Linshang Chemical
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3-Chloro-4-Methylnitrobenzene
Linshang Chemical
|
HS Code |
268961 |
| Chemical Formula | C7H6ClNO2 |
| Molar Mass | 171.58 g/mol |
| Appearance | Yellow - brown solid |
| Melting Point | 37 - 39 °C |
| Boiling Point | 238 - 240 °C |
| Density | 1.36 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in ethanol, ether, etc. |
| Flash Point | 110 °C |
| Odor | Pungent |
As an accredited 3-Chloro-4-Methylnitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 3 - chloro - 4 - methylnitrobenzene packaged in a sealed, corrosion - resistant bottle. |
| Storage | 3 - Chloro - 4 - methylnitrobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from sources of ignition, heat, and oxidizing agents. Store in tightly - sealed containers to prevent leakage. It is a hazardous chemical, so store it in a dedicated chemical storage facility, separate from incompatible substances, following all safety regulations. |
| Shipping | 3 - Chloro - 4 - methylnitrobenzene is a hazardous chemical. It must be shipped in accordance with strict regulations. Use appropriate packaging to prevent leakage, and label containers clearly for safe and compliant transportation. |
Competitive 3-Chloro-4-Methylnitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
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As a leading 3-Chloro-4-Methylnitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the physical properties of 3-chloro-4-methylnitrobenzene?
3-Chloro-4-methylbenzoylpyridine is a kind of organic compound. Its physical properties are as follows:
Appearance properties are often white to light yellow crystalline powder, which makes it easy to identify and handle in many scenarios.
Melting point is about a specific temperature range, which is of great significance in the purification, identification and stability of substances under different temperature environments. The exact value of melting point is often an important basis for determining the purity and quality of the substance.
In terms of solubility, it shows a certain solubility in organic solvents such as ethanol and chloroform. This property allows it to build a reaction environment with the help of suitable solvents in organic synthesis reactions to promote the progress of the reaction. When dissolved in ethanol, a uniform solution system can be formed, which is conducive to full contact and collision between the reactant molecules, and then promotes the efficient occurrence of chemical reactions. In water, its solubility is relatively limited, which is closely related to the molecular structure of the compound. The polarity distribution in the molecule makes the interaction between it and water molecules weak.
In addition, 3-chloro-4-methylbenzoylpyridine has a certain odor. Although it is not strong and pungent, it is unique. This odor can also be used as one of the clues for the initial identification of the substance. Its density is also a specific value, which is used in practical operations involving the conversion of mass and volume of substances, the separation of mixtures, etc. During storage and transportation, knowing its density can help to rationally plan packaging and storage space to ensure the safety and stability of the substance.
Appearance properties are often white to light yellow crystalline powder, which makes it easy to identify and handle in many scenarios.
Melting point is about a specific temperature range, which is of great significance in the purification, identification and stability of substances under different temperature environments. The exact value of melting point is often an important basis for determining the purity and quality of the substance.
In terms of solubility, it shows a certain solubility in organic solvents such as ethanol and chloroform. This property allows it to build a reaction environment with the help of suitable solvents in organic synthesis reactions to promote the progress of the reaction. When dissolved in ethanol, a uniform solution system can be formed, which is conducive to full contact and collision between the reactant molecules, and then promotes the efficient occurrence of chemical reactions. In water, its solubility is relatively limited, which is closely related to the molecular structure of the compound. The polarity distribution in the molecule makes the interaction between it and water molecules weak.
In addition, 3-chloro-4-methylbenzoylpyridine has a certain odor. Although it is not strong and pungent, it is unique. This odor can also be used as one of the clues for the initial identification of the substance. Its density is also a specific value, which is used in practical operations involving the conversion of mass and volume of substances, the separation of mixtures, etc. During storage and transportation, knowing its density can help to rationally plan packaging and storage space to ensure the safety and stability of the substance.
What are the chemical properties of 3-chloro-4-methylnitrobenzene?
3-Bromo-4-methylbenzoylnaphthalene is one of the organic compounds. Its chemical properties are unique and related to many chemical reactions and characteristics.
From the perspective of the properties of halogenated aromatics, the bromine atom is at the 3 position, which makes this compound have the typical reaction of halogenated hydrocarbons. Bromine atoms are highly active and easily participate in nucleophilic substitution reactions. When encountering nucleophiles, such as sodium alcohols and amines, bromine atoms can be replaced by nucleophilic groups to form new compounds. This reaction mechanism follows the SN2 or SN1 pathway, depending on the reaction conditions. For example, in polar aprotic solvents, nucleophilic reagents have strong nucleophilicity and use SN2 mechanism. Nucleophilic reagents attack from the back of bromine atoms, expel bromine ions, and form new bonds.
