Linshang Chemical
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3-Chloro-4-Fluoro-1-Iodobenzene
Linshang Chemical
|
HS Code |
911140 |
| Chemical Formula | C6H3ClFI |
| Molecular Weight | 256.445 |
| Appearance | Typically a colorless to light - yellow liquid |
| Boiling Point | Around 208 - 210°C |
| Density | Data may vary, but expected to be denser than water |
| Solubility In Water | Insoluble in water |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, ethyl acetate |
| Vapor Pressure | Low vapor pressure at room temperature |
As an accredited 3-Chloro-4-Fluoro-1-Iodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 3 - chloro - 4 - fluoro - 1 - iodobenzene packaged in a sealed glass bottle. |
| Storage | 3 - Chloro - 4 - fluoro - 1 - iodobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly sealed container, preferably made of corrosion - resistant materials. Label the container clearly. This is to prevent decomposition, potential fire hazards, and reactions that could release harmful substances. |
| Shipping | 3 - chloro - 4 - fluoro - 1 - iodobenzene is shipped in sealed, corrosion - resistant containers. It follows strict hazardous material regulations, with proper labeling for safe handling during transportation to prevent any chemical - related risks. |
Competitive 3-Chloro-4-Fluoro-1-Iodobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
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As a leading 3-Chloro-4-Fluoro-1-Iodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 3-chloro-4-fluoro-1-iodobenzene?
3-Chloro-4-fluoro-1-iodobenzene is a crucial compound in the field of organic synthesis. It has a wide range of uses and is of critical significance in many fields.
Bearing the brunt, in the field of medicinal chemistry, this compound is often used as a key intermediate. Due to the unique chemical properties of halogen atoms, complex drug molecular structures can be constructed through various chemical reactions. For example, through nucleophilic substitution reactions, halogen atoms can be replaced by various active groups to synthesize compounds with specific pharmacological activities. In the synthesis of many antibacterial and antiviral drugs, 3-chloro-4-fluoro-1-iodobenzene plays an indispensable role, providing an important structural basis for the creation of new and efficient drugs.
Furthermore, in the field of materials science, it also has extraordinary performance. Because it contains halogen atoms, it can endow materials with special physical and chemical properties. For example, introducing it into the structure of polymer materials may improve the thermal stability, flame retardancy and electrical properties of materials. In the research and development of organic optoelectronic materials, 3-chloro-4-fluoro-1-iodobenzene can participate in the construction of materials through specific reactions, so that the materials can exhibit better performance in optoelectronic devices, such as organic Light Emitting Diode (OLED), solar cells, etc., and contribute to the development of new high-performance materials.
In addition, in the field of fine chemistry, this compound is often used to synthesize special dyes, fragrances and additives. With its unique molecular structure and halogen atom properties, fine chemicals with unique colors, smells or specific functions can be derived. In dye synthesis, by chemically modifying it, dyes with bright colors and good stability can be prepared to meet the needs of high-quality dyes in textile, printing and other industries.
In summary, 3-chloro-4-fluoro-1-iodobenzene occupies an important position in many fields such as medicine, materials, and fine chemicals due to its unique chemical structure and properties, providing a key material foundation and technical support for the development of various fields.
Bearing the brunt, in the field of medicinal chemistry, this compound is often used as a key intermediate. Due to the unique chemical properties of halogen atoms, complex drug molecular structures can be constructed through various chemical reactions. For example, through nucleophilic substitution reactions, halogen atoms can be replaced by various active groups to synthesize compounds with specific pharmacological activities. In the synthesis of many antibacterial and antiviral drugs, 3-chloro-4-fluoro-1-iodobenzene plays an indispensable role, providing an important structural basis for the creation of new and efficient drugs.
Furthermore, in the field of materials science, it also has extraordinary performance. Because it contains halogen atoms, it can endow materials with special physical and chemical properties. For example, introducing it into the structure of polymer materials may improve the thermal stability, flame retardancy and electrical properties of materials. In the research and development of organic optoelectronic materials, 3-chloro-4-fluoro-1-iodobenzene can participate in the construction of materials through specific reactions, so that the materials can exhibit better performance in optoelectronic devices, such as organic Light Emitting Diode (OLED), solar cells, etc., and contribute to the development of new high-performance materials.
