Linshang Chemical
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3-Chloro-4-Iodofluorobenzene
Linshang Chemical
|
HS Code |
727564 |
| Chemical Formula | C6H3ClFI |
| Molecular Weight | 256.44 |
| Appearance | Liquid (usually) |
| Boiling Point | Data needed |
| Melting Point | Data needed |
| Density | Data needed |
| Solubility In Water | Low (organic compound) |
| Solubility In Organic Solvents | Good (in common organic solvents like ethanol, ether) |
| Flash Point | Data needed |
| Vapor Pressure | Data needed |
| Stability | Stable under normal conditions, but reactive with strong oxidizing agents |
As an accredited 3-Chloro-4-Iodofluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 - gram vial of 3 - chloro - 4 - iodofluorobenzene, tightly sealed for chemical safety. |
| Storage | 3 - Chloro - 4 - iodofluorobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly sealed container to prevent leakage. Store it separately from oxidizing agents, reducing agents, and other reactive chemicals. Label the storage container clearly with the chemical name and relevant hazard warnings. |
| Shipping | 3 - Chloro - 4 - iodofluorobenzene is a chemical. It should be shipped in tightly sealed, corrosion - resistant containers. Follow all relevant hazardous material shipping regulations to ensure safe transportation. |
Competitive 3-Chloro-4-Iodofluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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What is the chemistry of 3-chloro-4-iodofluorobenzene?
3-Chloro-4-iodine fluorobenzene is also an organic compound. Its molecules contain chlorine, iodine, and fluorine atoms, which have unique structures and therefore have special chemical properties.
As far as its reactivity is concerned, the electron cloud density of the benzene ring changes due to the influence of halogen atoms. Chlorine, fluorine, and iodine are all electron-withdrawing groups, which reduce the electron cloud density of the benzene ring, and the electrophilic substitution reaction activity is lower than that of benzene. However, different halogen atoms have different electron-withdrawing capabilities. Fluorine has the strongest electronegativity and the largest electron-withdrawing induction effect, followed by chlorine and iodine. This difference causes the electron cloud density distribution at different positions of the benzene ring to be different, thus affecting the attack position of the electrophilic reagent.
In the electrophilic substitution reaction, the halogen atom is an ortho-and para-site locator. Although its electron-absorbing makes the benzene ring passivated, the density of the ortho-and para-site electron clouds is relatively high. For example, during the nitration reaction, the nitro group tends to enter the ortho-and para-sites of chlorine, fluorine, and iodine. However, the steric hindrance also has an effect. Near the larger iodine atom, it is slightly difficult for the electrophilic reagent to attack, and the proportion of ortho-substitution products may be affected.
And because it contains a variety of halogen atoms, halogen-related reactions can occur. Chlorine and iodine can be replaced by nucleophiles. When conditions are appropriate, such as reaction with nucleophiles such as sodium alcohol and amine, chlorine and i This property makes it an important intermediate in organic synthesis, and can construct a variety of complex organic molecular structures through a series of reactions.
Furthermore, its chemical stability is also worthy of attention. Because the fluorine atom is connected to the benzene ring, the C-F bond energy is higher, which enhances the molecular stability to a certain extent, making 3-chloro-4-iodofluorobenzene difficult to decompose under some conditions, providing a relatively stable basis for its participation in various reactions. However, under extreme conditions such as strong reducing agents and strong acids and bases, the molecular structure can still be damaged and corresponding chemical changes occur.
As far as its reactivity is concerned, the electron cloud density of the benzene ring changes due to the influence of halogen atoms. Chlorine, fluorine, and iodine are all electron-withdrawing groups, which reduce the electron cloud density of the benzene ring, and the electrophilic substitution reaction activity is lower than that of benzene. However, different halogen atoms have different electron-withdrawing capabilities. Fluorine has the strongest electronegativity and the largest electron-withdrawing induction effect, followed by chlorine and iodine. This difference causes the electron cloud density distribution at different positions of the benzene ring to be different, thus affecting the attack position of the electrophilic reagent.