And methyl is connected to the 4-position of the benzene ring, which has an impact on the electron cloud distribution of the benzene ring. Methyl is the power supply radical, and the electron cloud density of the benzene ring increases through the superconjugation effect, especially the ortho and para-position. This makes the benzene ring more prone to electrophilic substitution reactions, which are higher than benzene itself. Common electrophilic substitutions such as nitrification, sulfonation, halogenation and other reactions, and the ortho and para-position of methyl are more susceptible to attack by electrophilic reagents.
< br The carbonyl group in the benzoyl group is polar, and the carbon is positively charged, which is easily attacked by nucleophiles and occurs nucleophilic addition reactions. For example, when reacting with Grignard's reagent, the carbon anion in the Grignard's reagent attacks the carbonyl carbon, and the corresponding alcohol compound can be obtained by hydrolysis. The naphthalene ring part also has aromatic properties and can participate in some specific aromatic reactions.
This compound has complex and rich chemical properties. In the field of organic synthesis, it can use its different activity check points to construct various organic molecules through a series of reactions, laying the foundation for the preparation of new drugs and materials.
From the perspective of the properties of halogenated aromatics, the bromine atom is at the 3 position, which makes this compound have the typical reaction of halogenated hydrocarbons. Bromine atoms are highly active and easily participate in nucleophilic substitution reactions. When encountering nucleophiles, such as sodium alcohols and amines, bromine atoms can be replaced by nucleophilic groups to form new compounds. This reaction mechanism follows the SN2 or SN1 pathway, depending on the reaction conditions. For example, in polar aprotic solvents, nucleophilic reagents have strong nucleophilicity and use SN2 mechanism. Nucleophilic reagents attack from the back of bromine atoms, expel bromine ions, and form new bonds.
And methyl is connected to the 4-position of the benzene ring, which has an impact on the electron cloud distribution of the benzene ring. Methyl is the power supply radical, and the electron cloud density of the benzene ring increases through the superconjugation effect, especially the ortho and para-position. This makes the benzene ring more prone to electrophilic substitution reactions, which are higher than benzene itself. Common electrophilic substitutions such as nitrification, sulfonation, halogenation and other reactions, and the ortho and para-position of methyl are more susceptible to attack by electrophilic reagents.
< br The carbonyl group in the benzoyl group is polar, and the carbon is positively charged, which is easily attacked by nucleophiles and occurs nucleophilic addition reactions. For example, when reacting with Grignard's reagent, the carbon anion in the Grignard's reagent attacks the carbonyl carbon, and the corresponding alcohol compound can be obtained by hydrolysis. The naphthalene ring part also has aromatic properties and can participate in some specific aromatic reactions.
This compound has complex and rich chemical properties. In the field of organic synthesis, it can use its different activity check points to construct various organic molecules through a series of reactions, laying the foundation for the preparation of new drugs and materials.
What are the main uses of 3-chloro-4-methylnitrobenzene?
3-Deuterium-4-methylimidazolidinyl urea, a preservative commonly found in cosmetics and other products. Its main uses are quite extensive, let me tell them one by one.
In the cosmetics industry, its primary use is preservative. Cosmetics are rich in many nutrients. If not properly stored, it is easy to breed microorganisms, causing product deterioration and affecting the use effect and safety. 3-Deuterium-4-methylimidazolidinyl urea can effectively inhibit the growth and reproduction of microorganisms such as bacteria, molds and yeasts, thereby prolonging the shelf life of cosmetics. Whether it is skin care products, such as creams, lotions, or makeup products, such as foundations, eyeshadows, etc., this substance is often added to ensure the stable quality of the product before and after opening, and to prevent problems such as odor, discoloration, and delamination due to microbial contamination.
Furthermore, in the field of personal care products, such as shampoos, body washes, etc., its shadow can also be found. These products also have an environment where microorganisms are easy to breed. Adding 3-deuterium-4-methylimidazolidinyl urea can ensure that the product remains in good condition during the use cycle, providing users with a safe and stable use experience.
However, although it has antiseptic effects, some people may have allergic reactions to it. Therefore, when using products with such ingredients, users should pay attention to their own skin reactions. If there are uncomfortable symptoms such as redness, swelling, itching, etc., they should stop using it immediately and seek professional advice. Therefore, while giving full play to its antiseptic effect, it is also necessary to weigh its possible adverse reactions to some individuals to ensure the safety and applicability of the product.
