Linshang Chemical
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3-Chloro-4-Fluorobenzenesulfonyl Chloride
Linshang Chemical
|
HS Code |
831941 |
| Name | 3-Chloro-4-Fluorobenzenesulfonyl Chloride |
| Chemical Formula | C6H3Cl2FO2S |
| Molar Mass | 231.056 g/mol |
| Appearance | Colorless to light yellow liquid |
| Density | 1.64 g/cm³ (estimated) |
| Boiling Point | 254 - 256 °C |
| Solubility In Water | Reacts with water |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane |
| Flash Point | 107.4 °C |
| Hazard Class | Corrosive |
As an accredited 3-Chloro-4-Fluorobenzenesulfonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 3 - chloro - 4 - fluorobenzenesulfonyl chloride in sealed, corrosion - resistant containers. |
| Storage | 3 - Chloro - 4 - fluorobenzenesulfonyl chloride should be stored in a cool, dry, well - ventilated area, away from sources of heat and ignition. Keep it in a tightly sealed container to prevent moisture ingress, as it can react with water. Store it separately from incompatible substances like bases, amines, and reducing agents to avoid dangerous reactions. |
| Shipping | 3 - chloro - 4 - fluorobenzenesulfonyl chloride is a hazardous chemical. It should be shipped in accordance with strict regulations. Packed in appropriate corrosion - resistant containers, labeled clearly, and transported by carriers approved for hazardous materials. |
Competitive 3-Chloro-4-Fluorobenzenesulfonyl Chloride prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 3-Chloro-4-Fluorobenzenesulfonyl Chloride in China?
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 3-Chloro-4-Fluorobenzenesulfonyl Chloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 3-chloro-4-fluorobenzenesulfonyl Chloride?
3-Chloro-4-fluorobenzenesulfonyl chloride is a crucial chemical reagent in the field of organic synthesis. It has a wide range of uses, mainly demonstrating its value in the following aspects.
First, in the synthesis of medicine, this reagent is often a key intermediate. Taking the synthesis of specific antibacterial drugs as an example, by reacting 3-chloro-4-fluorobenzenesulfonyl chloride with specific amine compounds, a molecular structure with unique antibacterial activity can be cleverly constructed. Because of its chlorine and fluorine atoms, it can significantly affect the electron cloud distribution and spatial configuration of drug molecules, thereby enhancing the affinity between drugs and targets and enhancing antibacterial efficacy.
Second, in the process of pesticide creation, 3-chloro-4-fluorobenzenesulfonyl chloride also plays an important role. It can be introduced into the molecular structure of pesticides to enhance the ability of pesticides to interfere with the physiological processes of pests or weeds. For example, by combining with certain heterocyclic compounds, an insecticide with high selectivity and high-efficiency killing ability for specific pests, or an efficient herbicide for specific weeds, can be created.
Third, in the field of materials science, this reagent makes a difference. In the synthesis of special functional polymer materials, 3-chloro-4-fluorobenzenesulfonyl chloride can provide active functional groups, so that polymer materials have excellent properties such as weather resistance and chemical stability. For example, when preparing high-performance engineering plastics, its participation in the reaction can optimize the physical and chemical properties of the material and broaden the application scenarios of the material.
Fourth, in the field of dye synthesis, 3-chloro-4-fluorobenzenesulfonyl chloride can be used to construct dye molecular structures with special color and stability. By reacting with different aromatic amines or phenolic compounds, specific chromophores and chromophores can be introduced, thus endowing the dye with excellent dyeing properties, such as high color fastness, bright color, etc., to meet the needs of high-quality dyes in textile, printing and dyeing industries.
All of this shows that 3-chloro-4-fluorobenzenesulfonyl chloride is an indispensable key material in many chemical-related industries, and plays a crucial role in promoting technological progress and product innovation in various fields.
First, in the synthesis of medicine, this reagent is often a key intermediate. Taking the synthesis of specific antibacterial drugs as an example, by reacting 3-chloro-4-fluorobenzenesulfonyl chloride with specific amine compounds, a molecular structure with unique antibacterial activity can be cleverly constructed. Because of its chlorine and fluorine atoms, it can significantly affect the electron cloud distribution and spatial configuration of drug molecules, thereby enhancing the affinity between drugs and targets and enhancing antibacterial efficacy.
