Linshang Chemical
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3-Chloro-4-Fluorobenzenethiol
Linshang Chemical
|
HS Code |
476022 |
| Chemical Formula | C6H4ClFS |
| Appearance | Typically a liquid with a characteristic odor (specific details may vary) |
| Solubility In Water | Expected to be low, as it is an organic sulfur - containing compound |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, acetone, etc. (qualitative estimate) |
As an accredited 3-Chloro-4-Fluorobenzenethiol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 - gram bottle of 3 - chloro - 4 - fluorobenzenethiol, tightly sealed for safety. |
| Storage | 3 - Chloro - 4 - fluorobenzenethiol should be stored in a cool, dry, well - ventilated area away from heat sources and ignition sources. Keep it in a tightly closed container to prevent evaporation and exposure to air. Store it separately from oxidizing agents, as it may react. Given its potential hazards, ensure proper labeling and secure storage to avoid accidental spills or misuse. |
| Shipping | 3 - Chloro - 4 - fluorobenzenethiol is shipped in specialized, tightly - sealed containers to prevent leakage. It follows strict hazardous chemical shipping regulations, ensuring safe transport to destination. |
Competitive 3-Chloro-4-Fluorobenzenethiol prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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What are the main uses of 3-chloro-4-fluorobenzenethiol?
3-Chloro-4-fluoro-thiophenol, this substance has a wide range of uses. In the field of organic synthesis, it is an extremely important intermediate.
The art of organic synthesis is often based on 3-chloro-4-fluoro-thiophenol to construct various complex and delicate organic compounds. Due to the characteristics of chlorine, fluorine and thiophenol groups in the molecule, it can initiate a variety of chemical reactions.
Such as nucleophilic substitution reactions, the sulfur atom of thiophenol groups is rich in electrons and has strong nucleophilic properties. It can interact with many halogenated hydrocarbons or other electrophilic reagents. In this process, thiophenyl groups replace halogen atoms of halogenated hydrocarbons to form novel sulfur-containing organic compounds. Such compounds may have unique biological activities in the field of medicinal chemistry, and can be used as lead compounds. After modification and optimization, they are expected to become good drugs for treating specific diseases.
In the field of materials science, 3-chloro-4-fluorophenylthiophenol also has extraordinary performance. The polymer materials involved in the synthesis may have specific physical and chemical properties due to the synergy effect of thiophenyl groups with chlorine and fluorine atoms. Such as enhancing the stability of materials, improving their electrical properties, or even endowing materials with unique optical properties.
In addition, in the field of pesticide chemistry, pesticides made from 3-chloro-4-fluorothiophenol may have the characteristics of high efficiency, low toxicity and environmental friendliness. Due to its special structure, it can precisely act on specific physiological targets of pests, effectively kill pests, and reduce the harm to the environment and non-target organisms.
In short, 3-chloro-4-fluorothiophenol, with its unique molecular structure, plays a key role in many fields such as organic synthesis, medicine, materials, and pesticides, promoting the progress and innovation of various technologies.
The art of organic synthesis is often based on 3-chloro-4-fluoro-thiophenol to construct various complex and delicate organic compounds. Due to the characteristics of chlorine, fluorine and thiophenol groups in the molecule, it can initiate a variety of chemical reactions.
Such as nucleophilic substitution reactions, the sulfur atom of thiophenol groups is rich in electrons and has strong nucleophilic properties. It can interact with many halogenated hydrocarbons or other electrophilic reagents. In this process, thiophenyl groups replace halogen atoms of halogenated hydrocarbons to form novel sulfur-containing organic compounds. Such compounds may have unique biological activities in the field of medicinal chemistry, and can be used as lead compounds. After modification and optimization, they are expected to become good drugs for treating specific diseases.
