Linshang Chemical
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3-Chloro-4-Methylbenzenesulphonyl Chloride
Linshang Chemical
|
HS Code |
805177 |
| Chemical Formula | C7H6Cl2O2S |
| Molar Mass | 225.09 g/mol |
| Appearance | Solid (usually white or off - white) |
| Physical State At Room Temp | Solid |
| Odor | Pungent, irritating odor |
| Solubility In Water | Reacts with water |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, toluene |
| Boiling Point | Decomposes before boiling |
| Melting Point | 38 - 40 °C |
| Density | 1.489 g/cm³ (approximate, depending on purity) |
As an accredited 3-Chloro-4-Methylbenzenesulphonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 3 - chloro - 4 - methylbenzenesulphonyl chloride packaged in a sealed glass bottle. |
| Storage | 3 - Chloro - 4 - methylbenzenesulphonyl chloride should be stored in a cool, dry, and well - ventilated area. It must be kept away from heat, flames, and incompatible substances like strong oxidizers, bases, and moisture. Store it in a tightly sealed container, preferably made of corrosion - resistant material, to prevent leakage and degradation. |
| Shipping | 3 - Chloro - 4 - methylbenzenesulphonyl chloride is a hazardous chemical. Shipping must comply with strict regulations. It should be packaged in appropriate corrosion - resistant containers, clearly labeled, and transported by approved carriers following safety protocols. |
Competitive 3-Chloro-4-Methylbenzenesulphonyl Chloride prices that fit your budget—flexible terms and customized quotes for every order.
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What is the chemistry of 3-chloro-4-methylbenzenesulphonyl Chloride?
3-Chloro-4-methylbenzenesulfonyl chloride is an organic compound with unique chemical properties. It is active and has a wide range of uses in the field of organic synthesis.
First of all, in terms of its nucleophilic substitution reaction, the sulfonyl chloride group (-SO ² Cl) is extremely active. Chlorine atoms can be easily replaced by various nucleophilic reagents, such as alcohols, amines, mercaptans, etc. Taking the reaction with alcohols as an example, under suitable alkali-catalyzed conditions, corresponding sulfonates can be formed. During this reaction, the base first interacts with alcohols to form alcohol negative ions, which have strong nucleophilic properties and attack the sulfur atoms of sulfonyl chloride. Then the chlorine negative ions leave to form sulfonates. This reaction is often used in the preparation of organic compounds with specific functions and drug synthesis. Sulfonate groups can be introduced to endow the compounds with specific solubility, stability and biological activity.
Secondly, when 3-chloro-4-methylbenzenesulfonyl chloride reacts with amines, sulfonamides can be formed. This reaction is of great significance in the field of drug development and materials science. The generated sulfonamides have stable structures and some have good biological activities, which are widely used in the preparation of antibacterial, anti-inflammatory and other drugs. Moreover, due to the diverse structures of amines, sulfonamide derivatives with rich structures can be synthesized by selecting different amine compounds, providing a broad space for screening active compounds.
Furthermore, the hydrolysis reaction is also worthy of attention. In the presence of water and alkali, 3-chloro-4-methylbenzenesulfonyl chloride will hydrolyze, and the sulfonyl chloride group will be converted into a sulfonic acid group (-SO 🥰 H). This reaction is commonly used in the preparation of benzenesulfonic acid compounds, which play an important role in certain catalytic reactions and the preparation of surfactants. During the hydrolysis process, the alkali accelerates the reaction, first interacts with the sulfonyl chloride, and then converts into a series of intermediates, eventually generating benzenesulfonate, which is then acidified to obtain the corresponding benzenesulfonic acid.
In addition, methyl and chlorine atoms in the 3-chloro-4-methylbenzenesulfonyl chloride molecule also affect its reactivity and properties. Methyl is an electron-supplying group, which can increase the electron cloud density of the benzene ring and change the electrophilic substitution reactivity on the benzene ring. The chlorine atom has both electron-absorbing induction and electron-supplying conjugation effects, which comprehensively affect the reactivity of the benzene ring and the sulfonyl chloride group. In some reactions, chlorine atoms may also participate in further substitution or elimination reactions, providing more possible paths for organic synthesis.
