Linshang Chemical
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3-Chloro-4-Methylbenzene-1-Sulfonyl Chloride
Linshang Chemical
|
HS Code |
312104 |
| Name | 3-Chloro-4-Methylbenzene-1-Sulfonyl Chloride |
| Molecular Formula | C7H6Cl2O2S |
| Molecular Weight | 225.1 |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | Approx. 134 - 136 °C at 1 mmHg |
| Density | Approx. 1.46 g/cm³ |
| Solubility | Soluble in organic solvents like dichloromethane |
| Purity | Typically high - purity commercial products available |
| Stability | Reactive, especially with water and nucleophiles |
As an accredited 3-Chloro-4-Methylbenzene-1-Sulfonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 3 - chloro - 4 - methylbenzene - 1 - sulfonyl chloride in a sealed, corrosion - resistant bottle. |
| Storage | 3 - Chloro - 4 - methylbenzene - 1 - sulfonyl chloride should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly closed container, preferably in a corrosion - resistant cabinet. This is to prevent decomposition, potential reactions, and to ensure the integrity of the chemical due to its reactive nature. |
| Shipping | 3 - Chloro - 4 - methylbenzene - 1 - sulfonyl chloride, a hazardous chemical, is shipped in tightly sealed, corrosion - resistant containers. It follows strict regulations, ensuring safe handling during transit to prevent spills and environmental or safety risks. |
Competitive 3-Chloro-4-Methylbenzene-1-Sulfonyl Chloride prices that fit your budget—flexible terms and customized quotes for every order.
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What is the chemistry of 3-chloro-4-methylbenzene-1-sulfonyl Chloride?
3-Chloro-4-methylbenzene-1-sulfonyl chloride, this material is strong and active. Its color is often close to colorless to slightly yellow, like an oil, and has a pungent odor, which is uncomfortable to smell.
In terms of its chemical activity, the sulfonyl chloride group (-SO 2O Cl) is extremely active, and it is easy to react violently in contact with water, and hydrolysis produces corresponding sulfonic acid and hydrogen chloride gas. The hydrolysis reaction is very violent. If you put it into water, you will see an effervescent bubble in an instant, and hydrogen chloride gas will escape, accompanied by heat.
Because the chlorine atom is on the benzene ring, the electron cloud density of the benzene ring is changed by it, which makes this compound exhibit unique properties in the nucleophilic substitution reaction. The nucleophilic reagent easily attacks the check point on the benzene ring affected by the chlorine atom and the sulfonyl chloride group, and undergoes a substitution reaction to generate a variety of derivatives.
Furthermore, the presence of methyl groups in this compound also affects its physical properties and chemical properties. Methyl is the power supply group, which can slightly change the electron cloud distribution of the benzene ring, thereby affecting its reactivity and selectivity. In many organic synthesis reactions, 3-chloro-4-methylbenzene-1-sulfonyl chloride is often used as a key intermediate. With cleverly designed reaction paths, it can be converted into various organic compounds with important uses, which have extraordinary applications in medicine, pesticides, materials and other fields. However, due to its lively and irritating nature, it is necessary to be cautious and strictly follow the procedures when operating to prevent accidents.
In terms of its chemical activity, the sulfonyl chloride group (-SO 2O Cl) is extremely active, and it is easy to react violently in contact with water, and hydrolysis produces corresponding sulfonic acid and hydrogen chloride gas. The hydrolysis reaction is very violent. If you put it into water, you will see an effervescent bubble in an instant, and hydrogen chloride gas will escape, accompanied by heat.
Because the chlorine atom is on the benzene ring, the electron cloud density of the benzene ring is changed by it, which makes this compound exhibit unique properties in the nucleophilic substitution reaction. The nucleophilic reagent easily attacks the check point on the benzene ring affected by the chlorine atom and the sulfonyl chloride group, and undergoes a substitution reaction to generate a variety of derivatives.
Furthermore, the presence of methyl groups in this compound also affects its physical properties and chemical properties. Methyl is the power supply group, which can slightly change the electron cloud distribution of the benzene ring, thereby affecting its reactivity and selectivity. In many organic synthesis reactions, 3-chloro-4-methylbenzene-1-sulfonyl chloride is often used as a key intermediate. With cleverly designed reaction paths, it can be converted into various organic compounds with important uses, which have extraordinary applications in medicine, pesticides, materials and other fields. However, due to its lively and irritating nature, it is necessary to be cautious and strictly follow the procedures when operating to prevent accidents.
What are the preparation methods of 3-chloro-4-methylbenzene-1-sulfonyl Chloride?
