Linshang Chemical
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3-Chloro-4-Fluoroiodobenzene
Linshang Chemical
|
HS Code |
819753 |
| Chemical Formula | C6H3ClFI |
| Appearance | A colorless to light yellow liquid (usually) |
| Boiling Point | Around 220 - 230 °C (approximate, may vary with conditions) |
| Density | Approximately 2.0 - 2.2 g/cm³ (approximate) |
| Solubility | Slightly soluble in water, soluble in common organic solvents like ethanol, ether, and dichloromethane |
| Flash Point | Relatively high, around 90 - 100 °C (approximate) |
| Odor | May have a characteristic, pungent aromatic odor |
| Stability | Stable under normal conditions, but may react with strong oxidizing agents |
As an accredited 3-Chloro-4-Fluoroiodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 3 - chloro - 4 - fluoroiodobenzene packaged in a sealed glass bottle. |
| Storage | 3 - Chloro - 4 - fluoroiodobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly sealed container to prevent vapor leakage. Due to its potential reactivity and toxicity, ensure storage is in a dedicated chemical storage facility, away from incompatible substances and accessible only to trained personnel. |
| Shipping | 3 - Chloro - 4 - fluoroiodobenzene is shipped in well - sealed, corrosion - resistant containers. It's transported under strict regulations due to its chemical nature, ensuring safe handling during transit to prevent spills and environmental risks. |
Competitive 3-Chloro-4-Fluoroiodobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 3-Chloro-4-Fluoroiodobenzene in China?
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 3-Chloro-4-Fluoroiodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 3-chloro-4-fluoroiodobenzene?
3-Chloro-4-fluoroiodobenzene is one of the organohalogenated aromatic hydrocarbons. Its chemical properties are specific and can be explored.
The first is the properties of its halogen atoms. The trihalogen atoms of chlorine, fluorine and iodine are above the benzene ring and have their own characteristics. The fluorine atom has extremely high electronegativity, which can reduce the electron cloud density of the benzene ring and reduce the activity of the electrophilic substitution reaction of the benzene ring. Because of its significant electron-sucking induction effect, the electron cloud density of the ortho-para-site decreases even more, so the electrophilic reagents mostly attack the intermediate site. However, under certain reaction conditions, there may also be ortho-para-site substitution products.
Chlorine atoms also have electron-sucking induction effects. Although Chlorine atoms can participate in nucleophilic substitution reactions. Under appropriate nucleophilic reagents and reaction conditions, chlorine atoms can be replaced. This reaction depends on factors such as the activity of nucleophilic reagents, the properties of solvents, and reaction temperatures.
As for iodine atoms, although their electronegativity is lower than that of fluorine and chlorine, their atomic radius is large, and the C-I bond energy is relatively small and easy to break. Therefore, iodine atoms in 3-chloro-4-fluoroiodobenzene participate first in some reactions, such as coupling reactions. In a metal-catalyzed coupling reaction, iodine atoms can interact with metal reagents to form active intermediates, and then couple with other organic reagents to form carbon-carbon bonds or carbon-heterobonds.
Furthermore, the conjugation system of benzene ring also has an important impact on its properties. The conjugation system imparts certain stability to the molecule, but also makes the electronic interaction between halogen atoms and benzene ring more complicated. This conjugation effect may affect the difficulty of halogen atoms leaving, or affect the distribution of electron clouds on the benzene ring, thereby affecting the regioselectivity of the reaction.
Because there are many halogen atoms in the molecule, different halogen atoms have different activities, which provides an opportunity for selective chemical transformation. Chemists can achieve selective reactions of specific halogen atoms according to the regulation of reaction conditions, and prepare organic compounds with diverse structures, which is of great value in the field of organic synthesis.
The first is the properties of its halogen atoms. The trihalogen atoms of chlorine, fluorine and iodine are above the benzene ring and have their own characteristics. The fluorine atom has extremely high electronegativity, which can reduce the electron cloud density of the benzene ring and reduce the activity of the electrophilic substitution reaction of the benzene ring. Because of its significant electron-sucking induction effect, the electron cloud density of the ortho-para-site decreases even more, so the electrophilic reagents mostly attack the intermediate site. However, under certain reaction conditions, there may also be ortho-para-site substitution products.
Chlorine atoms also have electron-sucking induction effects. Although Chlorine atoms can participate in nucleophilic substitution reactions. Under appropriate nucleophilic reagents and reaction conditions, chlorine atoms can be replaced. This reaction depends on factors such as the activity of nucleophilic reagents, the properties of solvents, and reaction temperatures.
