Linshang Chemical
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3-Chloro-4,5-Difluoronitrobenzene
Linshang Chemical
|
HS Code |
249004 |
| Chemical Formula | C6H2ClF2NO2 |
| Molecular Weight | 195.54 |
| Appearance | Solid (Typical) |
| Color | Off - white to light yellow |
| Odor | Characteristic, likely pungent |
| Melting Point | Data needed (varies by source) |
| Boiling Point | Data needed (varies by source) |
| Density | Data needed (varies by source) |
| Solubility In Water | Low solubility (organic compound) |
| Solubility In Organic Solvents | Soluble in common organic solvents like toluene, dichloromethane |
| Flash Point | Data needed (varies by source) |
| Hazard Class | Irritant, potentially harmful if swallowed or inhaled |
As an accredited 3-Chloro-4,5-Difluoronitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 kg of 3 - chloro - 4,5 - difluoronitrobenzene packaged in a sealed chemical - grade drum. |
| Storage | 3 - Chloro - 4,5 - difluoronitrobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly - sealed container to prevent leakage and exposure to air or moisture. It's also crucial to label the storage container clearly for easy identification and to ensure compliance with safety regulations. |
| Shipping | 3 - Chloro - 4,5 - difluoronitrobenzene is a chemical. Shipping should be in accordance with hazardous chemical regulations. Use proper packaging to prevent leakage, and ensure transportation by carriers licensed for such chemicals. |
Competitive 3-Chloro-4,5-Difluoronitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the physical properties of 3-chloro-4,5-difluoronitrobenzene?
3-Bromo-4,5-diethoxy benzyl has specific physical properties. Its appearance is usually solid, which is due to the strong interaction force between molecules, so that the molecules are arranged in an orderly manner to form a solid structure.
From the perspective of melting point, the presence of bromine atoms and ethoxy groups in the molecular structure affects the intermolecular forces, causing its melting point to be within a certain range. The relative atomic mass of bromine atoms is large, which increases the intermolecular dispersion force; ethoxy groups interact with neighboring molecules through their spatial structure and electronic effects, and the combined effect determines the melting point characteristics of the substance.
Solubility is also one of the important physical properties. In view of the fact that the molecule contains polar ethoxy groups, it is soluble in polar organic solvents to a certain extent, such as ethanol, acetone, etc. However, the hydrophobicity of bromine atoms and the non-polar characteristics of the benzyl moiety limit its solubility in water. Therefore, the substance exhibits a specific dissolution distribution behavior between organic solvents and water.
In addition, its density is related to the relative molecular mass and the way of molecular packing. The type and quantity of each atom in the molecular structure determine the relative molecular mass, and the degree of molecular packing in crystals or liquids affects the density value. In general, the physical properties of 3-bromo-4,5-diethoxybenzyl are determined by its molecular structure, and the atoms and functional groups cooperate with each other to give the substance its unique physical performance, which is of great significance in chemical research and related application fields.
From the perspective of melting point, the presence of bromine atoms and ethoxy groups in the molecular structure affects the intermolecular forces, causing its melting point to be within a certain range. The relative atomic mass of bromine atoms is large, which increases the intermolecular dispersion force; ethoxy groups interact with neighboring molecules through their spatial structure and electronic effects, and the combined effect determines the melting point characteristics of the substance.
Solubility is also one of the important physical properties. In view of the fact that the molecule contains polar ethoxy groups, it is soluble in polar organic solvents to a certain extent, such as ethanol, acetone, etc. However, the hydrophobicity of bromine atoms and the non-polar characteristics of the benzyl moiety limit its solubility in water. Therefore, the substance exhibits a specific dissolution distribution behavior between organic solvents and water.
In addition, its density is related to the relative molecular mass and the way of molecular packing. The type and quantity of each atom in the molecular structure determine the relative molecular mass, and the degree of molecular packing in crystals or liquids affects the density value. In general, the physical properties of 3-bromo-4,5-diethoxybenzyl are determined by its molecular structure, and the atoms and functional groups cooperate with each other to give the substance its unique physical performance, which is of great significance in chemical research and related application fields.
What are the chemical properties of 3-chloro-4,5-difluoronitrobenzene?
3-Cyanogen-4,5-diethoxycarbonyl benzyl has many chemical properties. The cyanyl group (-CN) in its molecule has high reactivity and can participate in a variety of reactions. For example, in the nucleophilic substitution reaction, the carbon atoms in the cyanyl group have a partial positive charge, which is vulnerable to the attack of nucleophilic reagents. It can react with nucleophilic reagents containing active hydrogen, such as alcohols and amines, to generate corresponding nitrile derivatives, whereby the molecular structure can be modified and functionalized.