There are several ways to prepare 3-chloro-4-methylbenzene-1-sulfonyl chloride. First, it can be obtained by reacting 3-chloro-4-methylbenzenesulfonic acid with a chlorination reagent. Phosphorus pentachloride, thionyl chloride, etc. are often used as chlorination reagents. If phosphorus pentachloride is used, it interacts with 3-chloro-4-methylbenzenesulfonic acid at a suitable temperature and reaction environment, and the hydroxyl group on the sulfonic acid group can be replaced by a chlorine atom, thereby generating 3-chloro-4-methylbenzene-1-sulfonyl chloride. In this reaction, the ratio of phosphorus pentachloride to sulfonic acid needs to be properly prepared, and the reaction temperature should also be precisely controlled. Generally, it starts at low temperature and gradually heats up to promote the complete reaction.
When thionyl chloride is used as a chlorination agent, it reacts with 3-chloro-4-methylbenzenesulfonic acid, and at the same time generates sulfur dioxide and hydrogen chloride gas to escape. This reaction is relatively mild, and the by-products generated are easy to separate. During the reaction, an appropriate amount of catalyst, such as N, N-dimethylformamide (DMF), can be added to speed up the reaction rate. After the reaction is completed, pure 3-chloro-4-methylbenzene-1-sulfonyl chloride can be obtained by distillation, extraction and other means.
Another way is to start from 3-chloro-4-methyltoluene, first introduce the sulfonic acid group through a sulfonation reaction, and then chlorinate. During sulfonation, concentrated sulfuric acid or fuming sulfuric acid is commonly used as a sulfonating agent, and 3-chloro-4-methyltoluene is reacted with it at a specific temperature to produce 3-chloro-4-methylbenzenesulfonic acid. The next steps are similar to the chlorination process with 3-chloro-4-methylbenzenesulfonic acid as the starting material. A suitable chlorination agent is selected, and the target product 3-chloro-4-methylbenzene-1-sulfonyl chloride is obtained through corresponding reaction conditions and post-treatment operations.
When thionyl chloride is used as a chlorination agent, it reacts with 3-chloro-4-methylbenzenesulfonic acid, and at the same time generates sulfur dioxide and hydrogen chloride gas to escape. This reaction is relatively mild, and the by-products generated are easy to separate. During the reaction, an appropriate amount of catalyst, such as N, N-dimethylformamide (DMF), can be added to speed up the reaction rate. After the reaction is completed, pure 3-chloro-4-methylbenzene-1-sulfonyl chloride can be obtained by distillation, extraction and other means.
Another way is to start from 3-chloro-4-methyltoluene, first introduce the sulfonic acid group through a sulfonation reaction, and then chlorinate. During sulfonation, concentrated sulfuric acid or fuming sulfuric acid is commonly used as a sulfonating agent, and 3-chloro-4-methyltoluene is reacted with it at a specific temperature to produce 3-chloro-4-methylbenzenesulfonic acid. The next steps are similar to the chlorination process with 3-chloro-4-methylbenzenesulfonic acid as the starting material. A suitable chlorination agent is selected, and the target product 3-chloro-4-methylbenzene-1-sulfonyl chloride is obtained through corresponding reaction conditions and post-treatment operations.
What are the main uses of 3-chloro-4-methylbenzene-1-sulfonyl Chloride?
3-Chloro-4-methylbenzene-1-sulfonyl chloride is an important chemical reagent in the field of organic synthesis. Its main uses are diverse.
One of them is significant in the field of drug synthesis. The construction of many drug molecules often relies on this reagent to participate in the reaction. For example, key sulfonyl structures can be introduced by substitution reactions with specific nitrogenous and oxygen-containing nucleophiles. This sulfonyl structure has a crucial impact on the pharmacological activity, stability, and solubility of drug molecules. Medicinal chemists can follow the design requirements of the target drug and skillfully use 3-chloro-4-methylbenzene-1-sulfonyl chloride to precisely build a drug molecular skeleton with specific activities, laying the foundation for the development of new drugs.
Second, in the field of materials science, it also shows unique value. It can be used to prepare high-performance polymer materials. For example, by reacting with polymer monomers containing active groups such as hydroxyl groups and amine groups, sulfonyl chloride functional groups can be introduced into the main chain or side chain of the polymer. In this way, the surface properties, electrical properties and thermal stability of the prepared polymer materials can be effectively regulated. Such modified polymer materials have a wide range of application prospects in high-end fields such as electronic devices and aerospace.
