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3-Chloro-4-(Trifluoromethoxy)Nitrobenzene
Linshang Chemical
|
HS Code |
229468 |
| Chemical Formula | C7H3ClF3NO3 |
| Molar Mass | 241.55 g/mol |
| Appearance | Solid (usually) |
| Melting Point | Data may vary, check specific sources |
| Boiling Point | Data may vary, check specific sources |
| Density | Data may vary, check specific sources |
| Solubility In Water | Low solubility |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane |
| Vapor Pressure | Data may vary, check specific sources |
As an accredited 3-Chloro-4-(Trifluoromethoxy)Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 250g of 3 - chloro - 4 - (trifluoromethoxy)nitrobenzene in a sealed chemical - grade bottle. |
| Storage | 3 - Chloro - 4 - (trifluoromethoxy)nitrobenzene should be stored in a cool, dry, well - ventilated area, away from sources of heat, ignition, and incompatible substances. Keep it in a tightly sealed container to prevent leakage and exposure to air and moisture. Store it separately from oxidizing agents, reducing agents, and bases to avoid potential chemical reactions. |
| Shipping | 3 - chloro - 4 - (trifluoromethoxy) nitrobenzene is shipped in well - sealed, corrosion - resistant containers. Special handling precautions are taken due to its chemical nature, and it's transported following strict regulations for hazardous chemicals. |
Competitive 3-Chloro-4-(Trifluoromethoxy)Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
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What are the physical properties of 3-chloro-4- (trifluoromethoxy) nitrobenzene
3-Chloro-4- (trifluoromethoxy) nitrobenzene is one of the organic compounds. Its physical properties are quite important and are related to many chemical applications.
Looking at its appearance, it is usually a light yellow to light brown crystalline powder. The characterization of this color state can help chemists to initially identify it in experimental observations. Its melting point is in a specific range, about [specific melting point value]. The melting point is an important physical constant of the substance. At this temperature, the compound changes from solid state to liquid state. This property can be used for preliminary determination of purity. If impurities are present, the melting point is often offset.
Furthermore, its boiling point is also of critical significance, about [specific boiling point value]. The boiling point reflects the temperature at which a substance changes from liquid to gaseous under a specific pressure, which is very important for the separation and purification of the compound. In the chemical process, the difference in boiling point can be used to achieve effective separation from other substances.
The density of this compound is about [specific density value]. This physical quantity describes the mass of a substance per unit volume, which is of great significance for the measurement and mixing ratio control of materials in chemical production.
In terms of solubility, 3-chloro-4- (trifluoromethoxy) nitrobenzene has different solubility in common organic solvents. In some organic solvents such as toluene and dichloromethane, it has a certain solubility. This property facilitates its participation in various organic reactions, providing a homogeneous environment for the reaction to proceed, which is conducive to the contact and collision between the reactant molecules, and then promotes the occurrence of the reaction. In water, its solubility is very small, and this property also determines its behavior in the aqueous system.
In addition, the vapor pressure of the compound varies at different temperatures, although the value is relatively small. However, under certain conditions, such as high temperature or reduced pressure environment, the influence of vapor pressure cannot be ignored. It is related to the volatile characteristics of the compound and affects its stability during storage and use.
The above physical properties are all factors that must be considered in the study and application of 3-chloro-4- (trifluoromethoxy) nitrobenzene. Chemists and chemical practitioners design experiments and optimize production processes accordingly to give full play to the chemical value of the compound.
Looking at its appearance, it is usually a light yellow to light brown crystalline powder. The characterization of this color state can help chemists to initially identify it in experimental observations. Its melting point is in a specific range, about [specific melting point value]. The melting point is an important physical constant of the substance. At this temperature, the compound changes from solid state to liquid state. This property can be used for preliminary determination of purity. If impurities are present, the melting point is often offset.
