemistry, 3-chloro-2-methylbenzenesulfonyl chloride also has a place. It can be used as a precursor to synthesize specific dyes. Through a series of chemical reactions, it is converted into dye molecules with specific structures and colors. Due to the characteristics of benzene ring and sulfonyl chloride group, it is helpful to build a stable dye structure with good dyeing properties, which can endow fabrics, fibers and other materials with lasting and bright colors.
What is the synthesis method of 3-chloro-2-methylbenzenesulphonyl Chloride?
To prepare 3-chloro-2-methylbenzenesulfonyl chloride, the method is as follows:
First take 2-methylchlorobenzene as the starting material. In an appropriate reaction vessel, add 2-methylchlorobenzene and use an appropriate amount of chlorosulfonic acid as a sulfonation reagent. During the reaction, pay attention to the regulation of temperature, and slowly heat up to a suitable temperature range, generally between about 40-60 degrees Celsius, because too high or too low temperature may affect the process of the reaction and the purity of the product. At this temperature, the two undergo a sulfonation reaction, and a sulfonyl group is introduced at a specific position on the benzene ring of 2-methylchlorobenzene to form 3-chloro-2-benzenesulfonic acid.
After the sulfonation reaction is completed, the reaction mixture is cooled to room temperature. Then, an appropriate amount of sulfoxide chloride is slowly added. In this step, the sulfoxide chloride reacts with 3-chloro-2-methylbenzenesulfonic acid, and the hydroxyl group of the sulfonic acid group is replaced by a chlorine atom to obtain 3-chloro-2-methylbenzenesulfonyl chloride. This process also requires precise control of the reaction temperature and feeding rate to prevent side reactions from occurring.
After the reaction is completed, the reaction products are separated and purified. Distillation can be used to initially remove unreacted raw materials and low boiling point by-products. Then, the product was further purified by recrystallization or column chromatography to obtain high purity 3-chloro-2-methylbenzenesulfonyl chloride. In this way, the target product can be obtained.
First take 2-methylchlorobenzene as the starting material. In an appropriate reaction vessel, add 2-methylchlorobenzene and use an appropriate amount of chlorosulfonic acid as a sulfonation reagent. During the reaction, pay attention to the regulation of temperature, and slowly heat up to a suitable temperature range, generally between about 40-60 degrees Celsius, because too high or too low temperature may affect the process of the reaction and the purity of the product. At this temperature, the two undergo a sulfonation reaction, and a sulfonyl group is introduced at a specific position on the benzene ring of 2-methylchlorobenzene to form 3-chloro-2-benzenesulfonic acid.
After the sulfonation reaction is completed, the reaction mixture is cooled to room temperature. Then, an appropriate amount of sulfoxide chloride is slowly added. In this step, the sulfoxide chloride reacts with 3-chloro-2-methylbenzenesulfonic acid, and the hydroxyl group of the sulfonic acid group is replaced by a chlorine atom to obtain 3-chloro-2-methylbenzenesulfonyl chloride. This process also requires precise control of the reaction temperature and feeding rate to prevent side reactions from occurring.
After the reaction is completed, the reaction products are separated and purified. Distillation can be used to initially remove unreacted raw materials and low boiling point by-products. Then, the product was further purified by recrystallization or column chromatography to obtain high purity 3-chloro-2-methylbenzenesulfonyl chloride. In this way, the target product can be obtained.
What are the precautions for 3-chloro-2-methylbenzenesulphonyl Chloride during storage and transportation?
3-Chloro-2-methylbenzenesulfonyl chloride is a chemical substance, and many things must be paid attention to when storing and transporting.
Let's talk about storage first. Because of its active nature and easy to cause chemical reactions, it should be stored in a cool, dry and well-ventilated place. It must not be close to fire or heat sources to prevent it from decomposing or triggering dangerous reactions due to excessive temperature. This substance is quite sensitive to humidity and is highly susceptible to moisture and deterioration, so the humidity of the storage environment should be strictly controlled, and it is best to use a desiccant to keep the environment dry. In addition, it is corrosive and should be stored separately from oxidants and alkalis. It should not be mixed in storage to prevent accidents caused by mutual reactions. When storing, make sure that the container is tightly sealed to prevent leakage. At the same time, it is necessary to set up obvious warning signs in the storage area to inform others that this is a dangerous chemical.
As for transportation, it is necessary to ensure that the packaging is complete and well sealed before transportation to prevent leakage during transportation. Transportation vehicles need to be equipped with corresponding varieties and quantities of fire protection equipment and leakage emergency treatment equipment. During transportation, be careful to load and unload to avoid collisions, dragging and dumping to prevent package damage. When driving, you should follow the specified route and do not stop in densely populated areas and places with open flames. Transportation personnel also need to undergo professional training, familiar with the dangerous characteristics of the chemical and emergency treatment methods.