Second, in the process of pesticide creation, 3-chloro-4-fluorobenzenesulfonyl chloride also plays an important role. It can be introduced into the molecular structure of pesticides to enhance the ability of pesticides to interfere with the physiological processes of pests or weeds. For example, by combining with certain heterocyclic compounds, an insecticide with high selectivity and high-efficiency killing ability for specific pests, or an efficient herbicide for specific weeds, can be created.
Third, in the field of materials science, this reagent makes a difference. In the synthesis of special functional polymer materials, 3-chloro-4-fluorobenzenesulfonyl chloride can provide active functional groups, so that polymer materials have excellent properties such as weather resistance and chemical stability. For example, when preparing high-performance engineering plastics, its participation in the reaction can optimize the physical and chemical properties of the material and broaden the application scenarios of the material.
Fourth, in the field of dye synthesis, 3-chloro-4-fluorobenzenesulfonyl chloride can be used to construct dye molecular structures with special color and stability. By reacting with different aromatic amines or phenolic compounds, specific chromophores and chromophores can be introduced, thus endowing the dye with excellent dyeing properties, such as high color fastness, bright color, etc., to meet the needs of high-quality dyes in textile, printing and dyeing industries.
All of this shows that 3-chloro-4-fluorobenzenesulfonyl chloride is an indispensable key material in many chemical-related industries, and plays a crucial role in promoting technological progress and product innovation in various fields.
What are the physical properties of 3-chloro-4-fluorobenzenesulfonyl Chloride?
3-Chloro-4-fluorobenzenesulfonyl chloride is an important chemical raw material in organic synthesis. Its physical properties are particularly critical and are related to many practical applications.
Bearing the brunt, looking at its appearance, under room temperature and pressure, 3-chloro-4-fluorobenzenesulfonyl chloride is mostly colorless to light yellow liquid. This color and state can be used as an important basis for preliminary identification and determination of its purity.
Furthermore, when it comes to the boiling point, the boiling point of this substance is quite high, about 250 ° C to 260 ° C. A higher boiling point means that it will boil and vaporize in a relatively high temperature environment. This property is essential for controlling the reaction conditions in chemical operations such as distillation and separation. Effective separation or purification can be achieved due to the need to ensure that the temperature reaches a specific height. The melting point of
is also an important property. Its melting point is in the range of -20 ° C to -15 ° C. The low melting point indicates that the substance can easily remain liquid near room temperature, which is convenient for full mixing and contact with other reactants in various reaction systems to promote the smooth progress of the reaction. In terms of density, the density of 3-chloro-4-fluorobenzenesulfonyl chloride is about 1.6 g/cm ³. This density property is of great significance when it comes to solution preparation, phase separation, etc. For example, when mixing different liquid reactants, the density difference helps to predict the distribution and mixing of each component, and then rationally design the reaction device and process.
In terms of solubility, it can be soluble in common organic solvents such as dichloromethane, chloroform, and ether. Good solubility facilitates organic synthesis reactions. Many organic reactions are often carried out in organic solvent media. 3-chloro-4-fluorobenzenesulfonyl chloride can be uniformly dispersed in the solvent with other reactants to improve the reaction rate and efficiency. However, its solubility in water is poor, which warns that during treatment and use, it is necessary to avoid extensive contact with water to prevent unnecessary side reactions or affect product quality.
In addition, 3-chloro-4-fluorobenzenesulfonyl chloride is volatile to a certain extent, and it will partially evaporate when exposed to the environment or slightly higher temperatures. Therefore, when storing and using, it is necessary to pay attention to sealing and control the ambient temperature to reduce volatilization losses, and at the same time avoid the presence of harmful gases in the environment due to volatilization, which endangers the health and environmental safety of operators.
In summary, the physical properties of 3-chloro-4-fluorobenzenesulfonyl chloride, from its appearance, melting point, density, solubility and volatility, have a profound impact on its application in the field of organic synthesis. In practice, these properties need to be carefully considered in order to achieve efficient and safe chemical synthesis.
Bearing the brunt, looking at its appearance, under room temperature and pressure, 3-chloro-4-fluorobenzenesulfonyl chloride is mostly colorless to light yellow liquid. This color and state can be used as an important basis for preliminary identification and determination of its purity.
