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3-Chloro-5-Fluorobenzeneboronic Acid
Linshang Chemical
|
HS Code |
188550 |
| Name | 3-Chloro-5-Fluorobenzeneboronic Acid |
| Chemical Formula | C6H5BClFO2 |
| Molar Mass | 174.37 g/mol |
| Appearance | White to off - white solid |
| Purity | Typically high - purity, e.g., 95%+ |
| Solubility In Water | Slightly soluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, THF |
| Melting Point | 153 - 157 °C |
| Boiling Point | Decomposes before boiling |
| Stability | Air - sensitive, moisture - sensitive |
| Cas Number | 850568 - 36 - 6 |
As an accredited 3-Chloro-5-Fluorobenzeneboronic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 3 - chloro - 5 - fluorobenzeneboronic acid packaged in a sealed plastic bottle. |
| Storage | 3 - Chloro - 5 - fluorobenzeneboronic acid should be stored in a cool, dry place, away from heat sources and direct sunlight. Keep it in a well - sealed container to prevent moisture absorption and contact with air, which could potentially lead to decomposition. Store it separately from incompatible substances like strong oxidizing agents and bases to ensure its stability and safety. |
| Shipping | 3 - chloro - 5 - fluorobenzeneboronic acid is shipped in well - sealed, corrosion - resistant containers. Special care is taken to prevent moisture and physical damage during transit, adhering to strict chemical transportation regulations. |
Competitive 3-Chloro-5-Fluorobenzeneboronic Acid prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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What are the chemical properties of 3-chloro-5-fluorobenzeneboronic Acid?
3-Chloro-5-fluorophenylboronic acid is an important reagent in organic synthesis. It has many unique chemical properties.
From an acidic point of view, due to the presence of boric acid groups (-B (OH) ³), protons can be given under certain conditions, showing weak acidity. This acidity allows it to react with bases to form corresponding borates. For example, when met with a sodium hydroxide solution, the hydrogen of the hydroxyl group in the boric acid group can combine with hydroxyl ions to form water and salts containing boron anions.
In terms of reactivity, boric acid groups can participate in many classical organic reactions. The most typical example is the Suzuki-Miyaura reaction. In this reaction, 3-chloro-5-fluorophenylboronic acid can form new carbon-carbon bonds with halogenated aromatics or alkenes under the action of palladium catalysts and bases. This reaction is widely used in the construction of complex organic molecular structures, and can effectively synthesize various bioactive compounds, pharmaceutical intermediates and functional materials.
Furthermore, the presence of chlorine and fluorine atoms in its molecules also gives the compound unique properties. Chlorine and fluorine are both halogen atoms and have certain electronegativity. Fluorine atoms are particularly electronegative, which can have a significant impact on the distribution of the electron cloud of the molecule, thereby changing the polarity and reactivity of the molecule. In some reactions, chlorine atoms can be replaced by nucleophiles to achieve molecular structure modification and modification.
In addition, the physical properties of 3-chloro-5-fluorophenylboronic acid, such as solubility in common organic solvents, also play a role in its application in organic synthesis operations. Generally speaking, it has a certain solubility in some polar organic solvents such as tetrahydrofuran and dichloromethane. This property facilitates its participation in various chemical reactions in homogeneous reaction systems, providing organic synthesis chemists with convenient conditions, enabling them to design and implement synthetic routes more flexibly to obtain target compounds.
From an acidic point of view, due to the presence of boric acid groups (-B (OH) ³), protons can be given under certain conditions, showing weak acidity. This acidity allows it to react with bases to form corresponding borates. For example, when met with a sodium hydroxide solution, the hydrogen of the hydroxyl group in the boric acid group can combine with hydroxyl ions to form water and salts containing boron anions.
In terms of reactivity, boric acid groups can participate in many classical organic reactions. The most typical example is the Suzuki-Miyaura reaction. In this reaction, 3-chloro-5-fluorophenylboronic acid can form new carbon-carbon bonds with halogenated aromatics or alkenes under the action of palladium catalysts and bases. This reaction is widely used in the construction of complex organic molecular structures, and can effectively synthesize various bioactive compounds, pharmaceutical intermediates and functional materials.