Furthermore, the two ethoxy carbonyl groups in the molecule (-COOCH -2 CH) also have important reactivity. Carbonyl carbons in ethoxy carbonyl groups are positively charged and vulnerable to attack by nucleophilic reagents. For example, in the hydrolysis reaction, under acidic or alkaline conditions, ethoxycarbonyl can be hydrolyzed to form carboxyl groups (-COOH), resulting in 3-cyanogen-4,5-dicarboxylbenzyl. After hydrolysis under alkaline conditions, the corresponding carboxylic acid can be obtained by acidification.
In the reduction reaction, the cyano group can be reduced to an amino group (-NH2O). If the reaction conditions are controlled, the cyano group can be selectively reduced while the ethoxycarbonyl group is retained, thereby obtaining 3-amino-4,5-diethoxycarbonylbenzyl. This product is widely used in drug synthesis, material preparation and other fields. In addition, ethoxycarbonyl can be reduced to alcohol hydroxyl groups under the action of some reducing agents, so that derivatives with alcohol hydroxyl groups can be formed.
Moreover, the benzene ring in the 3-cyanogen-4,5-diethoxycarbonyl benzyl molecule, due to the influence of cyano and ethoxycarbonyl, the electron cloud density distribution changes, and the electrophilic substitution reaction activity and selectivity on the benzene ring also change. Under suitable conditions, halogenation, nitrification, sulfonation and other electrophilic substitution reactions can occur, and other functional groups can be introduced into the benzene ring, laying the foundation for the synthesis of more complex compounds.
Furthermore, the two ethoxy carbonyl groups in the molecule (-COOCH -2 CH) also have important reactivity. Carbonyl carbons in ethoxy carbonyl groups are positively charged and vulnerable to attack by nucleophilic reagents. For example, in the hydrolysis reaction, under acidic or alkaline conditions, ethoxycarbonyl can be hydrolyzed to form carboxyl groups (-COOH), resulting in 3-cyanogen-4,5-dicarboxylbenzyl. After hydrolysis under alkaline conditions, the corresponding carboxylic acid can be obtained by acidification.
In the reduction reaction, the cyano group can be reduced to an amino group (-NH2O). If the reaction conditions are controlled, the cyano group can be selectively reduced while the ethoxycarbonyl group is retained, thereby obtaining 3-amino-4,5-diethoxycarbonylbenzyl. This product is widely used in drug synthesis, material preparation and other fields. In addition, ethoxycarbonyl can be reduced to alcohol hydroxyl groups under the action of some reducing agents, so that derivatives with alcohol hydroxyl groups can be formed.
Moreover, the benzene ring in the 3-cyanogen-4,5-diethoxycarbonyl benzyl molecule, due to the influence of cyano and ethoxycarbonyl, the electron cloud density distribution changes, and the electrophilic substitution reaction activity and selectivity on the benzene ring also change. Under suitable conditions, halogenation, nitrification, sulfonation and other electrophilic substitution reactions can occur, and other functional groups can be introduced into the benzene ring, laying the foundation for the synthesis of more complex compounds.
What are the main uses of 3-chloro-4,5-difluoronitrobenzene?
3-Cyano-4,5-diethoxycarbonyl indole is a key intermediate in organic synthesis and is widely used in many fields such as medicine, pesticides and materials.
In the field of medicine, it is mainly used to synthesize compounds with biological activity and can be developed as potential drugs. For example, with the help of specific chemical reactions, it can be converted into drug molecules that have therapeutic effects on certain diseases. For example, in the development of anti-tumor drugs, this intermediate can be combined with tumor cell targets through multi-step reactions, so as to achieve the purpose of inhibiting tumor cell growth and proliferation. At the same time, in the development of drugs for the treatment of nervous system diseases, with 3-cyanogen-4,5-diethoxycarbonyl indole as the starting material, through reasonable molecular design and modification, drugs that regulate neurotransmitters and repair nerve damage can be synthesized.
In the field of pesticides, it can be used as an important raw material for the synthesis of new pesticides. For example, pesticide products with high insecticidal, bactericidal or herbicidal activities can be prepared through a series of reactions. With their unique chemical structure, these pesticides can specifically act on the specific physiological processes of pests, pathogens or weeds, achieve precise strikes, and have little impact on the environment, meeting the needs of the development of modern green pesticides. For some stubborn pests, pesticides synthesized based on this intermediate can damage the nervous system of pests or interfere with their growth and development, achieving good control effect.