Furthermore, its boiling point is also of critical significance, about [specific boiling point value]. The boiling point reflects the temperature at which a substance changes from liquid to gaseous under a specific pressure, which is very important for the separation and purification of the compound. In the chemical process, the difference in boiling point can be used to achieve effective separation from other substances.
The density of this compound is about [specific density value]. This physical quantity describes the mass of a substance per unit volume, which is of great significance for the measurement and mixing ratio control of materials in chemical production.
In terms of solubility, 3-chloro-4- (trifluoromethoxy) nitrobenzene has different solubility in common organic solvents. In some organic solvents such as toluene and dichloromethane, it has a certain solubility. This property facilitates its participation in various organic reactions, providing a homogeneous environment for the reaction to proceed, which is conducive to the contact and collision between the reactant molecules, and then promotes the occurrence of the reaction. In water, its solubility is very small, and this property also determines its behavior in the aqueous system.
In addition, the vapor pressure of the compound varies at different temperatures, although the value is relatively small. However, under certain conditions, such as high temperature or reduced pressure environment, the influence of vapor pressure cannot be ignored. It is related to the volatile characteristics of the compound and affects its stability during storage and use.
The above physical properties are all factors that must be considered in the study and application of 3-chloro-4- (trifluoromethoxy) nitrobenzene. Chemists and chemical practitioners design experiments and optimize production processes accordingly to give full play to the chemical value of the compound.
What are the chemical synthesis methods of 3-chloro-4- (trifluoromethoxy) nitrobenzene
In order to make 3-chloro-4- (trifluoromethoxy) nitrobenzene, there are many methods, and each has its advantages and disadvantages, which must be selected according to the actual situation.
First, 3-chloro-4-hydroxynitrobenzene is reacted with trifluoromethyl halogenation reagents. In this way, 3-chloro-4-hydroxynitrobenzene is more easily obtained and can be prepared by common nitrogenation, halogenation and other reactions. Then, it is reacted with trifluoromethyl halogenation reagents, such as trifluoromethyl sulfonic acid anhydride, trifluoromethyl iodine, etc., in the presence of appropriate solvents and bases. For example, when N, N-dimethylformamide is used as a solvent and potassium carbonate is used as a base, and heated to a suitable temperature, a nucleophilic substitution reaction can occur between the two to obtain the target product. The advantages of this method are that the raw materials are easy to prepare and the reaction conditions are relatively mild. However, the disadvantages are also obvious. Trifluoromethyl halogenation reagents are expensive, and some reagents are highly toxic, unfriendly to the environment, and the post-processing is complicated.
Second, with a benzene derivative containing trifluoromethoxy as the starting material, chlorine atoms are introduced first, and then nitrification is carried out. For example, with trifluoromethoxy benzene as the starting material, under the action of an appropriate catalyst, it reacts with chlorine gas or chlorine-containing reagents to introduce chlorine atoms at a specific position in the benzene ring The key to this process is to precisely control the reaction conditions to ensure that the chlorine atoms and nitro groups are introduced into the check point correctly. The advantage of this method is that the steps are orderly, which is conducive to improving the purity of the product; but the difficulty is that the reaction selectivity is high, the catalyst and reaction conditions need to be carefully screened, and the yield of each step has a great impact on the final result.
Third, the coupling reaction catalyzed by transition metals. For example, the coupling of halogenated nitrobenzene and trifluoromethoxylation reagents occurs in the presence of transition metal catalysts and ligands such as palladium and copper. This method is highly selective and can efficiently construct carbon-oxygen bonds; however, the cost of transition metal catalysts is high, the reaction system is complex, and the reaction equipment and operation requirements are strict, and the synthesis of partial distributors is
In conclusion, there are various methods for synthesizing 3-chloro-4- (trifluoromethoxy) nitrobenzene. In actual operation, it is necessary to comprehensively consider the cost of raw materials, reaction conditions, yield, purity and environmental protection, and weigh the advantages and disadvantages to choose the best method.
