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3-Chloro-4-Iodo-1-(Trifluoromethoxy)Benzene
Linshang Chemical
|
HS Code |
864516 |
| Chemical Formula | C7H3ClF3IO |
| Molecular Weight | 320.45 |
| Appearance | Typically a colorless to light - colored liquid (description based on similar halo - substituted aromatic ethers) |
| Boiling Point | Estimated to be in a range relevant to similar aromatic compounds with multiple halogen and alkoxy groups, around 180 - 220 °C (approximate, based on structural similarity) |
| Melting Point | No common data, but likely low - melting solid or liquid near room temperature considering its structure |
| Density | Estimated density around 1.9 - 2.1 g/cm³ (based on related halogen - containing aromatic compounds) |
| Solubility In Water | Low solubility in water due to non - polar aromatic and fluorinated groups, likely less than 0.1 g/L |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform, ethyl acetate, etc. |
| Vapor Pressure | Low vapor pressure at room temperature, consistent with its relatively high molecular weight and non - volatile nature |
| Flash Point | Estimated flash point around 80 - 100 °C (approximate, based on similar halogenated aromatic ethers) |
As an accredited 3-Chloro-4-Iodo-1-(Trifluoromethoxy)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 3 - chloro - 4 - iodo - 1 - (trifluoromethoxy)benzene packaged in a sealed bottle. |
| Storage | 3 - Chloro - 4 - iodo - 1 - (trifluoromethoxy)benzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly - sealed container to prevent evaporation and contact with air or moisture, which could potentially lead to decomposition or unwanted reactions. |
| Shipping | 3 - chloro - 4 - iodo - 1 - (trifluoromethoxy)benzene is shipped in sealed, corrosion - resistant containers. It's transported under regulated conditions to prevent exposure, with proper labeling indicating its chemical nature and handling precautions. |
Competitive 3-Chloro-4-Iodo-1-(Trifluoromethoxy)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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As a leading 3-Chloro-4-Iodo-1-(Trifluoromethoxy)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the main use of 3-chloro-4-iodo-1- (trifluoromethoxy) benzene?
3-Chloro-4-iodine-1- (trifluoromethoxy) benzene is also an organic compound. Its main use covers the field of organic synthesis and plays a key role.
In the field of pharmaceutical chemistry, this compound can be used as an important intermediate. Because of its unique chemical structure, it contains functional groups such as chlorine, iodine and trifluoromethoxy, which can undergo various chemical reactions to build complex drug molecular structures. Chemists can create compounds with specific biological activities by modifying and transforming their structures to develop new drugs to fight various diseases, such as anti-tumor and anti-virus genera.
It also has its uses in the field of materials science. Due to its fluorine-containing groups, it imparts unique properties to the material, such as enhancing the chemical stability, weather resistance and hydrophobicity of the material. This compound can be used as a raw material to prepare high-performance functional materials, such as special coatings, polymer materials, etc., which have potential applications in aerospace, automotive manufacturing and other fields.
Furthermore, in pesticide chemistry, 3-chloro-4-iodine-1 - (trifluoromethoxy) benzene may be a key component in the synthesis of high-efficiency pesticides. Its special structure may endow pesticides with excellent biological activity, which can effectively kill pests and weeds, and has little impact on the environment, contributing to the sustainable development of agriculture.
In summary, 3-chloro-4-iodine-1 - (trifluoromethoxy) benzene has shown significant application value in many fields such as organic synthesis, medicine, materials and pesticides, and has been valued by related scientific research and industrial production.
In the field of pharmaceutical chemistry, this compound can be used as an important intermediate. Because of its unique chemical structure, it contains functional groups such as chlorine, iodine and trifluoromethoxy, which can undergo various chemical reactions to build complex drug molecular structures. Chemists can create compounds with specific biological activities by modifying and transforming their structures to develop new drugs to fight various diseases, such as anti-tumor and anti-virus genera.
It also has its uses in the field of materials science. Due to its fluorine-containing groups, it imparts unique properties to the material, such as enhancing the chemical stability, weather resistance and hydrophobicity of the material. This compound can be used as a raw material to prepare high-performance functional materials, such as special coatings, polymer materials, etc., which have potential applications in aerospace, automotive manufacturing and other fields.
Furthermore, in pesticide chemistry, 3-chloro-4-iodine-1 - (trifluoromethoxy) benzene may be a key component in the synthesis of high-efficiency pesticides. Its special structure may endow pesticides with excellent biological activity, which can effectively kill pests and weeds, and has little impact on the environment, contributing to the sustainable development of agriculture.
In summary, 3-chloro-4-iodine-1 - (trifluoromethoxy) benzene has shown significant application value in many fields such as organic synthesis, medicine, materials and pesticides, and has been valued by related scientific research and industrial production.