In the field of materials, 3-cyano-4,5-diethoxycarbonyl indole can be used to synthesize functional materials. For example, the synthesis of materials with special optical and electrical properties shows potential application value in the field of optoelectronics such as organic Light Emitting Diode (OLED) and solar cells. In the synthesis of OLED materials, the introduction of this intermediate can improve the luminous efficiency and stability of the material, enhance the performance of OLED devices, and lay the foundation for achieving better display effects.
In the field of medicine, it is mainly used to synthesize compounds with biological activity and can be developed as potential drugs. For example, with the help of specific chemical reactions, it can be converted into drug molecules that have therapeutic effects on certain diseases. For example, in the development of anti-tumor drugs, this intermediate can be combined with tumor cell targets through multi-step reactions, so as to achieve the purpose of inhibiting tumor cell growth and proliferation. At the same time, in the development of drugs for the treatment of nervous system diseases, with 3-cyanogen-4,5-diethoxycarbonyl indole as the starting material, through reasonable molecular design and modification, drugs that regulate neurotransmitters and repair nerve damage can be synthesized.
In the field of pesticides, it can be used as an important raw material for the synthesis of new pesticides. For example, pesticide products with high insecticidal, bactericidal or herbicidal activities can be prepared through a series of reactions. With their unique chemical structure, these pesticides can specifically act on the specific physiological processes of pests, pathogens or weeds, achieve precise strikes, and have little impact on the environment, meeting the needs of the development of modern green pesticides. For some stubborn pests, pesticides synthesized based on this intermediate can damage the nervous system of pests or interfere with their growth and development, achieving good control effect.
In the field of materials, 3-cyano-4,5-diethoxycarbonyl indole can be used to synthesize functional materials. For example, the synthesis of materials with special optical and electrical properties shows potential application value in the field of optoelectronics such as organic Light Emitting Diode (OLED) and solar cells. In the synthesis of OLED materials, the introduction of this intermediate can improve the luminous efficiency and stability of the material, enhance the performance of OLED devices, and lay the foundation for achieving better display effects.
What are the synthesis methods of 3-chloro-4,5-difluoronitrobenzene?
There are several ways to synthesize 3-bromo-4,5-diethoxybenzaldehyde in ancient times, and now I will describe them in detail.
One of them can be started with phenols. First, take the corresponding phenols, and use appropriate halogenating reagents, such as bromine or bromine-containing compounds, to carry out a halogenation reaction under specific reaction conditions, so that bromine atoms are introduced into the phenol ring of the phenol to obtain bromine-containing phenolic derivatives. Then, a halogenated hydrocarbon, such as haloethane, is reacted with a brominated phenol derivative under the help of an alkaline environment and a phase transfer catalyst to transform the phenolic hydroxyl group into an ethoxy group to form a bromine-containing and ethoxy-containing phenyl ring structure. Finally, by mild oxidation means, such as the use of a specific oxidizing agent, at a suitable temperature, pH and other conditions, the specific group on the benzene ring is oxidized to an aldehyde group, and then 3-bromo-4,5-diethoxybenzaldehyde is obtained.
Second, it can also be started from benzaldehyde derivatives. If the starting material is benzaldehyde with appropriate substituents, it should be ethoxylated first. Ethanol and suitable catalysts, such as acidic or basic catalysts, can be selected to promote the introduction of ethoxy groups into specific positions in the benzene ring under heating, reflux and other conditions. After that, the bromination step is carried out, the appropriate brominating agent is selected, the reaction temperature, time and the ratio of the reactants are controlled, so that the bromine atom is precisely connected to the target position, so as to obtain the desired product.
Third, the route of aryl boric acid derivatives can be considered. First, the aryl boric acid containing ethoxy group is prepared, and the halogen containing bromine is coupled with the halogen in the presence of palladium catalyst and ligand. This reaction requires fine regulation of the reaction solvent, the type and dosage of base, temperature and other conditions to effectively form a carbon-carbon bond and build the required benzene ring skeleton. Subsequent appropriate treatment, such as oxidation steps, to form an aldehyde group to complete the synthesis of 3-bromo-4,5-diethoxybenzaldehyde.
One of them can be started with phenols. First, take the corresponding phenols, and use appropriate halogenating reagents, such as bromine or bromine-containing compounds, to carry out a halogenation reaction under specific reaction conditions, so that bromine atoms are introduced into the phenol ring of the phenol to obtain bromine-containing phenolic derivatives. Then, a halogenated hydrocarbon, such as haloethane, is reacted with a brominated phenol derivative under the help of an alkaline environment and a phase transfer catalyst to transform the phenolic hydroxyl group into an ethoxy group to form a bromine-containing and ethoxy-containing phenyl ring structure. Finally, by mild oxidation means, such as the use of a specific oxidizing agent, at a suitable temperature, pH and other conditions, the specific group on the benzene ring is oxidized to an aldehyde group, and then 3-bromo-4,5-diethoxybenzaldehyde is obtained.