In addition, in the field of fine chemistry, this compound is often used to synthesize special dyes, fragrances and additives. With its unique molecular structure and halogen atom properties, fine chemicals with unique colors, smells or specific functions can be derived. In dye synthesis, by chemically modifying it, dyes with bright colors and good stability can be prepared to meet the needs of high-quality dyes in textile, printing and other industries.
In summary, 3-chloro-4-fluoro-1-iodobenzene occupies an important position in many fields such as medicine, materials, and fine chemicals due to its unique chemical structure and properties, providing a key material foundation and technical support for the development of various fields.
What are the physical properties of 3-chloro-4-fluoro-1-iodobenzene?
3-Chloro-4-fluoro-1-iodobenzene is one of the organic compounds. Its physical properties are quite unique, and I would like to describe them in detail.
In terms of its appearance, under room temperature and pressure, it is mostly colorless to light yellow liquid with clear texture. This state is closely related to its molecular structure, and its intermolecular forces are specific, which makes it exist in this form under this condition.
Looking at its boiling point, it is about a certain temperature range. Due to the presence of halogen atoms such as chlorine, fluorine, and iodine in the molecule, the intermolecular forces are enhanced, causing the boiling point to rise. The exact value of its boiling point is determined by many factors such as molecular mass and intermolecular interactions. The electronegativity of the halogen atom is large, which causes the molecule to produce polarity. The interaction between polar molecules, such as the dipole-dipole force, has a significant effect on raising the boiling point.
As for the melting point, it is also a specific value. The arrangement and interaction of the molecules determine the melting point. The steric resistance and electronic effect of the halogen atom affect the difficulty of molecular crystallization, which in turn determines the melting point. When the molecules are arranged in a regular and orderly manner, the lattice energy is larger and the melting point is higher; conversely, if the molecular arrangement is messy, the melting point is relatively low.
The density of 3-chloro-4-fluoro-1-iodobenzene is higher than that of water, so it often sinks at the bottom in water. This is due to the relatively large atomic mass of the halogen atoms in the molecule, resulting in an increase in the mass of the substance per unit volume.
In terms of solubility, this compound is slightly soluble in water. Because it is an organic molecule, it has a certain hydrophobicity. The interaction between water molecules and organic molecules is weak, and it is difficult to form strong interactions such as hydrogen bonds with water molecules. However, it is soluble in many organic solvents, such as ether, dichloromethane, etc. The molecular structure of organic solvents is similar to 3-chloro-4-fluoro-1-iodobenzene. According to the principle of "similar miscibility", the two are miscible with each other.
The vapor pressure of this compound is lower at room temperature. Due to the strong intermolecular force, it is difficult for molecules to escape from the liquid phase and become gas phase molecules. However, when the temperature increases, the thermal motion of the molecules intensifies, and the vapor pressure also increases.
In summary, the physical properties of 3-chloro-4-fluoro-1-iodobenzene are determined by its unique molecular structure, and all properties are of great significance in organic synthesis, chemical analysis and other fields.
In terms of its appearance, under room temperature and pressure, it is mostly colorless to light yellow liquid with clear texture. This state is closely related to its molecular structure, and its intermolecular forces are specific, which makes it exist in this form under this condition.
Looking at its boiling point, it is about a certain temperature range. Due to the presence of halogen atoms such as chlorine, fluorine, and iodine in the molecule, the intermolecular forces are enhanced, causing the boiling point to rise. The exact value of its boiling point is determined by many factors such as molecular mass and intermolecular interactions. The electronegativity of the halogen atom is large, which causes the molecule to produce polarity. The interaction between polar molecules, such as the dipole-dipole force, has a significant effect on raising the boiling point.
As for the melting point, it is also a specific value. The arrangement and interaction of the molecules determine the melting point. The steric resistance and electronic effect of the halogen atom affect the difficulty of molecular crystallization, which in turn determines the melting point. When the molecules are arranged in a regular and orderly manner, the lattice energy is larger and the melting point is higher; conversely, if the molecular arrangement is messy, the melting point is relatively low.
The density of 3-chloro-4-fluoro-1-iodobenzene is higher than that of water, so it often sinks at the bottom in water. This is due to the relatively large atomic mass of the halogen atoms in the molecule, resulting in an increase in the mass of the substance per unit volume.