First, 3-chloro-4-hydroxynitrobenzene is reacted with trifluoromethyl halogenation reagents. In this way, 3-chloro-4-hydroxynitrobenzene is more easily obtained and can be prepared by common nitrogenation, halogenation and other reactions. Then, it is reacted with trifluoromethyl halogenation reagents, such as trifluoromethyl sulfonic acid anhydride, trifluoromethyl iodine, etc., in the presence of appropriate solvents and bases. For example, when N, N-dimethylformamide is used as a solvent and potassium carbonate is used as a base, and heated to a suitable temperature, a nucleophilic substitution reaction can occur between the two to obtain the target product. The advantages of this method are that the raw materials are easy to prepare and the reaction conditions are relatively mild. However, the disadvantages are also obvious. Trifluoromethyl halogenation reagents are expensive, and some reagents are highly toxic, unfriendly to the environment, and the post-processing is complicated.
Second, with a benzene derivative containing trifluoromethoxy as the starting material, chlorine atoms are introduced first, and then nitrification is carried out. For example, with trifluoromethoxy benzene as the starting material, under the action of an appropriate catalyst, it reacts with chlorine gas or chlorine-containing reagents to introduce chlorine atoms at a specific position in the benzene ring The key to this process is to precisely control the reaction conditions to ensure that the chlorine atoms and nitro groups are introduced into the check point correctly. The advantage of this method is that the steps are orderly, which is conducive to improving the purity of the product; but the difficulty is that the reaction selectivity is high, the catalyst and reaction conditions need to be carefully screened, and the yield of each step has a great impact on the final result.
Third, the coupling reaction catalyzed by transition metals. For example, the coupling of halogenated nitrobenzene and trifluoromethoxylation reagents occurs in the presence of transition metal catalysts and ligands such as palladium and copper. This method is highly selective and can efficiently construct carbon-oxygen bonds; however, the cost of transition metal catalysts is high, the reaction system is complex, and the reaction equipment and operation requirements are strict, and the synthesis of partial distributors is
In conclusion, there are various methods for synthesizing 3-chloro-4- (trifluoromethoxy) nitrobenzene. In actual operation, it is necessary to comprehensively consider the cost of raw materials, reaction conditions, yield, purity and environmental protection, and weigh the advantages and disadvantages to choose the best method.
What is the main use of 3-chloro-4- (trifluoromethoxy) nitrobenzene?
3-Chloro-4- (trifluoromethoxy) nitrobenzene is an important compound in the field of organic synthesis. Its main uses probably have the following ends.
In the synthesis of medicine, this compound is often a key intermediate. Due to its unique structure, the chlorine atom, trifluoromethoxy group and nitro group all give it special chemical activity. Chemists can modify and transform it through delicate chemical reactions. For example, by nucleophilic substitution reaction, chlorine atoms are replaced with other functional groups, and then molecular structures with specific pharmacological activities are constructed to develop new drugs, such as the creation of antibacterial, anti-inflammatory and other drugs, or this compound can be used as a starting material to achieve the synthesis of target molecules through multi-step reactions.
In the process of pesticide creation, 3-chloro-4 - (trifluoromethoxy) nitrobenzene also plays an important role. Its structural characteristics can make the derived pesticides have excellent biological activity and environmental adaptability. Through appropriate reactions, the introduction of specific groups can regulate the mechanism of action of pesticides, enhance their control effect against pests and weeds, and because of their fluorine-containing structure, it often helps to improve the stability and fat solubility of pesticides, making them easier to penetrate biofilms, thereby improving drug efficacy.
Furthermore, in the field of materials science, this compound can also be used. Through a series of reactions, it can be introduced into the structure of polymer materials. Because of its fluorine-containing groups, it can give materials special properties, such as improving the chemical corrosion resistance, heat resistance and surface hydrophobicity of materials. In this way, the application range of materials can be expanded, and they can be found in high-end fields such as aerospace and electronic devices.