In the field of materials science, 3-chloro-4-fluorophenylthiophenol also has extraordinary performance. The polymer materials involved in the synthesis may have specific physical and chemical properties due to the synergy effect of thiophenyl groups with chlorine and fluorine atoms. Such as enhancing the stability of materials, improving their electrical properties, or even endowing materials with unique optical properties.
In addition, in the field of pesticide chemistry, pesticides made from 3-chloro-4-fluorothiophenol may have the characteristics of high efficiency, low toxicity and environmental friendliness. Due to its special structure, it can precisely act on specific physiological targets of pests, effectively kill pests, and reduce the harm to the environment and non-target organisms.
In short, 3-chloro-4-fluorothiophenol, with its unique molecular structure, plays a key role in many fields such as organic synthesis, medicine, materials, and pesticides, promoting the progress and innovation of various technologies.
What are the physical properties of 3-chloro-4-fluorobenzenethiol?
3-Chloro-4-fluorothiophenol, this is an organic compound. Its physical properties are particularly important and are of key significance in many chemical processes and industrial applications.
Looking at its properties, under room temperature and pressure, 3-chloro-4-fluorothiophenol is mostly colorless to pale yellow liquid. This color feature is easy to identify and make a preliminary judgment. The reason why it appears like this is caused by the arrangement of atoms in the molecular structure and the distribution of electron clouds.
Smell it, it has a special smell. The generation of this smell is derived from the characteristics of sulfur atoms. Sulfur-containing compounds often have a unique smell, and 3-chloro-4-fluorothiophenol is no exception. Although this smell is unique, in practical applications, it may need to be paid attention to because it may affect the environment and human sense of smell.
When it comes to melting point and boiling point, the melting point is about -20 ° C, and the boiling point is about 200-210 ° C. The low melting point indicates that it can be melted into a liquid state at relatively low temperatures; the high boiling point indicates that a higher temperature is required to convert it into a gaseous state. This melting boiling point characteristic is of great significance in the separation, purification and storage of substances.
Furthermore, its density is about 1.35-1.45 g/cm ³, which is heavier than water. The property of density, which depends on its position in the liquid mixture, provides a key basis for the design and implementation of related separation operations.
In terms of solubility, 3-chloro-4-fluorothiophenol is insoluble in water, but easily soluble in organic solvents such as ethanol, ether, and dichloromethane. This difference in solubility is based on the principle of "similarity and miscibility", and the characteristics of its molecular structure determine the interaction mode with different solvents.
In summary, the physical properties of 3-chloro-4-fluorothiophenol, such as color state, odor, melting boiling point, density and solubility, have laid an important foundation for its application in chemical, pharmaceutical and other fields, which will help relevant practitioners to use it rationally according to its characteristics and achieve the desired purpose.
Looking at its properties, under room temperature and pressure, 3-chloro-4-fluorothiophenol is mostly colorless to pale yellow liquid. This color feature is easy to identify and make a preliminary judgment. The reason why it appears like this is caused by the arrangement of atoms in the molecular structure and the distribution of electron clouds.
Smell it, it has a special smell. The generation of this smell is derived from the characteristics of sulfur atoms. Sulfur-containing compounds often have a unique smell, and 3-chloro-4-fluorothiophenol is no exception. Although this smell is unique, in practical applications, it may need to be paid attention to because it may affect the environment and human sense of smell.
When it comes to melting point and boiling point, the melting point is about -20 ° C, and the boiling point is about 200-210 ° C. The low melting point indicates that it can be melted into a liquid state at relatively low temperatures; the high boiling point indicates that a higher temperature is required to convert it into a gaseous state. This melting boiling point characteristic is of great significance in the separation, purification and storage of substances.
Furthermore, its density is about 1.35-1.45 g/cm ³, which is heavier than water. The property of density, which depends on its position in the liquid mixture, provides a key basis for the design and implementation of related separation operations.
In terms of solubility, 3-chloro-4-fluorothiophenol is insoluble in water, but easily soluble in organic solvents such as ethanol, ether, and dichloromethane. This difference in solubility is based on the principle of "similarity and miscibility", and the characteristics of its molecular structure determine the interaction mode with different solvents.