In the electrophilic substitution reaction, the halogen atom is an ortho-and para-site locator. Although its electron-absorbing makes the benzene ring passivated, the density of the ortho-and para-site electron clouds is relatively high. For example, during the nitration reaction, the nitro group tends to enter the ortho-and para-sites of chlorine, fluorine, and iodine. However, the steric hindrance also has an effect. Near the larger iodine atom, it is slightly difficult for the electrophilic reagent to attack, and the proportion of ortho-substitution products may be affected.
And because it contains a variety of halogen atoms, halogen-related reactions can occur. Chlorine and iodine can be replaced by nucleophiles. When conditions are appropriate, such as reaction with nucleophiles such as sodium alcohol and amine, chlorine and i This property makes it an important intermediate in organic synthesis, and can construct a variety of complex organic molecular structures through a series of reactions.
Furthermore, its chemical stability is also worthy of attention. Because the fluorine atom is connected to the benzene ring, the C-F bond energy is higher, which enhances the molecular stability to a certain extent, making 3-chloro-4-iodofluorobenzene difficult to decompose under some conditions, providing a relatively stable basis for its participation in various reactions. However, under extreme conditions such as strong reducing agents and strong acids and bases, the molecular structure can still be damaged and corresponding chemical changes occur.
What are the main uses of 3-chloro-4-iodofluorobenzene?
3-Chloro-4-iodofluorobenzene is also an organic compound. It has a wide range of uses and is often used as a key intermediate in the field of organic synthesis.
First, it can be used to create pesticides. By introducing it into the molecular structure of pesticides through specific chemical reactions, it can increase the activity and selectivity of pesticides. For example, the preparation of insecticides for specific pests can accurately act on specific physiological targets of pests, effectively remove insects and have little impact on the environment, achieving green environmental protection.
Second, it also plays an important role in the synthesis of medicines. It can be reacted in multiple steps to build complex drug molecular structures. For example, in the synthesis of some antibacterial and antiviral drugs, the halogen atoms and fluorine atoms of 3-chloro-4-iodofluorobenzene can adjust the lipophilicity, stability and biological activity of the drug, and help to develop new drugs with better efficacy and less side effects.
Furthermore, in the field of materials science, it can be used as a raw material for the synthesis of special functional materials. Because of its unique chemical structure, it can endow materials with special properties, such as the synthesis of materials with special optical and electrical properties, which can be used in optoelectronic devices, sensors, etc., to promote technological innovation and development in related fields. In short, 3-chloro-4-iodofluorobenzene plays an important role in the chemical industry, medicine, materials and other fields, and is of great significance to the development of various industries.
First, it can be used to create pesticides. By introducing it into the molecular structure of pesticides through specific chemical reactions, it can increase the activity and selectivity of pesticides. For example, the preparation of insecticides for specific pests can accurately act on specific physiological targets of pests, effectively remove insects and have little impact on the environment, achieving green environmental protection.
Second, it also plays an important role in the synthesis of medicines. It can be reacted in multiple steps to build complex drug molecular structures. For example, in the synthesis of some antibacterial and antiviral drugs, the halogen atoms and fluorine atoms of 3-chloro-4-iodofluorobenzene can adjust the lipophilicity, stability and biological activity of the drug, and help to develop new drugs with better efficacy and less side effects.
Furthermore, in the field of materials science, it can be used as a raw material for the synthesis of special functional materials. Because of its unique chemical structure, it can endow materials with special properties, such as the synthesis of materials with special optical and electrical properties, which can be used in optoelectronic devices, sensors, etc., to promote technological innovation and development in related fields. In short, 3-chloro-4-iodofluorobenzene plays an important role in the chemical industry, medicine, materials and other fields, and is of great significance to the development of various industries.
What are 3-chloro-4-iodofluorobenzene synthesis methods?
The synthesis methods of 3-chloro-4-iodofluorobenzene have many different paths. First, fluorobenzene can be started from fluorobenzene. First, the fluorobenzene is chlorinated. In this reaction, an appropriate catalyst, such as ferric trichloride, and chlorine gas is used as the chlorination reagent. Under the appropriate temperature and reaction environment, the chlorinated fluorobenzene isomer mixture can be obtained. Then, the required 3-chlorofluorobenzene is separated by efficient separation methods, such as distillation, column chromatography, etc. Then, the iodization reaction of 3-chlorofluorobenzene is carried out, and iodine is used as the iodizing agent, with appropriate oxidants, such as nitric acid, etc. Under specific reaction conditions, the 4-position of 3-chlorofluorobenzene is introduced into the iodine atom, so as to obtain 3-chloro-4-iodofluorobenzene.