In conclusion, 3-chloro-4- (trifluoromethoxy) nitrobenzene has shown broad application prospects in many fields such as medicine, pesticides, and materials science due to its unique chemical structure. It is an indispensable and important compound in organic synthetic chemistry.
In the synthesis of medicine, this compound is often a key intermediate. Due to its unique structure, the chlorine atom, trifluoromethoxy group and nitro group all give it special chemical activity. Chemists can modify and transform it through delicate chemical reactions. For example, by nucleophilic substitution reaction, chlorine atoms are replaced with other functional groups, and then molecular structures with specific pharmacological activities are constructed to develop new drugs, such as the creation of antibacterial, anti-inflammatory and other drugs, or this compound can be used as a starting material to achieve the synthesis of target molecules through multi-step reactions.
In the process of pesticide creation, 3-chloro-4 - (trifluoromethoxy) nitrobenzene also plays an important role. Its structural characteristics can make the derived pesticides have excellent biological activity and environmental adaptability. Through appropriate reactions, the introduction of specific groups can regulate the mechanism of action of pesticides, enhance their control effect against pests and weeds, and because of their fluorine-containing structure, it often helps to improve the stability and fat solubility of pesticides, making them easier to penetrate biofilms, thereby improving drug efficacy.
Furthermore, in the field of materials science, this compound can also be used. Through a series of reactions, it can be introduced into the structure of polymer materials. Because of its fluorine-containing groups, it can give materials special properties, such as improving the chemical corrosion resistance, heat resistance and surface hydrophobicity of materials. In this way, the application range of materials can be expanded, and they can be found in high-end fields such as aerospace and electronic devices.
In conclusion, 3-chloro-4- (trifluoromethoxy) nitrobenzene has shown broad application prospects in many fields such as medicine, pesticides, and materials science due to its unique chemical structure. It is an indispensable and important compound in organic synthetic chemistry.
What are the precautions for 3-chloro-4- (trifluoromethoxy) nitrobenzene during storage and transportation?
3-Chloro-4- (trifluoromethoxy) nitrobenzene is also an organic compound. During storage and transportation, many matters need to be paid attention to.
First words storage, this compound should be placed in a cool, dry and well ventilated place. Because it is more sensitive to heat, heat can easily lead to decomposition and other adverse events, so be sure to keep away from fire and heat sources. The temperature of the warehouse should be strictly controlled, not too high, to prevent accidents. And it needs to be stored separately from oxidants, reducing agents, acids, alkalis and other substances. Because of its chemical properties, it is active, mixed with the above substances, or causes violent chemical reactions, causing danger. At the same time, the storage area should be equipped with suitable materials to contain leaks in case of leakage, which can be properly handled in a timely manner.
As for transportation, it is necessary to ensure that the packaging is complete and sealed before transportation. Packaging materials must have good protective properties, which can effectively resist the influence of external factors on compounds. During transportation, it is necessary to ensure that the container does not leak, collapse, fall, or damage. Transportation vehicles should be equipped with corresponding varieties and quantities of fire fighting equipment and leakage emergency treatment equipment. Driving routes also need to be carefully planned to avoid passing through densely populated areas and environmentally sensitive areas. Escort personnel must be familiar with the nature of the goods transported and emergency treatment measures, and pay close attention to the transportation situation throughout the process. If there is an abnormality, they can respond quickly and properly to ensure the safety of transportation.
First words storage, this compound should be placed in a cool, dry and well ventilated place. Because it is more sensitive to heat, heat can easily lead to decomposition and other adverse events, so be sure to keep away from fire and heat sources. The temperature of the warehouse should be strictly controlled, not too high, to prevent accidents. And it needs to be stored separately from oxidants, reducing agents, acids, alkalis and other substances. Because of its chemical properties, it is active, mixed with the above substances, or causes violent chemical reactions, causing danger. At the same time, the storage area should be equipped with suitable materials to contain leaks in case of leakage, which can be properly handled in a timely manner.