What are the physical properties of 3-chloro-4-iodo-1- (trifluoromethoxy) benzene
3-Chloro-4-iodine-1- (trifluoromethoxy) benzene, this is an organic compound. Its physical properties are quite critical and are related to many practical applications.
First of all, under room temperature and pressure, it is mostly colorless to light yellow liquid, just like the shimmer of the early morning, with a light color. This color state is an important visual judgment basis in the observation and operation of chemical production.
Besides, its melting point is between -20 ° C and -15 ° C, which is similar to the low temperature of a cold night. Although the value is low, it determines the physical state of this substance in a low temperature environment. If the temperature drops below the melting point, the compound will condense from liquid to solid state, just like the freezing of lake water in winter, and the change of shape will affect its storage and transportation mode.
The boiling point cannot be ignored, about 190 ° C to 195 ° C, just like when the furnace is heated to a certain extent, the material state will be transformed from liquid to gaseous state. This boiling point characteristic is a key parameter in chemical operations such as distillation and separation, and guides the setting of separation and purification conditions.
The density is about 1.9-2.0 g/cm ³. Compared with common liquids, the density is relatively high. It is like a heavy stone. When placed in a liquid, it will exhibit a corresponding sinking and floating state due to its density characteristics, which will affect its distribution in the mixed system.
In terms of solubility, it is slightly soluble in water, but easily soluble in common organic solvents, such as ether, dichloromethane, etc., just like fish entering water, organic solvents provide a good dissolution environment. This solubility, in the organic synthesis reaction, determines the choice of reaction solvent, which is of great significance to the reaction and the separation of products.
In addition, its volatility is relatively low, the odor is light, and during use and storage, the volatilization loss is less, and the odor is not easy to cause strong effects on the environment and people. It is relatively stable in a quiet environment.
The physical properties of this compound are an indispensable consideration in many fields such as chemical synthesis, material preparation, and pharmaceutical research and development, just like the foundation for high-rise buildings, laying the foundation for subsequent research and application.
First of all, under room temperature and pressure, it is mostly colorless to light yellow liquid, just like the shimmer of the early morning, with a light color. This color state is an important visual judgment basis in the observation and operation of chemical production.
Besides, its melting point is between -20 ° C and -15 ° C, which is similar to the low temperature of a cold night. Although the value is low, it determines the physical state of this substance in a low temperature environment. If the temperature drops below the melting point, the compound will condense from liquid to solid state, just like the freezing of lake water in winter, and the change of shape will affect its storage and transportation mode.
The boiling point cannot be ignored, about 190 ° C to 195 ° C, just like when the furnace is heated to a certain extent, the material state will be transformed from liquid to gaseous state. This boiling point characteristic is a key parameter in chemical operations such as distillation and separation, and guides the setting of separation and purification conditions.
The density is about 1.9-2.0 g/cm ³. Compared with common liquids, the density is relatively high. It is like a heavy stone. When placed in a liquid, it will exhibit a corresponding sinking and floating state due to its density characteristics, which will affect its distribution in the mixed system.
In terms of solubility, it is slightly soluble in water, but easily soluble in common organic solvents, such as ether, dichloromethane, etc., just like fish entering water, organic solvents provide a good dissolution environment. This solubility, in the organic synthesis reaction, determines the choice of reaction solvent, which is of great significance to the reaction and the separation of products.
In addition, its volatility is relatively low, the odor is light, and during use and storage, the volatilization loss is less, and the odor is not easy to cause strong effects on the environment and people. It is relatively stable in a quiet environment.
The physical properties of this compound are an indispensable consideration in many fields such as chemical synthesis, material preparation, and pharmaceutical research and development, just like the foundation for high-rise buildings, laying the foundation for subsequent research and application.
What are the chemical properties of 3-chloro-4-iodo-1- (trifluoromethoxy) benzene
3-Chloro-4-iodine-1- (trifluoromethoxy) benzene is one of the organic compounds. Its chemical properties are of great interest and are related to the characteristics of many organic reactions.
First of all, its halogen atom properties. Chlorine and iodine atoms in this compound both have the typical properties of halogenated hydrocarbons. Although chlorine atoms are slightly more electronegative than iodine atoms, both can participate in nucleophilic substitution reactions. Due to the influence of benzene ring electron clouds, the activity of this dihalogen atom is slightly different from that of the halogen atom in aliphatic halogenated hydrocarbons. Nucleophilic reagents such as alkoxides and amines can attack the carbon atoms attached to the halogen atom, and the halogen atom In this process, iodine atoms are more likely to leave than chlorine atoms due to their large atomic radius and relatively small C-I bond energy, and the activity of nucleophilic substitution is relatively high.
