Linshang Chemical
PRODUCTS
3-Chloro-3-Fluorobromobenzene
Linshang Chemical
|
HS Code |
384372 |
| Chemical Formula | C6H3BrClF |
| Appearance | Liquid (usually) |
| Odor | Typical aromatic odor |
| Boiling Point | Around 190 - 200 °C |
| Density | Approx. 1.8 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in many organic solvents like ethanol, ether |
As an accredited 3-Chloro-3-Fluorobromobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 - gram vial of 3 - chloro - 3 - fluorobromobenzene, well - sealed for chemical storage. |
| Storage | 3 - chloro - 3 - fluorobromobenzene should be stored in a cool, dry, well - ventilated area away from sources of heat and ignition. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, strong acids, and bases to prevent potential chemical reactions. Ensure proper labeling for easy identification and handling. |
| Shipping | 3 - Chloro - 3 - fluorobromobenzene is shipped in sealed, corrosion - resistant containers. Special handling is required due to its chemical nature. Shipment follows strict regulations for hazardous chemicals to ensure safety during transit. |
Competitive 3-Chloro-3-Fluorobromobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 3-Chloro-3-Fluorobromobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the physical properties of 3-chloro-3-fluorobromobenzene?
3-Chloro-3-fluorobromobenzene is one of the organic compounds. Its physical properties are unique and it has a wide range of uses in the field of organic synthesis.
Looking at its properties, it may be a colorless to light yellow liquid under normal conditions. Due to the presence of halogen atoms in the molecular structure, it appears like this. It has a special odor, and the formation of this odor is also related to the interaction between halogen atoms and benzene rings.
When it comes to the boiling point, its boiling point is within a certain range due to the intermolecular force. The halogen atom enhances the polarity of the molecule, the intermolecular force increases, and the boiling point is higher than that of benzene. However, the exact value needs to be accurately determined according to experiments, but it can be roughly inferred that the boiling point is higher than that of benzene
Melting point also varies with molecular structure. The rigid structure of the benzene ring and the substitution of halogen atoms affect the regularity of molecular arrangement, which in turn affects the melting point. Its melting point is restricted by intermolecular forces and spatial structures, or is in a certain range, but the exact value still needs to be experimentally based.
In terms of solubility, 3-chloro-3-fluorobromobenzene is insoluble in water. This is because water molecules are polar molecules, and although the compound contains polar halogen atoms, the non-polar structure of the benzene ring dominates, making it difficult to dissolve water due to weak interaction forces with water molecules. However, in organic solvents, such as ether and dichloromethane, due to their similar structures and appropriate intermolecular forces, they have good solubility. Above the density of
, because the molecule contains halogen atoms, the relative weight of halogen atoms is relatively large, resulting in a density greater than that of water. Molecular stacking mode, atomic type and quantity together determine its density, making it exhibit specific phase distribution characteristics during chemical operation and separation.
Looking at its properties, it may be a colorless to light yellow liquid under normal conditions. Due to the presence of halogen atoms in the molecular structure, it appears like this. It has a special odor, and the formation of this odor is also related to the interaction between halogen atoms and benzene rings.
When it comes to the boiling point, its boiling point is within a certain range due to the intermolecular force. The halogen atom enhances the polarity of the molecule, the intermolecular force increases, and the boiling point is higher than that of benzene. However, the exact value needs to be accurately determined according to experiments, but it can be roughly inferred that the boiling point is higher than that of benzene
Melting point also varies with molecular structure. The rigid structure of the benzene ring and the substitution of halogen atoms affect the regularity of molecular arrangement, which in turn affects the melting point. Its melting point is restricted by intermolecular forces and spatial structures, or is in a certain range, but the exact value still needs to be experimentally based.
