Linshang Chemical
PRODUCTS
3-Chloro-4-(Cyclopropylcarbamoyl)Benzeneboronic Acid
Linshang Chemical
|
HS Code |
195230 |
| Chemical Formula | C11H12BClNO3 |
| Molecular Weight | 253.48 |
| Appearance | Solid (Typical) |
| Purity | Typically High Purity for Synthesis |
| Solubility In Organic Solvents | Moderate solubility in common organic solvents like dichloromethane |
| Melting Point | Data may vary, specific value depends on purity and measurement method |
| Acidity Pka | Related to the boronic acid group, approximate pKa around 8 - 9 |
| Stability | Should be stored under appropriate conditions, can be sensitive to moisture |
| Reactivity | Reactive towards various coupling reagents in cross - coupling reactions |
As an accredited 3-Chloro-4-(Cyclopropylcarbamoyl)Benzeneboronic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 3 - chloro - 4 - (cyclopropylcarbamoyl)benzeneboronic Acid in sealed chemical - grade packaging. |
| Storage | Store 3 - chloro - 4 - (cyclopropylcarbamoyl)benzeneboronic acid in a cool, dry place, away from direct sunlight. Keep it in a tightly sealed container to prevent moisture absorption, as boronic acids can react with water. Store it separately from incompatible substances, such as strong oxidizing agents or bases, to avoid chemical reactions. |
| Shipping | 3 - Chloro - 4 - (cyclopropylcarbamoyl)benzeneboronic acid is shipped in sealed, corrosion - resistant containers. Special care is taken to prevent exposure to moisture and incompatible substances during transportation, following strict chemical shipping regulations. |
Competitive 3-Chloro-4-(Cyclopropylcarbamoyl)Benzeneboronic Acid prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 3-Chloro-4-(Cyclopropylcarbamoyl)Benzeneboronic Acid in China?
As a trusted 3-Chloro-4-(Cyclopropylcarbamoyl)Benzeneboronic Acid manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 3-Chloro-4-(Cyclopropylcarbamoyl)Benzeneboronic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemical structure of 3-chloro-4- (cyclopropylcarbamoyl) benzeneboronic Acid?
This is the analysis of the chemical structure of 3-chloro-4- (cyclopropylcarbamido) phenylboronic acid. In its structure, the benzene ring is the core structure, and there are chlorine atoms connected to the benzene ring at position 3. This chlorine atom is a halogen element atom with certain electronegativity, which can affect the electron cloud distribution of the benzene ring. At position 4 of the benzene ring, there is a specific structure connected, that is, cyclopropylcarbamido. In this structure, cyclopropyl is a ternary carbon ring with unique tension, and its ring tension plays a role in the stability and reactivity of the whole molecule; formamido is composed of carbonyl and amino groups, which have certain polarity and reactivity. On the benzene ring, there is also a boric acid group. In the boric acid group-B (OH) -2, the boron atom has electron deficiency, which makes the molecule participate in many organic synthesis reactions, such as the Suzuki reaction. Overall, the chemical structure of this compound is centered on the benzene ring, which connects different groups such as chlorine atom, cyclopropylcarbamide group and boric acid group. The interaction of each group endows the compound with unique chemical properties and reactivity.
What are the main uses of 3-chloro-4- (cyclopropylcarbamoyl) benzeneboronic Acid
3-Chloro-4- (cyclopropylaminoformyl) phenylboronic acid is a key raw material for organic synthesis and has important uses in many fields.
In the field of medicinal chemistry, its role is crucial. Due to its unique structure, it can participate in the construction of a variety of drug molecules. It can be used as a key building block to react with other active groups to build complex molecular structures with specific biological activities. In the development of many new anti-cancer drugs, this compound is often relied on as a starting material to shape drug molecules that precisely bind to specific targets of cancer cells through multi-step reactions, so as to achieve the purpose of efficiently inhibiting the growth and spread of cancer cells.
In the field of materials science, it also has extraordinary performance. It can be used to prepare functional organic materials. For example, in the synthesis of organic optoelectronic materials, by rationally designing the reaction path, it is introduced into the polymer chain to endow the material with unique optical and electrical properties. The materials synthesized by this compound may have good fluorescence properties, which can be applied to optoelectronic devices such as Light Emitting Diode (LED) to improve the luminous efficiency and stability of the device.