Furthermore, when it comes to the boiling point, the boiling point of this substance is quite high, about 250 ° C to 260 ° C. A higher boiling point means that it will boil and vaporize in a relatively high temperature environment. This property is essential for controlling the reaction conditions in chemical operations such as distillation and separation. Effective separation or purification can be achieved due to the need to ensure that the temperature reaches a specific height. The melting point of
is also an important property. Its melting point is in the range of -20 ° C to -15 ° C. The low melting point indicates that the substance can easily remain liquid near room temperature, which is convenient for full mixing and contact with other reactants in various reaction systems to promote the smooth progress of the reaction. In terms of density, the density of 3-chloro-4-fluorobenzenesulfonyl chloride is about 1.6 g/cm ³. This density property is of great significance when it comes to solution preparation, phase separation, etc. For example, when mixing different liquid reactants, the density difference helps to predict the distribution and mixing of each component, and then rationally design the reaction device and process.
In terms of solubility, it can be soluble in common organic solvents such as dichloromethane, chloroform, and ether. Good solubility facilitates organic synthesis reactions. Many organic reactions are often carried out in organic solvent media. 3-chloro-4-fluorobenzenesulfonyl chloride can be uniformly dispersed in the solvent with other reactants to improve the reaction rate and efficiency. However, its solubility in water is poor, which warns that during treatment and use, it is necessary to avoid extensive contact with water to prevent unnecessary side reactions or affect product quality.
In addition, 3-chloro-4-fluorobenzenesulfonyl chloride is volatile to a certain extent, and it will partially evaporate when exposed to the environment or slightly higher temperatures. Therefore, when storing and using, it is necessary to pay attention to sealing and control the ambient temperature to reduce volatilization losses, and at the same time avoid the presence of harmful gases in the environment due to volatilization, which endangers the health and environmental safety of operators.
In summary, the physical properties of 3-chloro-4-fluorobenzenesulfonyl chloride, from its appearance, melting point, density, solubility and volatility, have a profound impact on its application in the field of organic synthesis. In practice, these properties need to be carefully considered in order to achieve efficient and safe chemical synthesis.
What is the synthesis method of 3-chloro-4-fluorobenzenesulfonyl Chloride?
The synthesis of 3-chloro-4-fluorobenzenesulfonyl chloride is a crucial technique in organic synthesis. To obtain this compound, there are many ways to achieve it. Let's describe one method now.
First take 3-chloro-4-fluoroaniline as the starting material, which is the foundation of synthesis. Dissolve it in an appropriate amount of organic solvent, such as glacial acetic acid, to create a suitable reaction environment. Then, slowly add the aqueous solution of sodium nitrite. This step requires careful temperature control to maintain the reaction temperature between 0-5 ° C, just like grasping the delicate heat to prevent side reactions from breeding. This process generates a diazonium salt intermediate, which is active in nature and is a key bridge for subsequent reactions.
When the diazonium salt is complete, prepare a solution of potassium thiocyanate and add it dropwise to the above reaction system. At this point, the diazonium group will be replaced by thiocyanyl to form 3-chloro-4-fluorobenzene thiocyanide. This step of the reaction requires attention to monitor the reaction process to ensure that the reaction is complete.
Next, oxidize 3-chloro-4-fluorobenzene thiocyanide. Select a suitable oxidizing agent, such as a mixture of hydrogen peroxide and sulfuric acid, to convert the thiocyanyl group into a sulfonyl chloride group. In this oxidation step, the control of the reaction conditions is crucial. The temperature and the proportion of reactants need to be finely adjusted to promote the smooth progress of the reaction towards the formation of 3-chloro-4-fluorobenzenesulfonyl chloride.
The reaction is over, and multiple purification processes are required. First, the organic phase is extracted with an organic solvent; then, it is distilled and recrystallized to remove impurities and improve the purity of the product, just like removing barren and storing cyanine, and finally the pure 3-chloro-4-fluorobenzenesulfonyl chloride is obtained.
Although this synthesis method is only one of them, the fine regulation of the reaction conditions at each step is the key to obtaining high-purity products. The road to synthesis requires step by step and caution.
First take 3-chloro-4-fluoroaniline as the starting material, which is the foundation of synthesis. Dissolve it in an appropriate amount of organic solvent, such as glacial acetic acid, to create a suitable reaction environment. Then, slowly add the aqueous solution of sodium nitrite. This step requires careful temperature control to maintain the reaction temperature between 0-5 ° C, just like grasping the delicate heat to prevent side reactions from breeding. This process generates a diazonium salt intermediate, which is active in nature and is a key bridge for subsequent reactions.