In terms of solubility, 3-chloro-3-fluorobromobenzene is insoluble in water. This is because water molecules are polar molecules, and although the compound contains polar halogen atoms, the non-polar structure of the benzene ring dominates, making it difficult to dissolve water due to weak interaction forces with water molecules. However, in organic solvents, such as ether and dichloromethane, due to their similar structures and appropriate intermolecular forces, they have good solubility. Above the density of
, because the molecule contains halogen atoms, the relative weight of halogen atoms is relatively large, resulting in a density greater than that of water. Molecular stacking mode, atomic type and quantity together determine its density, making it exhibit specific phase distribution characteristics during chemical operation and separation.
What are the chemical properties of 3-chloro-3-fluorobromobenzene?
3-Chloro-3-fluorobromobenzene is one of the organic compounds. Its chemical properties are unique, and it is related to the process and results of many chemical reactions.
First of all, its substitution reaction. Due to the existence of halogen atoms, the electron cloud density on the benzene ring is disturbed, making this compound vulnerable to electrophilic attack. If under suitable conditions, electrophilic substitution reactions can occur with electrophilic reagents, and new groups are introduced at specific positions in the benzene ring. Its substitution check point is often related to the positioning effect of halogen atoms. Both chlorine and fluorine are ortho and para-localized groups, but fluorine has extremely strong electronegativity, and its ortho-site electron cloud density decreases, so the electrophilic substitution reaction tends to be more para-localized.
The second discussion on its reduction reaction. Halogen atoms can be reduced under the action of specific reducing agents. For example, in the system of metal zinc and acid, halogen atoms can be gradually removed to form corresponding reduction products. In this process, the carbon-halogen bond is broken to obtain a reduced benzene derivative.
Furthermore, due to the different activities of chlorine, fluorine and bromine halogen atoms, in the nucleophilic substitution reaction, a certain halogen atom can be selectively replaced by a nucleophilic reagent according to different reaction conditions. Generally speaking, the activity of bromine is relatively high, and it is easy to be replaced by nucleophilic reagents under milder conditions, while chlorine and fluorine require more severe reaction conditions before nucleophilic substitution can occur.
And because there are a variety of halogen atoms in the molecule, when reacting with metal-organic reagents, it can exhibit a variety of reaction paths, or metallization reactions, and then couple with other organic halides to construct more complex organic molecular structures.
3-chloro-3-fluorobromobenzene has a variety of chemical reactivity due to its unique chemical structure. It can be used as an important intermediate in the field of organic synthesis and participates in the construction and transformation of many organic compounds.
First of all, its substitution reaction. Due to the existence of halogen atoms, the electron cloud density on the benzene ring is disturbed, making this compound vulnerable to electrophilic attack. If under suitable conditions, electrophilic substitution reactions can occur with electrophilic reagents, and new groups are introduced at specific positions in the benzene ring. Its substitution check point is often related to the positioning effect of halogen atoms. Both chlorine and fluorine are ortho and para-localized groups, but fluorine has extremely strong electronegativity, and its ortho-site electron cloud density decreases, so the electrophilic substitution reaction tends to be more para-localized.
The second discussion on its reduction reaction. Halogen atoms can be reduced under the action of specific reducing agents. For example, in the system of metal zinc and acid, halogen atoms can be gradually removed to form corresponding reduction products. In this process, the carbon-halogen bond is broken to obtain a reduced benzene derivative.
Furthermore, due to the different activities of chlorine, fluorine and bromine halogen atoms, in the nucleophilic substitution reaction, a certain halogen atom can be selectively replaced by a nucleophilic reagent according to different reaction conditions. Generally speaking, the activity of bromine is relatively high, and it is easy to be replaced by nucleophilic reagents under milder conditions, while chlorine and fluorine require more severe reaction conditions before nucleophilic substitution can occur.
And because there are a variety of halogen atoms in the molecule, when reacting with metal-organic reagents, it can exhibit a variety of reaction paths, or metallization reactions, and then couple with other organic halides to construct more complex organic molecular structures.
