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3-Chloro-4-Fluorobenzene-1-Thiol
Linshang Chemical
|
HS Code |
513411 |
| Chemical Formula | C6H4ClFS |
As an accredited 3-Chloro-4-Fluorobenzene-1-Thiol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 3 - chloro - 4 - fluorobenzene - 1 - thiol in a sealed, chemical - resistant bottle. |
| Storage | 3 - Chloro - 4 - fluorobenzene - 1 - thiol should be stored in a cool, dry, well - ventilated area away from heat, flames, and oxidizing agents. It should be kept in a tightly sealed container, preferably made of corrosion - resistant material. Label the storage container clearly. Store it separately from incompatible substances to prevent potential reactions. |
| Shipping | 3 - Chloro - 4 - fluorobenzene - 1 - thiol is shipped in well - sealed, corrosion - resistant containers. It's transported in accordance with hazardous chemical regulations, ensuring proper handling to prevent leakage and exposure during transit. |
Competitive 3-Chloro-4-Fluorobenzene-1-Thiol prices that fit your budget—flexible terms and customized quotes for every order.
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What is the chemistry of 3-chloro-4-fluorobenzene-1-thiol?
3-Chloro-4-fluorobenzene-1-mercaptan is one of the organic compounds. It has unique chemical properties and has attracted much attention in the field of organic synthesis.
In this compound, the chlorine atom and the fluorine atom are connected to the benzene ring, and the thiol group is also connected to it. Chlorine and fluorine atoms have a significant impact on the electron cloud distribution of the benzene ring due to their electronegativity. Although chlorine atoms have a certain electron-giving conjugation effect, their electron-withdrawing induction effect is more prominent. Fluorine atoms have strong electronegativity, mainly showing an electron-withdrawing induction effect. The two work together to reduce the electron cloud density of the benzene ring and reduce the electrophilic substitution activity of the benzene ring compared with
The thiol group is an active functional group with strong acidity and can react with bases to form corresponding salts. Its sulfur atom contains lone pair electrons and can participate in nucleophilic substitution reactions as nucleophilic reagents. Under appropriate conditions, it can undergo nucleophilic substitution with halogenated hydrocarbons, acyl halides and other electrophilic reagents to construct new carbon-sulfur bonds.
The thiol group of 3-chloro-4-fluorobenzene-1-mercaptan is easily oxidized and can be converted into disulfide. This oxidation reaction can occur in the presence of air or oxidants. At the same time, because it contains a variety of functional groups, it can participate in a variety of complex organic reactions, and can be used as a key intermediate in the fields of medicinal chemistry, materials science, etc., and can be converted into compounds with specific functions through a series of reactions.
In this compound, the chlorine atom and the fluorine atom are connected to the benzene ring, and the thiol group is also connected to it. Chlorine and fluorine atoms have a significant impact on the electron cloud distribution of the benzene ring due to their electronegativity. Although chlorine atoms have a certain electron-giving conjugation effect, their electron-withdrawing induction effect is more prominent. Fluorine atoms have strong electronegativity, mainly showing an electron-withdrawing induction effect. The two work together to reduce the electron cloud density of the benzene ring and reduce the electrophilic substitution activity of the benzene ring compared with
The thiol group is an active functional group with strong acidity and can react with bases to form corresponding salts. Its sulfur atom contains lone pair electrons and can participate in nucleophilic substitution reactions as nucleophilic reagents. Under appropriate conditions, it can undergo nucleophilic substitution with halogenated hydrocarbons, acyl halides and other electrophilic reagents to construct new carbon-sulfur bonds.
The thiol group of 3-chloro-4-fluorobenzene-1-mercaptan is easily oxidized and can be converted into disulfide. This oxidation reaction can occur in the presence of air or oxidants. At the same time, because it contains a variety of functional groups, it can participate in a variety of complex organic reactions, and can be used as a key intermediate in the fields of medicinal chemistry, materials science, etc., and can be converted into compounds with specific functions through a series of reactions.
What are the main uses of 3-chloro-4-fluorobenzene-1-thiol?
3-Chloro-4-fluorobenzene-1-mercaptan is one of the organic compounds. It has a wide range of uses and is involved in many fields.
