Linshang Chemical
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3-Chloro-4-Fluorobromobenzene
Linshang Chemical
|
HS Code |
988974 |
| Chemical Formula | C6H3BrClF |
| Molecular Weight | 225.44 |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | Around 200 - 205 °C |
| Density | Approx. 1.8 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Flash Point | Caution: Flammable, flash point relevant for handling |
| Vapor Pressure | Low vapor pressure at room temperature |
| Odor | Typical aromatic halogenated compound odor |
As an accredited 3-Chloro-4-Fluorobromobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 3 - chloro - 4 - fluorobromobenzene packaged in a sealed glass bottle. |
| Storage | Store 3 - chloro - 4 - fluorobromobenzene in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. It should be stored in a tightly sealed container, preferably made of corrosion - resistant materials like stainless steel or certain plastics, to prevent leakage and contact with air or moisture that could cause degradation or reaction. |
| Shipping | 3 - Chloro - 4 - fluorobromobenzene is a chemical. Ship it in tightly sealed, appropriate containers. Follow hazardous material shipping regulations, ensuring proper labeling and handling to prevent spills and ensure safe transport. |
Competitive 3-Chloro-4-Fluorobromobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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What is the chemical structure of 3-chloro-4-fluorobromobenzene?
3-Chloro-4-fluorobromobenzene is also an organic compound. Among its molecular structures, the benzene ring is the base, which is the core structure of aromatic hydrocarbons and has unique stability and chemical activity. On the benzene ring, there are three substituents according to their positions.
One is a bromine atom (-Br). The bromine element is connected to the benzene ring in an atomic state. The bromine atom has a certain electronegativity, which affects the electron cloud distribution of the benzene ring, causing the relative change of the electron cloud density of the adjacent and para-sites. In chemical reactions, it can affect the activity and check point of reactions such as electrophilic substitution.
The second is a chlorine atom (-Cl), which is also electronegative and connected to the benzene ring. Although both chlorine atoms and bromine atoms are halogen atoms, their electronegativity and other properties are slightly different. The two interact to change the electron cloud state of the benzene ring. According to the naming rules, it is at position 3.
The third is fluorine atom (-F), which is an element with strong electronegativity and is connected to position 4 of the benzene ring. The existence of fluorine atoms further adjusts the electron cloud of the benzene ring. Because of its high electronegativity and strong ability to attract electrons, the electron cloud of the benzene ring is more inclined to the direction of the fluorine atom, which has a great impact on the physical and chemical properties of the compound.
These three substitutions are based on the specific location distribution of the benzene ring, which together constitute the unique chemical structure of 3-chloro-4-fluorobromobenzene, and also determine its unique physical and chemical properties. They have shown unique application value in many fields such as organic synthesis and medicinal chemistry.
One is a bromine atom (-Br). The bromine element is connected to the benzene ring in an atomic state. The bromine atom has a certain electronegativity, which affects the electron cloud distribution of the benzene ring, causing the relative change of the electron cloud density of the adjacent and para-sites. In chemical reactions, it can affect the activity and check point of reactions such as electrophilic substitution.
The second is a chlorine atom (-Cl), which is also electronegative and connected to the benzene ring. Although both chlorine atoms and bromine atoms are halogen atoms, their electronegativity and other properties are slightly different. The two interact to change the electron cloud state of the benzene ring. According to the naming rules, it is at position 3.
The third is fluorine atom (-F), which is an element with strong electronegativity and is connected to position 4 of the benzene ring. The existence of fluorine atoms further adjusts the electron cloud of the benzene ring. Because of its high electronegativity and strong ability to attract electrons, the electron cloud of the benzene ring is more inclined to the direction of the fluorine atom, which has a great impact on the physical and chemical properties of the compound.
These three substitutions are based on the specific location distribution of the benzene ring, which together constitute the unique chemical structure of 3-chloro-4-fluorobromobenzene, and also determine its unique physical and chemical properties. They have shown unique application value in many fields such as organic synthesis and medicinal chemistry.
What are the physical properties of 3-chloro-4-fluorobromobenzene?
3-Chloro-4-fluorobromobenzene is one of the organic compounds. Its physical properties are quite important and are related to many practical applications.
First of all, under normal temperature and pressure, 3-chloro-4-fluorobrobenzene is often colorless to light yellow liquid, clear and with a specific luster, which can help to identify it initially.
The boiling point is about a certain temperature range, and this value is of great significance for its distillation, separation and other operations. After many experiments, its boiling point is roughly in a certain range. At this temperature, the substance changes from liquid to gas state, which is the key parameter for separating and purifying the substance.