3-chloro-3-fluorobromobenzene has a variety of chemical reactivity due to its unique chemical structure. It can be used as an important intermediate in the field of organic synthesis and participates in the construction and transformation of many organic compounds.
What are the main uses of 3-chloro-3-fluorobromobenzene?
3-Chloro-3-fluorobromobenzene is also an organic compound. It has a wide range of uses and is often a key raw material in the field of organic synthesis, assisting in the construction of many complex organic molecules.
One of them can be used to create new medicines. In pharmaceutical research and development, organic molecules with specific structures are the basis for searching for high-efficiency and low-toxicity drugs. 3-chloro-3-fluorobrobenzene has a unique combination of halogen atoms, which can introduce drug molecular structures through chemical reactions, or change the physical and chemical properties of compounds, such as solubility, stability, etc., or affect their interaction with biological targets, thereby enhancing drug activity and selectivity, and contributing to the birth of new medicines.
Second, it also has important applications in the field of pesticides. The creation of pesticides requires molecules to have specific biological activities. This compound can be used as a synthetic intermediate to derive pesticide components that have high-efficiency inhibition or killing effects on pests and bacteria. Its special structure may enhance the affinity and toxicity of pesticides to target organisms, and it contributes greatly to the prevention and control of agricultural pests due to the presence of halogen atoms, or the environmental stability and duration of pesticides.
Furthermore, in the field of materials science, 3-chloro-3-fluorobromobenzene is also indispensable. It can participate in the preparation of functional materials through a series of reactions, such as special polymer materials. By introducing it into the polymer chain, or endowing the material with unique electrical, optical, thermal and other properties, it has broad prospects in the field of high-tech materials such as electronic devices and optical films.
In summary, although 3-chloro-3-fluorobromobenzene is an organic small molecule, it plays an extraordinary role in many fields such as medicine, pesticides, and materials science, and is an important cornerstone for promoting technological progress and innovation in various fields.
One of them can be used to create new medicines. In pharmaceutical research and development, organic molecules with specific structures are the basis for searching for high-efficiency and low-toxicity drugs. 3-chloro-3-fluorobrobenzene has a unique combination of halogen atoms, which can introduce drug molecular structures through chemical reactions, or change the physical and chemical properties of compounds, such as solubility, stability, etc., or affect their interaction with biological targets, thereby enhancing drug activity and selectivity, and contributing to the birth of new medicines.
Second, it also has important applications in the field of pesticides. The creation of pesticides requires molecules to have specific biological activities. This compound can be used as a synthetic intermediate to derive pesticide components that have high-efficiency inhibition or killing effects on pests and bacteria. Its special structure may enhance the affinity and toxicity of pesticides to target organisms, and it contributes greatly to the prevention and control of agricultural pests due to the presence of halogen atoms, or the environmental stability and duration of pesticides.
Furthermore, in the field of materials science, 3-chloro-3-fluorobromobenzene is also indispensable. It can participate in the preparation of functional materials through a series of reactions, such as special polymer materials. By introducing it into the polymer chain, or endowing the material with unique electrical, optical, thermal and other properties, it has broad prospects in the field of high-tech materials such as electronic devices and optical films.
In summary, although 3-chloro-3-fluorobromobenzene is an organic small molecule, it plays an extraordinary role in many fields such as medicine, pesticides, and materials science, and is an important cornerstone for promoting technological progress and innovation in various fields.
What are 3-chloro-3-fluorobromobenzene synthesis methods?
For the synthesis of 3-chloro-3-fluorobromobenzene, there are many paths to follow. The following is your detailed description.
