Linshang Chemical
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3-Chloro-4-Fluorobenzene Bromide
Linshang Chemical
|
HS Code |
775779 |
| Chemical Formula | C6H3BrClF |
| Appearance | Solid (usually) |
| Physical State At Room Temp | Solid |
| Boiling Point | N/A (specific value may vary, needs further research) |
| Melting Point | N/A (specific value may vary, needs further research) |
| Density | N/A (specific value may vary, needs further research) |
| Solubility In Water | Low (organic compound, relatively insoluble in water) |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, acetone |
| Odor | Typical organic compound odor (specific description may vary) |
As an accredited 3-Chloro-4-Fluorobenzene Bromide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500 - gram bottle packaging for 3 - chloro - 4 - fluorobenzene bromide chemical. |
| Storage | 3 - chloro - 4 - fluorobenzene bromide should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. It should be kept in a tightly sealed container to prevent exposure to air and moisture, which could potentially lead to degradation. Store it separately from oxidizing agents, bases, and other reactive chemicals to avoid hazardous reactions. |
| Shipping | 3 - chloro - 4 - fluorobenzene bromide is a chemical. Shipping requires it to be properly packaged in a corrosion - resistant container, labeled clearly. Follow all regulations for hazardous chemicals during transport to ensure safety. |
Competitive 3-Chloro-4-Fluorobenzene Bromide prices that fit your budget—flexible terms and customized quotes for every order.
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As a leading 3-Chloro-4-Fluorobenzene Bromide supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
3-chloro-4-fluorobenzene the chemistry of Bromide
3-Chloro-4-fluorobenzene meets bromide, and its chemical properties are quite interesting. When the two interact, it is a subtle chemical change. 3-Chloro-4-fluorobenzene, the presence of chlorine atoms and fluorine atoms in this compound gives it unique chemical activity. Chlorine atoms and fluorine atoms, because of their electronegativity, can change the electron cloud density distribution of the benzene ring, which in turn affects the reactivity of the whole molecule.
Bromide, common ones such as sodium bromide, potassium bromide, etc. Bromine ions often play a specific role in the reaction. When 3-chloro-4-fluorobenzene meets bromide, a nucleophilic substitution reaction may occur under suitable conditions. Bromine ions are nucleophilic, and their electron clouds are relatively loose and easy to attack areas with lower electron cloud density.
On the benzene ring of 3-chloro-4-fluorobenzene, the electron cloud density at some locations decreases due to the action of chlorine and fluorine, which becomes a potential check point for the nucleophilic attack of bromine ions. If the reaction conditions are appropriate, such as under the action of suitable solvents, temperatures and catalysts, bromine ions may replace chlorine atoms or fluorine atoms on the benzene ring to form new compounds. The occurrence of this substitution reaction requires consideration of many factors. The polarity of the solvent has a great influence on the reaction. Polar solvents can promote the dissolution of ions and the reaction progress. Temperature is also critical. The appropriate temperature can speed up the reaction rate. If it is too high or too low, the reaction may not occur or produce side reactions.
In addition, the reaction of 3-chloro-4-fluorobenzene with bromide may also be affected by the concentration of the reactants. When the concentration is high, the chance of collision between the reactants increases, which is conducive to the reaction to produce products. However, at the same time, too high concentration may also lead to unnecessary side reactions. The reaction of the two is a complex and delicate chemical process. It is necessary to comprehensively consider various factors in order to grasp the essence of its chemical changes.
Bromide, common ones such as sodium bromide, potassium bromide, etc. Bromine ions often play a specific role in the reaction. When 3-chloro-4-fluorobenzene meets bromide, a nucleophilic substitution reaction may occur under suitable conditions. Bromine ions are nucleophilic, and their electron clouds are relatively loose and easy to attack areas with lower electron cloud density.
On the benzene ring of 3-chloro-4-fluorobenzene, the electron cloud density at some locations decreases due to the action of chlorine and fluorine, which becomes a potential check point for the nucleophilic attack of bromine ions. If the reaction conditions are appropriate, such as under the action of suitable solvents, temperatures and catalysts, bromine ions may replace chlorine atoms or fluorine atoms on the benzene ring to form new compounds. The occurrence of this substitution reaction requires consideration of many factors. The polarity of the solvent has a great influence on the reaction. Polar solvents can promote the dissolution of ions and the reaction progress. Temperature is also critical. The appropriate temperature can speed up the reaction rate. If it is too high or too low, the reaction may not occur or produce side reactions.