Furthermore, the presence of chlorine and fluorine atoms in its molecules also gives the compound unique properties. Chlorine and fluorine are both halogen atoms and have certain electronegativity. Fluorine atoms are particularly electronegative, which can have a significant impact on the distribution of the electron cloud of the molecule, thereby changing the polarity and reactivity of the molecule. In some reactions, chlorine atoms can be replaced by nucleophiles to achieve molecular structure modification and modification.
In addition, the physical properties of 3-chloro-5-fluorophenylboronic acid, such as solubility in common organic solvents, also play a role in its application in organic synthesis operations. Generally speaking, it has a certain solubility in some polar organic solvents such as tetrahydrofuran and dichloromethane. This property facilitates its participation in various chemical reactions in homogeneous reaction systems, providing organic synthesis chemists with convenient conditions, enabling them to design and implement synthetic routes more flexibly to obtain target compounds.
What are the common uses of 3-chloro-5-fluorobenzeneboronic Acid?
3-Chloro-5-fluorophenylboronic acid is a commonly used reagent in organic synthesis. Its common uses are generally as follows.
First, it is used to construct carbon-carbon bonds. In many coupling reactions, such as Suzuki coupling reaction, this reagent can interact with halogenated aromatics, halogenated olefins and other substrates. In the presence of suitable catalysts (such as palladium catalysts) and bases, coupling occurs to form new carbon-carbon bonds. With this reaction, aromatic compounds with complex structures can be prepared, which are widely used in drug synthesis, materials science and other fields. For example, when synthesizing certain pharmaceutical molecules with specific pharmacological activities, or preparing organic materials with special photoelectric properties, this reaction will be used, and 3-chloro-5-fluorophenylboronic acid plays a key role in this process.
Second, it is used to modify and functionalize organic molecules. Due to the special chemical properties of boron atoms, organic molecules can be modified through a series of chemical reactions. For example, it can react with compounds containing hydroxyl groups, amino groups and other functional groups, introduce specific functional groups, and thereby change the physical and chemical properties of organic molecules. In terms of surface modification of materials, such reactions can impart specific functions to materials, such as improving their hydrophilicity and biocompatibility.
Third, it also has applications in the synthesis of new ligands. Coordinating with metal ions, metal complexes with unique properties can be formed. These complexes exhibit unique properties in catalysis, luminescent materials and other fields. For example, some metal complexes can be used as efficient catalysts for catalyzing specific organic reactions; or as luminescent materials, used in optical display and other fields.
Fourth, it is also very important in the synthesis of heterocyclic compounds. Boron-containing heterocyclic structures can be constructed by reacting with substrates containing heteroatoms. These heterocyclic compounds have potential application value in pharmaceutical chemistry, pesticide chemistry and other fields, or can become precursor compounds for new drugs or pesticides.
First, it is used to construct carbon-carbon bonds. In many coupling reactions, such as Suzuki coupling reaction, this reagent can interact with halogenated aromatics, halogenated olefins and other substrates. In the presence of suitable catalysts (such as palladium catalysts) and bases, coupling occurs to form new carbon-carbon bonds. With this reaction, aromatic compounds with complex structures can be prepared, which are widely used in drug synthesis, materials science and other fields. For example, when synthesizing certain pharmaceutical molecules with specific pharmacological activities, or preparing organic materials with special photoelectric properties, this reaction will be used, and 3-chloro-5-fluorophenylboronic acid plays a key role in this process.
Second, it is used to modify and functionalize organic molecules. Due to the special chemical properties of boron atoms, organic molecules can be modified through a series of chemical reactions. For example, it can react with compounds containing hydroxyl groups, amino groups and other functional groups, introduce specific functional groups, and thereby change the physical and chemical properties of organic molecules. In terms of surface modification of materials, such reactions can impart specific functions to materials, such as improving their hydrophilicity and biocompatibility.
Third, it also has applications in the synthesis of new ligands. Coordinating with metal ions, metal complexes with unique properties can be formed. These complexes exhibit unique properties in catalysis, luminescent materials and other fields. For example, some metal complexes can be used as efficient catalysts for catalyzing specific organic reactions; or as luminescent materials, used in optical display and other fields.