First of all, in terms of its nucleophilic substitution reaction, the sulfonyl chloride group (-SO ² Cl) is extremely active. Chlorine atoms can be easily replaced by various nucleophilic reagents, such as alcohols, amines, mercaptans, etc. Taking the reaction with alcohols as an example, under suitable alkali-catalyzed conditions, corresponding sulfonates can be formed. During this reaction, the base first interacts with alcohols to form alcohol negative ions, which have strong nucleophilic properties and attack the sulfur atoms of sulfonyl chloride. Then the chlorine negative ions leave to form sulfonates. This reaction is often used in the preparation of organic compounds with specific functions and drug synthesis. Sulfonate groups can be introduced to endow the compounds with specific solubility, stability and biological activity.
Secondly, when 3-chloro-4-methylbenzenesulfonyl chloride reacts with amines, sulfonamides can be formed. This reaction is of great significance in the field of drug development and materials science. The generated sulfonamides have stable structures and some have good biological activities, which are widely used in the preparation of antibacterial, anti-inflammatory and other drugs. Moreover, due to the diverse structures of amines, sulfonamide derivatives with rich structures can be synthesized by selecting different amine compounds, providing a broad space for screening active compounds.
Furthermore, the hydrolysis reaction is also worthy of attention. In the presence of water and alkali, 3-chloro-4-methylbenzenesulfonyl chloride will hydrolyze, and the sulfonyl chloride group will be converted into a sulfonic acid group (-SO 🥰 H). This reaction is commonly used in the preparation of benzenesulfonic acid compounds, which play an important role in certain catalytic reactions and the preparation of surfactants. During the hydrolysis process, the alkali accelerates the reaction, first interacts with the sulfonyl chloride, and then converts into a series of intermediates, eventually generating benzenesulfonate, which is then acidified to obtain the corresponding benzenesulfonic acid.
In addition, methyl and chlorine atoms in the 3-chloro-4-methylbenzenesulfonyl chloride molecule also affect its reactivity and properties. Methyl is an electron-supplying group, which can increase the electron cloud density of the benzene ring and change the electrophilic substitution reactivity on the benzene ring. The chlorine atom has both electron-absorbing induction and electron-supplying conjugation effects, which comprehensively affect the reactivity of the benzene ring and the sulfonyl chloride group. In some reactions, chlorine atoms may also participate in further substitution or elimination reactions, providing more possible paths for organic synthesis.
What are the main uses of 3-chloro-4-methylbenzenesulphonyl Chloride?
3-Chloro-4-methylbenzenesulfonyl chloride has a wide range of uses and is useful in many fields.
First, it is often used as a key intermediate in the field of pharmaceutical synthesis. In order to create specific pharmaceutical ingredients, with its unique chemical structure, it can react delicately with other compounds to build a complex molecular structure with specific pharmacological activities. For example, when synthesizing some antibacterial drugs, it can participate in the reaction, introduce specific functional groups, endow the drug with precise antibacterial efficacy, and add to the human body's resistance to the invasion of pathogens.
Second, it also plays an important role in the preparation of pesticides. It can be used as a raw material for the synthesis of high-efficiency pesticides, and through a series of chemical transformations, pesticide products with specific killing effects on crop pests can be prepared. These pesticides can effectively protect crops from pests, ensure a good harvest of crops, and ensure a stable food supply, which is of great significance to agricultural production.
Third, in the field of materials science, 3-chloro-4-methylbenzenesulfonyl chloride also shows unique value. For example, in the synthesis of special polymer materials, it can be used as a modifier to optimize the properties of polymer materials. For example, by improving the heat resistance and corrosion resistance of materials, the materials can be used stably in harsher environments, expanding the application range of materials, whether it is aerospace, automotive industry, or electronic equipment manufacturing and other high-end fields, all benefit from it.