In the field of organic synthesis chemistry, it is an indispensable and important reagent. As a phenylboronic acid compound, it can participate in classic coupling reactions, such as Suzuki-Miyaura coupling reaction. This reaction is an effective means to construct carbon-carbon bonds. 3-chloro-4 - (cyclopropylaminoformyl) phenylboronic acid can be coupled with substrates such as halogenated aromatics or olefins under appropriate catalyst and reaction conditions to achieve efficient synthesis of complex organic molecules, providing a powerful tool for organic synthesis chemists to create novel organic compounds with structures.
In the field of medicinal chemistry, its role is crucial. Due to its unique structure, it can participate in the construction of a variety of drug molecules. It can be used as a key building block to react with other active groups to build complex molecular structures with specific biological activities. In the development of many new anti-cancer drugs, this compound is often relied on as a starting material to shape drug molecules that precisely bind to specific targets of cancer cells through multi-step reactions, so as to achieve the purpose of efficiently inhibiting the growth and spread of cancer cells.
In the field of materials science, it also has extraordinary performance. It can be used to prepare functional organic materials. For example, in the synthesis of organic optoelectronic materials, by rationally designing the reaction path, it is introduced into the polymer chain to endow the material with unique optical and electrical properties. The materials synthesized by this compound may have good fluorescence properties, which can be applied to optoelectronic devices such as Light Emitting Diode (LED) to improve the luminous efficiency and stability of the device.
In the field of organic synthesis chemistry, it is an indispensable and important reagent. As a phenylboronic acid compound, it can participate in classic coupling reactions, such as Suzuki-Miyaura coupling reaction. This reaction is an effective means to construct carbon-carbon bonds. 3-chloro-4 - (cyclopropylaminoformyl) phenylboronic acid can be coupled with substrates such as halogenated aromatics or olefins under appropriate catalyst and reaction conditions to achieve efficient synthesis of complex organic molecules, providing a powerful tool for organic synthesis chemists to create novel organic compounds with structures.
What are the synthesis methods of 3-chloro-4- (cyclopropylcarbamoyl) benzeneboronic Acid
There are several methods for the synthesis of 3-chloro-4- (cyclopropylaminoformyl) phenylboronic acid.
First, the corresponding halogenated aromatic hydrocarbon is used as the starting material. First, the halogenated benzene derivative interacts with a metal reagent (such as n-butyl lithium, etc.) to form an active intermediate, which then reacts with borate esters (such as trimethoxyborane) to form boric acid derivatives. Then, cyclopropylaminoformyl is introduced through a specific acylation reaction. In the acylation process, a suitable cyclopropylaminoformylation reagent is selected, and a nucleophilic substitution reaction occurs in the presence of a suitable base (such as potassium carbonate, etc.) and a reaction solvent (such as dichloromethane, etc.) to obtain the target product. This route requires precise control of the amount of metal reagents and reaction conditions to avoid overreaction or side reactions.
Second, starting from phenylboronic acid. First protect phenylboronic acid, and commonly use protective groups such as pinacol esters. The protected phenylboronic acid derivatives react with reagents containing chlorine and acyl active groups. For example, it can react with halogenated aromatics containing cyclopropylcarbamoyl groups and chlorine atoms in suitable positions. Under the action of palladium-catalyzed systems (such as tetra (triphenylphosphine) palladium, etc.), the coupling is achieved through the formation of carbon-boron bonds. After the reaction is completed, the protective group is removed to obtain 3-chloro-4- (cyclopropylcarbamoyl) phenylboronic acid. This method requires attention to the selection and removal conditions of the protective group to ensure the purity and yield of the product.
Third, the benzoic acid derivative is used as the starting material. The benzoic acid is first chlorinated and chlorine atoms are introduced to obtain chlorinated benzoic acid. After that, it is converted into the corresponding acid chloride, and then reacts with cyclopropylamine to form cyclopropylaminoformyl derivatives. Finally, the phenylboronic acid structure is constructed by reacting with boronizing reagents (such as pinacol borane, etc.) under suitable catalytic conditions to complete the synthesis of the target product. In this path, the selectivity of the chlorination reaction and the efficiency of the boration reaction are key points, and the reaction parameters need to be carefully regulated.
