3-Chloro-4-(Trifluoromethoxy)Isopoxybenzene
Linshang Chemical
HS Code |
448324 |
Chemical Formula | C8H6ClF3O2 |
Molecular Weight | 226.58 |
As an accredited 3-Chloro-4-(Trifluoromethoxy)Isopoxybenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
Packing | 100g of 3 - chloro - 4 - (trifluoromethoxy)isopoxybenzene in sealed chemical - grade containers. |
Storage | 3 - Chloro - 4 - (trifluoromethoxy)isopoxybenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly - sealed container, preferably made of corrosion - resistant materials, to prevent leakage and exposure to air or moisture, which could potentially cause decomposition or reactivity issues. |
Shipping | 3 - chloro - 4 - (trifluoromethoxy)isopoxybenzene is shipped in accordance with chemical transport regulations. It's carefully packaged in suitable containers to prevent leakage during transit to ensure safety. |
Competitive 3-Chloro-4-(Trifluoromethoxy)Isopoxybenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com


As a leading 3-Chloro-4-(Trifluoromethoxy)Isopoxybenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
In the field of medicinal chemistry, it is often a key intermediate. Due to its unique chemical structure, it can be cleverly combined with other compounds through specific chemical reactions to construct molecules with specific pharmacological activities. Through organic synthesis, its structure can be carefully modified to develop new drugs or optimize the efficacy and safety of existing drugs. For example, in the development of antibacterial drugs, it can be used as a starting material to generate compounds with strong inhibitory effects on specific pathogens through a series of reactions.
In the field of materials science, it also has a role that cannot be ignored. Due to its fluorine-containing groups, the material is endowed with unique physical and chemical properties. For example, it can be introduced into the structure of polymer materials, so that the material has excellent weather resistance, low surface energy and chemical stability. In this way, the material can be used in high-end coatings, special plastics, etc., and used in aerospace, automobile manufacturing and other industries that require strict material properties. If the outer coating of the aircraft contains such materials, it can resist harsh environmental erosion and prolong the service life of the aircraft.
In the field of agricultural chemistry, it has also made a name for itself. Based on this, it may be able to synthesize new pesticides, such as insecticides, fungicides, etc. Such pesticides may have the characteristics of high efficiency, low toxicity, and environmental friendliness. They can precisely act on harmful organisms, ensure a good harvest of crops, and have little impact on the ecological environment.
In summary, 3-chloro-4- (trifluoromethoxy) isoepoxy benzene has shown broad application prospects in many fields such as medicine, materials, and agriculture due to its unique structure, which is of great significance for promoting technological innovation and development in related fields.
Smell it, this substance has a unique smell. Although it is not pungent and intolerable, it also has a certain degree of recognition. It is like a mixture of slight ether breath and halogenated hydrocarbons, lingering in the nose and lasting for a long time.
As for the melting point, its melting point is about -10 ° C. If the external temperature drops to this, this substance may gradually change from liquid to solid state, just like water forming ice, and its shape changes. The boiling point is in the range of 180-190 ° C. When heated to this temperature range, the liquid boils and turns into a gaseous rising, like the dissipation of clouds and mists.
In terms of density, it is about 1.3-1.4 g/cm ³, which is heavier than water. If it is placed in the same place as water, it will sink to the bottom of the water, just like a stone abyss pool. Its solubility is soluble in common organic solvents such as ethanol, acetone, toluene, etc., just like the melting of salt in water, which is seamless; however, in water, the solubility is very small, and the two meet, distinct and difficult to blend.
In addition, its vapor pressure is relatively low, and under normal temperature and pressure, the volatilization rate is relatively slow, such as a long flow of water, which quickly dissipates in the air like a non-hurricane. And the stability of the substance is acceptable. Under normal conditions, it does not easily react with surrounding substances. When it encounters special substances such as strong oxidants and strong bases, it may undergo biochemical changes, resulting in changes in structure and properties.
In terms of its stability, due to the presence of chlorine atoms and trifluoromethoxy groups in the molecule, both of which contribute to the stability of the molecular structure. Chlorine atoms can affect the electron cloud distribution of molecules to a certain extent by virtue of their own electronegativity, which stabilizes the molecular structure. And trifluoromethoxy, because it contains fluorine atoms, fluorine atoms are highly electronegative, and C-F bond energy is quite large, so it can significantly enhance the stability of molecules.