Second, phenol can also be used as a raw material. Phenol is first fluorinated by a fluorination reaction, using suitable fluorination reagents, such as potassium fluoride, etc., with the help of a phase transfer catalyst, fluoridation is achieved to produce fluorophenol. Then, fluorophenol is chlorinated to obtain 3-chloro-4-fluorophenol. After that, the hydroxyl group in this product is converted into a group that is easy to leave, such as sulfonate, etc. Then with iodizing reagents, such as sodium iodide, nucleophilic substitution reaction is carried out, and finally 3-chloro-4-iodofluorobenzene is obtained.
Third, benzene is used as the starting material. First, benzene is chlorinated to obtain chlorobenzene. Chlorobenzene is then fluorinated to form chlorofluorobenzene. Subsequently, chlorofluorobenzene is iodinated, and iodine atoms are introduced at specific positions of chlorofluorobenzene through suitable reaction conditions and reagents to synthesize 3-chloro-4-iodofluorobenzene. However, there are many steps in this path, and each step of the reaction needs to strictly control the conditions to improve the yield and product purity. Each method has its advantages and disadvantages. In actual synthesis, it is necessary to comprehensively choose according to factors such as raw material availability, cost, and difficulty of reaction conditions.
Second, phenol can also be used as a raw material. Phenol is first fluorinated by a fluorination reaction, using suitable fluorination reagents, such as potassium fluoride, etc., with the help of a phase transfer catalyst, fluoridation is achieved to produce fluorophenol. Then, fluorophenol is chlorinated to obtain 3-chloro-4-fluorophenol. After that, the hydroxyl group in this product is converted into a group that is easy to leave, such as sulfonate, etc. Then with iodizing reagents, such as sodium iodide, nucleophilic substitution reaction is carried out, and finally 3-chloro-4-iodofluorobenzene is obtained.
Third, benzene is used as the starting material. First, benzene is chlorinated to obtain chlorobenzene. Chlorobenzene is then fluorinated to form chlorofluorobenzene. Subsequently, chlorofluorobenzene is iodinated, and iodine atoms are introduced at specific positions of chlorofluorobenzene through suitable reaction conditions and reagents to synthesize 3-chloro-4-iodofluorobenzene. However, there are many steps in this path, and each step of the reaction needs to strictly control the conditions to improve the yield and product purity. Each method has its advantages and disadvantages. In actual synthesis, it is necessary to comprehensively choose according to factors such as raw material availability, cost, and difficulty of reaction conditions.
3-chloro-4-iodofluorobenzene What are the precautions during storage and transportation?
3-Chloro-4-iodofluorobenzene is also an organic compound. During storage and transportation, many matters need to be paid attention to.
First words storage, this compound should be stored in a cool, dry and well-ventilated place. Because it may be sensitive to heat and light, it should be avoided from high temperature and direct sunlight. High temperature can increase its chemical reaction activity, and even cause decomposition, which will damage its quality. Therefore, the temperature should be controlled in an appropriate range, usually 2-8 ° C. And because it is volatile and toxic, it must be sealed to prevent leakage into the air, endangering the surrounding environment and human health. And should be stored separately from oxidants, acids, alkalis, etc., because it may react violently with them and cause dangerous accidents.
When transporting 3-chloro-4-iodofluorobenzene, it must be operated in accordance with relevant regulations and standards. The transport container must be strong and well sealed to prevent it from leaking during transportation. The material of the container used is also exquisite, and it should be able to resist the corrosion of this compound, such as stainless steel, Teflon and other materials. During transportation, vibration, impact and friction should be avoided to prevent leakage due to damage to the container. And the transport vehicle must have good ventilation and fire protection equipment to prepare for accidents. Escort personnel must also be familiar with the nature of this compound and emergency treatment methods. In case of leakage and other accidents, effective measures can be taken quickly to minimize the harm. In short, the storage and transportation of 3-chloro-4-iodofluorobenzene should be done with caution to ensure its safety and quality.