First, the corresponding halogenated aromatic hydrocarbon is used as the starting material. First, the halogenated benzene derivative interacts with a metal reagent (such as n-butyl lithium, etc.) to form an active intermediate, which then reacts with borate esters (such as trimethoxyborane) to form boric acid derivatives. Then, cyclopropylaminoformyl is introduced through a specific acylation reaction. In the acylation process, a suitable cyclopropylaminoformylation reagent is selected, and a nucleophilic substitution reaction occurs in the presence of a suitable base (such as potassium carbonate, etc.) and a reaction solvent (such as dichloromethane, etc.) to obtain the target product. This route requires precise control of the amount of metal reagents and reaction conditions to avoid overreaction or side reactions.
Second, starting from phenylboronic acid. First protect phenylboronic acid, and commonly use protective groups such as pinacol esters. The protected phenylboronic acid derivatives react with reagents containing chlorine and acyl active groups. For example, it can react with halogenated aromatics containing cyclopropylcarbamoyl groups and chlorine atoms in suitable positions. Under the action of palladium-catalyzed systems (such as tetra (triphenylphosphine) palladium, etc.), the coupling is achieved through the formation of carbon-boron bonds. After the reaction is completed, the protective group is removed to obtain 3-chloro-4- (cyclopropylcarbamoyl) phenylboronic acid. This method requires attention to the selection and removal conditions of the protective group to ensure the purity and yield of the product.
Third, the benzoic acid derivative is used as the starting material. The benzoic acid is first chlorinated and chlorine atoms are introduced to obtain chlorinated benzoic acid. After that, it is converted into the corresponding acid chloride, and then reacts with cyclopropylamine to form cyclopropylaminoformyl derivatives. Finally, the phenylboronic acid structure is constructed by reacting with boronizing reagents (such as pinacol borane, etc.) under suitable catalytic conditions to complete the synthesis of the target product. In this path, the selectivity of the chlorination reaction and the efficiency of the boration reaction are key points, and the reaction parameters need to be carefully regulated.
What are the physical properties of 3-chloro-4- (cyclopropylcarbamoyl) benzeneboronic Acid
3-Chloro-4- (cyclopropylaminoformyl) phenylboronic acid, this material has unique physical and chemical properties. Looking at its appearance, it is mostly white to off-white solid powder at room temperature. This morphology is easy to store and use, and it is also easy to disperse in many reaction systems.
Regarding solubility, it shows some solubility in common organic solvents such as dichloromethane, N, N-dimethylformamide (DMF). In dichloromethane, due to the presence of moderate van der Waals forces and dipole-dipole interactions between the molecule and the solvent, it can have a good solubility performance, which is crucial for organic synthesis reactions using dichloromethane as the reaction medium; in DMF, with the strong polarity of DMF and the compound to form hydrogen bonds and other interactions, a certain degree of dissolution can also be achieved, which is conducive to the development of related homogeneous reactions. However, its solubility in water is poor, and the hydrophobic cyclopropyl and aromatic ring structures in the Gain molecule account for a large proportion, making it difficult to form effective interactions with water molecules.
In terms of stability, under conventional storage conditions, it can exist stably in a dry and cool environment. However, it should be noted that it is more sensitive to humidity. In high humidity environments, boric acid groups are prone to hydrolysis and other reactions, resulting in structural changes, which affect their chemical activity and application performance. In addition, high temperature will also pose a challenge to its stability. When heated, the internal chemical bond energy of the molecule increases, which may trigger reactions such as rearrangement and decomposition. Therefore, temperature control is required during storage and use.
Its melting point is an important physical property. It can be known that it is in a specific temperature range through experimental measurement. This property is of great significance for product purity identification and reaction process monitoring. In the post-processing stage of organic synthesis, the purity of the product can be judged by melting point measurement. If the measured melting point is consistent with the theoretical value and the melting range is narrow, it indicates that the product purity is high.
The above physical properties of 3-chloro-4- (cyclopropylaminoformyl) phenylboronic acid have far-reaching influence in the fields of organic synthesis and drug development. According to its characteristics, researchers need to rationally design the reaction conditions and process flow to achieve the expected experimental and production goals.
Regarding solubility, it shows some solubility in common organic solvents such as dichloromethane, N, N-dimethylformamide (DMF). In dichloromethane, due to the presence of moderate van der Waals forces and dipole-dipole interactions between the molecule and the solvent, it can have a good solubility performance, which is crucial for organic synthesis reactions using dichloromethane as the reaction medium; in DMF, with the strong polarity of DMF and the compound to form hydrogen bonds and other interactions, a certain degree of dissolution can also be achieved, which is conducive to the development of related homogeneous reactions. However, its solubility in water is poor, and the hydrophobic cyclopropyl and aromatic ring structures in the Gain molecule account for a large proportion, making it difficult to form effective interactions with water molecules.