Melting point is also an important property. Its melting point is at a certain temperature. This temperature determines the conditions under which the substance changes from solid to liquid, and is crucial to the definition of its storage and use conditions.
In terms of density, 3-chloro-4-fluorobromobenzene has a specific density value, which is heavier or lighter than water. This property is indispensable in processes such as liquid-liquid separation and can provide an important basis for practical operation.
In terms of solubility, it has a certain solubility in organic solvents such as ethanol and ether, but it has little solubility in water. This property determines its behavior in different solvent systems. In organic synthesis reactions, suitable solvents can be selected accordingly to promote the reaction.
Volatility, although not highly volatile substances, they will also evaporate to a certain extent under specific temperatures and environments. This property needs to be considered during storage. A well-sealed container should be selected to prevent its volatilization loss and avoid impact on the environment.
Odor has a certain special smell. Although it is not strong and pungent, it is also different from common odorless substances. This odor characteristic can be used as a preliminary judgment material during actual contact and operation.
In summary, the physical properties of 3-chloro-4-fluorobromobenzene, from appearance, melting point, density, solubility, and volatility to odor, all play an important guiding role in its application in chemical engineering, scientific research, and other fields. When operating and using, it is necessary to understand these properties in detail and deal with them properly.
First of all, under normal temperature and pressure, 3-chloro-4-fluorobrobenzene is often colorless to light yellow liquid, clear and with a specific luster, which can help to identify it initially.
The boiling point is about a certain temperature range, and this value is of great significance for its distillation, separation and other operations. After many experiments, its boiling point is roughly in a certain range. At this temperature, the substance changes from liquid to gas state, which is the key parameter for separating and purifying the substance.
Melting point is also an important property. Its melting point is at a certain temperature. This temperature determines the conditions under which the substance changes from solid to liquid, and is crucial to the definition of its storage and use conditions.
In terms of density, 3-chloro-4-fluorobromobenzene has a specific density value, which is heavier or lighter than water. This property is indispensable in processes such as liquid-liquid separation and can provide an important basis for practical operation.
In terms of solubility, it has a certain solubility in organic solvents such as ethanol and ether, but it has little solubility in water. This property determines its behavior in different solvent systems. In organic synthesis reactions, suitable solvents can be selected accordingly to promote the reaction.
Volatility, although not highly volatile substances, they will also evaporate to a certain extent under specific temperatures and environments. This property needs to be considered during storage. A well-sealed container should be selected to prevent its volatilization loss and avoid impact on the environment.
Odor has a certain special smell. Although it is not strong and pungent, it is also different from common odorless substances. This odor characteristic can be used as a preliminary judgment material during actual contact and operation.
In summary, the physical properties of 3-chloro-4-fluorobromobenzene, from appearance, melting point, density, solubility, and volatility to odor, all play an important guiding role in its application in chemical engineering, scientific research, and other fields. When operating and using, it is necessary to understand these properties in detail and deal with them properly.
What are 3-chloro-4-fluorobromobenzene synthesis methods?
There are several ways to prepare 3-chloro-4-fluorobromobenzene.
First, aromatic derivatives can be started. First, take a suitable benzene derivative, and introduce chlorine atoms and fluorine atoms through a halogenation reaction. This halogenation reaction can select suitable halogenation reagents and reaction conditions. If benzene is used as a raw material, through a specific halogenation process, chlorine atoms and fluorine atoms are introduced at specific positions in the benzene ring to obtain chlorine-containing and fluorine-containing benzene derivatives. Subsequently, through a bromination reaction, bromine atoms are introduced at suitable positions. This bromination step requires the selection of appropriate brominating reagents, such as bromine, and the control of reaction conditions, such as temperature, catalyst, etc., to promote the precise substitution of bromine atoms in the desired position, so as to obtain 3-chloro-4-fluorobromobenzene.
Second, the strategy of gradually constructing the benzene ring can be adopted. First, small molecule compounds are used as raw materials, and the benzene ring structure containing chlorine, fluorine and bromine atoms is gradually constructed through organic synthesis reactions. For example, select suitable organic small molecules containing chlorine and fluorine, and through a series of condensation, cyclization and other reactions, construct a benzene ring, and accurately locate the substitution check point of bromine atoms. This method requires precise control of the mechanism and conditions of various organic reactions in order to achieve the synthesis of the target product.
