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3-Chloro-4-Fluorobenzeneboronic Acid
Linshang Chemical
|
HS Code |
923279 |
| Name | 3-Chloro-4-Fluorobenzeneboronic Acid |
| Chemical Formula | C6H5BClFO2 |
| Appearance | White to off - white solid |
| Purity | Typically high purity for chemical synthesis, e.g., 95%+ |
| Melting Point | 160 - 165°C |
| Solubility In Water | Slightly soluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, dichloromethane |
| Acidity | Weakly acidic due to the boronic acid functional group |
| Stability | Should be stored under inert atmosphere to prevent oxidation |
As an accredited 3-Chloro-4-Fluorobenzeneboronic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 3 - chloro - 4 - fluorobenzeneboronic acid packaged in a sealed plastic bottle. |
| Storage | 3 - Chloro - 4 - fluorobenzeneboronic acid should be stored in a cool, dry place away from heat and direct sunlight. Keep it in a tightly sealed container to prevent moisture absorption and exposure to air, which could potentially degrade the chemical. Store it separately from incompatible substances, such as strong oxidizing agents, to avoid hazardous reactions. |
| Shipping | 3 - Chloro - 4 - fluorobenzeneboronic acid is shipped in well - sealed, corrosion - resistant containers. Shipment follows strict chemical transport regulations to ensure safety during transit, protecting from moisture and physical damage. |
Competitive 3-Chloro-4-Fluorobenzeneboronic Acid prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 3-Chloro-4-Fluorobenzeneboronic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 3-chloro-4-fluorobenzeneboronic Acid?
3-Chloro-4-fluorophenylboronic acid, which is a very important reagent in organic synthesis. This compound has the general properties of boric acid and is weakly acidic. It can condense with alcohols under appropriate conditions to form borate esters. This reaction is often used in organic synthesis to protect hydroxyl groups or to construct boron-containing ring structures.
Because there are chlorine atoms and fluorine atoms in the molecule, the two give it unique reactivity. Chlorine atoms can undergo nucleophilic substitution reactions. Under the action of suitable nucleophilic reagents, they can be replaced by other groups, thereby introducing various functional groups and expanding the structural diversity of molecules. Fluorine atoms have high electronegativity, which can significantly affect the electron cloud distribution of molecules, reduce the electron cloud density of benzene rings, and then affect their chemical reactivity, making benzene rings more prone to electrophilic substitution reactions. The presence of fluorine atoms often enhances the stability and biological activity of compounds, which is of great significance in the field of medicinal chemistry.
In organometallic catalytic reactions, 3-chloro-4-fluorophenylboronic acid can be used as an important reaction substrate. Suzuki-Miyaura coupling reactions occur with halogenated aromatics and other halogenated aromatics under palladium catalysis, thereby forming carbon-carbon bonds to form a series of chlorine and fluorine-containing biphenyl compounds. Such compounds are widely used in materials science and drug development. At the same time, because it contains boron, chlorine, fluorine and other atoms, in the field of crystal engineering, it can build novel crystal structures by virtue of the coordination ability of boron atoms and the weak interaction of halogen atoms, providing more possibilities for material design.
Because there are chlorine atoms and fluorine atoms in the molecule, the two give it unique reactivity. Chlorine atoms can undergo nucleophilic substitution reactions. Under the action of suitable nucleophilic reagents, they can be replaced by other groups, thereby introducing various functional groups and expanding the structural diversity of molecules. Fluorine atoms have high electronegativity, which can significantly affect the electron cloud distribution of molecules, reduce the electron cloud density of benzene rings, and then affect their chemical reactivity, making benzene rings more prone to electrophilic substitution reactions. The presence of fluorine atoms often enhances the stability and biological activity of compounds, which is of great significance in the field of medicinal chemistry.
In organometallic catalytic reactions, 3-chloro-4-fluorophenylboronic acid can be used as an important reaction substrate. Suzuki-Miyaura coupling reactions occur with halogenated aromatics and other halogenated aromatics under palladium catalysis, thereby forming carbon-carbon bonds to form a series of chlorine and fluorine-containing biphenyl compounds. Such compounds are widely used in materials science and drug development. At the same time, because it contains boron, chlorine, fluorine and other atoms, in the field of crystal engineering, it can build novel crystal structures by virtue of the coordination ability of boron atoms and the weak interaction of halogen atoms, providing more possibilities for material design.
What are the main uses of 3-chloro-4-fluorobenzeneboronic Acid?
3-Chloro-4-fluorophenylboronic acid has a wide range of uses. It is a key intermediate in the field of organic synthesis. First, it is often used to construct carbon-carbon bonds. Through the Suzuki-Miyaura coupling reaction, it can be cleverly combined with halogenated aromatics, halogenated olefins and other substrates to form new carbon-carbon bonds, and then synthesize various complex organic molecules, such as drug molecules, natural products and functional materials. This reaction condition is relatively mild and highly selective, and plays a pivotal role in organic synthesis chemistry.
