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3-Chloro-4-Fluoronitrobenzene
Linshang Chemical
|
HS Code |
433031 |
| Name | 3-Chloro-4-Fluoronitrobenzene |
| Molecular Formula | C6H3ClFNO2 |
| Molecular Weight | 175.545 |
| Appearance | Yellow to light brown solid |
| Boiling Point | 232 - 234 °C |
| Melting Point | 41 - 43 °C |
| Density | 1.489 g/cm³ |
| Flash Point | 101.9 °C |
| Solubility | Insoluble in water |
| Vapor Pressure | 0.04 mmHg (25 °C) |
| Logp | 2.84 |
As an accredited 3-Chloro-4-Fluoronitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 3 - chloro - 4 - fluoronitrobenzene packaged in a sealed, corrosion - resistant container. |
| Storage | 3 - Chloro - 4 - fluoronitrobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and incompatible substances like strong oxidizers and reducing agents. Store in a tightly - sealed container to prevent leakage and vapor release, as it is potentially hazardous. Follow proper safety regulations for chemical storage. |
| Shipping | 3 - Chloro - 4 - fluoronitrobenzene is shipped in tightly sealed, corrosion - resistant containers. It's transported under regulated conditions, following safety protocols for hazardous chemicals to prevent spills and ensure safe transit. |
Competitive 3-Chloro-4-Fluoronitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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What are the main uses of 3-chloro-4-fluoronitrobenzene?
3-Bromo-4-ethoxycarbonyl phenylhydrazine has a wide range of main uses. In the field of pharmaceutical synthesis, this compound is often a key intermediate. The structure of phenylhydrazine has unique reactivity, which can react with many compounds to build complex drug molecular structures.
For example, in the preparation of some antidepressant drugs, 3-bromo-4-ethoxycarbonyl phenylhydrazine can be condensed with specific carbonyl compounds to generate substances with specific pharmacological activities through a series of reactions. Its bromine atom can participate in nucleophilic substitution reactions and introduce other functional groups precisely to optimize drug activity and selectivity. The presence of ethoxycarbonyl can not only affect the solubility of molecules, but also perform functional group transformation in subsequent reactions, expanding the path of drug synthesis.
In the field of materials science, it also has applications. Functional polymer materials can be prepared by taking advantage of the properties of phenylhydrazine. For example, polymerization with double-bonded monomers produces polymers with special optical or electrical properties. Bromine atoms and ethoxycarbonyl can regulate the properties of polymers, such as changing their thermal stability and fluorescence properties.
In the study of organic synthetic chemistry, 3-bromo-4-ethoxycarbonyl phenylhydrazine is an extremely important synthetic block. Chemists can use it to design and synthesize novel organic compounds and explore new reaction pathways and mechanisms. Because of its multiple activity checking points in the structure, it can carry out diverse chemical reactions, providing rich materials and ideas for the development of organic synthetic chemistry.
For example, in the preparation of some antidepressant drugs, 3-bromo-4-ethoxycarbonyl phenylhydrazine can be condensed with specific carbonyl compounds to generate substances with specific pharmacological activities through a series of reactions. Its bromine atom can participate in nucleophilic substitution reactions and introduce other functional groups precisely to optimize drug activity and selectivity. The presence of ethoxycarbonyl can not only affect the solubility of molecules, but also perform functional group transformation in subsequent reactions, expanding the path of drug synthesis.
In the field of materials science, it also has applications. Functional polymer materials can be prepared by taking advantage of the properties of phenylhydrazine. For example, polymerization with double-bonded monomers produces polymers with special optical or electrical properties. Bromine atoms and ethoxycarbonyl can regulate the properties of polymers, such as changing their thermal stability and fluorescence properties.
In the study of organic synthetic chemistry, 3-bromo-4-ethoxycarbonyl phenylhydrazine is an extremely important synthetic block. Chemists can use it to design and synthesize novel organic compounds and explore new reaction pathways and mechanisms. Because of its multiple activity checking points in the structure, it can carry out diverse chemical reactions, providing rich materials and ideas for the development of organic synthetic chemistry.
What are the synthesis methods of 3-chloro-4-fluoronitrobenzene?
The synthesis method of 3-bromo-4-ethoxyphenylpropane is difficult to find a direct correspondence in ancient books, but according to the principles of ancient chemistry, the method can be deduced as follows.