As for transportation, it is necessary to ensure that the packaging is complete and sealed before transportation. Packaging materials must have good protective properties, which can effectively resist the influence of external factors on compounds. During transportation, it is necessary to ensure that the container does not leak, collapse, fall, or damage. Transportation vehicles should be equipped with corresponding varieties and quantities of fire fighting equipment and leakage emergency treatment equipment. Driving routes also need to be carefully planned to avoid passing through densely populated areas and environmentally sensitive areas. Escort personnel must be familiar with the nature of the goods transported and emergency treatment measures, and pay close attention to the transportation situation throughout the process. If there is an abnormality, they can respond quickly and properly to ensure the safety of transportation.
What are the effects of 3-chloro-4- (trifluoromethoxy) nitrobenzene on the environment and human health?
3-Chloro-4- (trifluoromethoxy) nitrobenzene is one of the organic compounds. It has a wide range of uses in the industrial field, but its impact on the environment and human health cannot be ignored.
As far as the environment is concerned, if this compound is released in nature, its chemical properties are relatively stable, and it is not easy to degrade. In the soil, or long-term residue, causing soil quality malignant changes and affecting plant growth. Plant roots ingest soil nutrients containing this substance, or are poisoned by it, causing growth and development to be hindered, resulting in reduced crop production and destruction of ecosystem balance.
In water bodies, it will cause water quality to deteriorate. Aquatic organisms are extremely sensitive to it, or affect their reproduction, growth and survival. Or interfere with the physiological functions of aquatic organisms, causing a decrease in population and destroying the biodiversity of aquatic ecosystems. And through the enrichment of the food chain, it will pose a potential threat to higher organisms.
As for human health, this compound has certain toxicity. Inhaled through the respiratory tract, or through skin contact, accidental ingestion, etc., or harmful to health. In the human body, or interfere with normal physiological and biochemical processes. It contains nitro and halogen atoms, or affect the metabolism of human cells and damage the normal function of cells. Long-term exposure, or increase the risk of cancer, can cause cell gene mutations. It may also affect the nervous system, causing symptoms such as headache, dizziness, fatigue, and even damage the liver, kidneys and other important organs, affecting the body's normal metabolism and detoxification function.
In short, 3-chloro-4- (trifluoromethoxy) nitrobenzene has a latent risk to the environment and human health, and must be treated with caution and strictly controlled during production, use and disposal to reduce its harm to the ecological environment and human health.
As far as the environment is concerned, if this compound is released in nature, its chemical properties are relatively stable, and it is not easy to degrade. In the soil, or long-term residue, causing soil quality malignant changes and affecting plant growth. Plant roots ingest soil nutrients containing this substance, or are poisoned by it, causing growth and development to be hindered, resulting in reduced crop production and destruction of ecosystem balance.
In water bodies, it will cause water quality to deteriorate. Aquatic organisms are extremely sensitive to it, or affect their reproduction, growth and survival. Or interfere with the physiological functions of aquatic organisms, causing a decrease in population and destroying the biodiversity of aquatic ecosystems. And through the enrichment of the food chain, it will pose a potential threat to higher organisms.
As for human health, this compound has certain toxicity. Inhaled through the respiratory tract, or through skin contact, accidental ingestion, etc., or harmful to health. In the human body, or interfere with normal physiological and biochemical processes. It contains nitro and halogen atoms, or affect the metabolism of human cells and damage the normal function of cells. Long-term exposure, or increase the risk of cancer, can cause cell gene mutations. It may also affect the nervous system, causing symptoms such as headache, dizziness, fatigue, and even damage the liver, kidneys and other important organs, affecting the body's normal metabolism and detoxification function.
In short, 3-chloro-4- (trifluoromethoxy) nitrobenzene has a latent risk to the environment and human health, and must be treated with caution and strictly controlled during production, use and disposal to reduce its harm to the ecological environment and human health.
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