In addition, the reaction of 3-chloro-4-fluorobenzene with bromide may also be affected by the concentration of the reactants. When the concentration is high, the chance of collision between the reactants increases, which is conducive to the reaction to produce products. However, at the same time, too high concentration may also lead to unnecessary side reactions. The reaction of the two is a complex and delicate chemical process. It is necessary to comprehensively consider various factors in order to grasp the essence of its chemical changes.
What are the main uses of 3-chloro-4-fluorobenzene Bromide?
3-Chloro-4-fluorobenzene and bromide are widely used and play an important role in many fields.
In the field of organic synthesis, it can be used as a key intermediate. Taking the preparation of complex organic compounds as an example, 3-chloro-4-fluorobenzene can react with bromide through specific chemical reactions, such as nucleophilic substitution, to form novel carbon-bromine bonds or other chemical bonds, and then generate organic molecules with specific functions and structures. These products may become potential pharmaceutical active ingredients in the process of pharmaceutical research and development, laying the foundation for the creation of new drugs; or in the field of materials science, used to prepare polymer materials with special properties, functional materials, etc., such as some optoelectronic materials, by precisely regulating the molecular structure, endowing the material with unique optical and electrical properties.
In the fine chemical industry, its use should not be underestimated. Products derived from bromide and 3-chloro-4-fluorobenzene can be used as additives in coatings, inks and other products. For example, adding specific products to coatings may improve coating adhesion, corrosion resistance and other properties; when used in inks, it may optimize ink drying speed, color stability, etc. In addition, in the synthesis of fine chemicals such as fragrances and dyes, through rational reaction paths, unique fragrances and dye intermediates can be prepared, which can help to develop novel fragrances and dyes with bright colors and excellent fastness.
In the field of pesticides, 3-chloro-4-fluorobenzene and bromide participate in the synthesis of compounds, or have biological activities such as insecticidal, bactericidal, and herbicide. Through careful design and synthesis, pesticide products with efficient control of specific crop diseases and pests can be created. Compared with traditional pesticides, such new pesticides may have the advantages of environmental friendliness, low toxicity and high efficiency, providing strong support for sustainable agricultural development.
In the field of organic synthesis, it can be used as a key intermediate. Taking the preparation of complex organic compounds as an example, 3-chloro-4-fluorobenzene can react with bromide through specific chemical reactions, such as nucleophilic substitution, to form novel carbon-bromine bonds or other chemical bonds, and then generate organic molecules with specific functions and structures. These products may become potential pharmaceutical active ingredients in the process of pharmaceutical research and development, laying the foundation for the creation of new drugs; or in the field of materials science, used to prepare polymer materials with special properties, functional materials, etc., such as some optoelectronic materials, by precisely regulating the molecular structure, endowing the material with unique optical and electrical properties.
In the fine chemical industry, its use should not be underestimated. Products derived from bromide and 3-chloro-4-fluorobenzene can be used as additives in coatings, inks and other products. For example, adding specific products to coatings may improve coating adhesion, corrosion resistance and other properties; when used in inks, it may optimize ink drying speed, color stability, etc. In addition, in the synthesis of fine chemicals such as fragrances and dyes, through rational reaction paths, unique fragrances and dye intermediates can be prepared, which can help to develop novel fragrances and dyes with bright colors and excellent fastness.
In the field of pesticides, 3-chloro-4-fluorobenzene and bromide participate in the synthesis of compounds, or have biological activities such as insecticidal, bactericidal, and herbicide. Through careful design and synthesis, pesticide products with efficient control of specific crop diseases and pests can be created. Compared with traditional pesticides, such new pesticides may have the advantages of environmental friendliness, low toxicity and high efficiency, providing strong support for sustainable agricultural development.
3-chloro-4-fluorobenzene Bromide's method of synthesis
To prepare 3-chloro-4-fluorobenzene bromide, the following method can be followed.
Take 3-chloro-4-fluorobenzene first, which is the starting material for the reaction. It is often based on halogenation reaction, and to introduce bromine atoms, bromination reagents can be considered. Among them, N-bromosuccinimide (NBS) is a commonly used brominating agent, and its reaction conditions are relatively mild and its selectivity is good.
