Linshang Chemical
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3-Chloro-4-Fluorobenzenesulphonyl Chloride
Linshang Chemical
|
HS Code |
298137 |
| Chemical Formula | C6H3Cl2FO2S |
| Molar Mass | 231.05 g/mol |
| Appearance | Colorless to pale yellow liquid |
| Boiling Point | Approx. 270 - 272 °C |
| Solubility In Water | Reacts with water |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane |
| Hazard Class | Corrosive, causes burns to skin and eyes |
As an accredited 3-Chloro-4-Fluorobenzenesulphonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 3 - chloro - 4 - fluorobenzenesulphonyl Chloride packaged in a sealed glass bottle. |
| Storage | 3 - Chloro - 4 - fluorobenzenesulphonyl chloride should be stored in a cool, dry, well - ventilated area, away from sources of heat, ignition, and direct sunlight. It must be kept in a tightly - sealed container to prevent moisture ingress, as it can react with water. Store it separately from incompatible substances like bases, reducing agents, and reactive metals to avoid hazardous reactions. |
| Shipping | 3 - Chloro - 4 - fluorobenzenesulphonyl chloride is a hazardous chemical. Shipping requires compliance with regulations. It must be properly packaged in corrosion - resistant containers, labeled clearly, and transported by approved carriers following safety protocols. |
Competitive 3-Chloro-4-Fluorobenzenesulphonyl Chloride prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 3-Chloro-4-Fluorobenzenesulphonyl Chloride in China?
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 3-Chloro-4-Fluorobenzenesulphonyl Chloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 3-chloro-4-fluorobenzenesulphonyl Chloride?
3-Chloro-4-fluorobenzenesulfonyl chloride has a wide range of uses. In the field of organic synthesis, it is often a key intermediate. In terms of drug synthesis, it can be used to introduce specific functional groups to construct compound structures with unique pharmacological activities. The preparation of many antibacterial and anti-inflammatory drugs often relies on this as the starting material, and through delicate chemical reactions, molecules with therapeutic effects are derived.
It also plays an important role in materials science. It can be used to prepare special polymer materials. By reacting with specific monomers, the materials are endowed with unique properties such as excellent chemical stability and thermal stability. For example, in the synthesis of some high-performance engineering plastics, the addition of this substance can significantly improve the chemical corrosion resistance and high temperature resistance of the material, broaden the application scenarios of the material, and make it suitable for harsh environments.
In addition, in the dye industry, 3-chloro-4-fluorobenzenesulfonyl chloride also has a place. It can be used as a precursor to synthesize new dyes, and its chemical properties can be used to design and synthesize dyes with unique colors and dyeing properties. It can meet the needs of high-quality and diverse dyes in textile, printing and dyeing industries, and add to the colorful fabric world. In short, due to its unique chemical structure and active reaction activity, it plays an indispensable role in many important industrial fields, promoting technological innovation and product upgrading in various industries.
It also plays an important role in materials science. It can be used to prepare special polymer materials. By reacting with specific monomers, the materials are endowed with unique properties such as excellent chemical stability and thermal stability. For example, in the synthesis of some high-performance engineering plastics, the addition of this substance can significantly improve the chemical corrosion resistance and high temperature resistance of the material, broaden the application scenarios of the material, and make it suitable for harsh environments.
In addition, in the dye industry, 3-chloro-4-fluorobenzenesulfonyl chloride also has a place. It can be used as a precursor to synthesize new dyes, and its chemical properties can be used to design and synthesize dyes with unique colors and dyeing properties. It can meet the needs of high-quality and diverse dyes in textile, printing and dyeing industries, and add to the colorful fabric world. In short, due to its unique chemical structure and active reaction activity, it plays an indispensable role in many important industrial fields, promoting technological innovation and product upgrading in various industries.
What are the physical properties of 3-chloro-4-fluorobenzenesulphonyl Chloride?
3-Chloro-4-fluorobenzenesulfonyl chloride is an important reagent in organic synthesis. Its physical properties are as follows:
Looking at its appearance, under room temperature and pressure, it usually appears as a colorless to light yellow liquid, which is easy to mix with other reactants in many reaction systems to facilitate the reaction.
Smell its smell, it has a strong pungent smell, which is significant and unique. Due to the presence of chlorine, fluorine and other halogen elements and sulfonyl chloride groups, this strong pungent smell needs special attention when using, because it may cause serious irritation to the human respiratory tract, eyes and other parts. The use environment must be well ventilated, and necessary protective measures must be taken.