When the diazonium salt is complete, prepare a solution of potassium thiocyanate and add it dropwise to the above reaction system. At this point, the diazonium group will be replaced by thiocyanyl to form 3-chloro-4-fluorobenzene thiocyanide. This step of the reaction requires attention to monitor the reaction process to ensure that the reaction is complete.
Next, oxidize 3-chloro-4-fluorobenzene thiocyanide. Select a suitable oxidizing agent, such as a mixture of hydrogen peroxide and sulfuric acid, to convert the thiocyanyl group into a sulfonyl chloride group. In this oxidation step, the control of the reaction conditions is crucial. The temperature and the proportion of reactants need to be finely adjusted to promote the smooth progress of the reaction towards the formation of 3-chloro-4-fluorobenzenesulfonyl chloride.
The reaction is over, and multiple purification processes are required. First, the organic phase is extracted with an organic solvent; then, it is distilled and recrystallized to remove impurities and improve the purity of the product, just like removing barren and storing cyanine, and finally the pure 3-chloro-4-fluorobenzenesulfonyl chloride is obtained.
Although this synthesis method is only one of them, the fine regulation of the reaction conditions at each step is the key to obtaining high-purity products. The road to synthesis requires step by step and caution.
3-chloro-4-fluorobenzenesulfonyl Chloride in Storage and Transportation
3-Chloro-4-fluorobenzenesulfonyl chloride is a chemical substance. When storing and transporting, many matters need to be paid attention to.
First word storage. This material is very active and reacts easily in case of moisture, so it must be stored in a dry place, protected from water vapor. In the warehouse, the humidity should be controlled at a low degree to prevent its deterioration. And it is corrosive. The selected storage container must be resistant to corrosion. For those made of glass, certain plastics or stainless steel, do not use containers that are easily corroded to avoid leakage. In addition, this product should be stored in a cool place, away from heat and fire sources, and the temperature should be maintained at a lower range.
Times and transportation. When transporting, it is necessary to ensure that the packaging is tight. The outer packaging should be solid and stable, able to withstand a certain external force impact, to prevent damage to the container. During the handling process, the operator should be careful, handle it with care, and do not drop, touch or drag it. Because it is a dangerous chemical, the transportation vehicle should be equipped with corresponding emergency treatment equipment and protective equipment in case of accidents. At the same time, the transportation route planning should also pay attention to avoid densely populated areas and important facilities, and follow the route designated by relevant laws and regulations. In addition, the transportation personnel should be professionally trained and familiar with the characteristics of the substance and emergency response methods to ensure the safety of transportation.
First word storage. This material is very active and reacts easily in case of moisture, so it must be stored in a dry place, protected from water vapor. In the warehouse, the humidity should be controlled at a low degree to prevent its deterioration. And it is corrosive. The selected storage container must be resistant to corrosion. For those made of glass, certain plastics or stainless steel, do not use containers that are easily corroded to avoid leakage. In addition, this product should be stored in a cool place, away from heat and fire sources, and the temperature should be maintained at a lower range.
Times and transportation. When transporting, it is necessary to ensure that the packaging is tight. The outer packaging should be solid and stable, able to withstand a certain external force impact, to prevent damage to the container. During the handling process, the operator should be careful, handle it with care, and do not drop, touch or drag it. Because it is a dangerous chemical, the transportation vehicle should be equipped with corresponding emergency treatment equipment and protective equipment in case of accidents. At the same time, the transportation route planning should also pay attention to avoid densely populated areas and important facilities, and follow the route designated by relevant laws and regulations. In addition, the transportation personnel should be professionally trained and familiar with the characteristics of the substance and emergency response methods to ensure the safety of transportation.
What are the safety precautions for 3-chloro-4-fluorobenzenesulfonyl Chloride?
3-Chloro-4-fluorobenzenesulfonyl chloride is highly corrosive and toxic. It is a matter of safety and must be very careful.