First, start with a halogenation reaction. Choose a suitable halogenating agent, such as a brominating agent, to react with the substrate containing the corresponding benzene ring structure. Although there is no name for modern precise brominating agents in ancient books, but with the experience of ancient halogenation, a similar halogenation method can be found. Make the bromine atom just replace the specific position of the benzene ring to obtain a bromine-containing intermediate. In this step, it is necessary to control the temperature, time and amount of the reaction, just like the ancient method of alchemy to control the temperature and dosage, in order to achieve precise substitution, to obtain 3-bromobenzene intermediates.
Second, the ethoxy group is introduced. The ancient etherification method can be found, and the ethanol derivative reacts with the intermediate containing an active check point. Select an appropriate base or catalyst to help the ether bond. Although ancient chemistry has no modern catalytic theory, it also has a way to promote the reaction based on experience. After this step, 3-bromo-4-ethoxybenzene intermediates are obtained.
Third, the propynyl group is constructed. The alkyne derivatives are reacted with the above intermediates, or the ancient reagents that can induce alkynyl groups are selected, and the propynyl groups are introduced at the appropriate check point where the benzene ring is connected by the ancient bonding method. This step requires attention to the reaction conditions to prevent side reactions, such as isomerization or overreaction of alkynyl groups. After multiple steps of delicate reactions, the target molecule 3-bromo-4-ethoxyphenylpropane is gradually constructed. Although the chemical expressions and operations of ancient times are different from those of today, the basic principles of chemical products are similar. According to the wisdom and experience of ancient times, the way of synthesis can also be deduced.
First, start with a halogenation reaction. Choose a suitable halogenating agent, such as a brominating agent, to react with the substrate containing the corresponding benzene ring structure. Although there is no name for modern precise brominating agents in ancient books, but with the experience of ancient halogenation, a similar halogenation method can be found. Make the bromine atom just replace the specific position of the benzene ring to obtain a bromine-containing intermediate. In this step, it is necessary to control the temperature, time and amount of the reaction, just like the ancient method of alchemy to control the temperature and dosage, in order to achieve precise substitution, to obtain 3-bromobenzene intermediates.
Second, the ethoxy group is introduced. The ancient etherification method can be found, and the ethanol derivative reacts with the intermediate containing an active check point. Select an appropriate base or catalyst to help the ether bond. Although ancient chemistry has no modern catalytic theory, it also has a way to promote the reaction based on experience. After this step, 3-bromo-4-ethoxybenzene intermediates are obtained.
Third, the propynyl group is constructed. The alkyne derivatives are reacted with the above intermediates, or the ancient reagents that can induce alkynyl groups are selected, and the propynyl groups are introduced at the appropriate check point where the benzene ring is connected by the ancient bonding method. This step requires attention to the reaction conditions to prevent side reactions, such as isomerization or overreaction of alkynyl groups. After multiple steps of delicate reactions, the target molecule 3-bromo-4-ethoxyphenylpropane is gradually constructed. Although the chemical expressions and operations of ancient times are different from those of today, the basic principles of chemical products are similar. According to the wisdom and experience of ancient times, the way of synthesis can also be deduced.
What are the physical properties of 3-chloro-4-fluoronitrobenzene?
3-Bromo-4-ethoxybenzaldehyde is a key raw material in organic synthesis. Its physical properties are unique, and it is also similar to the discussion of the properties of various substances described in Tiangong Kaiwu, which are all related to the characteristics and applications of the substance.
This compound is mostly solid at room temperature, and its color may be white to light yellow. The melting point range is about [X] ° C to [X] ° C. This melting point characteristic is of great significance in the separation and purification process of substances. For example, in ancient alchemy and pharmaceuticals, the melting point of materials can be accurately grasped to ensure that the refining process is appropriate.
Its boiling point is about [X] ° C to [X] ° C. When a liquid substance boils, the state will change significantly. In many processes involved in "Tiangong Kaiji", such as boiling, distillation, etc., the control of the boiling point is also the key, which is related to the purity and quality of the product.
3-Bromo-4-ethoxybenzaldehyde has good solubility in common organic solvents such as ethanol and ether. However, it has poor solubility in water. This difference in solubility is also reflected in many ancient chemical processes, such as the insolubility of oil and water. People use this property to achieve separation and processing of substances.
Furthermore, this compound has a certain degree of volatility and will gradually evaporate in the air. This characteristic also needs to be paid attention to during storage and use. As recorded in Tiangong Kaiwu, the storage of many materials needs to consider their volatilization and other characteristics to prevent deterioration and loss.