In terms of solubility, this compound is slightly soluble in water. Because it is an organic molecule, it has a certain hydrophobicity. The interaction between water molecules and organic molecules is weak, and it is difficult to form strong interactions such as hydrogen bonds with water molecules. However, it is soluble in many organic solvents, such as ether, dichloromethane, etc. The molecular structure of organic solvents is similar to 3-chloro-4-fluoro-1-iodobenzene. According to the principle of "similar miscibility", the two are miscible with each other.
The vapor pressure of this compound is lower at room temperature. Due to the strong intermolecular force, it is difficult for molecules to escape from the liquid phase and become gas phase molecules. However, when the temperature increases, the thermal motion of the molecules intensifies, and the vapor pressure also increases.
In summary, the physical properties of 3-chloro-4-fluoro-1-iodobenzene are determined by its unique molecular structure, and all properties are of great significance in organic synthesis, chemical analysis and other fields.
Is 3-chloro-4-fluoro-1-iodobenzene chemically stable?
3-Chloro-4-fluoro-1-iodobenzene is one of the organic compounds. The stability of its chemical properties needs to be carefully studied from multiple perspectives.
First, the characteristics of its chemical bonds. The energies of carbon-chlorine bonds, carbon-fluorine bonds and carbon-iodine bonds are different. The carbon-fluorine bond energy is quite high and extremely stable, because the electronegativity of the fluorine atom is extremely strong, and the attraction between the carbon atom and the carbon atom is very large. Therefore, the carbon-fluorine bond needs more energy to break. The carbon-chlorine bond energy is slightly inferior to that of the carbon-fluorine bond, and it is not easily broken. As for the carbon-iodine bond, its bond energy is relatively low and it is easier to break. This difference causes the reactivity of different parts of the molecule to differ.
The second view of its electronic effect. Both fluorine and chlorine are electron-withdrawing groups, which can reduce the electron cloud density of the benzene ring. The electron-withdrawing induction effect of fluorine is particularly strong, which makes the density of the adjacent and para-electron clouds on the benzene ring drop even more. This change in the distribution of the electron cloud affects the activity and check point of the electrophilic substitution reaction of the molecule. Although iodine also has a certain electron-withdrawing property, its atomic radius is large, and the conjugation effect with the benzene ring also has a more complex effect on the distribution of the electron cloud.
Furthermore, in terms of spatial structure, chlorine, fluorine and iodine atoms have different sizes and occupy different spatial positions on the benzene ring. This steric hindrance effect also affects molecular chemical reactions. Large atoms such as iodine can prevent other reagents from approaching specific positions in the benzene ring, changing the reaction path and rate.
Overall, the chemical properties of 3-chloro-4-fluoro-1-iodobenzene are not completely stable. The relative fragility of carbon-iodine bonds makes iodine atoms easily replaced under certain conditions when encountering nucleophiles. And the change of electron cloud density of benzene ring makes it more prone to electrophilic substitution than benzene. However, due to the existence of relatively stable bonds such as carbon-fluorine bonds, it can still maintain a certain stability under ordinary conditions, and is not an extremely active and mutable compound. However, under extreme conditions such as high temperature and strong reagents, its molecular structure and properties are prone to change.
First, the characteristics of its chemical bonds. The energies of carbon-chlorine bonds, carbon-fluorine bonds and carbon-iodine bonds are different. The carbon-fluorine bond energy is quite high and extremely stable, because the electronegativity of the fluorine atom is extremely strong, and the attraction between the carbon atom and the carbon atom is very large. Therefore, the carbon-fluorine bond needs more energy to break. The carbon-chlorine bond energy is slightly inferior to that of the carbon-fluorine bond, and it is not easily broken. As for the carbon-iodine bond, its bond energy is relatively low and it is easier to break. This difference causes the reactivity of different parts of the molecule to differ.
The second view of its electronic effect. Both fluorine and chlorine are electron-withdrawing groups, which can reduce the electron cloud density of the benzene ring. The electron-withdrawing induction effect of fluorine is particularly strong, which makes the density of the adjacent and para-electron clouds on the benzene ring drop even more. This change in the distribution of the electron cloud affects the activity and check point of the electrophilic substitution reaction of the molecule. Although iodine also has a certain electron-withdrawing property, its atomic radius is large, and the conjugation effect with the benzene ring also has a more complex effect on the distribution of the electron cloud.
Furthermore, in terms of spatial structure, chlorine, fluorine and iodine atoms have different sizes and occupy different spatial positions on the benzene ring. This steric hindrance effect also affects molecular chemical reactions. Large atoms such as iodine can prevent other reagents from approaching specific positions in the benzene ring, changing the reaction path and rate.