In terms of stability, under conventional storage conditions, it can exist stably in a dry and cool environment. However, it should be noted that it is more sensitive to humidity. In high humidity environments, boric acid groups are prone to hydrolysis and other reactions, resulting in structural changes, which affect their chemical activity and application performance. In addition, high temperature will also pose a challenge to its stability. When heated, the internal chemical bond energy of the molecule increases, which may trigger reactions such as rearrangement and decomposition. Therefore, temperature control is required during storage and use.
Its melting point is an important physical property. It can be known that it is in a specific temperature range through experimental measurement. This property is of great significance for product purity identification and reaction process monitoring. In the post-processing stage of organic synthesis, the purity of the product can be judged by melting point measurement. If the measured melting point is consistent with the theoretical value and the melting range is narrow, it indicates that the product purity is high.
The above physical properties of 3-chloro-4- (cyclopropylaminoformyl) phenylboronic acid have far-reaching influence in the fields of organic synthesis and drug development. According to its characteristics, researchers need to rationally design the reaction conditions and process flow to achieve the expected experimental and production goals.
What to pay attention to when storing and transporting 3-chloro-4- (cyclopropylcarbamoyl) benzeneboronic Acid
3-Chloro-4- (cyclopropylcarbamido) phenylboronic acid This product requires attention to many key matters during storage and transportation.
Bear the brunt, and temperature control is essential. Due to its nature or sensitivity to temperature, it should be stored in a cool place to avoid hot topics. High temperature can easily cause its chemical structure to change, which can damage quality and even cause dangerous chemical reactions. The ideal storage temperature is 2-8 ° C, just like a cool place in a humble house, which can keep it stable.
Furthermore, humidity cannot be ignored. This substance should be stored in a dry place, moisture-proof and waterproof. Moisture is easy to hydrolyze, destroy the molecular structure, and reduce the purity. If it is placed in a sealed container and then placed in a dryer, it will be like building a shelter from rain.
Protection from light is also key. Light may cause photochemical reactions to occur, affecting quality. When storing, use a brown bottle or wrap a black light-shielding material, as if to add a curtain to protect it from light.
When transporting, the packaging must be sturdy. Choose suitable packaging materials to ensure that it will not be damaged and leaked during the bumpy journey. And it should be properly isolated from other chemicals to prevent mutual reactions, just like arranging passengers to sit in separate seats to avoid conflicts.
In addition, operators need to strictly abide by safety procedures. Wearing protective equipment, such as protective clothing, gloves, goggles, etc., is like wearing armor to prevent contact hazards.
In short, careful care and compliance with regulations can ensure the quality and avoid risks of 3-chloro-4- (cyclopropylformamido) phenylboronic acid during storage and transportation.
Bear the brunt, and temperature control is essential. Due to its nature or sensitivity to temperature, it should be stored in a cool place to avoid hot topics. High temperature can easily cause its chemical structure to change, which can damage quality and even cause dangerous chemical reactions. The ideal storage temperature is 2-8 ° C, just like a cool place in a humble house, which can keep it stable.
Furthermore, humidity cannot be ignored. This substance should be stored in a dry place, moisture-proof and waterproof. Moisture is easy to hydrolyze, destroy the molecular structure, and reduce the purity. If it is placed in a sealed container and then placed in a dryer, it will be like building a shelter from rain.
Protection from light is also key. Light may cause photochemical reactions to occur, affecting quality. When storing, use a brown bottle or wrap a black light-shielding material, as if to add a curtain to protect it from light.
When transporting, the packaging must be sturdy. Choose suitable packaging materials to ensure that it will not be damaged and leaked during the bumpy journey. And it should be properly isolated from other chemicals to prevent mutual reactions, just like arranging passengers to sit in separate seats to avoid conflicts.
In addition, operators need to strictly abide by safety procedures. Wearing protective equipment, such as protective clothing, gloves, goggles, etc., is like wearing armor to prevent contact hazards.
In short, careful care and compliance with regulations can ensure the quality and avoid risks of 3-chloro-4- (cyclopropylformamido) phenylboronic acid during storage and transportation.
Scan to WhatsApp