In terms of reactivity, the chlorine atom is a good leaving group. Under appropriate reaction conditions, such as in nucleophilic substitution reactions, the chlorine atom is easily replaced by nucleophilic reagents. This is because the carbon positive ions formed after the chlorine atom leaves have a certain stability under the action of the conjugation effect of the molecular structure, which makes the nucleophilic substitution reaction easier to occur.
As for the trifluoromethoxy group, its strong electron absorption can reduce the electron cloud density on the benzene ring. As a result, the reactivity of the benzene ring to the electrophilic reagent will be weakened. However, from another perspective, this also makes the hydrogen atoms at the ortho and para-sites of the benzene ring more acidic. In case of strong bases and other reagents, these hydrogen atoms may undergo deprotonation reactions, which may lead to subsequent reactions.
In terms of solubility, since the compound contains a polar trifluoromethoxy group, and the benzene ring part has a certain degree of non-polar, it should exhibit moderate solubility in some polar and non-polar organic solvents. In polar organic solvents such as acetone and acetonitrile, the trifluoromethoxy group can form a certain interaction with the solvent molecule to promote dissolution; in non-polar organic solvents such as toluene, the benzene ring part can interact with the solvent molecule, so that the compound can also be dissolved to a certain extent.
In summary, the chemical properties of 3-chloro-4- (trifluoromethoxy) isoxy benzene are influenced by the comprehensive effects of various groups in its molecular structure, and they all exhibit unique characteristics in terms of stability, reactivity and solubility.
First take the benzene compound containing hydroxyl group, in a suitable reaction environment, such as in an organic solvent, add suitable alkali substances to convert the phenolic hydroxyl group into phenoxy negative ion, which may be potassium carbonate, etc. Then, introduce halogenated hydrocarbons containing trifluoromethoxy groups, and the halogens in the halogenated hydrocarbons can be chlorine, bromine, etc. The phenoxy negative ion and the halogenated hydrocarbon can be nucleophilic substitution reaction to obtain benzene intermediates containing trifluoromethoxy groups.
On the basis of this intermediate, find another chlorine-containing reagent with suitable reactivity, such as a specific chlorination reagent. With the help of catalysts, such as some metal salt catalysts, the intermediate undergoes a substitution reaction at a suitable temperature and reaction time, introducing chlorine atoms at a specific position in the benzene ring, and then obtaining the target product 3-chloro-4- (trifluoromethoxy) isoxy benzene.
Or there are other methods, starting with the benzene ring with a specific substituent, by gradually modifying the substituent, first introducing the trifluoromethoxy group, and then introducing the chlorine atom, and paying attention to the control of the reaction conditions, such as temperature, pH, reaction time, etc., can also achieve the purpose of preparation. After the reaction, it is necessary to separate and purify the steps, such as column chromatography, recrystallization method, etc., to obtain pure 3-chloro-4 - (trifluoromethoxy) isoxy benzene.
If it is difficult to prepare, if the preparation method is cumbersome, multiple steps are required, and the reaction conditions of each step are harsh, and the requirements for equipment and technology are very high, the cost will increase, and the price will also be high. On the contrary, if the preparation is relatively simple, the cost may be reduced, and the price will follow.
The price of raw materials is also the key. If the raw materials required to synthesize this compound are scarce, it is not easy to collect or produce, and the price is high, the price of the product will not be low. On the contrary, if the raw materials are easy to obtain and cheap, the price of the product may be close to the people.
Market supply and demand situation has a great impact. If the market demand for this product is strong and the supply is limited, the price will rise; if the demand is weak and the supply is excessive, the price will fall.
Furthermore, differences in quality specifications also lead to different prices. Products with high purity and meeting specific standards must be higher than those of ordinary quality.
Due to the intertwined and rapidly changing factors mentioned above, it is difficult to determine the exact price range of 3-chloro-4- (trifluoromethoxy) isoxy benzene in the market. For details, please consult chemical product suppliers, traders, or refer to recent relevant market reports and transaction data to obtain relatively accurate price information.

Scan to WhatsApp