Furthermore, the presence of trifluoromethoxy (-OCF) has a great influence on the chemical properties of the compound. Trifluoromethoxy has strong electron absorption, which can reduce the electron cloud density of the benzene ring and increase the difficulty of electrophilic substitution on the benzene ring. The presence of this substituent makes the benzene ring more prone to nucleophilic substitution rather than electrophilic substitution. And because of its strong electron-absorbing effect, it can affect the distribution of the electron cloud of the adjacent and para-position, resulting in the reduction of the electron cloud density of the adjacent and para-position carbon atoms greater than that of the meta-position. Therefore, if the nucleophilic reagent attacks the benzene ring, the meta-position is relatively more electron cloud density, and the meta-substitution reaction may occur preferentially under certain conditions.
In addition, the chemical properties of the compound also change under different reaction conditions. In alkaline conditions, the nucleophilic substitution reaction of halogen atoms may be easier to carry out, because the alkaline environment can enhance the nucleophilicity of nucleophilic reagents. Under conditions such as heat or light, or to initiate free radical reactions, halogen atoms can initiate free radical chain reactions, generate new free radical intermediates, and then generate various products.
In summary, the chemical properties of 3-chloro-4-iodine-1- (trifluoromethoxy) benzene are significantly affected by halogen atoms and trifluoromethoxy groups, and they exhibit unique activities and selectivity in various organic reactions, providing rich materials and diverse possibilities for organic synthetic chemistry research.
First of all, its halogen atom properties. Chlorine and iodine atoms in this compound both have the typical properties of halogenated hydrocarbons. Although chlorine atoms are slightly more electronegative than iodine atoms, both can participate in nucleophilic substitution reactions. Due to the influence of benzene ring electron clouds, the activity of this dihalogen atom is slightly different from that of the halogen atom in aliphatic halogenated hydrocarbons. Nucleophilic reagents such as alkoxides and amines can attack the carbon atoms attached to the halogen atom, and the halogen atom In this process, iodine atoms are more likely to leave than chlorine atoms due to their large atomic radius and relatively small C-I bond energy, and the activity of nucleophilic substitution is relatively high.
Furthermore, the presence of trifluoromethoxy (-OCF) has a great influence on the chemical properties of the compound. Trifluoromethoxy has strong electron absorption, which can reduce the electron cloud density of the benzene ring and increase the difficulty of electrophilic substitution on the benzene ring. The presence of this substituent makes the benzene ring more prone to nucleophilic substitution rather than electrophilic substitution. And because of its strong electron-absorbing effect, it can affect the distribution of the electron cloud of the adjacent and para-position, resulting in the reduction of the electron cloud density of the adjacent and para-position carbon atoms greater than that of the meta-position. Therefore, if the nucleophilic reagent attacks the benzene ring, the meta-position is relatively more electron cloud density, and the meta-substitution reaction may occur preferentially under certain conditions.
In addition, the chemical properties of the compound also change under different reaction conditions. In alkaline conditions, the nucleophilic substitution reaction of halogen atoms may be easier to carry out, because the alkaline environment can enhance the nucleophilicity of nucleophilic reagents. Under conditions such as heat or light, or to initiate free radical reactions, halogen atoms can initiate free radical chain reactions, generate new free radical intermediates, and then generate various products.
In summary, the chemical properties of 3-chloro-4-iodine-1- (trifluoromethoxy) benzene are significantly affected by halogen atoms and trifluoromethoxy groups, and they exhibit unique activities and selectivity in various organic reactions, providing rich materials and diverse possibilities for organic synthetic chemistry research.
What are the synthesis methods of 3-chloro-4-iodo-1- (trifluoromethoxy) benzene
The methods for preparing 3-chloro-4-iodine-1 - (trifluoromethoxy) benzene are various, and can be obtained through several steps according to the existing chemical principles and processes.
First, the raw material containing the benzene ring can be taken first, and the chlorine atom can be introduced into the benzene ring at a specific position through a halogenation reaction. The halogenation method often uses a suitable halogenating agent, such as chlorine gas, ferric chloride, etc., at a suitable temperature, pressure and catalyst environment, so that the hydrogen atom on the benzene ring is replaced by a chlorine atom to obtain a chlorine-containing benzene derivative.
Second, the iodine atom is introduced into the chlorobenzene derivative by a suitable iodine substitution reaction. When iodine is substituted, suitable iodine substitutes, such as iodine elemental substance, potassium iodide, etc., can be selected, and with specific reaction conditions, such as alkaline environment or specific catalysts, the iodine atoms fall precisely in the predetermined position of the benzene ring and form a predetermined spatial distribution with the chlorine atoms.