In summary, the physical properties of 3-chloro-4-fluorothiophenol, such as color state, odor, melting boiling point, density and solubility, have laid an important foundation for its application in chemical, pharmaceutical and other fields, which will help relevant practitioners to use it rationally according to its characteristics and achieve the desired purpose.
Is 3-chloro-4-fluorobenzenethiol chemically stable?
3-Chloro-4-fluoro-thiophenol, this physical property is not constant and varies depending on the conditions of the environment.
It is under normal temperature and pressure, or in a liquid state. However, if the temperature and pressure change, its physical state will also change. Looking at its chemical stability, the thiophenol group is active and easy to involve many chemical reactions. The sulfur-hydrogen bond of thiophenol is easier to break than the oxygen-hydrogen bond of phenol, so its acidity is slightly stronger than that of phenols. Because of the alkaline environment, it is easy to interact with alkalis and produce corresponding salts.
Because of its chlorine and fluorine dihalogen atoms, halogen atoms have electron-absorbing effects, resulting in a decrease in the electron cloud density of the benzene ring, which in turn affects the electrophilic substitution reaction activity on the benzene ring. Compared with benzene, the electrophilic substitution reaction is slightly more difficult to occur. However, under appropriate conditions, such as the presence of catalysts and suitable temperatures, halogen atoms can participate in substitution and other reactions, or be replaced by other groups.
And 3-chloro-4-fluorophenylthiophenol in air, or a gradual change in quality due to oxidation, thiophenol groups are easily oxidized to sulfur-containing compounds with disulfide bonds or even higher valence states. Factors such as light and humidity also affect its stability. Light may accelerate the process of some photochemical reactions, and humidity may involve hydrolysis and other reactions. Although hydrolysis of halogen atoms in its molecular structure is difficult, it may also occur under extreme or specific conditions.
In summary, the chemical properties of 3-chloro-4-fluorothiophenol are not absolutely stable, and it is affected by a variety of environmental and chemical factors. When storing and using, it is necessary to pay attention to the corresponding conditions to prevent its deterioration or unwanted reactions.
It is under normal temperature and pressure, or in a liquid state. However, if the temperature and pressure change, its physical state will also change. Looking at its chemical stability, the thiophenol group is active and easy to involve many chemical reactions. The sulfur-hydrogen bond of thiophenol is easier to break than the oxygen-hydrogen bond of phenol, so its acidity is slightly stronger than that of phenols. Because of the alkaline environment, it is easy to interact with alkalis and produce corresponding salts.
Because of its chlorine and fluorine dihalogen atoms, halogen atoms have electron-absorbing effects, resulting in a decrease in the electron cloud density of the benzene ring, which in turn affects the electrophilic substitution reaction activity on the benzene ring. Compared with benzene, the electrophilic substitution reaction is slightly more difficult to occur. However, under appropriate conditions, such as the presence of catalysts and suitable temperatures, halogen atoms can participate in substitution and other reactions, or be replaced by other groups.
And 3-chloro-4-fluorophenylthiophenol in air, or a gradual change in quality due to oxidation, thiophenol groups are easily oxidized to sulfur-containing compounds with disulfide bonds or even higher valence states. Factors such as light and humidity also affect its stability. Light may accelerate the process of some photochemical reactions, and humidity may involve hydrolysis and other reactions. Although hydrolysis of halogen atoms in its molecular structure is difficult, it may also occur under extreme or specific conditions.
In summary, the chemical properties of 3-chloro-4-fluorothiophenol are not absolutely stable, and it is affected by a variety of environmental and chemical factors. When storing and using, it is necessary to pay attention to the corresponding conditions to prevent its deterioration or unwanted reactions.
What are the preparation methods of 3-chloro-4-fluorobenzenethiol?