Fourth, it is also very important in the synthesis of heterocyclic compounds. Boron-containing heterocyclic structures can be constructed by reacting with substrates containing heteroatoms. These heterocyclic compounds have potential application value in pharmaceutical chemistry, pesticide chemistry and other fields, or can become precursor compounds for new drugs or pesticides.
What is the synthesis method of 3-chloro-5-fluorobenzeneboronic Acid?
The synthesis of 3-chloro-5-fluorophenylboronic acid is an important issue in the field of organic synthesis. Its synthesis route can be achieved by multiple methods.
First, halogenated aromatic hydrocarbons are often used as starting materials. First take 3-chloro-5-fluorobromobenzene and react it with metal magnesium to form Grignard's reagent. This process needs to be operated in a harsh environment without water and oxygen, because Grignard's reagent is extremely active and easily decomposes in contact with water or oxygen. After the Grignard reagent is made, it is reacted with borate esters, such as trimethyl borate. After the reaction is completed, 3-chloro-5-fluorophenylboronic acid can be obtained through a hydrolysis step. The key to this method lies in the control of the conditions for the preparation of Grignard reagents and the precise operation of subsequent reactions.
Second, the cross-coupling reaction catalyzed by palladium can also be used. The reaction of 3-chloro-5-fluorohalobenzene with boron-containing reagents, such as pinacol borane, is carried out in the presence of a suitable base, such as potassium carbonate, catalyzed by a palladium catalyst, such as tetra (triphenylphosphine) palladium (0). This reaction condition is relatively mild and the selectivity is good. However, the cost of the catalyst is high, which may limit the large-scale production. In the reaction, the palladium catalyst promotes the coupling between the halobenzene and the boron-containing reagent to form a carbon-boron bond, and then the target product is obtained.
Third, 3-chloro-5-fluoroaniline can also be considered as the starting material. First, the amino group is converted into a diazonium salt through the diazotization reaction. Subsequently, the diazonium salt is reacted with the boron-containing reagent to realize the conversion to phenylboronic acid. This path has a little more steps, and attention should be paid to the conditions of the diazotization reaction. Due to its high reactivity, improper control of the conditions can easily lead to side reactions.
The above synthesis methods have their own advantages and disadvantages. In practical application, it is necessary to weigh the availability of raw materials, cost considerations, product purity requirements and other factors to choose the optimal synthesis path.
First, halogenated aromatic hydrocarbons are often used as starting materials. First take 3-chloro-5-fluorobromobenzene and react it with metal magnesium to form Grignard's reagent. This process needs to be operated in a harsh environment without water and oxygen, because Grignard's reagent is extremely active and easily decomposes in contact with water or oxygen. After the Grignard reagent is made, it is reacted with borate esters, such as trimethyl borate. After the reaction is completed, 3-chloro-5-fluorophenylboronic acid can be obtained through a hydrolysis step. The key to this method lies in the control of the conditions for the preparation of Grignard reagents and the precise operation of subsequent reactions.
Second, the cross-coupling reaction catalyzed by palladium can also be used. The reaction of 3-chloro-5-fluorohalobenzene with boron-containing reagents, such as pinacol borane, is carried out in the presence of a suitable base, such as potassium carbonate, catalyzed by a palladium catalyst, such as tetra (triphenylphosphine) palladium (0). This reaction condition is relatively mild and the selectivity is good. However, the cost of the catalyst is high, which may limit the large-scale production. In the reaction, the palladium catalyst promotes the coupling between the halobenzene and the boron-containing reagent to form a carbon-boron bond, and then the target product is obtained.
Third, 3-chloro-5-fluoroaniline can also be considered as the starting material. First, the amino group is converted into a diazonium salt through the diazotization reaction. Subsequently, the diazonium salt is reacted with the boron-containing reagent to realize the conversion to phenylboronic acid. This path has a little more steps, and attention should be paid to the conditions of the diazotization reaction. Due to its high reactivity, improper control of the conditions can easily lead to side reactions.