Overall, the physical properties of 3-bromo-4-ethoxybenzaldehyde have far-reaching effects in organic synthesis and other fields. In storage, separation, purification and other operations, it needs to be properly handled according to its melting point, boiling point, solubility, volatility and other characteristics.
This compound is mostly solid at room temperature, and its color may be white to light yellow. The melting point range is about [X] ° C to [X] ° C. This melting point characteristic is of great significance in the separation and purification process of substances. For example, in ancient alchemy and pharmaceuticals, the melting point of materials can be accurately grasped to ensure that the refining process is appropriate.
Its boiling point is about [X] ° C to [X] ° C. When a liquid substance boils, the state will change significantly. In many processes involved in "Tiangong Kaiji", such as boiling, distillation, etc., the control of the boiling point is also the key, which is related to the purity and quality of the product.
3-Bromo-4-ethoxybenzaldehyde has good solubility in common organic solvents such as ethanol and ether. However, it has poor solubility in water. This difference in solubility is also reflected in many ancient chemical processes, such as the insolubility of oil and water. People use this property to achieve separation and processing of substances.
Furthermore, this compound has a certain degree of volatility and will gradually evaporate in the air. This characteristic also needs to be paid attention to during storage and use. As recorded in Tiangong Kaiwu, the storage of many materials needs to consider their volatilization and other characteristics to prevent deterioration and loss.
Overall, the physical properties of 3-bromo-4-ethoxybenzaldehyde have far-reaching effects in organic synthesis and other fields. In storage, separation, purification and other operations, it needs to be properly handled according to its melting point, boiling point, solubility, volatility and other characteristics.
What are the chemical properties of 3-chloro-4-fluoronitrobenzene?
3-Bromo-4-ethoxyphenylboronic acid is a crucial reagent in organic synthesis. Its chemical properties are rich and diverse, and it has significant uses in many fields.
First of all, this compound is acidic. Because the outer electrons of the boron atom in the structure do not reach the octet structure, it can accept electron pairs, so it presents Lewis acidity. This acidic property enables 3-bromo-4-ethoxyphenylboronic acid to form stable complexes with compounds containing lone pairs of electrons, such as amines and ethers. In organic synthesis, this coordination can change the electron cloud density of the reaction substrate, which in turn affects the rate and selectivity of the reaction.
Secondly, the aromatic ring structure of 3-bromo-4-ethoxyphenylboronic acid gives it aromaticity. The aromatic ring has a high degree of conjugation system and is quite stable. This not only determines the physical properties of the compound, such as melting point and boiling point, but also has a profound impact on its chemical properties. The bromine atom and the ethoxy group on the aromatic ring have different electron effects on the electron cloud distribution of the aromatic ring. The bromine atom has electron-absorbing induction effect and the ethoxy group has electron-donator conjugation effect. The interaction between the two causes the electron cloud density at different positions on the aromatic ring to differ, thus determining the position selectivity of the electrophilic substitution reaction.
Furthermore, the boric acid group (-B (OH) -2) is a key activity check point for 3-bromo-4-ethoxyphenylboronic acid to participate in many reactions. It can condensate with hydroxyl compounds such as alcohols and phenols under specific conditions to form borate esters. Such borate esters are often used as intermediates in organic synthesis to construct more complex organic molecular structures. At the same time, in transition metal catalyzed reactions, such as Suzuki coupling reaction, 3-bromo-4-ethoxyphenylboronic acid is an important reaction substrate, and the boric acid group and the transition metal catalyst undergo a series of reactions such as coordination and oxidative addition, and finally couple with halogenated aromatics or olefins to form carbon-carbon bonds, which realizes the efficient construction of complex organic molecules.
In addition, 3-bromo-4-ethoxyphenylboronic acid is more sensitive to moisture. Boric acid groups are prone to react with water, and in high humidity environments, side reactions such as hydrolysis may occur, resulting in changes in the structure and purity of the compound, which in turn affect its performance in related reactions. Therefore, when storing and using the compound, it is necessary to properly control the humidity conditions of the environment to ensure the stability of its chemical properties.
First of all, this compound is acidic. Because the outer electrons of the boron atom in the structure do not reach the octet structure, it can accept electron pairs, so it presents Lewis acidity. This acidic property enables 3-bromo-4-ethoxyphenylboronic acid to form stable complexes with compounds containing lone pairs of electrons, such as amines and ethers. In organic synthesis, this coordination can change the electron cloud density of the reaction substrate, which in turn affects the rate and selectivity of the reaction.