Overall, the chemical properties of 3-chloro-4-fluoro-1-iodobenzene are not completely stable. The relative fragility of carbon-iodine bonds makes iodine atoms easily replaced under certain conditions when encountering nucleophiles. And the change of electron cloud density of benzene ring makes it more prone to electrophilic substitution than benzene. However, due to the existence of relatively stable bonds such as carbon-fluorine bonds, it can still maintain a certain stability under ordinary conditions, and is not an extremely active and mutable compound. However, under extreme conditions such as high temperature and strong reagents, its molecular structure and properties are prone to change.
What are the preparation methods of 3-chloro-4-fluoro-1-iodobenzene?
There are several common methods for preparing 3-chloro-4-fluoro-1-iodobenzene.
First, it can be started by the corresponding phenolic compound. First, phenol is used as raw material, and chlorine atoms and fluorine atoms are introduced into the phenolic ring of phenol through halogenation reaction. Specifically, suitable halogenating reagents can be selected, such as chlorine-containing and fluorine-containing halogenating agents, and under suitable reaction conditions, the phenolic ring is halogenated at a specific position to obtain chlorine-containing and fluorine-containing phenolic derivatives. Subsequently, the hydroxyl group is converted into a leaving group, and then an iodizing reagent is used for substitution reaction to introduce iodine atoms. If the hydroxyl group is first converted into a leaving group such as a sulfonate group, and then reacted with iodide salts, such as potassium iodide, in the presence of appropriate solvents and catalysts, the target product 3-chloro-4-fluoro-1-iodobenzene can be obtained.
Second, halogenated aromatics are used as starting materials. If there are halogenated aromatics containing chlorine and fluorine, metal-catalyzed coupling reactions of halogenated aromatics can be used. For example, in a palladium-catalyzed system, halogenated aromatics containing chlorine and fluorine are reacted with iodide reagents in the presence of bases and ligands. During the reaction, the palladium catalyst forms an active intermediate with halogenated aromatics and iodine reagents to promote the formation of carbon-iodine bonds, thereby constructing the target molecule 3-chloro-4-fluoro-1-iodobenzene. Among them, the base can adjust the pH of the reaction system, and the ligand helps to stabilize the catalyst and regulate the activity and selectivity of the reaction.
Third, the multi-step substitution construction is carried out directly from the benzene ring. First, benzene is used as the starting material, and chlorine atoms and fluorine atoms are introduced in turn through the electrophilic substitution reaction. Due to the difference in the localization effect of chlorine and fluorine atoms on the electrophilic substitution reaction of the benzene ring, the specific position substitution After the chlorine and fluorine atoms are introduced, the iodine atoms are introduced by suitable methods. If the free radical iodization reaction is used, under the action of light or initiator, the iodine free radical reacts with the benzene derivatives containing chlorine and fluorine to generate 3-chloro-4-fluoro-1-iodobenzene. This process requires fine control of the reaction conditions to ensure the selectivity and yield of each step.
First, it can be started by the corresponding phenolic compound. First, phenol is used as raw material, and chlorine atoms and fluorine atoms are introduced into the phenolic ring of phenol through halogenation reaction. Specifically, suitable halogenating reagents can be selected, such as chlorine-containing and fluorine-containing halogenating agents, and under suitable reaction conditions, the phenolic ring is halogenated at a specific position to obtain chlorine-containing and fluorine-containing phenolic derivatives. Subsequently, the hydroxyl group is converted into a leaving group, and then an iodizing reagent is used for substitution reaction to introduce iodine atoms. If the hydroxyl group is first converted into a leaving group such as a sulfonate group, and then reacted with iodide salts, such as potassium iodide, in the presence of appropriate solvents and catalysts, the target product 3-chloro-4-fluoro-1-iodobenzene can be obtained.
Second, halogenated aromatics are used as starting materials. If there are halogenated aromatics containing chlorine and fluorine, metal-catalyzed coupling reactions of halogenated aromatics can be used. For example, in a palladium-catalyzed system, halogenated aromatics containing chlorine and fluorine are reacted with iodide reagents in the presence of bases and ligands. During the reaction, the palladium catalyst forms an active intermediate with halogenated aromatics and iodine reagents to promote the formation of carbon-iodine bonds, thereby constructing the target molecule 3-chloro-4-fluoro-1-iodobenzene. Among them, the base can adjust the pH of the reaction system, and the ligand helps to stabilize the catalyst and regulate the activity and selectivity of the reaction.