There are several ways to prepare 3-chloro-4-fluorobromothiophenol as follows.
First, 3-chloro-4-fluorobrobenzene can be used as the starting material. First, 3-chloro-4-fluorobrobenzene is reacted with metal magnesium to make Grignard's reagent. This reaction requires anhydrous ether or tetrahydrofuran as a solvent in an anhydrous and oxygen-free environment, slowly adding magnesium chips and stirring the reaction to obtain 3-chloro-4-fluorophenyl magnesium bromide. Then, the Grignard reagent is reacted with sulfur powder to generate 3-chloro-4-fluorobenzene mercaptan magnesium salt, and then hydrolyzed with dilute acid to obtain 3-chloro-4-fluorobenzene thiophenol. In this process, the preparation of Grignard reagent needs to be strictly anhydrous, because water will decompose Grignard reagent. The hydrolysis step also needs to control the concentration and dosage of acid to prevent the product from overreacting.
Second, use 3-chloro-4-fluoronitrobenzene as raw material. First reduce it to 3-chloro-4-fluoroaniline, and the commonly used reducing agents are iron and hydrochloric acid, tin and hydrochloric acid. Take iron and hydrochloric acid as an example, at an appropriate temperature, stir the reaction to convert the nitro group into an amino group. Next, 3-chloro-4-fluoroaniline is diazotized, reacted with sodium nitrite and hydrochloric acid at a low temperature (0-5 ° C) to form a diazonium salt. After that, the diazonium salt reacts with potassium thiocyanate to form 3-chloro-4-fluorobenzene thiocyanate, and finally hydrolyzes to obtain 3-chloro-4-fluorothiophenol. The diazotization reaction requires strict control of the temperature to prevent the decomposition of the diazonium salt. The hydrolysis step also requires attention to conditions to ensure the purity and yield of the product.
Third, it can also be started from 3-chloro-4-fluorophenol. First, 3-chloro-4-fluorophenol is converted into the corresponding halogenate, such as reacting with phosphorus tribromide or phosphorus trichloride, so that the hydroxyl group is replaced by a halogen atom to obtain 3-chloro-4-fluorohalobenzene. Subsequently, the halobenzene is reacted with sodium hydride in a suitable solvent, such as in a polar aprotic solvent such as dimethyl sulfoxide, and the reaction is heated, and the halogen atom is replaced by a mercapto group to obtain 3-chloro-4-fluorothiophenol. In this pathway, the halogenation reaction conditions need to be suitable to ensure complete substitution of hydroxyl groups with few side reactions. The reaction with sodium hydride, the choice of solvent and the control of reaction temperature are also crucial for product formation.
First, 3-chloro-4-fluorobrobenzene can be used as the starting material. First, 3-chloro-4-fluorobrobenzene is reacted with metal magnesium to make Grignard's reagent. This reaction requires anhydrous ether or tetrahydrofuran as a solvent in an anhydrous and oxygen-free environment, slowly adding magnesium chips and stirring the reaction to obtain 3-chloro-4-fluorophenyl magnesium bromide. Then, the Grignard reagent is reacted with sulfur powder to generate 3-chloro-4-fluorobenzene mercaptan magnesium salt, and then hydrolyzed with dilute acid to obtain 3-chloro-4-fluorobenzene thiophenol. In this process, the preparation of Grignard reagent needs to be strictly anhydrous, because water will decompose Grignard reagent. The hydrolysis step also needs to control the concentration and dosage of acid to prevent the product from overreacting.