Measure its boiling point. Due to the characteristics of intermolecular forces, its boiling point is in a specific range. Specifically, due to the interaction of various atoms in the molecule and the influence of functional groups, its boiling point is about a relatively high value. This boiling point characteristic is quite critical when separating and purifying the substance. It can be effectively separated from the mixture according to the difference in boiling point by distillation and other methods.
Measure its density. Compared with water, 3-chloro-4-fluorobenzenesulfonyl chloride has a higher density. This characteristic is of great significance in operations involving liquid-liquid separation. If it is mixed with liquids with lower density such as water, it will be stratified due to density differences, which is conducive to separation by means such as liquid separation.
In terms of its solubility, it exhibits good solubility in common organic solvents such as dichloromethane, chloroform, ether, etc. This property makes it uniformly dispersed in many organic reaction systems, providing a suitable reaction environment for various organic synthesis reactions; however, its solubility in water is poor, and it will chemically react with water. This point needs to be carefully considered in practical applications, such as the choice of reaction system and post-treatment steps.
In summary, the many physical properties of 3-chloro-4-fluorobenzenesulfonyl chloride have a very important impact on its application in the field of organic synthesis, the operation process and the setting of related reaction conditions, which requires users to understand and grasp in detail.
Looking at its appearance, under room temperature and pressure, it usually appears as a colorless to light yellow liquid, which is easy to mix with other reactants in many reaction systems to facilitate the reaction.
Smell its smell, it has a strong pungent smell, which is significant and unique. Due to the presence of chlorine, fluorine and other halogen elements and sulfonyl chloride groups, this strong pungent smell needs special attention when using, because it may cause serious irritation to the human respiratory tract, eyes and other parts. The use environment must be well ventilated, and necessary protective measures must be taken.
Measure its boiling point. Due to the characteristics of intermolecular forces, its boiling point is in a specific range. Specifically, due to the interaction of various atoms in the molecule and the influence of functional groups, its boiling point is about a relatively high value. This boiling point characteristic is quite critical when separating and purifying the substance. It can be effectively separated from the mixture according to the difference in boiling point by distillation and other methods.
Measure its density. Compared with water, 3-chloro-4-fluorobenzenesulfonyl chloride has a higher density. This characteristic is of great significance in operations involving liquid-liquid separation. If it is mixed with liquids with lower density such as water, it will be stratified due to density differences, which is conducive to separation by means such as liquid separation.
In terms of its solubility, it exhibits good solubility in common organic solvents such as dichloromethane, chloroform, ether, etc. This property makes it uniformly dispersed in many organic reaction systems, providing a suitable reaction environment for various organic synthesis reactions; however, its solubility in water is poor, and it will chemically react with water. This point needs to be carefully considered in practical applications, such as the choice of reaction system and post-treatment steps.
In summary, the many physical properties of 3-chloro-4-fluorobenzenesulfonyl chloride have a very important impact on its application in the field of organic synthesis, the operation process and the setting of related reaction conditions, which requires users to understand and grasp in detail.
What are the chemical properties of 3-chloro-4-fluorobenzenesulphonyl Chloride?
3-Chloro-4-fluorobenzenesulfonyl chloride is an important compound in organic chemistry. Its chemical properties are unique and have many remarkable characteristics.
First of all, the sulfonyl chloride group (-SO 2O Cl) is highly active. This group is very easy to participate in nucleophilic substitution reactions. When exposed to water, it is prone to hydrolysis. The chlorine atoms in the sulfonyl chloride group will be replaced by hydroxyl groups to form corresponding sulfonic acids, and hydrogen chloride gas will be released in the process. For example, under mild aqueous conditions, it will slowly hydrolyze, and this hydrolysis reaction is quite rapid and thorough.
Furthermore, although the chlorine atom and fluorine atom in this compound are located in a special benzene ring environment, they also have their own reactivity. The chlorine atom on the benzene ring can undergo nucleophilic substitution reaction under specific conditions, such as in the presence of strong bases and appropriate catalysts, and be replaced by other nucleophilic reagents. The fluorine atom, due to its extremely strong electronegativity, changes the electron cloud density distribution of the benzene ring, which affects the reactivity and selectivity of the whole molecule.