The above synthesis methods have their own advantages and disadvantages. In practical application, it is necessary to weigh the availability of raw materials, cost considerations, product purity requirements and other factors to choose the optimal synthesis path.
3-chloro-5-fluorobenzeneboronic Acid during storage and transportation
3-Chloro-5-fluorophenylboronic acid is a commonly used reagent in organic synthesis. During storage and transportation, many matters need to be paid attention to.
First of all, storage, this compound is quite sensitive to moisture, so it should be stored in a dry place. If placed in a humid environment, it is easy to react with water and cause quality damage. It can be placed in a sealed container and then placed in a dryer to prevent moisture from invading. Temperature is also a key factor, and it should be stored in a cool place, usually 2-8 ° C. If the temperature is too high, it may cause decomposition or other adverse reactions, which will affect its chemical activity and purity.
As for transportation, due to the certain chemical activity of 3-chloro-5-fluorophenylboronic acid, it is necessary to ensure that the packaging is tight. Commonly used packaging materials should be able to effectively block moisture and air, such as using double-layer plastic bags to seal, and then placed in sturdy cartons or plastic boxes. During transportation, be sure to avoid violent vibration and collisions to prevent package damage. And the transportation environment should also be kept dry and cool, and must not be mixed with oxidants, acids, alkalis and other substances, because they may have chemical reactions with them, causing danger.
All of these are for the storage and transportation of 3-chloro-5-fluorophenylboronic acid, so as to ensure its quality and safety.
First of all, storage, this compound is quite sensitive to moisture, so it should be stored in a dry place. If placed in a humid environment, it is easy to react with water and cause quality damage. It can be placed in a sealed container and then placed in a dryer to prevent moisture from invading. Temperature is also a key factor, and it should be stored in a cool place, usually 2-8 ° C. If the temperature is too high, it may cause decomposition or other adverse reactions, which will affect its chemical activity and purity.
As for transportation, due to the certain chemical activity of 3-chloro-5-fluorophenylboronic acid, it is necessary to ensure that the packaging is tight. Commonly used packaging materials should be able to effectively block moisture and air, such as using double-layer plastic bags to seal, and then placed in sturdy cartons or plastic boxes. During transportation, be sure to avoid violent vibration and collisions to prevent package damage. And the transportation environment should also be kept dry and cool, and must not be mixed with oxidants, acids, alkalis and other substances, because they may have chemical reactions with them, causing danger.
All of these are for the storage and transportation of 3-chloro-5-fluorophenylboronic acid, so as to ensure its quality and safety.
What is the market price range for 3-chloro-5-fluorobenzeneboronic Acid?
The market for 3-chloro-5-fluorophenylboronic acid is often different due to various reasons. In the past, the market situation was influenced by factors such as the supply of raw materials, the ease of synthesis, and the amount of demand.
If the raw materials are abundant and the synthesis method is convenient, and the supply is sufficient, the price may be low and low. However, if the raw materials are scarce and the synthesis step is difficult, it will consume a lot of manpower and material resources, and its price will increase.
And the demand for this compound will also be affected. If the demand for this compound is strong in the world, such as in the fields of synthesis and material research, and the supply is matched, the price will rise. On the contrary, if the demand is low, the price may decline.
In previous market estimates, the market value per gram may range from 10 to 100 yuan. However, this estimate is rough, and the price often varies depending on the price, or varies depending on the quantity and supplier. In order to know the exact price, it is necessary to provide suppliers in order to check the true market price.
If the raw materials are abundant and the synthesis method is convenient, and the supply is sufficient, the price may be low and low. However, if the raw materials are scarce and the synthesis step is difficult, it will consume a lot of manpower and material resources, and its price will increase.
And the demand for this compound will also be affected. If the demand for this compound is strong in the world, such as in the fields of synthesis and material research, and the supply is matched, the price will rise. On the contrary, if the demand is low, the price may decline.
In previous market estimates, the market value per gram may range from 10 to 100 yuan. However, this estimate is rough, and the price often varies depending on the price, or varies depending on the quantity and supplier. In order to know the exact price, it is necessary to provide suppliers in order to check the true market price.
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