First, in the field of medicinal chemistry, this compound is often used as a key intermediate. Due to its unique chemical structure, it can participate in many drug synthesis reactions and help build molecular structures with specific pharmacological activities. Through ingenious chemical reactions, it can be combined with other compounds to generate drugs with therapeutic effects on specific diseases. For example, in the development of drugs for certain inflammatory and infectious diseases, 3-chloro-4-fluorobenzene-1-thiol may play an important role in contributing to human health and well-being.
Second, in the field of materials science, it also has outstanding performance. It can be used to prepare materials with special properties, such as in the modification of polymer materials. Adding an appropriate amount of this compound may improve the stability, corrosion resistance and other properties of the material. In this way, the resulting material can be applied to more severe environments, such as aerospace, automobile manufacturing and other fields, to improve the quality and durability of related products.
Furthermore, in the field of pesticide chemistry, 3-chloro-4-fluorobenzene-1-mercaptan may contribute to the synthesis of highly efficient and low-toxic pesticides. With its chemical properties, the synthesized pesticides may be more targeted and lethal to pests, while reducing the negative impact on the environment. It meets the needs of the current green agriculture development and helps to ensure the yield and quality of crops and promote sustainable agricultural development.
First, in the field of medicinal chemistry, this compound is often used as a key intermediate. Due to its unique chemical structure, it can participate in many drug synthesis reactions and help build molecular structures with specific pharmacological activities. Through ingenious chemical reactions, it can be combined with other compounds to generate drugs with therapeutic effects on specific diseases. For example, in the development of drugs for certain inflammatory and infectious diseases, 3-chloro-4-fluorobenzene-1-thiol may play an important role in contributing to human health and well-being.
Second, in the field of materials science, it also has outstanding performance. It can be used to prepare materials with special properties, such as in the modification of polymer materials. Adding an appropriate amount of this compound may improve the stability, corrosion resistance and other properties of the material. In this way, the resulting material can be applied to more severe environments, such as aerospace, automobile manufacturing and other fields, to improve the quality and durability of related products.
Furthermore, in the field of pesticide chemistry, 3-chloro-4-fluorobenzene-1-mercaptan may contribute to the synthesis of highly efficient and low-toxic pesticides. With its chemical properties, the synthesized pesticides may be more targeted and lethal to pests, while reducing the negative impact on the environment. It meets the needs of the current green agriculture development and helps to ensure the yield and quality of crops and promote sustainable agricultural development.
What are 3-chloro-4-fluorobenzene-1-thiol synthesis methods?
There are several common ways to prepare 3-chloro-4-fluorobromothiophenol.
First, 3-chloro-4-fluorohalobenzene can be used. Taking 3-chloro-4-fluorobromobenzene as an example, it is first reacted with metal magnesium to make Grignard's reagent. In an inert solvent such as anhydrous ether or tetrahydrofuran, under low temperature and nitrogen protection, 3-chloro-4-fluorobromobenzene is slowly added dropwise to the magnesium chips, and when the reaction number is stirred, 3-chloro-4-fluorophenyl magnesium bromide can be obtained. Then, hydrogen sulfide gas is introduced into the Grignard reagent to control the reaction temperature and time. After the reaction is completed, the reaction mixture is hydrolyzed and treated with a dilute acid solution such as dilute hydrochloric acid or dilute sulfuric acid, so that the generated magnesium mercaptan salt is converted into 3-chloro-4-fluorobenzothiophenol, and then the product is purified by extraction, distillation and other steps.
Second, 3-chloro-4-fluoronitrobenzene can also be started. First, 3-chloro-4-fluoronitrobenzene is reduced to 3-chloro-4-fluoroaniline. Reduction systems such as iron powder and hydrochloric acid can be selected, and the reaction number can be stirred at an appropriate temperature. After reduction, 3-chloro-4-fluoroaniline is obtained through separation, neutralization and other steps. Subsequently, 3-chloro-4-fluoroaniline is reacted with thiocyanate, such as reacting with potassium thiocyanate in appropriate solvents and conditions, to generate 3-chloro-4-fluorobenzene thiocyanate. Finally, the thiocyanate is hydrolyzed, treated with an alkali solution such as sodium hydroxide solution, and then acidified to produce 3-chloro-4-fluorothiophenol, which also requires subsequent separation and purification steps.