First, it is often used as a key intermediate in the field of pharmaceutical synthesis. In order to create specific pharmaceutical ingredients, with its unique chemical structure, it can react delicately with other compounds to build a complex molecular structure with specific pharmacological activities. For example, when synthesizing some antibacterial drugs, it can participate in the reaction, introduce specific functional groups, endow the drug with precise antibacterial efficacy, and add to the human body's resistance to the invasion of pathogens.
Second, it also plays an important role in the preparation of pesticides. It can be used as a raw material for the synthesis of high-efficiency pesticides, and through a series of chemical transformations, pesticide products with specific killing effects on crop pests can be prepared. These pesticides can effectively protect crops from pests, ensure a good harvest of crops, and ensure a stable food supply, which is of great significance to agricultural production.
Third, in the field of materials science, 3-chloro-4-methylbenzenesulfonyl chloride also shows unique value. For example, in the synthesis of special polymer materials, it can be used as a modifier to optimize the properties of polymer materials. For example, by improving the heat resistance and corrosion resistance of materials, the materials can be used stably in harsher environments, expanding the application range of materials, whether it is aerospace, automotive industry, or electronic equipment manufacturing and other high-end fields, all benefit from it.
What are the synthesis methods of 3-chloro-4-methylbenzenesulphonyl Chloride?
There are several common methods for preparing 3-chloro-4-methylbenzenesulfonyl chloride.
First, 3-chloro-4-methylbenzene is used as the starting material. Shilling 3-chloro-4-methylbenzene and fuming sulfuric acid are co-located at a specific temperature and reaction time to perform a sulfonation reaction. In this process, the sulfo group of sulfuric acid (-SO 🥰 H) replaces the hydrogen atom on the benzene ring to obtain 3-chloro-4-methylbenzenesulfonic acid. After the reaction is completed, the product is properly processed to remove impurities. Then sulfoxide chloride is used to react with it, and heating prompts the reaction between the two. The chlorine atom of thionyl chloride replaces the hydroxyl group of the sulfonic acid group to obtain 3-chloro-4-methylbenzenesulfonyl chloride. This reaction requires attention to the precise control of the reaction conditions. If the temperature is too high or too low, the yield and purity of the reaction may be affected.
Second, 4-methyl-3-nitrobenzenesulfonyl chloride can be started. First, 4-methyl-3-nitrobenzenesulfonyl chloride is reduced to an amino group with a suitable reducing agent, such as a mixed system of iron and hydrochloric acid, or a catalytic hydrogenation method, to obtain 4-methyl-3-aminobenzenesulfonyl chloride. Then, it is reacted with sodium nitrite and hydrochloric acid at low temperature to perform diazotization reaction to form a diazonium salt. Then the diazonium salt is reacted with cuprous chloride and hydrochloric acid, and the diazonium group is replaced by a chlorine atom, and the final product is 3-chloro-4-methylbenzenesulfonyl chloride. This route step is slightly complicated, but if the reaction conditions of each step are appropriate, a product with high purity can also be obtained.
Or there are other methods, such as directly halogenating the benzene ring of 4-methylbenzenesulfonyl chloride with a suitable halogenation reagent, selectively introducing chlorine atoms at specific positions, and it is also expected to obtain 3-chloro-4-methylbenzenesul However, this process requires strict selectivity of halogenated reagents, and the reaction conditions need to be carefully adjusted to prevent excessive side reactions from affecting product quality and yield.
First, 3-chloro-4-methylbenzene is used as the starting material. Shilling 3-chloro-4-methylbenzene and fuming sulfuric acid are co-located at a specific temperature and reaction time to perform a sulfonation reaction. In this process, the sulfo group of sulfuric acid (-SO 🥰 H) replaces the hydrogen atom on the benzene ring to obtain 3-chloro-4-methylbenzenesulfonic acid. After the reaction is completed, the product is properly processed to remove impurities. Then sulfoxide chloride is used to react with it, and heating prompts the reaction between the two. The chlorine atom of thionyl chloride replaces the hydroxyl group of the sulfonic acid group to obtain 3-chloro-4-methylbenzenesulfonyl chloride. This reaction requires attention to the precise control of the reaction conditions. If the temperature is too high or too low, the yield and purity of the reaction may be affected.