React in a suitable reaction solvent, such as carbon tetrachloride ($CCl_ {4} $) and other inert solvents. Add an initiator, such as benzoyl peroxide (BPO), to the reaction system. This initiator can decompose to produce free radicals under heat or light conditions, thereby initiating a bromination reaction.
During the reaction, heat or light provides energy to decompose the initiator BPO into free radicals, which in turn initiates the generation of bromine free radicals in NBS. The bromine free radical undergoes a radical substitution reaction with 3-chloro-4-fluorobenzene, and bromine atoms are introduced at suitable positions in the benzene ring to form the target product 3-chloro-4-fluorobenzene bromide.
After the reaction is completed, a post-treatment step is required. The reaction mixture is first extracted with a suitable organic solvent to separate the organic phase. After that, the organic phase can be washed with a dilute alkali solution to remove impurities such as unreacted NBS and its by-products. The organic phase is dried by anhydrous sodium sulfate and other desiccants to remove the moisture. Finally, the product is purified by vacuum distillation or column chromatography, and the target fraction or suitable colored ribbon is collected to obtain pure 3-chloro-4-fluorobenzene bromide.
Take 3-chloro-4-fluorobenzene first, which is the starting material for the reaction. It is often based on halogenation reaction, and to introduce bromine atoms, bromination reagents can be considered. Among them, N-bromosuccinimide (NBS) is a commonly used brominating agent, and its reaction conditions are relatively mild and its selectivity is good.
React in a suitable reaction solvent, such as carbon tetrachloride ($CCl_ {4} $) and other inert solvents. Add an initiator, such as benzoyl peroxide (BPO), to the reaction system. This initiator can decompose to produce free radicals under heat or light conditions, thereby initiating a bromination reaction.
During the reaction, heat or light provides energy to decompose the initiator BPO into free radicals, which in turn initiates the generation of bromine free radicals in NBS. The bromine free radical undergoes a radical substitution reaction with 3-chloro-4-fluorobenzene, and bromine atoms are introduced at suitable positions in the benzene ring to form the target product 3-chloro-4-fluorobenzene bromide.
After the reaction is completed, a post-treatment step is required. The reaction mixture is first extracted with a suitable organic solvent to separate the organic phase. After that, the organic phase can be washed with a dilute alkali solution to remove impurities such as unreacted NBS and its by-products. The organic phase is dried by anhydrous sodium sulfate and other desiccants to remove the moisture. Finally, the product is purified by vacuum distillation or column chromatography, and the target fraction or suitable colored ribbon is collected to obtain pure 3-chloro-4-fluorobenzene bromide.
What are the precautions in storage and transportation of 3-chloro-4-fluorobenzene Bromide?
When storing and transporting 3-chloro-4-fluorobenzene and bromide, many precautions need to be taken with care.
First and foremost, it concerns the storage environment. Both should be stored in a cool, dry and well-ventilated place. Because a cool environment can avoid chemical reactions caused by high temperature, drying can prevent moisture and moisture from causing material deterioration, and good ventilation can disperse harmful gases that may accumulate. Do not place in direct sunlight, the energy in sunlight may stimulate its chemical reactions and damage the quality of the material.
Furthermore, when storing, be sure to properly isolate from other chemicals. 3-Chloro-4-fluorobenzene has unique properties with bromide, or reacts with other substances, such as oxidants, reducing agents, acids, bases, etc., should be placed separately to prevent unexpected chemical reactions, such as violent reactions, explosions, etc.
During transportation, the packaging must be solid and reliable. Appropriate packaging materials need to be selected to ensure that it can withstand bumps and vibrations during transportation without leakage. Containers should be tightly sealed to avoid contact with air and moisture.
Transportation tools should also be carefully selected to ensure cleanliness and no residual other chemicals. At the same time, transportation personnel should be familiar with the characteristics of relevant chemicals and emergency treatment methods, so that in case of leakage and other emergencies, they can respond quickly and correctly.
During handling, the operation must be gentle to prevent brutal loading and unloading to avoid packaging damage. In the event of a leak, the surrounding personnel should be evacuated immediately and corresponding emergency measures should be taken, such as using suitable materials to absorb the leak to prevent its spread from causing greater harm. In this way, the safety of 3-chloro-4-fluorobenzene and bromide during storage and transportation can be ensured.
