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3-Chloro-4-Fluorobenzene-1-Sulfonyl Chloride
Linshang Chemical
|
HS Code |
124521 |
| Chemical Formula | C6H3Cl2FO2S |
| Molar Mass | 231.055 g/mol |
| Appearance | Colorless to light yellow liquid |
| Density | 1.642 g/cm³ (estimated) |
| Boiling Point | 124 - 126 °C at 3 mmHg |
| Melting Point | N/A (liquid at room temperature) |
| Solubility In Water | Reacts with water |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane |
| Flash Point | 113.9 °C (estimated) |
| Vapor Pressure | Low at room temperature |
| Stability | Reactive, especially towards nucleophiles |
As an accredited 3-Chloro-4-Fluorobenzene-1-Sulfonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 3 - chloro - 4 - fluorobenzene - 1 - sulfonyl chloride in sealed chemical - grade bottle. |
| Storage | 3 - Chloro - 4 - fluorobenzene - 1 - sulfonyl chloride should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. It must be kept in a tightly sealed container to prevent moisture ingress, as it can react with water. Store it separately from incompatible substances like bases and reducing agents to avoid dangerous reactions. |
| Shipping | 3 - chloro - 4 - fluorobenzene - 1 - sulfonyl chloride is a chemical. Ship it in well - sealed, corrosion - resistant containers, following hazardous chemical shipping regulations. Ensure proper labeling for safe and compliant transportation. |
Competitive 3-Chloro-4-Fluorobenzene-1-Sulfonyl Chloride prices that fit your budget—flexible terms and customized quotes for every order.
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As a leading 3-Chloro-4-Fluorobenzene-1-Sulfonyl Chloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 3-chloro-4-fluorobenzene-1-sulfonyl Chloride?
3-Chloro-4-fluorobenzene-1-sulfonyl chloride is a crucial chemical raw material in the field of organic synthesis. Its main uses cover many fields such as medicine, pesticides, materials, etc., and occupy a key position in the modern chemical industry system.
In the field of medicine, this compound is often a key intermediate for the synthesis of new drugs. Due to its unique chemical structure, it can participate in a variety of chemical reactions and help build complex drug molecular structures. By reacting with other organic compounds, specific functional groups can be introduced to endow drugs with unique pharmacological activities, such as antibacterial, anti-inflammatory, and anti-tumor effects. For example, in the synthesis of some antibacterial drugs, 3-chloro-4-fluorobenzene-1-sulfonyl chloride is used as the starting material, and the active core is constructed through multi-step reaction to achieve effective inhibition of pathogens.
In the field of pesticides, it also plays an important role. It can be used as a key component in the synthesis of high-efficiency and low-toxicity pesticides. With its structural characteristics, the pesticides involved in the synthesis can be highly selective and active against specific pests or weeds, while reducing the harm to the environment and non-target organisms. For example, in the development of some new herbicides, 3-chloro-4-fluorobenzene-1-sulfonyl chloride plays a role in the construction of active ingredients that can precisely inhibit the growth of weeds without affecting crops.
In the field of materials science, this compound can be used to prepare special functional materials. By polymerizing with other monomers, its unique chemical structure can be introduced into the main chain or side chain of the polymer, giving the material special properties, such as improving the thermal stability, chemical stability or optical properties of the material. For example, in the synthesis of some high-performance engineering plastics, the introduction of 3-chloro-4-fluorobenzene-1-sulfonyl chloride-derived structures can improve the corrosion resistance and mechanical properties of plastics and broaden their application range.
In summary, 3-chloro-4-fluorobenzene-1-sulfonyl chloride is widely and important in the fields of medicine, pesticides, materials, etc. It is of great significance to promote the development of various related industries and is an indispensable and important substance in the field of modern chemical synthesis.
In the field of medicine, this compound is often a key intermediate for the synthesis of new drugs. Due to its unique chemical structure, it can participate in a variety of chemical reactions and help build complex drug molecular structures. By reacting with other organic compounds, specific functional groups can be introduced to endow drugs with unique pharmacological activities, such as antibacterial, anti-inflammatory, and anti-tumor effects. For example, in the synthesis of some antibacterial drugs, 3-chloro-4-fluorobenzene-1-sulfonyl chloride is used as the starting material, and the active core is constructed through multi-step reaction to achieve effective inhibition of pathogens.