Second, 4-methyl-3-nitrobenzenesulfonyl chloride can be started. First, 4-methyl-3-nitrobenzenesulfonyl chloride is reduced to an amino group with a suitable reducing agent, such as a mixed system of iron and hydrochloric acid, or a catalytic hydrogenation method, to obtain 4-methyl-3-aminobenzenesulfonyl chloride. Then, it is reacted with sodium nitrite and hydrochloric acid at low temperature to perform diazotization reaction to form a diazonium salt. Then the diazonium salt is reacted with cuprous chloride and hydrochloric acid, and the diazonium group is replaced by a chlorine atom, and the final product is 3-chloro-4-methylbenzenesulfonyl chloride. This route step is slightly complicated, but if the reaction conditions of each step are appropriate, a product with high purity can also be obtained.
Or there are other methods, such as directly halogenating the benzene ring of 4-methylbenzenesulfonyl chloride with a suitable halogenation reagent, selectively introducing chlorine atoms at specific positions, and it is also expected to obtain 3-chloro-4-methylbenzenesul However, this process requires strict selectivity of halogenated reagents, and the reaction conditions need to be carefully adjusted to prevent excessive side reactions from affecting product quality and yield.
What are the precautions for 3-chloro-4-methylbenzenesulphonyl Chloride during storage and transportation?
3-Chloro-4-methylbenzenesulfonyl chloride is a chemical substance. When storing and transporting, the following things should be paid attention to:
First, storage is essential. This substance should be stored in a cool, dry and well-ventilated place. Because the substance is sensitive to heat, high temperature can easily cause it to decompose or cause other chemical reactions, so it is necessary to avoid open flames and hot topics. It should be stored in a sealed container to prevent it from being hydrolyzed by moisture in contact with air, because water can cause hydrolysis of benzenesulfonyl chloride compounds, which affects its quality and stability. In addition, it needs to be stored separately from oxidants and bases to avoid mixed storage, because these substances come into contact with it or react violently, endangering safety.
Second, the rules of transportation. When transporting, it is necessary to ensure that the container is complete and sealed to prevent leakage. During the transportation of the substance, it is necessary to choose the appropriate means of transportation and packaging according to its dangerous characteristics, follow the relevant transportation regulations and standards, and choose the appropriate means of transportation and packaging. Transportation personnel should also have professional knowledge and be familiar with the dangerous characteristics of the substance and emergency treatment methods. During transportation, pay close attention to environmental conditions such as temperature and humidity to prevent sun exposure and rain. If there is a leak during transportation, effective emergency measures must be taken immediately, such as evacuating personnel, sealing the scene, collecting leaks, etc., to avoid causing greater harm to the environment and personal safety.
Furthermore, be careful in operation. Whether it is handling during storage or loading and unloading before transportation, operators should take strict protective measures, such as wearing appropriate protective gloves, protective glasses and gas masks, to prevent the substance from contacting the skin and respiratory tract and causing damage to the human body. Handle with care during the operation to avoid leakage caused by damage to the container. And the operating environment needs to be well ventilated to discharge harmful gases that may evaporate in time.
First, storage is essential. This substance should be stored in a cool, dry and well-ventilated place. Because the substance is sensitive to heat, high temperature can easily cause it to decompose or cause other chemical reactions, so it is necessary to avoid open flames and hot topics. It should be stored in a sealed container to prevent it from being hydrolyzed by moisture in contact with air, because water can cause hydrolysis of benzenesulfonyl chloride compounds, which affects its quality and stability. In addition, it needs to be stored separately from oxidants and bases to avoid mixed storage, because these substances come into contact with it or react violently, endangering safety.
Second, the rules of transportation. When transporting, it is necessary to ensure that the container is complete and sealed to prevent leakage. During the transportation of the substance, it is necessary to choose the appropriate means of transportation and packaging according to its dangerous characteristics, follow the relevant transportation regulations and standards, and choose the appropriate means of transportation and packaging. Transportation personnel should also have professional knowledge and be familiar with the dangerous characteristics of the substance and emergency treatment methods. During transportation, pay close attention to environmental conditions such as temperature and humidity to prevent sun exposure and rain. If there is a leak during transportation, effective emergency measures must be taken immediately, such as evacuating personnel, sealing the scene, collecting leaks, etc., to avoid causing greater harm to the environment and personal safety.