First, it is based on a halogenation reaction. Appropriate benzene derivatives can be taken first to react with reagents containing chlorine, fluorine and bromine. For example, starting with benzene, chlorine atoms are introduced through a halogenation reaction, so that benzene and chlorine can be obtained under the action of a suitable catalyst, such as ferric chloride. Then, chlorobenzene and fluorine-containing reagents, such as potassium fluoride, are subjected to a nucleophilic substitution reaction in specific solvents and reaction conditions to introduce fluorine atoms. Finally, through bromination reaction, fluorochlorobenzene and bromine are introduced into bromine atoms at specific positions under suitable catalysts and conditions to obtain 3-chloro-3-fluorobromobenzene. This path requires fine control of the reaction conditions of each step to obtain high-purity products.
Second, it is formed by the reaction of organometallic reagents. Organometallic reagents containing chlorine and fluorine, such as Grignard reagent or lithium reagent, can be prepared first. Appropriate halogenated aromatics are used as starting materials and react with magnesium or lithium to obtain corresponding organometallic reagents. Subsequently, the organometallic reagent is reacted with bromine-containing reagents, such as bromoalkanes or copper bromide, in a suitable reaction environment. By virtue of the nucleophilicity of organometallic reagents, bromine atoms are introduced into specific positions, while retaining chlorine and fluorine atoms, to achieve the synthesis of 3-chloro-3-fluorobromobenzene. In this approach, the preparation of organometallic reagents and the choice of reaction conditions have a great influence on the success or failure of the reaction and the purity of the product.
Third, the aromatic electrophilic substitution reaction is the most important. Select a suitable benzene derivative with a positioning group, and use the positioning effect of the positioning group on the electrophilic substitution reaction. If the positioning group can guide the chlorine, fluorine and bromine atoms to replace at the desired position, the halogenation reaction can be carried out in sequence. The chlorination reaction is first carried out with a chlorine-containing reagent, then fluorinated with a fluorine-containing reagent, and finally brominated. This process requires precise adjustment of the reaction conditions and reagent dosage according to the characteristics of the positioning group, so that the reaction proceeds in the expected direction to obtain the target product 3-chloro-3-fluorobromobenzene.
The above synthesis methods have their own advantages and disadvantages. In practical application, it is necessary to comprehensively consider the availability of starting materials, the difficulty of achieving reaction conditions, the purity and yield of the product, and choose the best way to efficiently synthesize 3-chloro-3-fluorobromobenzene.
First, it is based on a halogenation reaction. Appropriate benzene derivatives can be taken first to react with reagents containing chlorine, fluorine and bromine. For example, starting with benzene, chlorine atoms are introduced through a halogenation reaction, so that benzene and chlorine can be obtained under the action of a suitable catalyst, such as ferric chloride. Then, chlorobenzene and fluorine-containing reagents, such as potassium fluoride, are subjected to a nucleophilic substitution reaction in specific solvents and reaction conditions to introduce fluorine atoms. Finally, through bromination reaction, fluorochlorobenzene and bromine are introduced into bromine atoms at specific positions under suitable catalysts and conditions to obtain 3-chloro-3-fluorobromobenzene. This path requires fine control of the reaction conditions of each step to obtain high-purity products.
Second, it is formed by the reaction of organometallic reagents. Organometallic reagents containing chlorine and fluorine, such as Grignard reagent or lithium reagent, can be prepared first. Appropriate halogenated aromatics are used as starting materials and react with magnesium or lithium to obtain corresponding organometallic reagents. Subsequently, the organometallic reagent is reacted with bromine-containing reagents, such as bromoalkanes or copper bromide, in a suitable reaction environment. By virtue of the nucleophilicity of organometallic reagents, bromine atoms are introduced into specific positions, while retaining chlorine and fluorine atoms, to achieve the synthesis of 3-chloro-3-fluorobromobenzene. In this approach, the preparation of organometallic reagents and the choice of reaction conditions have a great influence on the success or failure of the reaction and the purity of the product.