In the electrophilic substitution reaction, the electron cloud density of the benzene ring decreases due to the strong electron absorption of the sulfonyl chloride group, which makes it difficult for the electrophilic substitution reaction to occur, and the substitution positions are mostly in the interposition. For example, during the nitration reaction, the nitro group mainly enters the benzene ring and
In addition, 3-chloro-4-fluorobenzenesulfonyl chloride can also react with compounds containing active hydrogen, such as alcohols and amines. When reacted with alcohols, sulfonates can be formed; when reacted with amines, sulfonamides are formed. Such reactions are widely used in the field of organic synthesis and are often used to construct various organic compound structures and prepare organic molecules such as drugs and materials with specific functions.
First of all, the sulfonyl chloride group (-SO 2O Cl) is highly active. This group is very easy to participate in nucleophilic substitution reactions. When exposed to water, it is prone to hydrolysis. The chlorine atoms in the sulfonyl chloride group will be replaced by hydroxyl groups to form corresponding sulfonic acids, and hydrogen chloride gas will be released in the process. For example, under mild aqueous conditions, it will slowly hydrolyze, and this hydrolysis reaction is quite rapid and thorough.
Furthermore, although the chlorine atom and fluorine atom in this compound are located in a special benzene ring environment, they also have their own reactivity. The chlorine atom on the benzene ring can undergo nucleophilic substitution reaction under specific conditions, such as in the presence of strong bases and appropriate catalysts, and be replaced by other nucleophilic reagents. The fluorine atom, due to its extremely strong electronegativity, changes the electron cloud density distribution of the benzene ring, which affects the reactivity and selectivity of the whole molecule.
In the electrophilic substitution reaction, the electron cloud density of the benzene ring decreases due to the strong electron absorption of the sulfonyl chloride group, which makes it difficult for the electrophilic substitution reaction to occur, and the substitution positions are mostly in the interposition. For example, during the nitration reaction, the nitro group mainly enters the benzene ring and
In addition, 3-chloro-4-fluorobenzenesulfonyl chloride can also react with compounds containing active hydrogen, such as alcohols and amines. When reacted with alcohols, sulfonates can be formed; when reacted with amines, sulfonamides are formed. Such reactions are widely used in the field of organic synthesis and are often used to construct various organic compound structures and prepare organic molecules such as drugs and materials with specific functions.
What is the synthesis method of 3-chloro-4-fluorobenzenesulphonyl Chloride?
To prepare 3-chloro-4-fluorobenzenesulfonyl chloride, the method is as follows:
Take 3-chloro-4-fluorobenzene as the starting material first, which is the foundation of the reaction. In a suitable reactor, add an appropriate amount of chlorosulfonic acid. Chlorosulfonic acid is a sulfonating agent in this reaction, and the sulfonic acid group can be introduced into the molecular structure of 3-chloro-4-fluorobenzene. During the reaction, the temperature and reaction time need to be strictly controlled. If the temperature is too low, the reaction will be slow, and if it is too high, side reactions will easily occur. Generally speaking, the temperature is maintained in a specific range, such as 40-60 ° C, and the reaction takes several times, such as 3-5, to
During this reaction, a specific position on the benzene ring of 3-chloro-4-fluorobenzene is affected by chlorosulfonic acid to generate 3-chloro-4-fluorobenzenesulfonic acid.
Subsequently, to obtain 3-chloro-4-fluorobenzenesulfonic acid chloride, 3-chloro-4-fluorobenzenesulfonic acid needs to be further converted. Phosphorus pentachloride can be added. Phosphorus pentachloride is a good chlorination reagent and can convert the sulfonic acid group into sulfonyl chloride. This step also needs to pay attention to the conditions, the temperature may be maintained at 50-70 ° C, and the reaction number is about 2-4.
After the reaction is completed, the product may contain unreacted raw materials, by-products, etc. A series of separation and purification methods are required, such as vacuum distillation, which takes advantage of the difference in boiling points of each component to separate the target product 3-chloro-4-fluorobenzenesulfonyl chloride. Or the method of extraction can be used to select a suitable extractant, extract the product from the reaction mixture system, and then dry, distillate and other subsequent treatments to obtain pure 3-chloro-4-fluorobenzenesulfonyl chloride. In this way, according to the above steps and conditions, the required 3-chloro-4-fluorobenzenesulfonyl chloride can be obtained.