As for iodine atoms, although their electronegativity is lower than that of fluorine and chlorine, their atomic radius is large, and the C-I bond energy is relatively small and easy to break. Therefore, iodine atoms in 3-chloro-4-fluoroiodobenzene participate first in some reactions, such as coupling reactions. In a metal-catalyzed coupling reaction, iodine atoms can interact with metal reagents to form active intermediates, and then couple with other organic reagents to form carbon-carbon bonds or carbon-heterobonds.
Furthermore, the conjugation system of benzene ring also has an important impact on its properties. The conjugation system imparts certain stability to the molecule, but also makes the electronic interaction between halogen atoms and benzene ring more complicated. This conjugation effect may affect the difficulty of halogen atoms leaving, or affect the distribution of electron clouds on the benzene ring, thereby affecting the regioselectivity of the reaction.
Because there are many halogen atoms in the molecule, different halogen atoms have different activities, which provides an opportunity for selective chemical transformation. Chemists can achieve selective reactions of specific halogen atoms according to the regulation of reaction conditions, and prepare organic compounds with diverse structures, which is of great value in the field of organic synthesis.
What are the main uses of 3-chloro-4-fluoroiodobenzene?
3-Chloro-4-fluoroiodobenzene is also an organic compound. It has a wide range of uses and has important applications in many fields such as medicine, pesticides, and materials.
In the field of medicine, this compound is often used as a key intermediate. Taking the synthesis of new antibacterial drugs as an example, its unique molecular structure can make it easier for the drug to penetrate the bacterial cell wall and enhance antibacterial activity. Pharmaceutical chemists can precisely regulate the interaction between the drug and the target by modifying its structure and introducing specific functional groups, improving the efficacy of the drug and reducing side effects.
In terms of pesticides, 3-chloro-4-fluoroiodobenzene is also an important raw material. After chemical conversion, high-efficiency insecticides can be prepared. Such insecticides can specifically act on the nervous system of pests, interfering with their normal physiological functions, and achieving the purpose of efficient pest control. And because of its special structure, compared with traditional pesticides, it has a smaller impact on the environment and a shorter residual period, which is more suitable for the current needs of green agriculture development.
In the field of materials science, its use should not be underestimated. In the synthesis of organic optoelectronic materials, it can be used as a building unit. Because it contains halogen atoms, it can adjust the electron cloud density and molecular interactions of the material, thereby optimizing the photoelectric properties of the material. The organic Light Emitting Diode (OLED) material prepared based on this compound has high luminous efficiency and good color purity, and has great application potential in the field of display technology. In conclusion, although 3-chloro-4-fluoroiodobenzene is an organic compound, it plays an important role in many fields due to its unique structure, providing assistance for the development of various industries.
In the field of medicine, this compound is often used as a key intermediate. Taking the synthesis of new antibacterial drugs as an example, its unique molecular structure can make it easier for the drug to penetrate the bacterial cell wall and enhance antibacterial activity. Pharmaceutical chemists can precisely regulate the interaction between the drug and the target by modifying its structure and introducing specific functional groups, improving the efficacy of the drug and reducing side effects.
In terms of pesticides, 3-chloro-4-fluoroiodobenzene is also an important raw material. After chemical conversion, high-efficiency insecticides can be prepared. Such insecticides can specifically act on the nervous system of pests, interfering with their normal physiological functions, and achieving the purpose of efficient pest control. And because of its special structure, compared with traditional pesticides, it has a smaller impact on the environment and a shorter residual period, which is more suitable for the current needs of green agriculture development.
In the field of materials science, its use should not be underestimated. In the synthesis of organic optoelectronic materials, it can be used as a building unit. Because it contains halogen atoms, it can adjust the electron cloud density and molecular interactions of the material, thereby optimizing the photoelectric properties of the material. The organic Light Emitting Diode (OLED) material prepared based on this compound has high luminous efficiency and good color purity, and has great application potential in the field of display technology. In conclusion, although 3-chloro-4-fluoroiodobenzene is an organic compound, it plays an important role in many fields due to its unique structure, providing assistance for the development of various industries.
What are 3-chloro-4-fluoroiodobenzene synthesis methods?
The synthesis method of 3-chloro-4-fluoroiodobenzene has been explored by many scholars in the past, and now the main one is selected.
First, halogenated aromatics are used as the starting material, and after metallization, lithium reagents or magnesium reagents are often used. For example, suitable halogenated benzene derivatives, under the protection of low temperature and inert gas, react with lithium reagents such as butyl lithium to form aryl metal intermediates. This intermediate is very active, and then reacts with iodine sources, such as iodine elemental substances, to introduce iodine atoms; and then through a specific halogen exchange reaction, chlorine and fluorine atoms are introduced. After careful regulation of reaction conditions, such as temperature, solvent, reactant ratio, etc., the target product 3-chloro-4-fluoroiodobenzene can be obtained.