Second, in the field of materials science, 3-chloro-4-fluorophenylboronic acid also has outstanding performance. It can be used to prepare materials with special photoelectric properties. For example, introducing it into conjugated polymer systems can effectively adjust the electronic structure and optical properties of materials, thus obtaining new materials suitable for optoelectronic devices such as organic Light Emitting Diodes (OLEDs) and organic solar cells, providing new paths and possibilities for improving the performance of these devices.
Furthermore, in the field of medicinal chemistry, due to its unique structure and reactivity, it can be introduced into drug molecules as key structural fragments. By specifically combining with biological targets, it is expected to develop new drugs with high efficiency and low toxicity, which will contribute to the development of human health. In short, 3-chloro-4-fluorophenylboronic acid plays an indispensable role in many important fields due to its unique properties, promoting the continuous development and progress of related fields.
Second, in the field of materials science, 3-chloro-4-fluorophenylboronic acid also has outstanding performance. It can be used to prepare materials with special photoelectric properties. For example, introducing it into conjugated polymer systems can effectively adjust the electronic structure and optical properties of materials, thus obtaining new materials suitable for optoelectronic devices such as organic Light Emitting Diodes (OLEDs) and organic solar cells, providing new paths and possibilities for improving the performance of these devices.
Furthermore, in the field of medicinal chemistry, due to its unique structure and reactivity, it can be introduced into drug molecules as key structural fragments. By specifically combining with biological targets, it is expected to develop new drugs with high efficiency and low toxicity, which will contribute to the development of human health. In short, 3-chloro-4-fluorophenylboronic acid plays an indispensable role in many important fields due to its unique properties, promoting the continuous development and progress of related fields.
What are the synthetic methods of 3-chloro-4-fluorobenzeneboronic Acid?
The synthesis of 3-chloro-4-fluorophenylboronic acid is usually based on halogenated aromatic hydrocarbons. For example, 3-chloro-4-fluorobromobenzene can be prepared by metallization reaction.
In a clean and dry reaction bottle, pass nitrogen to create an inert atmosphere. Add an appropriate amount of anhydrous ether as a solvent and cool the reaction system to a low temperature, such as -78 ° C. Slowly add n-butyl lithium dropwise, this reagent will undergo lithium-halogen exchange reaction with 3-chloro-4-fluorobrobenzene. The bromine atom in 3-chloro-4-fluorobromobenzene will be replaced by lithium atom to form 3-chloro-4-fluorophenyl lithium intermediate. This intermediate is highly active, and then a borate ester, such as trimethyl borate, is added to the system. After the nucleophilic substitution reaction, the lithium atom is replaced by a borate ester group. After the reaction is completed, the system is warmed to room temperature, and an appropriate amount of dilute acid, such as dilute hydrochloric acid, is added for hydrolysis to obtain 3-chloro-4-fluorophenylboronic acid.
In addition, palladium-catalyzed coupling reactions can also be used to synthesize. 3-Chloro-4-fluorobromobenzene and diphenylfluorobenzene borate were taken as raw materials, and an appropriate amount of palladium catalyst, such as tetra (triphenylphosphine) palladium, as well as ligands, bases, etc. Under the protection of suitable temperature and inert gas, 3-chloro-4-fluorobromobenzene and diphenylfluorobenzene borate were coupled to form 3-chloro-4-fluorobenzene borate. Subsequent hydrolysis treatment can obtain 3-chloro-4-fluorobenzene borate. When hydrolyzing, an acid or base can be selected as a catalyst, and appropriate conditions can be selected according to the specific situation to achieve good yield and purity.
In a clean and dry reaction bottle, pass nitrogen to create an inert atmosphere. Add an appropriate amount of anhydrous ether as a solvent and cool the reaction system to a low temperature, such as -78 ° C. Slowly add n-butyl lithium dropwise, this reagent will undergo lithium-halogen exchange reaction with 3-chloro-4-fluorobrobenzene. The bromine atom in 3-chloro-4-fluorobromobenzene will be replaced by lithium atom to form 3-chloro-4-fluorophenyl lithium intermediate. This intermediate is highly active, and then a borate ester, such as trimethyl borate, is added to the system. After the nucleophilic substitution reaction, the lithium atom is replaced by a borate ester group. After the reaction is completed, the system is warmed to room temperature, and an appropriate amount of dilute acid, such as dilute hydrochloric acid, is added for hydrolysis to obtain 3-chloro-4-fluorophenylboronic acid.