In the cosmetics industry, its primary use is preservative. Cosmetics are rich in many nutrients. If not properly stored, it is easy to breed microorganisms, causing product deterioration and affecting the use effect and safety. 3-Deuterium-4-methylimidazolidinyl urea can effectively inhibit the growth and reproduction of microorganisms such as bacteria, molds and yeasts, thereby prolonging the shelf life of cosmetics. Whether it is skin care products, such as creams, lotions, or makeup products, such as foundations, eyeshadows, etc., this substance is often added to ensure the stable quality of the product before and after opening, and to prevent problems such as odor, discoloration, and delamination due to microbial contamination.
Furthermore, in the field of personal care products, such as shampoos, body washes, etc., its shadow can also be found. These products also have an environment where microorganisms are easy to breed. Adding 3-deuterium-4-methylimidazolidinyl urea can ensure that the product remains in good condition during the use cycle, providing users with a safe and stable use experience.
However, although it has antiseptic effects, some people may have allergic reactions to it. Therefore, when using products with such ingredients, users should pay attention to their own skin reactions. If there are uncomfortable symptoms such as redness, swelling, itching, etc., they should stop using it immediately and seek professional advice. Therefore, while giving full play to its antiseptic effect, it is also necessary to weigh its possible adverse reactions to some individuals to ensure the safety and applicability of the product.
What are the synthesis methods of 3-chloro-4-methylnitrobenzene?
The synthesis method of 3-bromo-4-methyl benzyl ether is often involved in the field of organic synthesis. The methods vary and are described in detail below.
First, 4-methyl benzyl bromide can be obtained by the bromination reaction of 4-methyl benzyl alcohol and brominated reagents. Common brominated reagents such as the mixture of hydrobromic acid and sulfuric acid, or phosphorus tribromide, etc. 4-methyl benzyl alcohol and brominated reagents can be replaced by bromine atoms under suitable reaction conditions, such as temperature control and stirring, to generate 4-methyl benzyl bromide. Then, 4-methyl benzyl bromide undergoes a nucleophilic substitution reaction with alcohols under the action of bases, which depend on the desired target product 3-bromo-4-methyl benzyl ether. The base can be selected from potassium carbonate, sodium hydroxide, etc. In organic solvents such as N, N-dimethylformamide (DMF) or acetone, the bromine atom of the halogenated hydrocarbon is connected to the oxygen atom of the alcohol, and then the 3-bromo-4-methyl benzyl ether is obtained.
Second, 3-bromo-4-methyl phenol can be protected first to prevent the phenolic hydroxyl group from being affected in the reaction. Phenol hydroxyl groups are often protected by silanizing reagents such as tert-butyl dimethylchlorosilane (TBDMSCl) to form corresponding silicon ether derivatives. After that, halogenated methane such as iodomethane reacts with the protected phenol derivatives under alkali catalysis to form methylation products. The base can be reacted in an anhydrous environment with sodium hydride, etc. Finally, a suitable reagent is selected to remove the silyl protecting group, such as tetrabutylammonium fluoride (TBAF), to obtain 3-bromo-4-methylbenzyl ether.
Third, the coupling reaction catalyzed by palladium can also be done. If 3-bromo-4-methyl halobenzene and alcohol derivatives are used as raw materials, the halogen atoms of halobenzene can be chlorine, bromine, iodine, etc. In the presence of palladium catalysts such as tetra (triphenylphosphine) palladium (Pd (PPh)) and ligands, the coupling reaction occurs under the action of bases. Ligands such as 2-dicyclohexylphosphine-2 ', 6' -dimethoxybiphenyl (SPhos), etc., and bases such as cesium carbonate react in suitable organic solvents to generate 3-bromo-4-methylbenzyl ether.
All synthetic methods have their own advantages and disadvantages, and the actual application needs to be weighed according to factors such as the availability of raw materials, the difficulty of reaction conditions, yield and purity requirements.
First, 4-methyl benzyl bromide can be obtained by the bromination reaction of 4-methyl benzyl alcohol and brominated reagents. Common brominated reagents such as the mixture of hydrobromic acid and sulfuric acid, or phosphorus tribromide, etc. 4-methyl benzyl alcohol and brominated reagents can be replaced by bromine atoms under suitable reaction conditions, such as temperature control and stirring, to generate 4-methyl benzyl bromide. Then, 4-methyl benzyl bromide undergoes a nucleophilic substitution reaction with alcohols under the action of bases, which depend on the desired target product 3-bromo-4-methyl benzyl ether. The base can be selected from potassium carbonate, sodium hydroxide, etc. In organic solvents such as N, N-dimethylformamide (DMF) or acetone, the bromine atom of the halogenated hydrocarbon is connected to the oxygen atom of the alcohol, and then the 3-bromo-4-methyl benzyl ether is obtained.