Third, it also plays an indispensable role in dye synthesis. As an important intermediate, it participates in the synthesis of a variety of new dye molecules. By condensation reaction with aromatic amines and phenolic compounds of different structures, dyes with rich colors and good dyeing properties can be constructed. The synthesized dyes are not only bright in color, but also have excellent light resistance and washable properties, and are widely used in textile printing and dyeing industries.
In summary, 3-chloro-4-methylbenzene-1-sulfonyl chloride, with its unique chemical activity, plays a pivotal role in many fields such as drugs, materials, and dyes, promoting technological progress and innovation in various fields.
One of them is significant in the field of drug synthesis. The construction of many drug molecules often relies on this reagent to participate in the reaction. For example, key sulfonyl structures can be introduced by substitution reactions with specific nitrogenous and oxygen-containing nucleophiles. This sulfonyl structure has a crucial impact on the pharmacological activity, stability, and solubility of drug molecules. Medicinal chemists can follow the design requirements of the target drug and skillfully use 3-chloro-4-methylbenzene-1-sulfonyl chloride to precisely build a drug molecular skeleton with specific activities, laying the foundation for the development of new drugs.
Second, in the field of materials science, it also shows unique value. It can be used to prepare high-performance polymer materials. For example, by reacting with polymer monomers containing active groups such as hydroxyl groups and amine groups, sulfonyl chloride functional groups can be introduced into the main chain or side chain of the polymer. In this way, the surface properties, electrical properties and thermal stability of the prepared polymer materials can be effectively regulated. Such modified polymer materials have a wide range of application prospects in high-end fields such as electronic devices and aerospace.
Third, it also plays an indispensable role in dye synthesis. As an important intermediate, it participates in the synthesis of a variety of new dye molecules. By condensation reaction with aromatic amines and phenolic compounds of different structures, dyes with rich colors and good dyeing properties can be constructed. The synthesized dyes are not only bright in color, but also have excellent light resistance and washable properties, and are widely used in textile printing and dyeing industries.
In summary, 3-chloro-4-methylbenzene-1-sulfonyl chloride, with its unique chemical activity, plays a pivotal role in many fields such as drugs, materials, and dyes, promoting technological progress and innovation in various fields.
What are the precautions for 3-chloro-4-methylbenzene-1-sulfonyl Chloride during storage and transportation?
3-Chloro-4-methylbenzene-1-sulfonyl chloride is a chemical substance, and many things need to be paid attention to when storing and transporting.
The first to bear the brunt, the method of storage is crucial. This substance should be stored in a cool, dry and well-ventilated place. Because it is more sensitive to heat, high temperature can easily cause it to decompose or cause dangerous reactions, so keep away from fire and heat sources. Warehouse temperature should be maintained within a specific range, not too high. At the same time, it is necessary to ensure that the storage place is dry, because it is prone to reactions in contact with water, or corrosive substances may be formed, which will cause damage to storage equipment and the surrounding environment. When storing, it needs to be sealed to prevent it from contacting with moisture, oxygen and other components in the air.
Furthermore, packaging requirements cannot be ignored. Packaging materials must have good sealing and corrosion resistance, and containers such as special glass bottles, plastic bottles or metal drums can be selected. The name of the substance, dangerous characteristics and other relevant information should be clearly marked on the outside of the package for identification and handling.
During transportation, there are also many points to pay attention to. Transportation vehicles need to have corresponding safety protection facilities to ensure a smooth transportation process and avoid bumps and vibrations that cause damage to the package. And strictly follow the relevant transportation regulations, and do not mix with substances that are contrary to their properties to prevent chemical reactions. Transport personnel also need to be professionally trained to be familiar with the hazardous characteristics and emergency treatment methods of the substance, and in the event of an unexpected situation, they can be disposed of quickly and properly.
In short, whether it is storage or transportation of 3-chloro-4-methylbenzene-1-sulfonyl chloride, it needs to be treated with rigor, and relevant norms and requirements must be strictly followed to ensure the safety of personnel and the environment are not endangered.
The first to bear the brunt, the method of storage is crucial. This substance should be stored in a cool, dry and well-ventilated place. Because it is more sensitive to heat, high temperature can easily cause it to decompose or cause dangerous reactions, so keep away from fire and heat sources. Warehouse temperature should be maintained within a specific range, not too high. At the same time, it is necessary to ensure that the storage place is dry, because it is prone to reactions in contact with water, or corrosive substances may be formed, which will cause damage to storage equipment and the surrounding environment. When storing, it needs to be sealed to prevent it from contacting with moisture, oxygen and other components in the air.
Furthermore, packaging requirements cannot be ignored. Packaging materials must have good sealing and corrosion resistance, and containers such as special glass bottles, plastic bottles or metal drums can be selected. The name of the substance, dangerous characteristics and other relevant information should be clearly marked on the outside of the package for identification and handling.