Second, based on the benzene ring, the electrophilic substitution reaction can be carried out first. By selecting suitable halogenation reagents, such as reagents containing chlorine and fluorine, in the presence of a catalyst, the benzene ring can undergo an electrophilic halogenation reaction, and chlorine and fluorine atoms are gradually introduced to form the corresponding halogenated benzene Subsequently, through the coupling reaction of halogenated aromatics and iodine sources catalyzed by palladium, such as the use of palladium catalysts, ligands and bases, the cross-coupling of halogenated benzene and iodine reagents occurs to construct the structure of 3-chloro-4-fluoroiodobenzene. During the reaction, the type of palladium catalyst, the characteristics of ligands, and the strength and dosage of bases all have a great impact on the efficiency and selectivity of the reaction, which needs to be carefully optimized.
Third, the diazonium salt reaction is taken as the path. First, the corresponding aniline derivatives are converted into diazonium salts through diazotization. Diazonium salts are active and can react with reagents such as cuprous halides to undergo Sandmeier reactions. By cleverly selecting the types of cuprous halides, such as cuprous chloride and cuprous fluoride, chlorine atoms and fluorine atoms can be introduced. After that, 3-chloro-4-fluoroiodobenzene can be successfully prepared by suitable iodine substitution reactions, such as reaction with potassium iodide and other reagents. In this process, the control of the conditions of the diazotization reaction, such as reaction temperature, acid concentration, etc., as well as the time and conditions of the subsequent halogenation reaction, are the keys to the success or failure of the synthesis.
First, halogenated aromatics are used as the starting material, and after metallization, lithium reagents or magnesium reagents are often used. For example, suitable halogenated benzene derivatives, under the protection of low temperature and inert gas, react with lithium reagents such as butyl lithium to form aryl metal intermediates. This intermediate is very active, and then reacts with iodine sources, such as iodine elemental substances, to introduce iodine atoms; and then through a specific halogen exchange reaction, chlorine and fluorine atoms are introduced. After careful regulation of reaction conditions, such as temperature, solvent, reactant ratio, etc., the target product 3-chloro-4-fluoroiodobenzene can be obtained.
Second, based on the benzene ring, the electrophilic substitution reaction can be carried out first. By selecting suitable halogenation reagents, such as reagents containing chlorine and fluorine, in the presence of a catalyst, the benzene ring can undergo an electrophilic halogenation reaction, and chlorine and fluorine atoms are gradually introduced to form the corresponding halogenated benzene Subsequently, through the coupling reaction of halogenated aromatics and iodine sources catalyzed by palladium, such as the use of palladium catalysts, ligands and bases, the cross-coupling of halogenated benzene and iodine reagents occurs to construct the structure of 3-chloro-4-fluoroiodobenzene. During the reaction, the type of palladium catalyst, the characteristics of ligands, and the strength and dosage of bases all have a great impact on the efficiency and selectivity of the reaction, which needs to be carefully optimized.
Third, the diazonium salt reaction is taken as the path. First, the corresponding aniline derivatives are converted into diazonium salts through diazotization. Diazonium salts are active and can react with reagents such as cuprous halides to undergo Sandmeier reactions. By cleverly selecting the types of cuprous halides, such as cuprous chloride and cuprous fluoride, chlorine atoms and fluorine atoms can be introduced. After that, 3-chloro-4-fluoroiodobenzene can be successfully prepared by suitable iodine substitution reactions, such as reaction with potassium iodide and other reagents. In this process, the control of the conditions of the diazotization reaction, such as reaction temperature, acid concentration, etc., as well as the time and conditions of the subsequent halogenation reaction, are the keys to the success or failure of the synthesis.
3-chloro-4-fluoroiodobenzene What are the precautions during storage and transportation?
3-Chloro-4-fluoroiodobenzene is also an organic compound. When storing and transporting, many things need to be paid attention to.
First of all, the nature of this compound may be more active, and it should be placed in a cool and dry place. Cover the humid environment, or cause its hydrolysis and other reactions to cause deterioration. It also needs to be protected from heat. Under high temperature, its chemical stability is easy to lose, and it is afraid of decomposition or other adverse reactions. Where it is stored, air circulation should also be good to avoid the accumulation of harmful gases. And it should be kept away from fire sources and oxidants. If it is flammable, it is easy to react violently and cause danger.