In the field of pesticides, it also plays an important role. It can be used as a key component in the synthesis of high-efficiency and low-toxicity pesticides. With its structural characteristics, the pesticides involved in the synthesis can be highly selective and active against specific pests or weeds, while reducing the harm to the environment and non-target organisms. For example, in the development of some new herbicides, 3-chloro-4-fluorobenzene-1-sulfonyl chloride plays a role in the construction of active ingredients that can precisely inhibit the growth of weeds without affecting crops.
In the field of materials science, this compound can be used to prepare special functional materials. By polymerizing with other monomers, its unique chemical structure can be introduced into the main chain or side chain of the polymer, giving the material special properties, such as improving the thermal stability, chemical stability or optical properties of the material. For example, in the synthesis of some high-performance engineering plastics, the introduction of 3-chloro-4-fluorobenzene-1-sulfonyl chloride-derived structures can improve the corrosion resistance and mechanical properties of plastics and broaden their application range.
In summary, 3-chloro-4-fluorobenzene-1-sulfonyl chloride is widely and important in the fields of medicine, pesticides, materials, etc. It is of great significance to promote the development of various related industries and is an indispensable and important substance in the field of modern chemical synthesis.
What are the physical properties of 3-chloro-4-fluorobenzene-1-sulfonyl Chloride?
3-Chloro-4-fluorobenzene-1-sulfonyl chloride is an important compound in organic chemistry. Its physical properties are unique, let me tell them one by one.
Looking at its shape, under room temperature and pressure, this substance is mostly colorless to light yellow liquid, like a smart liquid, flashing with the unique luster of chemical substances. Its appearance is clear and transparent, and when it is pure, there are no visible impurities, just like a pure water, but it contains chemical mysteries.
When it comes to smell, this compound emits a pungent and uncomfortable smell. This smell is like a sharp sword, which can easily penetrate the nasal cavity and stimulate the olfactory nerve, allowing people to smell its strong chemical activity. This odor not only causes the human body's instinctive discomfort, but also warns people of the potential danger of this substance and should not be approached and touched at will.
Furthermore, its boiling point is also an important physical property. Under specific pressure conditions, its boiling point is within a certain range. This boiling point data is of key significance for the separation, purification and application of this substance in chemical reactions. By precisely controlling the temperature, when its boiling point is reached, 3-chloro-4-fluorobenzene-1-sulfonyl chloride can be converted from a liquid state to a gaseous state, thus achieving separation from other substances, just like a phoenix nirvana, showing different chemical changes in the form of a gaseous state.
Its melting point is also a property that cannot be ignored. At a certain temperature, the substance changes from a solid state to a liquid state. The melting point value accurately reflects the strength of the intermolecular forces. The melting point of 3-chloro-4-fluorobenzene-1-sulfonyl chloride determines its physical state under different temperature environments, just like a precise temperature valve, which controls the conversion between solid and liquid states.
In addition, the solubility of the compound is also one of its remarkable physical properties. In organic solvents such as dichloromethane and chloroform, its solubility is quite good, just like fish getting water, it can be evenly dispersed in these solvents to form a uniform and stable solution. However, in water, its solubility is extremely poor, just like the incompatibility of oil and water, the two are distinct. This difference in solubility has a significant impact on the choice of reaction medium and the separation of products in chemical experiments and industrial production.
The physical properties of 3-chloro-4-fluorobenzene-1-sulfonyl chloride are complex and delicate, and these properties are interrelated, which together constitute its unique chemical "identity" and play an important role in many chemical fields such as organic synthesis.
Looking at its shape, under room temperature and pressure, this substance is mostly colorless to light yellow liquid, like a smart liquid, flashing with the unique luster of chemical substances. Its appearance is clear and transparent, and when it is pure, there are no visible impurities, just like a pure water, but it contains chemical mysteries.
When it comes to smell, this compound emits a pungent and uncomfortable smell. This smell is like a sharp sword, which can easily penetrate the nasal cavity and stimulate the olfactory nerve, allowing people to smell its strong chemical activity. This odor not only causes the human body's instinctive discomfort, but also warns people of the potential danger of this substance and should not be approached and touched at will.