In short, the storage and transportation of 3-chloro-2-methylbenzenesulfonyl chloride must strictly follow relevant norms and requirements at every step, and operate with caution, so as to ensure the safety of personnel and the environment from harm.
Let's talk about storage first. Because of its active nature and easy to cause chemical reactions, it should be stored in a cool, dry and well-ventilated place. It must not be close to fire or heat sources to prevent it from decomposing or triggering dangerous reactions due to excessive temperature. This substance is quite sensitive to humidity and is highly susceptible to moisture and deterioration, so the humidity of the storage environment should be strictly controlled, and it is best to use a desiccant to keep the environment dry. In addition, it is corrosive and should be stored separately from oxidants and alkalis. It should not be mixed in storage to prevent accidents caused by mutual reactions. When storing, make sure that the container is tightly sealed to prevent leakage. At the same time, it is necessary to set up obvious warning signs in the storage area to inform others that this is a dangerous chemical.
As for transportation, it is necessary to ensure that the packaging is complete and well sealed before transportation to prevent leakage during transportation. Transportation vehicles need to be equipped with corresponding varieties and quantities of fire protection equipment and leakage emergency treatment equipment. During transportation, be careful to load and unload to avoid collisions, dragging and dumping to prevent package damage. When driving, you should follow the specified route and do not stop in densely populated areas and places with open flames. Transportation personnel also need to undergo professional training, familiar with the dangerous characteristics of the chemical and emergency treatment methods.
In short, the storage and transportation of 3-chloro-2-methylbenzenesulfonyl chloride must strictly follow relevant norms and requirements at every step, and operate with caution, so as to ensure the safety of personnel and the environment from harm.
3-chloro-2-methylbenzenesulphonyl Chloride Effects on the Environment and Human Health
3-Chloro-2-methylbenzenesulfonyl chloride, this is a chemical substance that has an impact on both the environment and human health.
In terms of the environment, if it accidentally flows into natural water bodies, it will change the chemical composition of water bodies due to its active chemical properties or react with water substances, causing water quality deterioration and threatening the survival of aquatic organisms. It may interfere with the photosynthesis and respiration of aquatic plants, inhibit the growth of aquatic plants and destroy the ecological balance of water bodies. If it enters the soil, it will affect the structure and function of soil microbial communities, hinder the decomposition of organic matter and nutrient circulation in the soil, and then affect plant growth. Diffusion in the atmosphere may also participate in photochemical reactions, generate secondary pollutants, and affect air quality.
As far as human health is concerned, it is corrosive and irritating. If the skin comes into contact with it, it can corrode the skin, causing redness, swelling, pain, and even ulceration, improper handling or scarring. Eye contact can seriously irritate the eye tissue, damage vision, and in extreme cases cause blindness. If inhaled its volatile gases, it will irritate the mucosa of the respiratory tract, causing symptoms such as cough, asthma, and breathing difficulties. Long-term inhalation or increased risk of respiratory diseases, such as bronchitis and emphysema. If taken inadvertently, it will burn the digestive tract, cause nausea, vomiting, abdominal pain and other symptoms, and in severe cases, it will be life-threatening. Therefore, when using and disposing of 3-chloro-2-methylbenzenesulfonyl chloride, it is necessary to follow strict safety operating procedures and take protective measures to avoid damage to the environment and human health.
In terms of the environment, if it accidentally flows into natural water bodies, it will change the chemical composition of water bodies due to its active chemical properties or react with water substances, causing water quality deterioration and threatening the survival of aquatic organisms. It may interfere with the photosynthesis and respiration of aquatic plants, inhibit the growth of aquatic plants and destroy the ecological balance of water bodies. If it enters the soil, it will affect the structure and function of soil microbial communities, hinder the decomposition of organic matter and nutrient circulation in the soil, and then affect plant growth. Diffusion in the atmosphere may also participate in photochemical reactions, generate secondary pollutants, and affect air quality.
As far as human health is concerned, it is corrosive and irritating. If the skin comes into contact with it, it can corrode the skin, causing redness, swelling, pain, and even ulceration, improper handling or scarring. Eye contact can seriously irritate the eye tissue, damage vision, and in extreme cases cause blindness. If inhaled its volatile gases, it will irritate the mucosa of the respiratory tract, causing symptoms such as cough, asthma, and breathing difficulties. Long-term inhalation or increased risk of respiratory diseases, such as bronchitis and emphysema. If taken inadvertently, it will burn the digestive tract, cause nausea, vomiting, abdominal pain and other symptoms, and in severe cases, it will be life-threatening. Therefore, when using and disposing of 3-chloro-2-methylbenzenesulfonyl chloride, it is necessary to follow strict safety operating procedures and take protective measures to avoid damage to the environment and human health.
Scan to WhatsApp