Furthermore, be careful in operation. Whether it is handling during storage or loading and unloading before transportation, operators should take strict protective measures, such as wearing appropriate protective gloves, protective glasses and gas masks, to prevent the substance from contacting the skin and respiratory tract and causing damage to the human body. Handle with care during the operation to avoid leakage caused by damage to the container. And the operating environment needs to be well ventilated to discharge harmful gases that may evaporate in time.
3-chloro-4-methylbenzenesulphonyl Chloride Effects on the Environment and Human Health
3-Chloro-4-methylbenzenesulfonyl chloride, which has a great impact on the environment and human health.
In terms of the environment, it is quite toxic. If it accidentally enters the water body, aquatic organisms will bear the brunt. Because the aquatic ecosystem is quite fragile, once this compound enters, it may cause the photosynthesis of aquatic plants to be disturbed, stunted or even withered. Aquatic animals are also not immune, or cause their physiological disorders, such as damage to the respiratory and reproductive functions of fish. Over time, the population will decrease sharply, breaking the ecological balance of the water body. If it enters the soil, it will change the physical and chemical properties of the soil, inhibit the activity of soil microorganisms, hinder the material cycle and nutrient transformation in the soil, resulting in a decrease in soil fertility, affecting plant growth, and destroying the stability of terrestrial ecosystems.
It is also very harmful to human health. Contact with the skin can cause serious irritation and burns. At first, the skin is red, swollen, itchy, and then blisters and ulcers appear. If it is not handled properly, it may cause infection and leave scars. If it is accidentally inhaled its volatile gases, it can cause strong irritation to the respiratory tract, which can cause cough, asthma, and breathing difficulties in mild cases. In severe cases, it may cause respiratory mucosal damage, causing lung inflammation. Long-term inhalation may even induce lung diseases, such as lung cancer. If taken incorrectly, it will corrode the digestive tract, causing burns in the mouth, throat, stomach and other parts, causing severe pain, vomiting, diarrhea and other symptoms. In severe cases, it can be life-threatening. Therefore, in the production, use and handling of 3-chloro-4-methylbenzenesulfonyl chloride, strict protective measures must be taken to reduce its harm to the environment and human health.
In terms of the environment, it is quite toxic. If it accidentally enters the water body, aquatic organisms will bear the brunt. Because the aquatic ecosystem is quite fragile, once this compound enters, it may cause the photosynthesis of aquatic plants to be disturbed, stunted or even withered. Aquatic animals are also not immune, or cause their physiological disorders, such as damage to the respiratory and reproductive functions of fish. Over time, the population will decrease sharply, breaking the ecological balance of the water body. If it enters the soil, it will change the physical and chemical properties of the soil, inhibit the activity of soil microorganisms, hinder the material cycle and nutrient transformation in the soil, resulting in a decrease in soil fertility, affecting plant growth, and destroying the stability of terrestrial ecosystems.
It is also very harmful to human health. Contact with the skin can cause serious irritation and burns. At first, the skin is red, swollen, itchy, and then blisters and ulcers appear. If it is not handled properly, it may cause infection and leave scars. If it is accidentally inhaled its volatile gases, it can cause strong irritation to the respiratory tract, which can cause cough, asthma, and breathing difficulties in mild cases. In severe cases, it may cause respiratory mucosal damage, causing lung inflammation. Long-term inhalation may even induce lung diseases, such as lung cancer. If taken incorrectly, it will corrode the digestive tract, causing burns in the mouth, throat, stomach and other parts, causing severe pain, vomiting, diarrhea and other symptoms. In severe cases, it can be life-threatening. Therefore, in the production, use and handling of 3-chloro-4-methylbenzenesulfonyl chloride, strict protective measures must be taken to reduce its harm to the environment and human health.
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