Or it can be processed by halogen exchange reaction of halogenated thiophenols. Select appropriate halogenated thiophenols, such as chlorine or bromine-containing thiophenol derivatives, and react with fluorinating reagents. The fluorinating reagents can be selected from potassium fluoride, etc. In the presence of a phase transfer catalyst, the reaction is heated in a suitable organic solvent, and the halogen is exchanged to obtain 3-chloro-4-fluorothiophenol. Finally, it needs to be purified to achieve the desired purity.
This number method has its own advantages and disadvantages. According to the actual situation, such as raw material availability, cost, product purity requirements, etc., choose an appropriate method to prepare 3-chloro-4-fluorothiophenol.
First, 3-chloro-4-fluorohalobenzene can be used. Taking 3-chloro-4-fluorobromobenzene as an example, it is first reacted with metal magnesium to make Grignard's reagent. In an inert solvent such as anhydrous ether or tetrahydrofuran, under low temperature and nitrogen protection, 3-chloro-4-fluorobromobenzene is slowly added dropwise to the magnesium chips, and when the reaction number is stirred, 3-chloro-4-fluorophenyl magnesium bromide can be obtained. Then, hydrogen sulfide gas is introduced into the Grignard reagent to control the reaction temperature and time. After the reaction is completed, the reaction mixture is hydrolyzed and treated with a dilute acid solution such as dilute hydrochloric acid or dilute sulfuric acid, so that the generated magnesium mercaptan salt is converted into 3-chloro-4-fluorobenzothiophenol, and then the product is purified by extraction, distillation and other steps.
Second, 3-chloro-4-fluoronitrobenzene can also be started. First, 3-chloro-4-fluoronitrobenzene is reduced to 3-chloro-4-fluoroaniline. Reduction systems such as iron powder and hydrochloric acid can be selected, and the reaction number can be stirred at an appropriate temperature. After reduction, 3-chloro-4-fluoroaniline is obtained through separation, neutralization and other steps. Subsequently, 3-chloro-4-fluoroaniline is reacted with thiocyanate, such as reacting with potassium thiocyanate in appropriate solvents and conditions, to generate 3-chloro-4-fluorobenzene thiocyanate. Finally, the thiocyanate is hydrolyzed, treated with an alkali solution such as sodium hydroxide solution, and then acidified to produce 3-chloro-4-fluorothiophenol, which also requires subsequent separation and purification steps.
Or it can be processed by halogen exchange reaction of halogenated thiophenols. Select appropriate halogenated thiophenols, such as chlorine or bromine-containing thiophenol derivatives, and react with fluorinating reagents. The fluorinating reagents can be selected from potassium fluoride, etc. In the presence of a phase transfer catalyst, the reaction is heated in a suitable organic solvent, and the halogen is exchanged to obtain 3-chloro-4-fluorothiophenol. Finally, it needs to be purified to achieve the desired purity.
This number method has its own advantages and disadvantages. According to the actual situation, such as raw material availability, cost, product purity requirements, etc., choose an appropriate method to prepare 3-chloro-4-fluorothiophenol.
3-chloro-4-fluorobenzene-1-thiol What are the precautions during storage and transportation?
3-Chloro-4-fluorobenzene-1-mercaptan is an organic compound. During storage and transportation, many matters need to be paid attention to.
Safety first. This compound is toxic and irritating. When handling, you must wear suitable protective equipment, such as gloves, goggles, gas masks, etc., to prevent contact with or inhalation of the human body and cause damage to the body.
Store in a cool, dry and well-ventilated place. Keep away from direct sunlight and heat sources. Due to heat or light exposure, or chemical reactions caused by chemical reactions, the stability is disturbed, and even dangerous. And should be stored separately from oxidants, acids, bases, etc., to prevent mutual reaction. Because of its sulfur alcohol group, it has strong reducing property and is easy to react with oxidants.
When transporting, it must also strictly follow the regulations. Choose suitable packaging materials to ensure good sealing and anti-leakage. During transportation, drive at a steady speed and avoid shock and collision to avoid package damage. At the same time, transportation vehicles should be equipped with corresponding emergency treatment equipment and materials. If there is an accident such as leakage, they can respond in time.