First, it is related to personnel protection. When starting to operate, it is necessary to wear complete protective equipment. Wear protective clothing, which can protect against its corrosion to clothing and damage to the skin; wear protective gloves, which must be chemically resistant to prevent it from contacting the skin of the hands; wear protective glasses or masks, because of its volatile aerosol or splashing droplets, which can cause serious eye damage. And respiratory protection is also indispensable. In poorly ventilated areas, a gas mask should be used. According to the concentration and type of toxins in the place, a suitable filter tank should be selected to ensure that the inhaled air is free from the harm of the substance.
Second, the operating environment is essential. The operation is suitable for well-ventilated places, such as fume hoods. The fume hood can remove volatile gaseous substances in time, reduce their concentration in the operating space, and reduce the risk of personnel inhalation. If it is a large-scale operation, the overall ventilation system of the workshop should also ensure high efficiency, so that the air is constantly replaced and updated. And the ground and countertops in the operation area should be selected with materials that are resistant to chemical corrosion. In case of material leakage, it is easy to clean up, and it is also prevented from corroding the ground and equipment, damaging the facility and causing greater danger.
Third, storage. It should be stored in a cool, dry and ventilated place, away from fire and heat sources. Due to its chemical activity, high temperature or humid environment can cause it to deteriorate or cause reactions. It needs to be stored separately from oxidants, alkalis, etc., and must not be mixed to prevent mutual reactions and violent chemical reactions, leading to fires, explosions and other disasters. Storage containers must be well sealed and made of corrosion-resistant materials, such as glass or specific plastics, with labels clearly marked with their names, characteristics, hazards and other information for easy identification and management.
Fourth, emergency treatment. In the event of a leak, immediately evacuate unrelated personnel and isolate the leakage area. Emergency response personnel must wear protective clothing and masks, and do not directly contact the leak. In the event of a small leak, it can be absorbed by inert materials such as sand and vermiculite, collected in a closed container, and disposed of according to regulations. Large leaks need to be built embankments or dug for containment, transferred to a tanker or a special collector by pump, recycled or transported to a waste disposal site for disposal. If someone comes into contact with or eats by mistake, quickly move to fresh air, remove contaminated clothing, and rinse the contact area with a large amount of water; those who eat by mistake, do not urge vomiting, and seek medical attention immediately.
First, it is related to personnel protection. When starting to operate, it is necessary to wear complete protective equipment. Wear protective clothing, which can protect against its corrosion to clothing and damage to the skin; wear protective gloves, which must be chemically resistant to prevent it from contacting the skin of the hands; wear protective glasses or masks, because of its volatile aerosol or splashing droplets, which can cause serious eye damage. And respiratory protection is also indispensable. In poorly ventilated areas, a gas mask should be used. According to the concentration and type of toxins in the place, a suitable filter tank should be selected to ensure that the inhaled air is free from the harm of the substance.
Second, the operating environment is essential. The operation is suitable for well-ventilated places, such as fume hoods. The fume hood can remove volatile gaseous substances in time, reduce their concentration in the operating space, and reduce the risk of personnel inhalation. If it is a large-scale operation, the overall ventilation system of the workshop should also ensure high efficiency, so that the air is constantly replaced and updated. And the ground and countertops in the operation area should be selected with materials that are resistant to chemical corrosion. In case of material leakage, it is easy to clean up, and it is also prevented from corroding the ground and equipment, damaging the facility and causing greater danger.
Third, storage. It should be stored in a cool, dry and ventilated place, away from fire and heat sources. Due to its chemical activity, high temperature or humid environment can cause it to deteriorate or cause reactions. It needs to be stored separately from oxidants, alkalis, etc., and must not be mixed to prevent mutual reactions and violent chemical reactions, leading to fires, explosions and other disasters. Storage containers must be well sealed and made of corrosion-resistant materials, such as glass or specific plastics, with labels clearly marked with their names, characteristics, hazards and other information for easy identification and management.
Fourth, emergency treatment. In the event of a leak, immediately evacuate unrelated personnel and isolate the leakage area. Emergency response personnel must wear protective clothing and masks, and do not directly contact the leak. In the event of a small leak, it can be absorbed by inert materials such as sand and vermiculite, collected in a closed container, and disposed of according to regulations. Large leaks need to be built embankments or dug for containment, transferred to a tanker or a special collector by pump, recycled or transported to a waste disposal site for disposal. If someone comes into contact with or eats by mistake, quickly move to fresh air, remove contaminated clothing, and rinse the contact area with a large amount of water; those who eat by mistake, do not urge vomiting, and seek medical attention immediately.
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