Second, 3-bromo-4-methyl phenol can be protected first to prevent the phenolic hydroxyl group from being affected in the reaction. Phenol hydroxyl groups are often protected by silanizing reagents such as tert-butyl dimethylchlorosilane (TBDMSCl) to form corresponding silicon ether derivatives. After that, halogenated methane such as iodomethane reacts with the protected phenol derivatives under alkali catalysis to form methylation products. The base can be reacted in an anhydrous environment with sodium hydride, etc. Finally, a suitable reagent is selected to remove the silyl protecting group, such as tetrabutylammonium fluoride (TBAF), to obtain 3-bromo-4-methylbenzyl ether.
Third, the coupling reaction catalyzed by palladium can also be done. If 3-bromo-4-methyl halobenzene and alcohol derivatives are used as raw materials, the halogen atoms of halobenzene can be chlorine, bromine, iodine, etc. In the presence of palladium catalysts such as tetra (triphenylphosphine) palladium (Pd (PPh)) and ligands, the coupling reaction occurs under the action of bases. Ligands such as 2-dicyclohexylphosphine-2 ', 6' -dimethoxybiphenyl (SPhos), etc., and bases such as cesium carbonate react in suitable organic solvents to generate 3-bromo-4-methylbenzyl ether.
All synthetic methods have their own advantages and disadvantages, and the actual application needs to be weighed according to factors such as the availability of raw materials, the difficulty of reaction conditions, yield and purity requirements.
What are the precautions for storing and transporting 3-chloro-4-methylnitrobenzene?
3-Bromo-4-methylbenzoylnaphthalene, this is an organic compound. During storage and transportation, many key matters need to be paid attention to.
First, when storing, it should be dry, cool and well ventilated. Because of its many chemical activities, humid environments may cause reactions such as hydrolysis, which affect the quality; if the temperature is too high, it is easy to accelerate its chemical reaction rate and even cause danger. Therefore, maintaining appropriate temperature and humidity is the key to ensuring its stability.
Second, it must be stored separately from oxidants, acids, bases, etc. This compound is chemically active, and contact with the above substances is likely to trigger violent chemical reactions, or cause serious consequences such as combustion and explosion. In the layout of the warehouse, strict zoning is required to avoid mixed storage.
Third, during transportation, ensure that the packaging is complete and the loading is safe. If the packaging is damaged, the substance or leakage will not only pollute the environment, but also endanger the safety of the transporters. Stable loading can prevent the packaging from being damaged due to collisions and bumps during transportation.
Fourth, the transportation vehicle must have good fire and explosion-proof facilities. In view of the possible flammable and explosive characteristics of the compound, if the transportation vehicle does not have corresponding safety facilities, once an accident occurs, the consequences will be unimaginable.
Fifth, whether it is storage or transportation, the relevant personnel must undergo professional training and be familiar with the properties, hazards and emergency treatment methods of the compound. Only in this way can we respond quickly and correctly in the face of emergencies, minimizing losses and hazards.
First, when storing, it should be dry, cool and well ventilated. Because of its many chemical activities, humid environments may cause reactions such as hydrolysis, which affect the quality; if the temperature is too high, it is easy to accelerate its chemical reaction rate and even cause danger. Therefore, maintaining appropriate temperature and humidity is the key to ensuring its stability.
Second, it must be stored separately from oxidants, acids, bases, etc. This compound is chemically active, and contact with the above substances is likely to trigger violent chemical reactions, or cause serious consequences such as combustion and explosion. In the layout of the warehouse, strict zoning is required to avoid mixed storage.
Third, during transportation, ensure that the packaging is complete and the loading is safe. If the packaging is damaged, the substance or leakage will not only pollute the environment, but also endanger the safety of the transporters. Stable loading can prevent the packaging from being damaged due to collisions and bumps during transportation.
Fourth, the transportation vehicle must have good fire and explosion-proof facilities. In view of the possible flammable and explosive characteristics of the compound, if the transportation vehicle does not have corresponding safety facilities, once an accident occurs, the consequences will be unimaginable.
Fifth, whether it is storage or transportation, the relevant personnel must undergo professional training and be familiar with the properties, hazards and emergency treatment methods of the compound. Only in this way can we respond quickly and correctly in the face of emergencies, minimizing losses and hazards.
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