Or, it can start from the existing compounds containing chlorine, fluorine and bromine and undergo a functional group conversion reaction. If there is a compound whose structure is similar to 3-chloro-4-fluorobromobenzene, only a functional group needs to be converted. Through a suitable reaction, the functional group is converted into the desired bromine atom, or the structure around the chlorine and fluorine atoms is fine-tuned to achieve the preparation of 3-chloro-4-fluorobromobenzene. The key to this approach is to find a suitable starting material and a precise conversion reaction.
All these methods require detailed investigation of reaction conditions, raw material selection, side reaction control and other factors in order to efficiently and accurately prepare 3-chloro-4-fluorobromobenzene.
First, aromatic derivatives can be started. First, take a suitable benzene derivative, and introduce chlorine atoms and fluorine atoms through a halogenation reaction. This halogenation reaction can select suitable halogenation reagents and reaction conditions. If benzene is used as a raw material, through a specific halogenation process, chlorine atoms and fluorine atoms are introduced at specific positions in the benzene ring to obtain chlorine-containing and fluorine-containing benzene derivatives. Subsequently, through a bromination reaction, bromine atoms are introduced at suitable positions. This bromination step requires the selection of appropriate brominating reagents, such as bromine, and the control of reaction conditions, such as temperature, catalyst, etc., to promote the precise substitution of bromine atoms in the desired position, so as to obtain 3-chloro-4-fluorobromobenzene.
Second, the strategy of gradually constructing the benzene ring can be adopted. First, small molecule compounds are used as raw materials, and the benzene ring structure containing chlorine, fluorine and bromine atoms is gradually constructed through organic synthesis reactions. For example, select suitable organic small molecules containing chlorine and fluorine, and through a series of condensation, cyclization and other reactions, construct a benzene ring, and accurately locate the substitution check point of bromine atoms. This method requires precise control of the mechanism and conditions of various organic reactions in order to achieve the synthesis of the target product.
Or, it can start from the existing compounds containing chlorine, fluorine and bromine and undergo a functional group conversion reaction. If there is a compound whose structure is similar to 3-chloro-4-fluorobromobenzene, only a functional group needs to be converted. Through a suitable reaction, the functional group is converted into the desired bromine atom, or the structure around the chlorine and fluorine atoms is fine-tuned to achieve the preparation of 3-chloro-4-fluorobromobenzene. The key to this approach is to find a suitable starting material and a precise conversion reaction.
All these methods require detailed investigation of reaction conditions, raw material selection, side reaction control and other factors in order to efficiently and accurately prepare 3-chloro-4-fluorobromobenzene.
What are the main uses of 3-chloro-4-fluorobromobenzene?
3-Chloro-4-fluorobromobenzene, an organic compound, is widely used in chemical and scientific research fields.
First, it is often a key intermediate in the process of drug synthesis. Due to the activity of halogen atoms, various functional groups can be introduced through many chemical reactions, such as nucleophilic substitution reactions, to construct the specific structure of drug molecules. For example, in the synthesis of some antibacterial drugs, 3-chloro-4-fluorobromobenzene can react with nucleophilic reagents such as nitrogen and oxygen through specific steps to build a molecular skeleton with antibacterial activity, which is of great significance for the development of new antibacterial drugs.
Second, in the field of materials science, it also has outstanding performance. It can be used as a monomer to participate in the polymerization reaction to prepare polymer materials with special properties. Because it contains halogen atoms, it can endow materials with properties such as flame retardancy. For example, polymer materials made by polymerization can be used in the shell of electronic and electrical products to enhance their fire resistance and improve product safety.
Third, in the study of organic synthetic chemistry, 3-chloro-4-fluorobromobenzene is used as a model compound to help scientists explore the reaction mechanism in depth. Due to the existence of different halogen atoms in the molecule and the difference in reactivity, scientists can use this to study the selectivity and reaction conditions of nucleophilic substitution, metal catalytic coupling and other reactions, providing theoretical basis and practical experience for the development of organic synthesis methodologies.
Fourth, it also plays an important role in the field of pesticide synthesis. It can be converted into pesticide ingredients with insecticidal, bactericidal or herbicidal activities through chemical modification. For example, by connecting phosphorus and sulfur-containing functional groups through specific reactions, new pesticides can be made, providing effective means for agricultural pest control.
First, it is often a key intermediate in the process of drug synthesis. Due to the activity of halogen atoms, various functional groups can be introduced through many chemical reactions, such as nucleophilic substitution reactions, to construct the specific structure of drug molecules. For example, in the synthesis of some antibacterial drugs, 3-chloro-4-fluorobromobenzene can react with nucleophilic reagents such as nitrogen and oxygen through specific steps to build a molecular skeleton with antibacterial activity, which is of great significance for the development of new antibacterial drugs.