Second, it can also be started from benzaldehyde derivatives. If the starting material is benzaldehyde with appropriate substituents, it should be ethoxylated first. Ethanol and suitable catalysts, such as acidic or basic catalysts, can be selected to promote the introduction of ethoxy groups into specific positions in the benzene ring under heating, reflux and other conditions. After that, the bromination step is carried out, the appropriate brominating agent is selected, the reaction temperature, time and the ratio of the reactants are controlled, so that the bromine atom is precisely connected to the target position, so as to obtain the desired product.
Third, the route of aryl boric acid derivatives can be considered. First, the aryl boric acid containing ethoxy group is prepared, and the halogen containing bromine is coupled with the halogen in the presence of palladium catalyst and ligand. This reaction requires fine regulation of the reaction solvent, the type and dosage of base, temperature and other conditions to effectively form a carbon-carbon bond and build the required benzene ring skeleton. Subsequent appropriate treatment, such as oxidation steps, to form an aldehyde group to complete the synthesis of 3-bromo-4,5-diethoxybenzaldehyde.
What are the precautions for storing and transporting 3-chloro-4,5-difluoronitrobenzene?
3-Bromo-4,5-diethoxybenzaldehyde is a key intermediate in organic synthesis. During storage and transportation, there are indeed many things to pay attention to:
First, when storing, be sure to choose a cool and dry place. This substance is quite sensitive to temperature and humidity. Excessive temperature or humidity may cause it to deteriorate. If the storage environment is hot, it may cause its chemical properties to change, such as aldehyde groups may be oxidized, which will affect its quality and purity. Store it in a well-ventilated place to prevent the accumulation of harmful gases. At the same time, it should be kept away from fire sources, heat sources and strong oxidants, because it is flammable to a certain extent, if it comes into contact with strong oxidants, it is easy to cause violent chemical reactions, and even the risk of combustion and explosion.
Second, the packaging must be tight. Appropriate packaging materials should be used, such as sealed glass bottles or iron drums lined with plastic bags, etc., to ensure that there is no risk of leakage. Once the packaging is damaged, the probability of the substance coming into contact with air and moisture increases greatly, accelerating the deterioration process.
Third, during transportation, it is necessary to prevent violent vibration and collision. Violent vibration or collision may cause damage to the packaging, and may stimulate potential internal chemical reactions. Transportation vehicles need to have good heat insulation, moisture resistance and fire resistance to maintain a stable transportation environment. It is also necessary to operate in strict accordance with the relevant regulations on the transportation of hazardous chemicals, and to be equipped with necessary emergency treatment equipment and protective equipment to prevent unexpected situations during transportation and to be able to respond properly in a timely manner. In short, the storage and transportation of 3-bromo-4,5-diethoxybenzaldehyde should be treated with caution to ensure its quality and safety.
First, when storing, be sure to choose a cool and dry place. This substance is quite sensitive to temperature and humidity. Excessive temperature or humidity may cause it to deteriorate. If the storage environment is hot, it may cause its chemical properties to change, such as aldehyde groups may be oxidized, which will affect its quality and purity. Store it in a well-ventilated place to prevent the accumulation of harmful gases. At the same time, it should be kept away from fire sources, heat sources and strong oxidants, because it is flammable to a certain extent, if it comes into contact with strong oxidants, it is easy to cause violent chemical reactions, and even the risk of combustion and explosion.
Second, the packaging must be tight. Appropriate packaging materials should be used, such as sealed glass bottles or iron drums lined with plastic bags, etc., to ensure that there is no risk of leakage. Once the packaging is damaged, the probability of the substance coming into contact with air and moisture increases greatly, accelerating the deterioration process.
Third, during transportation, it is necessary to prevent violent vibration and collision. Violent vibration or collision may cause damage to the packaging, and may stimulate potential internal chemical reactions. Transportation vehicles need to have good heat insulation, moisture resistance and fire resistance to maintain a stable transportation environment. It is also necessary to operate in strict accordance with the relevant regulations on the transportation of hazardous chemicals, and to be equipped with necessary emergency treatment equipment and protective equipment to prevent unexpected situations during transportation and to be able to respond properly in a timely manner. In short, the storage and transportation of 3-bromo-4,5-diethoxybenzaldehyde should be treated with caution to ensure its quality and safety.
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