Furthermore, its boiling point is also an important physical property. Under specific pressure conditions, its boiling point is within a certain range. This boiling point data is of key significance for the separation, purification and application of this substance in chemical reactions. By precisely controlling the temperature, when its boiling point is reached, 3-chloro-4-fluorobenzene-1-sulfonyl chloride can be converted from a liquid state to a gaseous state, thus achieving separation from other substances, just like a phoenix nirvana, showing different chemical changes in the form of a gaseous state.
Its melting point is also a property that cannot be ignored. At a certain temperature, the substance changes from a solid state to a liquid state. The melting point value accurately reflects the strength of the intermolecular forces. The melting point of 3-chloro-4-fluorobenzene-1-sulfonyl chloride determines its physical state under different temperature environments, just like a precise temperature valve, which controls the conversion between solid and liquid states.
In addition, the solubility of the compound is also one of its remarkable physical properties. In organic solvents such as dichloromethane and chloroform, its solubility is quite good, just like fish getting water, it can be evenly dispersed in these solvents to form a uniform and stable solution. However, in water, its solubility is extremely poor, just like the incompatibility of oil and water, the two are distinct. This difference in solubility has a significant impact on the choice of reaction medium and the separation of products in chemical experiments and industrial production.
The physical properties of 3-chloro-4-fluorobenzene-1-sulfonyl chloride are complex and delicate, and these properties are interrelated, which together constitute its unique chemical "identity" and play an important role in many chemical fields such as organic synthesis.
3-chloro-4-fluorobenzene-1-sulfonyl the chemistry of Chloride
3-Chloro-4-fluorobenzene-1-sulfonyl chloride, this is an organic compound. Looking at its structure, chlorine, fluorine atoms and sulfonyl chloride groups are all connected to the benzene ring, which gives it unique chemical properties.
Its chemical activity is quite high, and the sulfonyl chloride group is active, and it is easy to react with many nucleophilic reagents. For example, when it encounters alcohols, a nucleophilic substitution reaction can occur to form a sulfonate. The reaction mechanism is that the oxygen atom of the alcohol acts as a nucleophilic reagent to attack the sulfur atom of the sulfonyl chloride, and the chlorine atom leaves to form a sulfonate. This reaction condition is mild and is often used in organic synthesis to prepare sulfonate compounds.
Furthermore, it can also react with amines to form sulfonamides. The nitrogen atom of the amine attacks the sulfur atom of the sulfonyl chloride with its lone pair electron, and then the chlorine atom leaves, and finally the sulfonamide product is obtained. This reaction is widely used in the field of drug synthesis, and the construction of many drug molecules depends on it.
Because of the electronic effect of chlorine and fluorine atoms connected to the benzene ring, it affects the activity of the benzene ring and the selectivity of the reaction check point. The different electron-absorbing abilities of chlorine and fluorine atoms change the electron cloud density distribution of the benzene ring. In the electrophilic substitution reaction, chlorine and fluorine atoms are o-para-sites, but due to the electron-absorbing effect, the electrophilic substitution activity of the benzene ring is However, under certain conditions, electrophilic substitution reactions such as halogenation and nitrification can still occur, and the reaction check points are mostly in the ortho or para-position of chlorine and fluorine atoms.
In addition, 3-chloro-4-fluorobenzene-1-sulfonyl chloride is more sensitive to water and is prone to hydrolysis in contact with water. The hydrolysis of sulfonyl chloride groups generates sulfonic acid and hydrogen chloride. This hydrolysis reaction occurs spontaneously in an aqueous environment, so it is necessary to pay attention to moisture protection when storing.
From this perspective, 3-chloro-4-fluorobenzene-1-sulfonyl chloride has important application value in organic synthesis, medicinal chemistry and other fields due to its unique structure and diverse chemical reactivity. However, attention should be paid to its active characteristics and water sensitivity when using and storing.
Its chemical activity is quite high, and the sulfonyl chloride group is active, and it is easy to react with many nucleophilic reagents. For example, when it encounters alcohols, a nucleophilic substitution reaction can occur to form a sulfonate. The reaction mechanism is that the oxygen atom of the alcohol acts as a nucleophilic reagent to attack the sulfur atom of the sulfonyl chloride, and the chlorine atom leaves to form a sulfonate. This reaction condition is mild and is often used in organic synthesis to prepare sulfonate compounds.