Third, the aromatic electrophilic substitution reaction is the most important. Select a suitable benzene derivative with a positioning group, and use the positioning effect of the positioning group on the electrophilic substitution reaction. If the positioning group can guide the chlorine, fluorine and bromine atoms to replace at the desired position, the halogenation reaction can be carried out in sequence. The chlorination reaction is first carried out with a chlorine-containing reagent, then fluorinated with a fluorine-containing reagent, and finally brominated. This process requires precise adjustment of the reaction conditions and reagent dosage according to the characteristics of the positioning group, so that the reaction proceeds in the expected direction to obtain the target product 3-chloro-3-fluorobromobenzene.
The above synthesis methods have their own advantages and disadvantages. In practical application, it is necessary to comprehensively consider the availability of starting materials, the difficulty of achieving reaction conditions, the purity and yield of the product, and choose the best way to efficiently synthesize 3-chloro-3-fluorobromobenzene.
3-chloro-3-fluorobromobenzene What are the precautions during storage and transportation?
3-Chloro-3-fluorobromobenzene is an organic compound. When storing and transporting, the following items must be paid attention to:
First, the storage environment should be cool and ventilated. This compound is prone to decomposition when heated, or cause danger. Therefore, it is necessary to avoid open flames and hot topics, and choose a cool and ventilated warehouse for storage. If the storage temperature is too high, it may increase the volatilization of the substance, and may even catch fire and explode due to local overheating.
Second, it should be stored separately from oxidants, active metal powders, etc., and should not be mixed. 3-Chloro-3-fluorobromobenzene is prone to violent chemical reactions when it encounters oxidants, or causes combustion and explosion; while active metal powders come into contact with it, or trigger active reactions, which also threaten safety.
Third, the storage container must be sealed. The compound is volatile, and if it is not properly sealed, it is easy to evaporate and escape, not only polluting the environment, but also the volatile gas may be irritating and toxic, endangering human health.
Fourth, the transportation process should ensure that the container does not leak, collapse, fall, or damage. Due to bumps, collisions, or damage to the container, material leakage is caused. If a leak occurs, it will not only pollute the environment, but also be extremely difficult to clean up, and may also cause harm to surrounding personnel.
Fifth, when transporting, you should follow the specified route and do not stop in residential areas and densely populated areas. To prevent sudden accidents during transportation, such as leaks, fires, etc., which pose a threat to the lives and property of many residents.
Sixth, operators need to undergo special training and strictly abide by the operating procedures. Because of its certain danger, if the operator does not have professional knowledge and skills, the probability of misoperation will increase greatly, which will cause safety accidents.
First, the storage environment should be cool and ventilated. This compound is prone to decomposition when heated, or cause danger. Therefore, it is necessary to avoid open flames and hot topics, and choose a cool and ventilated warehouse for storage. If the storage temperature is too high, it may increase the volatilization of the substance, and may even catch fire and explode due to local overheating.
Second, it should be stored separately from oxidants, active metal powders, etc., and should not be mixed. 3-Chloro-3-fluorobromobenzene is prone to violent chemical reactions when it encounters oxidants, or causes combustion and explosion; while active metal powders come into contact with it, or trigger active reactions, which also threaten safety.
Third, the storage container must be sealed. The compound is volatile, and if it is not properly sealed, it is easy to evaporate and escape, not only polluting the environment, but also the volatile gas may be irritating and toxic, endangering human health.
Fourth, the transportation process should ensure that the container does not leak, collapse, fall, or damage. Due to bumps, collisions, or damage to the container, material leakage is caused. If a leak occurs, it will not only pollute the environment, but also be extremely difficult to clean up, and may also cause harm to surrounding personnel.
Fifth, when transporting, you should follow the specified route and do not stop in residential areas and densely populated areas. To prevent sudden accidents during transportation, such as leaks, fires, etc., which pose a threat to the lives and property of many residents.
Sixth, operators need to undergo special training and strictly abide by the operating procedures. Because of its certain danger, if the operator does not have professional knowledge and skills, the probability of misoperation will increase greatly, which will cause safety accidents.
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