In addition, palladium-catalyzed coupling reactions can also be used to synthesize. 3-Chloro-4-fluorobromobenzene and diphenylfluorobenzene borate were taken as raw materials, and an appropriate amount of palladium catalyst, such as tetra (triphenylphosphine) palladium, as well as ligands, bases, etc. Under the protection of suitable temperature and inert gas, 3-chloro-4-fluorobromobenzene and diphenylfluorobenzene borate were coupled to form 3-chloro-4-fluorobenzene borate. Subsequent hydrolysis treatment can obtain 3-chloro-4-fluorobenzene borate. When hydrolyzing, an acid or base can be selected as a catalyst, and appropriate conditions can be selected according to the specific situation to achieve good yield and purity.
3-chloro-4-fluorobenzeneboronic Acid during storage and transportation
3-Chloro-4-fluorophenylboronic acid, when storing and transporting, pay attention to everything. This is an organoboron compound with certain chemical activity, so when storing, the first environment is dry. Moisture can easily cause it to hydrolyze, causing it to deteriorate and damage its effectiveness. It should be stored in a dry place, away from shady places, away from water sources and places with high humidity.
Temperature is also critical. It should be controlled within an appropriate range, usually at a low temperature, but not too low to cause it to freeze. Excessive temperature will promote its chemical reaction and damage its stability. Generally stored in the refrigerated layer of the refrigerator, the temperature is about 2-8 degrees Celsius.
Furthermore, the storage container must be properly selected. It is appropriate to use glass or specific plastic materials, because its chemical properties are stable and do not chemically react with 3-chloro-4-fluorophenylboronic acid. And the container must be well sealed to prevent the intrusion of air and moisture.
When transporting, protective measures are indispensable. The packaging must be tight and wrapped with buffer material to prevent the container from cracking due to collision and vibration. Due to its chemical activity, it should be kept away from heat sources, fire sources and oxidants during transportation, because it encounters such substances, or reacts violently and causes safety accidents.
At the same time, transporters should also be familiar with its characteristics and emergency treatment methods. If there is an accident such as leakage, it can be disposed of in time and properly to prevent the harm from expanding. In this way, the safety and quality of 3-chloro-4-fluorophenylboronic acid during storage and transportation are guaranteed.
Temperature is also critical. It should be controlled within an appropriate range, usually at a low temperature, but not too low to cause it to freeze. Excessive temperature will promote its chemical reaction and damage its stability. Generally stored in the refrigerated layer of the refrigerator, the temperature is about 2-8 degrees Celsius.
Furthermore, the storage container must be properly selected. It is appropriate to use glass or specific plastic materials, because its chemical properties are stable and do not chemically react with 3-chloro-4-fluorophenylboronic acid. And the container must be well sealed to prevent the intrusion of air and moisture.
When transporting, protective measures are indispensable. The packaging must be tight and wrapped with buffer material to prevent the container from cracking due to collision and vibration. Due to its chemical activity, it should be kept away from heat sources, fire sources and oxidants during transportation, because it encounters such substances, or reacts violently and causes safety accidents.
At the same time, transporters should also be familiar with its characteristics and emergency treatment methods. If there is an accident such as leakage, it can be disposed of in time and properly to prevent the harm from expanding. In this way, the safety and quality of 3-chloro-4-fluorophenylboronic acid during storage and transportation are guaranteed.
What is the market price of 3-chloro-4-fluorobenzeneboronic Acid?
3-Chloro-4-fluorophenylboronic acid, the price of this product in the market often varies depending on the quality, quantity, supply and demand. In the past, the price of such fine chemicals in the market mostly depended on many conditions.
If it is of ordinary quality and the quantity is not huge, the price per gram may be around tens to hundreds of yuan. If it is of high quality and high purity, it is used for high-end scientific research or specific fine synthesis, and the price is higher. Or up to hundreds of yuan per gram.
However, if the purchase quantity is quite large, such as in kilograms, merchants often give in to the unit price due to large profits. At this time, the price per gram may drop to a few tens of yuan.
Moreover, the market supply and demand situation also affects its price. If there are many applicants, and the supply is scarce, the price will rise; on the contrary, if the supply exceeds the demand, the price may decline.
Overall, the market price of 3-chloro-4-fluorophenylboronic acid fluctuates between tens of yuan and hundreds of yuan per gram. It is difficult to determine an exact number. It depends on the specific trading situation.
If it is of ordinary quality and the quantity is not huge, the price per gram may be around tens to hundreds of yuan. If it is of high quality and high purity, it is used for high-end scientific research or specific fine synthesis, and the price is higher. Or up to hundreds of yuan per gram.
However, if the purchase quantity is quite large, such as in kilograms, merchants often give in to the unit price due to large profits. At this time, the price per gram may drop to a few tens of yuan.
Moreover, the market supply and demand situation also affects its price. If there are many applicants, and the supply is scarce, the price will rise; on the contrary, if the supply exceeds the demand, the price may decline.
Overall, the market price of 3-chloro-4-fluorophenylboronic acid fluctuates between tens of yuan and hundreds of yuan per gram. It is difficult to determine an exact number. It depends on the specific trading situation.
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