Secondly, the aromatic ring structure of 3-bromo-4-ethoxyphenylboronic acid gives it aromaticity. The aromatic ring has a high degree of conjugation system and is quite stable. This not only determines the physical properties of the compound, such as melting point and boiling point, but also has a profound impact on its chemical properties. The bromine atom and the ethoxy group on the aromatic ring have different electron effects on the electron cloud distribution of the aromatic ring. The bromine atom has electron-absorbing induction effect and the ethoxy group has electron-donator conjugation effect. The interaction between the two causes the electron cloud density at different positions on the aromatic ring to differ, thus determining the position selectivity of the electrophilic substitution reaction.
Furthermore, the boric acid group (-B (OH) -2) is a key activity check point for 3-bromo-4-ethoxyphenylboronic acid to participate in many reactions. It can condensate with hydroxyl compounds such as alcohols and phenols under specific conditions to form borate esters. Such borate esters are often used as intermediates in organic synthesis to construct more complex organic molecular structures. At the same time, in transition metal catalyzed reactions, such as Suzuki coupling reaction, 3-bromo-4-ethoxyphenylboronic acid is an important reaction substrate, and the boric acid group and the transition metal catalyst undergo a series of reactions such as coordination and oxidative addition, and finally couple with halogenated aromatics or olefins to form carbon-carbon bonds, which realizes the efficient construction of complex organic molecules.
In addition, 3-bromo-4-ethoxyphenylboronic acid is more sensitive to moisture. Boric acid groups are prone to react with water, and in high humidity environments, side reactions such as hydrolysis may occur, resulting in changes in the structure and purity of the compound, which in turn affect its performance in related reactions. Therefore, when storing and using the compound, it is necessary to properly control the humidity conditions of the environment to ensure the stability of its chemical properties.
What are the precautions for storing and transporting 3-chloro-4-fluoronitrobenzene?
3-Cyanogen-4-ethoxybenzonitrile has a number of important things to pay attention to during storage and transportation.
Its properties are chemical substances, and when stored, the first environment is suitable. It should be placed in a cool, dry and well-ventilated place, away from fire and heat sources. This is because if the substance is heated, it may cause chemical reactions, damage stability, and may even pose a safety risk. And it needs to be stored separately from oxidants, acids, bases, etc., and must not be mixed to prevent mutual reaction and cause danger.
Packaging is also crucial. Packaging must be tight to ensure no leakage. Packaging materials that meet relevant standards can be selected so that their quality and safety can be guaranteed during storage.
When transporting, the transport vehicle should be equipped with the corresponding variety and quantity of fire fighting equipment and leakage emergency treatment equipment. During transportation, ensure that the container does not leak, collapse, fall or damage. When driving, you should follow the specified route and do not stop in residential areas and densely populated areas.
The loading and unloading process also needs to be cautious. Operators should be specially trained and strictly abide by the operating procedures. When loading and unloading, it should be handled lightly to prevent damage to the packaging and containers.
These are all 3-cyanogen-4-ethoxybenzonitrile. Pay attention during storage and transportation, and do not be negligent to avoid unexpected changes.
Its properties are chemical substances, and when stored, the first environment is suitable. It should be placed in a cool, dry and well-ventilated place, away from fire and heat sources. This is because if the substance is heated, it may cause chemical reactions, damage stability, and may even pose a safety risk. And it needs to be stored separately from oxidants, acids, bases, etc., and must not be mixed to prevent mutual reaction and cause danger.
Packaging is also crucial. Packaging must be tight to ensure no leakage. Packaging materials that meet relevant standards can be selected so that their quality and safety can be guaranteed during storage.
When transporting, the transport vehicle should be equipped with the corresponding variety and quantity of fire fighting equipment and leakage emergency treatment equipment. During transportation, ensure that the container does not leak, collapse, fall or damage. When driving, you should follow the specified route and do not stop in residential areas and densely populated areas.
The loading and unloading process also needs to be cautious. Operators should be specially trained and strictly abide by the operating procedures. When loading and unloading, it should be handled lightly to prevent damage to the packaging and containers.
These are all 3-cyanogen-4-ethoxybenzonitrile. Pay attention during storage and transportation, and do not be negligent to avoid unexpected changes.
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