Take 3-chloro-4-fluorobenzene as the starting material first, which is the foundation of the reaction. In a suitable reactor, add an appropriate amount of chlorosulfonic acid. Chlorosulfonic acid is a sulfonating agent in this reaction, and the sulfonic acid group can be introduced into the molecular structure of 3-chloro-4-fluorobenzene. During the reaction, the temperature and reaction time need to be strictly controlled. If the temperature is too low, the reaction will be slow, and if it is too high, side reactions will easily occur. Generally speaking, the temperature is maintained in a specific range, such as 40-60 ° C, and the reaction takes several times, such as 3-5, to
During this reaction, a specific position on the benzene ring of 3-chloro-4-fluorobenzene is affected by chlorosulfonic acid to generate 3-chloro-4-fluorobenzenesulfonic acid.
Subsequently, to obtain 3-chloro-4-fluorobenzenesulfonic acid chloride, 3-chloro-4-fluorobenzenesulfonic acid needs to be further converted. Phosphorus pentachloride can be added. Phosphorus pentachloride is a good chlorination reagent and can convert the sulfonic acid group into sulfonyl chloride. This step also needs to pay attention to the conditions, the temperature may be maintained at 50-70 ° C, and the reaction number is about 2-4.
After the reaction is completed, the product may contain unreacted raw materials, by-products, etc. A series of separation and purification methods are required, such as vacuum distillation, which takes advantage of the difference in boiling points of each component to separate the target product 3-chloro-4-fluorobenzenesulfonyl chloride. Or the method of extraction can be used to select a suitable extractant, extract the product from the reaction mixture system, and then dry, distillate and other subsequent treatments to obtain pure 3-chloro-4-fluorobenzenesulfonyl chloride. In this way, according to the above steps and conditions, the required 3-chloro-4-fluorobenzenesulfonyl chloride can be obtained.
What are the precautions for 3-chloro-4-fluorobenzenesulphonyl Chloride during storage and transportation?
3-Chloro-4-fluorobenzenesulfonyl chloride, this is a chemical substance. During storage and transportation, many matters must not be ignored.
It is active and easy to react in contact with water. Therefore, the storage place must be very dry, away from water sources and moisture. And the humidity of the warehouse should be strictly controlled within an appropriate range to prevent it from deteriorating due to moisture and causing unexpected changes.
And because of its corrosive nature, it can cause serious harm to human skin, eyes, respiratory tract, etc. When storing, it must be far away from objects that are easily in contact with the human body, such as food, daily necessities, etc., and cannot be placed in the same room. When transporting, the operator should also be fully protected, wearing protective clothing, protective masks and gloves, etc., to prevent accidental contact and damage.
Furthermore, 3-chloro-4-fluorobenzenesulfonyl chloride is easily decomposed by heat, or harmful gases are generated. Therefore, the temperature of the storage place should be low and well ventilated. When transporting, it is also necessary to avoid sun exposure or high temperature environment. Vehicles must be well ventilated to prevent the accumulation of harmful gases and the occurrence of hazards.
In addition, this chemical is a dangerous product, and relevant regulations and standards must be followed for storage and transportation. The storage place should have obvious warning signs; the transportation vehicle should also have corresponding dangerous goods labels. All relevant personnel should be familiar with emergency response methods. If something happens, they can respond promptly to avoid major disasters.
It is active and easy to react in contact with water. Therefore, the storage place must be very dry, away from water sources and moisture. And the humidity of the warehouse should be strictly controlled within an appropriate range to prevent it from deteriorating due to moisture and causing unexpected changes.
And because of its corrosive nature, it can cause serious harm to human skin, eyes, respiratory tract, etc. When storing, it must be far away from objects that are easily in contact with the human body, such as food, daily necessities, etc., and cannot be placed in the same room. When transporting, the operator should also be fully protected, wearing protective clothing, protective masks and gloves, etc., to prevent accidental contact and damage.
Furthermore, 3-chloro-4-fluorobenzenesulfonyl chloride is easily decomposed by heat, or harmful gases are generated. Therefore, the temperature of the storage place should be low and well ventilated. When transporting, it is also necessary to avoid sun exposure or high temperature environment. Vehicles must be well ventilated to prevent the accumulation of harmful gases and the occurrence of hazards.
In addition, this chemical is a dangerous product, and relevant regulations and standards must be followed for storage and transportation. The storage place should have obvious warning signs; the transportation vehicle should also have corresponding dangerous goods labels. All relevant personnel should be familiar with emergency response methods. If something happens, they can respond promptly to avoid major disasters.
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