First and foremost, it concerns the storage environment. Both should be stored in a cool, dry and well-ventilated place. Because a cool environment can avoid chemical reactions caused by high temperature, drying can prevent moisture and moisture from causing material deterioration, and good ventilation can disperse harmful gases that may accumulate. Do not place in direct sunlight, the energy in sunlight may stimulate its chemical reactions and damage the quality of the material.
Furthermore, when storing, be sure to properly isolate from other chemicals. 3-Chloro-4-fluorobenzene has unique properties with bromide, or reacts with other substances, such as oxidants, reducing agents, acids, bases, etc., should be placed separately to prevent unexpected chemical reactions, such as violent reactions, explosions, etc.
During transportation, the packaging must be solid and reliable. Appropriate packaging materials need to be selected to ensure that it can withstand bumps and vibrations during transportation without leakage. Containers should be tightly sealed to avoid contact with air and moisture.
Transportation tools should also be carefully selected to ensure cleanliness and no residual other chemicals. At the same time, transportation personnel should be familiar with the characteristics of relevant chemicals and emergency treatment methods, so that in case of leakage and other emergencies, they can respond quickly and correctly.
During handling, the operation must be gentle to prevent brutal loading and unloading to avoid packaging damage. In the event of a leak, the surrounding personnel should be evacuated immediately and corresponding emergency measures should be taken, such as using suitable materials to absorb the leak to prevent its spread from causing greater harm. In this way, the safety of 3-chloro-4-fluorobenzene and bromide during storage and transportation can be ensured.
3-chloro-4-fluorobenzene Bromide's impact on the environment and human health
3-Chloro-4-fluorobenzene and bromide, both of which affect the environment and human body, are of great concern to the world.
3-chloro-4-fluorobenzene is also an organic compound. The presence of chlorine and fluorine atoms in its structure gives it unique chemical properties. In the environment, if such compounds enter water and soil, they may remain for a long time due to their difficulty in degradation. And because of their fat solubility, they are easy to accumulate in organisms, pass along the food chain, or cause toxicity to organisms at all levels. Such as affecting the growth and reproduction of aquatic organisms, causing deformities in their development, or destroying the structure of soil microbial communities, affecting the balance of soil ecosystems.
There are many kinds of bromide, common ones such as sodium bromide, potassium bromide, etc. Bromide in the environment may interfere with the ion balance in organisms. If its concentration in water is too high, it will have adverse effects on the nervous system and respiratory system of aquatic organisms. In the human body, excessive intake of bromide may lead to nausea, vomiting, abdominal pain and other digestive tract symptoms in the early stage. Long-term exposure to high concentrations of bromide may damage the nervous system, cause mental illness, memory loss, and in severe cases, or cause organic neuropathy.
When 3-chloro-4-fluorobenzene and bromide coexist in the environment, the two may cooperate to exacerbate the harm. Its combined effect may far exceed the harm of a single substance. Therefore, the impact of the two on the environment and the human body needs to be deeply studied in order to seek prevention and management strategies to ensure the safety of the environment and the health of the human body.
3-chloro-4-fluorobenzene is also an organic compound. The presence of chlorine and fluorine atoms in its structure gives it unique chemical properties. In the environment, if such compounds enter water and soil, they may remain for a long time due to their difficulty in degradation. And because of their fat solubility, they are easy to accumulate in organisms, pass along the food chain, or cause toxicity to organisms at all levels. Such as affecting the growth and reproduction of aquatic organisms, causing deformities in their development, or destroying the structure of soil microbial communities, affecting the balance of soil ecosystems.
There are many kinds of bromide, common ones such as sodium bromide, potassium bromide, etc. Bromide in the environment may interfere with the ion balance in organisms. If its concentration in water is too high, it will have adverse effects on the nervous system and respiratory system of aquatic organisms. In the human body, excessive intake of bromide may lead to nausea, vomiting, abdominal pain and other digestive tract symptoms in the early stage. Long-term exposure to high concentrations of bromide may damage the nervous system, cause mental illness, memory loss, and in severe cases, or cause organic neuropathy.
When 3-chloro-4-fluorobenzene and bromide coexist in the environment, the two may cooperate to exacerbate the harm. Its combined effect may far exceed the harm of a single substance. Therefore, the impact of the two on the environment and the human body needs to be deeply studied in order to seek prevention and management strategies to ensure the safety of the environment and the health of the human body.
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