Second, in the field of materials science, it also has outstanding performance. It can be used as a monomer to participate in the polymerization reaction to prepare polymer materials with special properties. Because it contains halogen atoms, it can endow materials with properties such as flame retardancy. For example, polymer materials made by polymerization can be used in the shell of electronic and electrical products to enhance their fire resistance and improve product safety.
Third, in the study of organic synthetic chemistry, 3-chloro-4-fluorobromobenzene is used as a model compound to help scientists explore the reaction mechanism in depth. Due to the existence of different halogen atoms in the molecule and the difference in reactivity, scientists can use this to study the selectivity and reaction conditions of nucleophilic substitution, metal catalytic coupling and other reactions, providing theoretical basis and practical experience for the development of organic synthesis methodologies.
Fourth, it also plays an important role in the field of pesticide synthesis. It can be converted into pesticide ingredients with insecticidal, bactericidal or herbicidal activities through chemical modification. For example, by connecting phosphorus and sulfur-containing functional groups through specific reactions, new pesticides can be made, providing effective means for agricultural pest control.
What do 3-chloro-4-fluorobromobenzene need to pay attention to when storing and transporting?
3-Chloro-4-fluorobromobenzene is an organic compound. When storing and transporting it, many key matters need to be paid attention to, so that the security is safe and the quality is not damaged.
The choice of the first storage environment. This compound should be placed in a cool, dry and well-ventilated place. Cool can prevent high temperature from causing it to evaporate faster, and even cause dangerous reactions; drying can prevent it from coming into contact with water, because many organic compounds are prone to hydrolysis and deterioration in contact with water; good ventilation can disperse harmful gases that may evaporate in time, reducing safety hazards.
Selection of times and packaging materials. A packaging container with good sealing performance must be used to prevent leakage. Due to its chemical properties, the packaging material should be chemically stable and not react with 3-chloro-4-fluorobromobenzene. If using glass bottles, make sure that the stopper is tightly sealed; if using metal containers, consider whether the metal will chemically react with the compound.
When transporting, there are also many points. Be sure to follow relevant regulations and standards and equip with necessary protective measures. Transport vehicles should run smoothly to avoid violent vibrations and collisions, otherwise the package may be damaged and cause leakage. At the same time, transport personnel need to be professionally trained and familiar with the characteristics of the compound and emergency treatment methods. In the event of leakage and other conditions, they can be disposed of quickly and properly to reduce hazards.
In addition, whether it is storage or transportation, it must be strictly separated from oxidants, acids, alkalis and other substances. Due to its active chemical properties, contact with these substances is likely to cause violent chemical reactions, resulting in serious consequences such as fire and explosion.
In short, the storage and transportation of 3-chloro-4-fluorobromobenzene needs to be carefully controlled from various aspects such as the environment, packaging, transportation operation and isolation. Any negligence in any link may lead to disaster, endangering personnel safety and the environment.
The choice of the first storage environment. This compound should be placed in a cool, dry and well-ventilated place. Cool can prevent high temperature from causing it to evaporate faster, and even cause dangerous reactions; drying can prevent it from coming into contact with water, because many organic compounds are prone to hydrolysis and deterioration in contact with water; good ventilation can disperse harmful gases that may evaporate in time, reducing safety hazards.
Selection of times and packaging materials. A packaging container with good sealing performance must be used to prevent leakage. Due to its chemical properties, the packaging material should be chemically stable and not react with 3-chloro-4-fluorobromobenzene. If using glass bottles, make sure that the stopper is tightly sealed; if using metal containers, consider whether the metal will chemically react with the compound.
When transporting, there are also many points. Be sure to follow relevant regulations and standards and equip with necessary protective measures. Transport vehicles should run smoothly to avoid violent vibrations and collisions, otherwise the package may be damaged and cause leakage. At the same time, transport personnel need to be professionally trained and familiar with the characteristics of the compound and emergency treatment methods. In the event of leakage and other conditions, they can be disposed of quickly and properly to reduce hazards.
In addition, whether it is storage or transportation, it must be strictly separated from oxidants, acids, alkalis and other substances. Due to its active chemical properties, contact with these substances is likely to cause violent chemical reactions, resulting in serious consequences such as fire and explosion.
In short, the storage and transportation of 3-chloro-4-fluorobromobenzene needs to be carefully controlled from various aspects such as the environment, packaging, transportation operation and isolation. Any negligence in any link may lead to disaster, endangering personnel safety and the environment.
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