Second, use 3-chloro-4-fluoronitrobenzene as raw material. First reduce it to 3-chloro-4-fluoroaniline, and the commonly used reducing agents are iron and hydrochloric acid, tin and hydrochloric acid. Take iron and hydrochloric acid as an example, at an appropriate temperature, stir the reaction to convert the nitro group into an amino group. Next, 3-chloro-4-fluoroaniline is diazotized, reacted with sodium nitrite and hydrochloric acid at a low temperature (0-5 ° C) to form a diazonium salt. After that, the diazonium salt reacts with potassium thiocyanate to form 3-chloro-4-fluorobenzene thiocyanate, and finally hydrolyzes to obtain 3-chloro-4-fluorothiophenol. The diazotization reaction requires strict control of the temperature to prevent the decomposition of the diazonium salt. The hydrolysis step also requires attention to conditions to ensure the purity and yield of the product.
Third, it can also be started from 3-chloro-4-fluorophenol. First, 3-chloro-4-fluorophenol is converted into the corresponding halogenate, such as reacting with phosphorus tribromide or phosphorus trichloride, so that the hydroxyl group is replaced by a halogen atom to obtain 3-chloro-4-fluorohalobenzene. Subsequently, the halobenzene is reacted with sodium hydride in a suitable solvent, such as in a polar aprotic solvent such as dimethyl sulfoxide, and the reaction is heated, and the halogen atom is replaced by a mercapto group to obtain 3-chloro-4-fluorothiophenol. In this pathway, the halogenation reaction conditions need to be suitable to ensure complete substitution of hydroxyl groups with few side reactions. The reaction with sodium hydride, the choice of solvent and the control of reaction temperature are also crucial for product formation.
3-chloro-4-fluorobenzenethiol What are the precautions during storage and transportation?
3-Chloro-4-fluorothiophenol is also an organic compound. During storage and transportation, many matters need careful attention.
First, storage, because it has a certain chemical activity, should find a cool, dry and well ventilated place to store. Avoid direct sunlight to prevent light from causing its decomposition or triggering other chemical reactions. Temperature should be constant, too high temperature or change the properties of this compound, resulting in damage to the quality. In addition, the storage place should be away from fire and heat sources. This substance may be flammable, and there is a risk of combustion or even explosion in case of open flames and hot topics. It also needs to be stored in isolation from oxidizing agents, acids, etc., because 3-chloro-4-fluorothiophenol and their substances are prone to chemical reactions, or dangerous products.
As for transportation, the packaging must be tight. Choose suitable packaging materials that can withstand certain external shocks and environmental changes to prevent leakage. During transportation, also ensure that the temperature and humidity are appropriate. And the transportation vehicle should be equipped with corresponding fire protection equipment and leakage emergency treatment equipment. If there is an accident such as leakage on the way, it can be dealt with in time. The escort personnel need to be professionally trained, familiar with the characteristics of this compound and emergency disposal methods, and operate cautiously throughout the transportation process to avoid severe vibration and impact and ensure stable transportation. Therefore, Fangbao 3-chloro-4-fluorothiophenol is safe during storage and transportation.
First, storage, because it has a certain chemical activity, should find a cool, dry and well ventilated place to store. Avoid direct sunlight to prevent light from causing its decomposition or triggering other chemical reactions. Temperature should be constant, too high temperature or change the properties of this compound, resulting in damage to the quality. In addition, the storage place should be away from fire and heat sources. This substance may be flammable, and there is a risk of combustion or even explosion in case of open flames and hot topics. It also needs to be stored in isolation from oxidizing agents, acids, etc., because 3-chloro-4-fluorothiophenol and their substances are prone to chemical reactions, or dangerous products.
As for transportation, the packaging must be tight. Choose suitable packaging materials that can withstand certain external shocks and environmental changes to prevent leakage. During transportation, also ensure that the temperature and humidity are appropriate. And the transportation vehicle should be equipped with corresponding fire protection equipment and leakage emergency treatment equipment. If there is an accident such as leakage on the way, it can be dealt with in time. The escort personnel need to be professionally trained, familiar with the characteristics of this compound and emergency disposal methods, and operate cautiously throughout the transportation process to avoid severe vibration and impact and ensure stable transportation. Therefore, Fangbao 3-chloro-4-fluorothiophenol is safe during storage and transportation.
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