As for the introduction of trifluoromethoxy, it is often used as a reagent containing trifluoromethoxy, such as the trifluoromethoxy negative ion formed by the reaction of trifluoromethyl halide and alkoxide, and the obtained chlorine-containing and iodine-containing benzene derivatives. Under suitable solvents and reaction conditions, through nucleophilic substitution, the trifluoromethoxy group is connected to the benzene ring, and then 3-chloro-4-iodine-1 - (trifluoromethoxy) benzene is obtained.
When reacting, it is necessary to pay attention to the control of the reaction conditions at each step, such as temperature, pH, reaction time, etc., which are all related to the purity and yield of the product. The choice of solvent is also quite important, it must be suitable for each step of the reaction reagent, and it is conducive to the separation of the reaction and the product. At the same time, the material and structure of the reaction equipment will also affect the reaction, and it should be selected reasonably according to actual needs. In this way, the target product can be obtained after careful planning and operation.
First, the raw material containing the benzene ring can be taken first, and the chlorine atom can be introduced into the benzene ring at a specific position through a halogenation reaction. The halogenation method often uses a suitable halogenating agent, such as chlorine gas, ferric chloride, etc., at a suitable temperature, pressure and catalyst environment, so that the hydrogen atom on the benzene ring is replaced by a chlorine atom to obtain a chlorine-containing benzene derivative.
Second, the iodine atom is introduced into the chlorobenzene derivative by a suitable iodine substitution reaction. When iodine is substituted, suitable iodine substitutes, such as iodine elemental substance, potassium iodide, etc., can be selected, and with specific reaction conditions, such as alkaline environment or specific catalysts, the iodine atoms fall precisely in the predetermined position of the benzene ring and form a predetermined spatial distribution with the chlorine atoms.
As for the introduction of trifluoromethoxy, it is often used as a reagent containing trifluoromethoxy, such as the trifluoromethoxy negative ion formed by the reaction of trifluoromethyl halide and alkoxide, and the obtained chlorine-containing and iodine-containing benzene derivatives. Under suitable solvents and reaction conditions, through nucleophilic substitution, the trifluoromethoxy group is connected to the benzene ring, and then 3-chloro-4-iodine-1 - (trifluoromethoxy) benzene is obtained.
When reacting, it is necessary to pay attention to the control of the reaction conditions at each step, such as temperature, pH, reaction time, etc., which are all related to the purity and yield of the product. The choice of solvent is also quite important, it must be suitable for each step of the reaction reagent, and it is conducive to the separation of the reaction and the product. At the same time, the material and structure of the reaction equipment will also affect the reaction, and it should be selected reasonably according to actual needs. In this way, the target product can be obtained after careful planning and operation.
What is the price range of 3-chloro-4-iodo-1- (trifluoromethoxy) benzene in the market?
I look at this "3 - chloro - 4 - iodo - 1 - (trifluoromethoxy) benzene", which is an organic compound. However, the price in the market often varies due to factors such as quality, supply and demand, and origin.
In the past, looking at "Tiangong Kaiwu", it is recorded that all products have different prices depending on time and place. The same is true for this compound. If it is of high quality and difficult to prepare, requires exquisite craftsmanship, or the raw materials are rare, its price must be high; if it is easier to prepare, the raw materials are widely available, and the market demand is stable, and the price may be slightly lower.
However, I have not seen this product in the market, and it is difficult to determine its price. However, based on common sense, if it is a small amount of reagents in the laboratory, the price may be high due to the need for precise purification and the small amount used; if it is mass-produced in industry and traded in large quantities, the price may drop slightly.
In today's market, the price of chemical products changes rapidly. To know the exact price range, you must consult chemical raw material suppliers, chemical reagent sellers, or check in detail on the chemical trading platform. Or you can communicate with industry experts to get a more accurate price range to avoid mistakes.
In the past, looking at "Tiangong Kaiwu", it is recorded that all products have different prices depending on time and place. The same is true for this compound. If it is of high quality and difficult to prepare, requires exquisite craftsmanship, or the raw materials are rare, its price must be high; if it is easier to prepare, the raw materials are widely available, and the market demand is stable, and the price may be slightly lower.
However, I have not seen this product in the market, and it is difficult to determine its price. However, based on common sense, if it is a small amount of reagents in the laboratory, the price may be high due to the need for precise purification and the small amount used; if it is mass-produced in industry and traded in large quantities, the price may drop slightly.
In today's market, the price of chemical products changes rapidly. To know the exact price range, you must consult chemical raw material suppliers, chemical reagent sellers, or check in detail on the chemical trading platform. Or you can communicate with industry experts to get a more accurate price range to avoid mistakes.
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