Furthermore, it can also react with amines to form sulfonamides. The nitrogen atom of the amine attacks the sulfur atom of the sulfonyl chloride with its lone pair electron, and then the chlorine atom leaves, and finally the sulfonamide product is obtained. This reaction is widely used in the field of drug synthesis, and the construction of many drug molecules depends on it.
Because of the electronic effect of chlorine and fluorine atoms connected to the benzene ring, it affects the activity of the benzene ring and the selectivity of the reaction check point. The different electron-absorbing abilities of chlorine and fluorine atoms change the electron cloud density distribution of the benzene ring. In the electrophilic substitution reaction, chlorine and fluorine atoms are o-para-sites, but due to the electron-absorbing effect, the electrophilic substitution activity of the benzene ring is However, under certain conditions, electrophilic substitution reactions such as halogenation and nitrification can still occur, and the reaction check points are mostly in the ortho or para-position of chlorine and fluorine atoms.
In addition, 3-chloro-4-fluorobenzene-1-sulfonyl chloride is more sensitive to water and is prone to hydrolysis in contact with water. The hydrolysis of sulfonyl chloride groups generates sulfonic acid and hydrogen chloride. This hydrolysis reaction occurs spontaneously in an aqueous environment, so it is necessary to pay attention to moisture protection when storing.
From this perspective, 3-chloro-4-fluorobenzene-1-sulfonyl chloride has important application value in organic synthesis, medicinal chemistry and other fields due to its unique structure and diverse chemical reactivity. However, attention should be paid to its active characteristics and water sensitivity when using and storing.
What are the synthesis methods of 3-chloro-4-fluorobenzene-1-sulfonyl Chloride?
There are various ways to synthesize 3-chloro-4-fluorobenzene-1-sulfonyl chloride, and each has its own ingenuity. Let me tell you one by one.
One of them can be started from 3-chloro-4-fluoroaniline. It can be reacted with sodium nitrite and hydrochloric acid at low temperature to form a diazonium salt. This diazonium salt has good activity, and then interacts with sodium bisulfite. After a series of transformations, sodium 3-chloro-4-fluorobenzene sulfonate can be obtained. Then the sodium sulfonate is treated with a chlorinating agent, such as phosphorus pentachloride or thionyl chloride, and the sodium sulfonate group can be converted into a sulfonyl chloride group to obtain 3-chloro-4-fluorobenzene-1-sulfonyl chloride. This path step is slightly complicated, but the reaction conditions at each step are relatively mild and easy to control. It is like fine carving, and it needs to be careful step by step to get a good product.
Second, 3-chloro-4-fluorobenzene is used as a raw material to react with chlorosulfonic acid. Chlorosulfonic acid has both the ability of sulfonation and chlorination, and can directly introduce sulfonyl chloride groups into the benzene ring to generate the target product in one This method is simple and efficient, such as a quick knife to cut through the mess, but chlorosulfonic acid is highly corrosive, and the reaction conditions are relatively harsh. It needs to be carried out at low temperature and good protective measures. The operation requirements are quite high, and if there is a little carelessness, it is prone to accidents.
Third, 3-chloro-4-fluorobenzoic acid can also be used as the starting material. First, it is converted into an acid chloride, which can be obtained by using sulfoxide chloride treatment. Then the obtained acid chloride reacts with sodium sulfite to generate the corresponding sulfonyl chloride. This approach is a different approach. Although the steps are relatively roundabout, the reagents used are relatively common, and the reaction conditions can be adjusted. It is like a winding path, which can be reached by ingenious design.
All synthetic methods have their own advantages and disadvantages. In practical application, it is necessary to weigh the choice according to the availability of raw materials, cost, equipment conditions and requirements for product purity, and proceed cautiously to find the optimal method to obtain the required 3-chloro-4-fluorobenzene-1-sulfonyl chloride.
One of them can be started from 3-chloro-4-fluoroaniline. It can be reacted with sodium nitrite and hydrochloric acid at low temperature to form a diazonium salt. This diazonium salt has good activity, and then interacts with sodium bisulfite. After a series of transformations, sodium 3-chloro-4-fluorobenzene sulfonate can be obtained. Then the sodium sulfonate is treated with a chlorinating agent, such as phosphorus pentachloride or thionyl chloride, and the sodium sulfonate group can be converted into a sulfonyl chloride group to obtain 3-chloro-4-fluorobenzene-1-sulfonyl chloride. This path step is slightly complicated, but the reaction conditions at each step are relatively mild and easy to control. It is like fine carving, and it needs to be careful step by step to get a good product.