First words storage, this compound should be stored in a cool, dry and well-ventilated place. Because it may be sensitive to heat and light, it should be avoided from high temperature and direct sunlight. High temperature can increase its chemical reaction activity, and even cause decomposition, which will damage its quality. Therefore, the temperature should be controlled in an appropriate range, usually 2-8 ° C. And because it is volatile and toxic, it must be sealed to prevent leakage into the air, endangering the surrounding environment and human health. And should be stored separately from oxidants, acids, alkalis, etc., because it may react violently with them and cause dangerous accidents.
When transporting 3-chloro-4-iodofluorobenzene, it must be operated in accordance with relevant regulations and standards. The transport container must be strong and well sealed to prevent it from leaking during transportation. The material of the container used is also exquisite, and it should be able to resist the corrosion of this compound, such as stainless steel, Teflon and other materials. During transportation, vibration, impact and friction should be avoided to prevent leakage due to damage to the container. And the transport vehicle must have good ventilation and fire protection equipment to prepare for accidents. Escort personnel must also be familiar with the nature of this compound and emergency treatment methods. In case of leakage and other accidents, effective measures can be taken quickly to minimize the harm. In short, the storage and transportation of 3-chloro-4-iodofluorobenzene should be done with caution to ensure its safety and quality.
3-chloro-4-iodofluorobenzene impact on the environment and human health
3-Chloro-4-iodine fluorobenzene is an organic halogenated aromatic compound. The impact on the environment and human health cannot be ignored.
In the environment, due to the halogen atom, the stability is quite high and the degradation is difficult. Once released into the environment, it can remain for a long time. And such halogenated aromatic hydrocarbons are easily adsorbed by soil and water bodies, causing environmental medium pollution. If it enters the aquatic ecosystem, it may have toxic effects on aquatic organisms. Due to bioaccumulation, it accumulates through the food chain and can eventually endanger advanced organisms and even humans.
As for human health, 3-chloro-4-iodine fluorobenzene may be potentially toxic. After ingesting the human body through respiratory tract, skin contact or diet, it may damage the human body's multiple organ systems. Such as the nervous system, or cause neurological disorders, causing headaches, dizziness, and fatigue; in the liver, kidneys and other metabolic and excretory organs, or interfere with their normal metabolism and detoxification functions, long-term organ damage and functional decline. And halogenated aromatic hydrocarbons, some of which have been proven to be carcinogenic, teratogenic, and mutagenic. Although 3-chloro-4-iodofluorobenzene has not been studied in detail in this regard, it cannot be ignored according to the characteristics of similar compounds. Its potential "three-cause" risk. Therefore, the production, use and discharge of 3-chloro-4-iodofluorobenzene should be strictly controlled to protect the environment and human health.
In the environment, due to the halogen atom, the stability is quite high and the degradation is difficult. Once released into the environment, it can remain for a long time. And such halogenated aromatic hydrocarbons are easily adsorbed by soil and water bodies, causing environmental medium pollution. If it enters the aquatic ecosystem, it may have toxic effects on aquatic organisms. Due to bioaccumulation, it accumulates through the food chain and can eventually endanger advanced organisms and even humans.
As for human health, 3-chloro-4-iodine fluorobenzene may be potentially toxic. After ingesting the human body through respiratory tract, skin contact or diet, it may damage the human body's multiple organ systems. Such as the nervous system, or cause neurological disorders, causing headaches, dizziness, and fatigue; in the liver, kidneys and other metabolic and excretory organs, or interfere with their normal metabolism and detoxification functions, long-term organ damage and functional decline. And halogenated aromatic hydrocarbons, some of which have been proven to be carcinogenic, teratogenic, and mutagenic. Although 3-chloro-4-iodofluorobenzene has not been studied in detail in this regard, it cannot be ignored according to the characteristics of similar compounds. Its potential "three-cause" risk. Therefore, the production, use and discharge of 3-chloro-4-iodofluorobenzene should be strictly controlled to protect the environment and human health.
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