As for transportation, the first heavy packaging is sturdy. When packing with suitable materials to prevent its leakage. The packaging material must be able to withstand the corrosion of this compound and not react with it. During transportation, temperature and humidity control are also critical. It is advisable to maintain stable temperature and humidity conditions to avoid damage due to sudden changes in the environment. At the same time, the transportation vehicle or container should be clean and free of impurities to avoid contamination of this compound. The escort must also be familiar with its characteristics and emergency methods. In case of leakage, etc., it can be disposed of quickly to avoid major disasters. In this way, when storing and transporting 3-chloro-4-fluoroiodobenzene, it is necessary to ensure safety and avoid danger.
First of all, the nature of this compound may be more active, and it should be placed in a cool and dry place. Cover the humid environment, or cause its hydrolysis and other reactions to cause deterioration. It also needs to be protected from heat. Under high temperature, its chemical stability is easy to lose, and it is afraid of decomposition or other adverse reactions. Where it is stored, air circulation should also be good to avoid the accumulation of harmful gases. And it should be kept away from fire sources and oxidants. If it is flammable, it is easy to react violently and cause danger.
As for transportation, the first heavy packaging is sturdy. When packing with suitable materials to prevent its leakage. The packaging material must be able to withstand the corrosion of this compound and not react with it. During transportation, temperature and humidity control are also critical. It is advisable to maintain stable temperature and humidity conditions to avoid damage due to sudden changes in the environment. At the same time, the transportation vehicle or container should be clean and free of impurities to avoid contamination of this compound. The escort must also be familiar with its characteristics and emergency methods. In case of leakage, etc., it can be disposed of quickly to avoid major disasters. In this way, when storing and transporting 3-chloro-4-fluoroiodobenzene, it is necessary to ensure safety and avoid danger.
3-chloro-4-fluoroiodobenzene impact on the environment and human health
3-Chloro-4-fluoroiodobenzene is one of the organic compounds. The impact on the environment and human health cannot be underestimated.
In the environment, due to the halogen atom, its properties are quite stable, difficult to degrade naturally, or cause long-term retention. If released in water bodies, or ingested by aquatic organisms, through the transmission and enrichment of the food chain, it will harm high-end organisms. In the soil, it may affect the activity and community structure of soil microorganisms, and disturb the balance of soil ecosystems. Its volatilization into the atmosphere, or interaction with other pollutants, affects air quality, and may change the chemical composition and physical properties of the atmospheric environment.
As for personal health, 3-chloro-4-fluoroiodobenzene may be ingested into the human body through respiratory tract, skin contact and diet. Studies have shown that halogenated aromatic hydrocarbons have many potential toxicity. They may interfere with the human endocrine system, affect the synthesis, secretion and metabolism of hormones, and cause various symptoms of endocrine disorders, such as reproductive dysfunction and developmental abnormalities. And such substances may be genetically toxic, can damage the DNA structure of human cells, increase the risk of genetic mutations and cancer. Long-term exposure may cause damage to the nervous system, causing neurological symptoms such as headache, dizziness, fatigue, and memory loss.
In summary, 3-chloro-4-fluoroiodobenzene poses a potential threat to both the environment and human health. Its production, use and disposal should be treated with caution and strictly controlled to reduce its harm to the ecological environment and human health.
In the environment, due to the halogen atom, its properties are quite stable, difficult to degrade naturally, or cause long-term retention. If released in water bodies, or ingested by aquatic organisms, through the transmission and enrichment of the food chain, it will harm high-end organisms. In the soil, it may affect the activity and community structure of soil microorganisms, and disturb the balance of soil ecosystems. Its volatilization into the atmosphere, or interaction with other pollutants, affects air quality, and may change the chemical composition and physical properties of the atmospheric environment.
As for personal health, 3-chloro-4-fluoroiodobenzene may be ingested into the human body through respiratory tract, skin contact and diet. Studies have shown that halogenated aromatic hydrocarbons have many potential toxicity. They may interfere with the human endocrine system, affect the synthesis, secretion and metabolism of hormones, and cause various symptoms of endocrine disorders, such as reproductive dysfunction and developmental abnormalities. And such substances may be genetically toxic, can damage the DNA structure of human cells, increase the risk of genetic mutations and cancer. Long-term exposure may cause damage to the nervous system, causing neurological symptoms such as headache, dizziness, fatigue, and memory loss.
In summary, 3-chloro-4-fluoroiodobenzene poses a potential threat to both the environment and human health. Its production, use and disposal should be treated with caution and strictly controlled to reduce its harm to the ecological environment and human health.
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