Third, the multi-step substitution construction is carried out directly from the benzene ring. First, benzene is used as the starting material, and chlorine atoms and fluorine atoms are introduced in turn through the electrophilic substitution reaction. Due to the difference in the localization effect of chlorine and fluorine atoms on the electrophilic substitution reaction of the benzene ring, the specific position substitution After the chlorine and fluorine atoms are introduced, the iodine atoms are introduced by suitable methods. If the free radical iodization reaction is used, under the action of light or initiator, the iodine free radical reacts with the benzene derivatives containing chlorine and fluorine to generate 3-chloro-4-fluoro-1-iodobenzene. This process requires fine control of the reaction conditions to ensure the selectivity and yield of each step.
What are the precautions in storage and transportation of 3-chloro-4-fluoro-1-iodobenzene?
3-Chloro-4-fluoro-1-iodobenzene is also an organic compound. During storage and transportation, many matters must be paid attention to.
First, storage, this compound is quite sensitive to environmental conditions. First, it should be placed in a cool place. Because the temperature is too high, or it may cause chemical reactions, and even cause decomposition. If it is overheated, the molecular structure may be damaged, affecting its chemical properties and application. Second, dry places are indispensable. Moisture easily reacts with the compound or deteriorates it. The presence of water, or reactions such as hydrolysis of halogen atoms, reduce its purity. Third, it should be stored in a well-ventilated place. If the storage space is not well ventilated, the volatile gas of the compound accumulates, which not only increases the risk of fire and explosion, but also is harmful to human health. Fourth, be sure to keep away from fire, heat sources and oxidants. 3-chloro-4-fluoro-1-iodobenzene has certain flammability. In case of open fire, hot topic or contact with oxidant, it is easy to cause the danger of combustion and explosion.
Second talk about transportation, when transporting, the packaging must be strong and tight. Because the compound is easily damaged in bumps and collisions, and then leaks. Once leaked, it not only pollutes the environment, but also poses a threat to the safety of transporters and surrounding people. Transportation vehicles must also meet relevant safety standards and be equipped with corresponding fire equipment and leakage emergency treatment equipment. During transportation, drivers and escorts must always pay attention to the status of the goods, and if there is any abnormality, they should be properly disposed of immediately. And the transportation route planning should also be cautious, avoiding sensitive areas such as water source protection areas and densely populated areas, in case of accidents, the harm should be minimized.
In short, the storage and transportation of 3-chloro-4-fluoro-1-iodobenzene is related to safety and quality, and all links should be strictly adhered to and must not be negligent.
First, storage, this compound is quite sensitive to environmental conditions. First, it should be placed in a cool place. Because the temperature is too high, or it may cause chemical reactions, and even cause decomposition. If it is overheated, the molecular structure may be damaged, affecting its chemical properties and application. Second, dry places are indispensable. Moisture easily reacts with the compound or deteriorates it. The presence of water, or reactions such as hydrolysis of halogen atoms, reduce its purity. Third, it should be stored in a well-ventilated place. If the storage space is not well ventilated, the volatile gas of the compound accumulates, which not only increases the risk of fire and explosion, but also is harmful to human health. Fourth, be sure to keep away from fire, heat sources and oxidants. 3-chloro-4-fluoro-1-iodobenzene has certain flammability. In case of open fire, hot topic or contact with oxidant, it is easy to cause the danger of combustion and explosion.
Second talk about transportation, when transporting, the packaging must be strong and tight. Because the compound is easily damaged in bumps and collisions, and then leaks. Once leaked, it not only pollutes the environment, but also poses a threat to the safety of transporters and surrounding people. Transportation vehicles must also meet relevant safety standards and be equipped with corresponding fire equipment and leakage emergency treatment equipment. During transportation, drivers and escorts must always pay attention to the status of the goods, and if there is any abnormality, they should be properly disposed of immediately. And the transportation route planning should also be cautious, avoiding sensitive areas such as water source protection areas and densely populated areas, in case of accidents, the harm should be minimized.
In short, the storage and transportation of 3-chloro-4-fluoro-1-iodobenzene is related to safety and quality, and all links should be strictly adhered to and must not be negligent.
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