Second, 3-chloro-4-fluorobenzene is used as a raw material to react with chlorosulfonic acid. Chlorosulfonic acid has both the ability of sulfonation and chlorination, and can directly introduce sulfonyl chloride groups into the benzene ring to generate the target product in one This method is simple and efficient, such as a quick knife to cut through the mess, but chlorosulfonic acid is highly corrosive, and the reaction conditions are relatively harsh. It needs to be carried out at low temperature and good protective measures. The operation requirements are quite high, and if there is a little carelessness, it is prone to accidents.
Third, 3-chloro-4-fluorobenzoic acid can also be used as the starting material. First, it is converted into an acid chloride, which can be obtained by using sulfoxide chloride treatment. Then the obtained acid chloride reacts with sodium sulfite to generate the corresponding sulfonyl chloride. This approach is a different approach. Although the steps are relatively roundabout, the reagents used are relatively common, and the reaction conditions can be adjusted. It is like a winding path, which can be reached by ingenious design.
All synthetic methods have their own advantages and disadvantages. In practical application, it is necessary to weigh the choice according to the availability of raw materials, cost, equipment conditions and requirements for product purity, and proceed cautiously to find the optimal method to obtain the required 3-chloro-4-fluorobenzene-1-sulfonyl chloride.
What are the precautions for 3-chloro-4-fluorobenzene-1-sulfonyl Chloride in storage and transportation?
3-Chloro-4-fluorobenzene-1-sulfonyl chloride is a chemical substance, and many matters need to be paid attention to during storage and transportation.
It is active, corrosive and irritating, and easily reacts with water, alkalis, etc. When storing, be sure to choose a dry, cool and well-ventilated place. Because it will hydrolyze quickly in contact with water, it must be strictly prevented from water vapor intrusion. The storage container used should be well sealed and made of materials that can resist corrosion, such as specific steel or containers lined with special materials. The ambient temperature should not be too high to avoid promoting its decomposition or exacerbating the reactivity.
During transportation, the packaging must be stable and tight, and comply with relevant laws and standards. During loading and unloading, the operator should wear appropriate protective equipment, such as protective clothing, gloves, goggles and gas masks, to prevent contact and inhalation. The means of transportation should also be clean and dry, and should not be mixed with substances that are easy to react with, such as alkalis and alcohols. Pay close attention to environmental factors such as temperature and humidity on the way to avoid bumps and collisions, so as to prevent leakage due to package damage.
If it is unfortunate to leak, the crowd should be evacuated immediately, the scene should be isolated, and the emergency response personnel should take professional protection and strictly prohibit fire. A small amount of leakage can be adsorbed by inert materials such as sand, and a large amount of leakage needs to be contained by building a dike or digging a pit, and then treated by suitable chemical methods to ensure the safety of the environment and personnel.
It is active, corrosive and irritating, and easily reacts with water, alkalis, etc. When storing, be sure to choose a dry, cool and well-ventilated place. Because it will hydrolyze quickly in contact with water, it must be strictly prevented from water vapor intrusion. The storage container used should be well sealed and made of materials that can resist corrosion, such as specific steel or containers lined with special materials. The ambient temperature should not be too high to avoid promoting its decomposition or exacerbating the reactivity.
During transportation, the packaging must be stable and tight, and comply with relevant laws and standards. During loading and unloading, the operator should wear appropriate protective equipment, such as protective clothing, gloves, goggles and gas masks, to prevent contact and inhalation. The means of transportation should also be clean and dry, and should not be mixed with substances that are easy to react with, such as alkalis and alcohols. Pay close attention to environmental factors such as temperature and humidity on the way to avoid bumps and collisions, so as to prevent leakage due to package damage.
If it is unfortunate to leak, the crowd should be evacuated immediately, the scene should be isolated, and the emergency response personnel should take professional protection and strictly prohibit fire. A small amount of leakage can be adsorbed by inert materials such as sand, and a large amount of leakage needs to be contained by building a dike or digging a pit, and then treated by suitable chemical methods to ensure the safety of the environment and personnel.
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