Furthermore, regardless of storage or transportation, relevant places and vehicles should be clearly marked, clearly indicating that the stored or transported is 3-chloro-4-fluorobenzene-1-thiol, as well as its dangerous characteristics, so that relevant personnel are alert and operate cautiously. In this way, the storage and transportation process is guaranteed to be smooth and accidents are avoided.
Safety first. This compound is toxic and irritating. When handling, you must wear suitable protective equipment, such as gloves, goggles, gas masks, etc., to prevent contact with or inhalation of the human body and cause damage to the body.
Store in a cool, dry and well-ventilated place. Keep away from direct sunlight and heat sources. Due to heat or light exposure, or chemical reactions caused by chemical reactions, the stability is disturbed, and even dangerous. And should be stored separately from oxidants, acids, bases, etc., to prevent mutual reaction. Because of its sulfur alcohol group, it has strong reducing property and is easy to react with oxidants.
When transporting, it must also strictly follow the regulations. Choose suitable packaging materials to ensure good sealing and anti-leakage. During transportation, drive at a steady speed and avoid shock and collision to avoid package damage. At the same time, transportation vehicles should be equipped with corresponding emergency treatment equipment and materials. If there is an accident such as leakage, they can respond in time.
Furthermore, regardless of storage or transportation, relevant places and vehicles should be clearly marked, clearly indicating that the stored or transported is 3-chloro-4-fluorobenzene-1-thiol, as well as its dangerous characteristics, so that relevant personnel are alert and operate cautiously. In this way, the storage and transportation process is guaranteed to be smooth and accidents are avoided.
3-chloro-4-fluorobenzene-1-thiol impact on the environment and human health
3-Chloro-4-fluorobenzene-1-mercaptan, this substance has an impact on both the environment and human health.
At the end of the environment, it enters the nature, or it is difficult to degrade. Because of its special chemical structure, microorganisms and enzymes that degrade this substance in nature may not work effectively on it, and it is easy to accumulate in the environment. And it will cause pollution to water bodies, soils, etc. If it flows into water bodies, it will affect the survival of aquatic organisms. Fish may be disturbed by the presence of this substance in water, causing growth obstruction, decreased fertility, and even death. In soil, it will change the structure and function of soil microbial community, affecting soil nutrient circulation and plant growth.
It is related to human health. This substance may be ingested into the human body through breathing, skin contact and diet. Inhalation through the respiratory tract will irritate the respiratory mucosa, causing symptoms such as cough, asthma, breathing difficulties. Contact with the skin may cause skin allergies, redness, swelling, itching and even burns. If ingested inadvertently, it will damage the digestive system, and there is a risk of nausea, vomiting, abdominal pain and diarrhea. Long-term exposure may cause more serious health problems, such as affecting the nervous system, causing headaches, dizziness, fatigue, memory loss, etc.; or interfering with the endocrine system, affecting hormone balance, and may also have adverse effects on the reproductive system and immune system. Therefore, 3-chloro-4-fluorobenzene-1-mercaptan must be treated with caution, and strict protection and treatment measures must be taken during production and use to reduce its harm to the environment and human health.
At the end of the environment, it enters the nature, or it is difficult to degrade. Because of its special chemical structure, microorganisms and enzymes that degrade this substance in nature may not work effectively on it, and it is easy to accumulate in the environment. And it will cause pollution to water bodies, soils, etc. If it flows into water bodies, it will affect the survival of aquatic organisms. Fish may be disturbed by the presence of this substance in water, causing growth obstruction, decreased fertility, and even death. In soil, it will change the structure and function of soil microbial community, affecting soil nutrient circulation and plant growth.
It is related to human health. This substance may be ingested into the human body through breathing, skin contact and diet. Inhalation through the respiratory tract will irritate the respiratory mucosa, causing symptoms such as cough, asthma, breathing difficulties. Contact with the skin may cause skin allergies, redness, swelling, itching and even burns. If ingested inadvertently, it will damage the digestive system, and there is a risk of nausea, vomiting, abdominal pain and diarrhea. Long-term exposure may cause more serious health problems, such as affecting the nervous system, causing headaches, dizziness, fatigue, memory loss, etc.; or interfering with the endocrine system, affecting hormone balance, and may also have adverse effects on the reproductive system and immune system. Therefore, 3-chloro-4-fluorobenzene-1-mercaptan must be treated with caution, and strict protection and treatment measures must be taken during production and use to reduce its harm to the environment and human health.
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