During transportation, there are also many points to pay attention to. Transportation vehicles need to have corresponding safety protection facilities to ensure a smooth transportation process and avoid bumps and vibrations that cause damage to the package. And strictly follow the relevant transportation regulations, and do not mix with substances that are contrary to their properties to prevent chemical reactions. Transport personnel also need to be professionally trained to be familiar with the hazardous characteristics and emergency treatment methods of the substance, and in the event of an unexpected situation, they can be disposed of quickly and properly.
In short, whether it is storage or transportation of 3-chloro-4-methylbenzene-1-sulfonyl chloride, it needs to be treated with rigor, and relevant norms and requirements must be strictly followed to ensure the safety of personnel and the environment are not endangered.
3-chloro-4-methylbenzene-1-sulfonyl Chloride affects the environment and the human body
3-Chloro-4-methylbenzene-1-sulfonyl chloride has effects on the environment and the human body.
In terms of the environment, if it is released in nature, it will first cause great harm to the soil. This substance contains elements such as chlorine and sulfur. After entering the soil, it may change the chemical properties of the soil and affect the pH balance of the soil. Soil microorganisms depend on acid-base environments to survive and multiply, and their changes will disrupt the structure and function of microbial communities, which in turn affect the material cycle and energy conversion of soil ecosystems. For example, some microorganisms that play a key role in soil nitrogen transformation have reduced their activity due to soil environmental changes, reducing soil fertility and affecting plant growth.
It is also harmful to water bodies. If it flows into rivers and lakes, it will dissolve in the water and pollute the water quality. Aquatic organisms are extremely sensitive to changes in water quality, and this substance may have toxic effects on them. Like fish, or cause damage to their gill tissues, affecting respiratory function; on plankton, or inhibit their photosynthesis and growth and reproduction, destroy the food chain structure of aquatic ecosystems, and cause ecological imbalance.
In terms of the human body, it is irritating. If the skin is inadvertently touched, it will strongly irritate the skin, causing skin redness, swelling, pain, and even allergic reactions. If the concentration is high, it may cause skin burns, ulceration, damage the skin barrier function, and make other harmful substances more likely to invade the human body.
If inhaled its volatile gaseous substances, it will irritate the respiratory tract. Light cause cough, asthma, breathing difficulties and other symptoms, severe or cause serious damage to respiratory mucosa, increase the risk of respiratory infection, long-term exposure may even induce respiratory system diseases, such as chronic obstructive pulmonary disease.
And this substance can harm the digestive system after oral ingestion. Can corrode the mouth, throat, gastrointestinal mucosa, cause nausea, vomiting, abdominal pain, diarrhea and other symptoms, seriously damage the normal function of the digestive system, affect the body's absorption and utilization of nutrients.
In terms of the environment, if it is released in nature, it will first cause great harm to the soil. This substance contains elements such as chlorine and sulfur. After entering the soil, it may change the chemical properties of the soil and affect the pH balance of the soil. Soil microorganisms depend on acid-base environments to survive and multiply, and their changes will disrupt the structure and function of microbial communities, which in turn affect the material cycle and energy conversion of soil ecosystems. For example, some microorganisms that play a key role in soil nitrogen transformation have reduced their activity due to soil environmental changes, reducing soil fertility and affecting plant growth.
It is also harmful to water bodies. If it flows into rivers and lakes, it will dissolve in the water and pollute the water quality. Aquatic organisms are extremely sensitive to changes in water quality, and this substance may have toxic effects on them. Like fish, or cause damage to their gill tissues, affecting respiratory function; on plankton, or inhibit their photosynthesis and growth and reproduction, destroy the food chain structure of aquatic ecosystems, and cause ecological imbalance.
In terms of the human body, it is irritating. If the skin is inadvertently touched, it will strongly irritate the skin, causing skin redness, swelling, pain, and even allergic reactions. If the concentration is high, it may cause skin burns, ulceration, damage the skin barrier function, and make other harmful substances more likely to invade the human body.
If inhaled its volatile gaseous substances, it will irritate the respiratory tract. Light cause cough, asthma, breathing difficulties and other symptoms, severe or cause serious damage to respiratory mucosa, increase the risk of respiratory infection, long-term exposure may even induce respiratory system diseases, such as chronic obstructive pulmonary disease.
And this substance can harm the digestive system after oral ingestion. Can corrode the mouth, throat, gastrointestinal mucosa, cause nausea, vomiting, abdominal pain, diarrhea and other symptoms, seriously damage the normal function of the digestive system, affect the body's absorption and utilization of nutrients.
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